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Covalent modification of hexokinase by biologically active quinones
(Oxford : Blackwell Publishing, 2005)
In this work, inhibition of sulfhydryl containing glycolytic enzyme hexokinase by avarone and its derivatives was studied. The enzyme contains lysine and sulfhydryl residues, which can be modified by the quinone moiety. ...
Ring closing metathesis/fragmentation route to (Z)-configured medium ring cycloalkenes. Total synthesis of (+/-)-periplanone C
(American Chemical Society (ACS), 2006)
The combination of ring closing metathesis and beta-fragmentation offers an efficient entry into (Z)-configured medium ring cycloalkenes. The fragmentation step can be effected under anionic or radical conditions. The ...
A novel lectin from the sponge Haliclona cratera: isolation, characterization and biological activity
(Elsevier Science Inc, New York, 2002)
A lectin from the Adriatic sponge Haliclona cratera was purified by ion-exchange and gel chromatography The molecular mass of the lectin is approximately 29 kDa. Purified lectin is rich in hydrophobic and basic amino acids ...
A model study of epothilone synthesis: An alternative synthetic approach to the C1-C7 fragment / Model studija u sintezi epotilona - alternativni pristup sintezi C1-C7 fragmenta
(Serbian Chemical Society, 2002)
In this model study an alternative synthetic approach to the C1–C7 fragment of epothilones was investigated. Starting from 4,4-dimethylcyclopentenone, a 7 step reaction sequence afforded the key intermediate 7 in 27% overall ...
Synthesis, biological evaluation, and modeling of a C,D-seco-taxoid
(Oxford : Pergamon-Elsevier Science Ltd, 2005)
A C,D-seco-paclitaxel derivative 12 was prepared and tested for biological activity. The key step in the synthesis was a free radical fragmentation of the bicyclic tertiary alcohol 7 under the conditions of the hypobromite ...
Reactions of α-4(20)-epoxy-5-O-mesyltriacetyltaxicine I induced by Bf3·Et2O/Bu4NBr / Reakcije α-4(20)-epoksi-5-O-meziltriacetiltaksicina I sa tetrabutilamonijum-bromidom u prisustvu bortrifluorid-eterata
(Serbian Chemical Society, 2006)
The reaction of α-4(20)-epoxy-5-O-mesyltriacetyltaxicine I (2) with BF3·Et2O/Bu4NBr can give rise to 4 different products. Each of these products can be obtained selectively, under the appropriate reaction conditions.
Erratum: Organocatalyzed Cyclizations of pi-allylpalladium complexes: A new method for the construction of five- and six-membered rings (vol 9, pg 5064, 2007)
(American Chemical Society (ACS), 2007)
Page 5064. Two references pertinent to the described work have been omitted in ref 13: For the first example of combining organocatalysis and transition metal catalysis, see: (e) Jellerichs, B. G.; Kong, J.-R.; Krische, ...
Titanium tetrachloride promoted reaction of silyl ketene acetals with epoxides: a new method for the synthesis of gamma-butanolides
(Oxford : Pergamon-Elsevier Science Ltd, 2002)
A new method for the synthesis of gamma-butanolides is described. The titanium tetrachloride promoted reaction of silyl ketene acetals with epoxides, followed by acidic work-up, affords the corresponding butyrolactones in ...