Covalent modification of hexokinase by biologically active quinones
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In this work, inhibition of sulfhydryl containing glycolytic enzyme hexokinase by avarone and its derivatives was studied. The enzyme contains lysine and sulfhydryl residues, which can be modified by the quinone moiety. Our results show that avarone and its derivatives are capable of covalent modification of hexokinase.
Keywords:antitumor agents / quinone / hexokinase / phosphofructokinase / oxygen radicals / avarone
Source:FEBS Journal / Federation of European of Biochemical Societies, 2005, 272, 302-302
- Oxford : Blackwell Publishing