CER - Central Repository
Institute of Chemistry, Technology and Metallurgy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrilic)
    • Serbian (Latin)
  • Login
View Item 
  •   Central Repository
  • IHTM
  • Radovi istraživača / Researchers' publications
  • View Item
  •   Central Repository
  • IHTM
  • Radovi istraživača / Researchers' publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

A model study of epothilone synthesis: An alternative synthetic approach to the C1-C7 fragment

Model studija u sintezi epotilona - alternativni pristup sintezi C1-C7 fragmenta

Thumbnail
2002
49.pdf (96.51Kb)
Authors
Lalić, Gojko
Galonić, Danica
Matović, Radomir
Saičić, Radomir N.
Article (Published version)
Metadata
Show full item record
Abstract
In this model study an alternative synthetic approach to the C1–C7 fragment of epothilones was investigated. Starting from 4,4-dimethylcyclopentenone, a 7 step reaction sequence afforded the key intermediate 7 in 27% overall yield. Surprisingly, the attempted deprotection of latent functionalities in 7 failed, indicating the incompatibility of the ethoxyethyl protective group with the reaction conditions employed.
U okviru model studije ispitivan je alternativni sintetički pristup C1–C7 fragmentu molekula epotilona. Polazeći od 4,4-dimetilciklopentenona, ključni intermedijer 7 dobijen je u sedam faza, u ukupnom prinosu od 27 %. Deprotekciju latentnih funkcionalnih grupa u molekulu 7 nije bilo moguće izvršiti, zbog iznenađujuće labilnosti etoksietil zaštitne grupe u baznim reakcionim uslovima.
Keywords:
epothilones / epoxides / enol ethers / alkylations / Lewis acids
Source:
Journal of the Serbian Chemical Society, 2002, 67, 4, 221-228
Publisher:
  • Serbian Chemical Society

DOI: 10.2298/JSC0204221L

ISSN: 0352-5139

WoS: 000174953500001

Scopus: 2-s2.0-0036000422
[ Google Scholar ]
5
5
URI
http://cer.ihtm.bg.ac.rs/handle/123456789/51
Collections
  • Radovi istraživača / Researchers' publications
Institution
IHTM

DSpace software copyright © 2002-2015  DuraSpace
About CeR – Central Repository | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceInstitutionsAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About CeR – Central Repository | Send Feedback

OpenAIRERCUB