A C,D-seco-paclitaxel derivative 12 was prepared and tested for biological activity. The key step in the synthesis was a free radical fragmentation of the bicyclic tertiary alcohol 7 under the conditions of the hypobromite reaction. The compound 12 showed no activity in the tubulin test. (c) 2005 Elsevier Ltd. All rights reserved.
Keywords:
taxane antitumor agents / radicals and radical reactions / medium sized rings / natural products / molecular modeling
TY - JOUR
AU - Ferjančić, Zorana
AU - Matović, Radomir
AU - Čeković, Živorad
AU - Snyder, James P.
AU - Saičić, Radomir N.
PY - 2005
UR - https://cer.ihtm.bg.ac.rs/handle/123456789/2770
AB - A C,D-seco-paclitaxel derivative 12 was prepared and tested for biological activity. The key step in the synthesis was a free radical fragmentation of the bicyclic tertiary alcohol 7 under the conditions of the hypobromite reaction. The compound 12 showed no activity in the tubulin test. (c) 2005 Elsevier Ltd. All rights reserved.
PB - Oxford : Pergamon-Elsevier Science Ltd
T2 - Tetrahedron Letters
T1 - Synthesis, biological evaluation, and modeling of a C,D-seco-taxoid
VL - 46
IS - 30
SP - 5049
EP - 5052
DO - 10.1016/j.tetlet.2005.05.071
ER -
@article{
author = "Ferjančić, Zorana and Matović, Radomir and Čeković, Živorad and Snyder, James P. and Saičić, Radomir N.",
year = "2005",
abstract = "A C,D-seco-paclitaxel derivative 12 was prepared and tested for biological activity. The key step in the synthesis was a free radical fragmentation of the bicyclic tertiary alcohol 7 under the conditions of the hypobromite reaction. The compound 12 showed no activity in the tubulin test. (c) 2005 Elsevier Ltd. All rights reserved.",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "Tetrahedron Letters",
title = "Synthesis, biological evaluation, and modeling of a C,D-seco-taxoid",
volume = "46",
number = "30",
pages = "5049-5052",
doi = "10.1016/j.tetlet.2005.05.071"
}
Ferjančić, Z., Matović, R., Čeković, Ž., Snyder, J. P.,& Saičić, R. N.. (2005). Synthesis, biological evaluation, and modeling of a C,D-seco-taxoid. in Tetrahedron Letters
Oxford : Pergamon-Elsevier Science Ltd., 46(30), 5049-5052.
https://doi.org/10.1016/j.tetlet.2005.05.071
Ferjančić Z, Matović R, Čeković Ž, Snyder JP, Saičić RN. Synthesis, biological evaluation, and modeling of a C,D-seco-taxoid. in Tetrahedron Letters. 2005;46(30):5049-5052.
doi:10.1016/j.tetlet.2005.05.071 .
Ferjančić, Zorana, Matović, Radomir, Čeković, Živorad, Snyder, James P., Saičić, Radomir N., "Synthesis, biological evaluation, and modeling of a C,D-seco-taxoid" in Tetrahedron Letters, 46, no. 30 (2005):5049-5052,
https://doi.org/10.1016/j.tetlet.2005.05.071 . .
