Synthesis, biological evaluation, and modeling of a C,D-seco-taxoid
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A C,D-seco-paclitaxel derivative 12 was prepared and tested for biological activity. The key step in the synthesis was a free radical fragmentation of the bicyclic tertiary alcohol 7 under the conditions of the hypobromite reaction. The compound 12 showed no activity in the tubulin test. (c) 2005 Elsevier Ltd. All rights reserved.
Keywords:taxane antitumor agents / radicals and radical reactions / medium sized rings / natural products / molecular modeling
Source:Tetrahedron Letters, 2005, 46, 30, 5049-5052
- Pergamon-Elsevier Science Ltd, Oxford