Titanium tetrachloride promoted reaction of silyl ketene acetals with epoxides: a new method for the synthesis of gamma-butanolides
Abstract
A new method for the synthesis of gamma-butanolides is described. The titanium tetrachloride promoted reaction of silyl ketene acetals with epoxides, followed by acidic work-up, affords the corresponding butyrolactones in 44-83%, yield. (C) 2002 Elsevier Science Ltd. All rights reserved.
Keywords:
epoxides / ketene acetals / lactones / titanium and compounds / alkylationSource:
Tetrahedron Letters, 2002, 43, 31, 5411-5413Publisher:
- Pergamon-Elsevier Science Ltd, Oxford
DOI: 10.1016/S0040-4039(02)01070-5
ISSN: 0040-4039