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Now showing items 3071-3080 of 3095
The interplay between spin states, geometries and biological activity of Fe(III) and Mn(II) complexes with thiosemicarbazone
(Elsevier, 2023)
Fe(III) and Mn(II) complexes with condensation product of thiosemicarbazide and 2-acetylthiazole (HL1, (E)-2-(1-(thiazol-2-yl)ethylidene)hydrazine-1-carbothioamide) have been synthesized and characterized by single-crystal ...
Substrate Stereocontrol in the Intramolecular Organocatalyzed Tsuji-Trost Reaction: Enantioselective Synthesis of Allokainates
(American Chemical Society (ACS), 2014)
Organocatalyzed Tsuji-Trost cyclization of 3b proceeds with asymmetric induction and allows for stereoselective synthesis of (+)-allokainic acid. The stereochemical outcome of the cyclization was predicted by calculations.
Total synthesis and biological evaluation of (-)-atrop-abyssomicin C
(Royal Soc Chemistry, Cambridge, 2013)
Enantioselective synthesis of a marine antibiotic (-)-atrop-abyssomicin C was accomplished in 21 steps, in 1.8% overall yield (4%, based on the recovered starting material). The key steps of the synthesis are the formation ...
Ring closing metathesis/fragmentation route to (Z)-configured medium ring cycloalkenes. Total synthesis of (+/-)-periplanone C
(American Chemical Society (ACS), 2006)
The combination of ring closing metathesis and beta-fragmentation offers an efficient entry into (Z)-configured medium ring cycloalkenes. The fragmentation step can be effected under anionic or radical conditions. The ...
A novel lectin from the sponge Haliclona cratera: isolation, characterization and biological activity
(Elsevier Science Inc, New York, 2002)
A lectin from the Adriatic sponge Haliclona cratera was purified by ion-exchange and gel chromatography The molecular mass of the lectin is approximately 29 kDa. Purified lectin is rich in hydrophobic and basic amino acids ...
Double Asymmetric Induction in Organocatalyzed Aldol Reactions: Total Synthesis of (+)-2-epi-Hyacinthacine A(2) and (-)-3-epi-Hyacinthacine A(1)
(Wiley-V C H Verlag Gmbh, Weinheim, 2013)
The stereodivergent synthesis of two hyacinthacine analogues, which relies on an organocatalyzed aldol addition, is described. The aldol addition of dioxanone to an -N-carbobenzyloxy-substituted chiral aldehyde, promoted ...
Synthesis, biological evaluation, and modeling of a C,D-seco-taxoid
(Oxford : Pergamon-Elsevier Science Ltd, 2005)
A C,D-seco-paclitaxel derivative 12 was prepared and tested for biological activity. The key step in the synthesis was a free radical fragmentation of the bicyclic tertiary alcohol 7 under the conditions of the hypobromite ...
Erratum: Organocatalyzed Cyclizations of pi-allylpalladium complexes: A new method for the construction of five- and six-membered rings (vol 9, pg 5064, 2007)
(American Chemical Society (ACS), 2007)
Page 5064. Two references pertinent to the described work have been omitted in ref 13: For the first example of combining organocatalysis and transition metal catalysis, see: (e) Jellerichs, B. G.; Kong, J.-R.; Krische, ...
Titanium tetrachloride promoted reaction of silyl ketene acetals with epoxides: a new method for the synthesis of gamma-butanolides
(Oxford : Pergamon-Elsevier Science Ltd, 2002)
A new method for the synthesis of gamma-butanolides is described. The titanium tetrachloride promoted reaction of silyl ketene acetals with epoxides, followed by acidic work-up, affords the corresponding butyrolactones in ...
Carbohydrate binding polypeptide of Savalia Savaglia
(The World Intellectual Property Organization, 2023)
The present invention relates to a novel polypeptide which displays specific carbohydrate binding activity, particularly against glycans that contain mannose, and in vivo and ex vivo methods of use thereof. Methods of use ...