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Synthesis and biological evaluation of some 17-picolyl and 17-picolinylidene androst-5-ene derivatives
(Elsevier, 2007)
Starting from dehydroepiandrosterone (1) 17-picolyl (2), 17-picolinylidene (7), 17-picolinylidene-16-one (10 and 11), and 17-picolyl-16-one (15) derivatives of androst-5-ene were synthesized in one, two, four and five steps ...
Antitumor effects of a natural anthracycline analog (Aloin) involve altered activity of antioxidant enzymes in HeLaS3 cells
(Taylor & Francis Inc, Philadelphia, 2007)
The anti proliferative and cytotoxic potential of the natural anthracycline aloin from Aloe vera was tested on human uterine carcinoma HeLaS3 cells. Aloin showed a pronounced antiproliferative effect at physiological ...
1-Cinnamyl-4-(2-methoxyphenyl)piperazines: Synthesis, binding properties, and docking to dopamine (D2) and serotonin (5-HT1A) receptors
(Wiley-V C H Verlag Gmbh, Weinheim, 2007)
Clinical properties of atypical antipsychotics are based on their interaction with D2 dopamine receptor and serotonin 5-HT1A and 5-HT2A receptors. As a part of our research program on new antipsychotics, we synthesized ...
Organic-geochemical differentiation of petroleum-type pollutants and study of their fate in Danube alluvial sediments and corresponding water (Pancevo Oil Refinery, Serbia)
(Springer, 2007)
A review is given in this paper of the up-to-date results observed in differentiation and transformation studies on petroleum-type pollutants in underground and surface waters. Water and particulate matter derived from the ...
Effect of pH and human serum albumin on the cytotoxicity of a glucuronide prodrug of 9-aminocamptothecin
(Switzerland : Springer Nature, 2007)
Purpose: 9-aminocamptothecin glucuronide (9ACG) is a prodrug of 9-aminocamptothecin (9AC) that displays potent antitumor activity against human tumor xenografts in nude mice. Camptothecins exist in a pH dependent equilibrium ...
Synthesis, characterization and crystal structure of palladium(II) complexes containing edta tetraalkyl ester ligands
(Ceska Republika : Akademie Ved Ceske Republiky, 2007)
The reaction of solutions of tetraalkyl ethylenediamine-N,N,N′, N′-tetraacetate esters (alkyl = Me, 1a; Et, 1b) with H 2[PdCl4] led to the complexes [PdCl2(R 4EDTA)] (R = Me, 2a; Et, 2b). The coordination of R4EDTA ligands ...
Surface modification of macroporous glycidyl methacrylate based copolymers for selective sorption of heavy metals
(Switzerland : Springer Nature, 2007)
Two samples of macroporous poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate), poly(GMA-co-EGDMA), were synthesized by suspension copolymerization and modified with amines. Initial poly(GMA-co-EGDMA), and the ...
Two new phenylpiperazines with atypical antipsychotic potential
(Oxford : Pergamon-Elsevier Science Ltd, 2007)
Two new series of substituted arylpiperazines with heterocyclic 3-propoxy-benzimidazole or 3-propoxy-benzimidazole-2-thione groups were synthesized and their in vitro binding affinities for the D2, 5-HT1A, 5-HT2A, and ...
Different responses of mesenteric artery from normotensive and spontaneously hypertensive rats to nitric oxide and its redox congeners
(Springer, 2007)
The conversion of nitric oxide (NO
) into its congeners nitrosonium (NO ) and nitroxyl (HNO/NO) ions may have important consequences for signal transduction and physiological responses. Manganese-containing superoxide ...
Immobilization of glucoamylase via its carbohydrate moiety on macroporous poly(GMA-co-EGDMA)
(Elsevier, 2007)
We succeeded in the immobilization of 190 mg of periodate oxidized glucoamylase per gram of macroporous polymer. The covalently immobilized enzyme had a specific activity of 1100 U/g. The temperature and pH optimum as well ...