Different responses of mesenteric artery from normotensive and spontaneously hypertensive rats to nitric oxide and its redox congeners
Само за регистроване кориснике
2007
Чланак у часопису (Објављена верзија)
,
Springer
Метаподаци
Приказ свих података о документуАпстракт
The conversion of nitric oxide (NO
) into its congeners nitrosonium (NO ) and nitroxyl (HNO/NO) ions may have important consequences for signal transduction and physiological responses. Manganese-containing superoxide dismutase (MnSOD) may convert
NO into its redox congeners. In our current work, we have examined the mechanism of sodium nitroprusside (SNP)-induced relaxation of arteries, with or without endothelium, from both normotensive and spontaneously hypertensive (SH) rats in the absence and
presence of MnSOD. SNP induced a greater degree of relaxation in normotensive than in SH rats. MnSOD antagonized SNPinduced relaxation and effect was greater in normotensive than hypertensive rats. However, MnSOD even potentiated SNP-induced
relaxation in mesenteric arteries with endothelium from SH rats. Our results indicate that HNO/NO-mediated relaxation is more effective in mesenteric artery smooth muscle from SH rats than from normotensive rats and that vascular dysfunction in SH rat...s is not
solely endothelium-derived but involves changes in vascular smooth muscl
Кључне речи:
Endothelium / Hypertension / Mesenteric artery / MnSOD / Sodium nitroprussideИзвор:
Pharmacological Report, 2007, 59, 315-322Издавач:
- Springer
Финансирање / пројекти:
Институција/група
IHTMTY - JOUR AU - Oreščanin, Zorana AU - Milovanović, Slobodan R. AU - Spasić, Snežana AU - Jones, David AU - Spasić, Mihajlo PY - 2007 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/3938 AB - The conversion of nitric oxide (NO ) into its congeners nitrosonium (NO ) and nitroxyl (HNO/NO) ions may have important consequences for signal transduction and physiological responses. Manganese-containing superoxide dismutase (MnSOD) may convert NO into its redox congeners. In our current work, we have examined the mechanism of sodium nitroprusside (SNP)-induced relaxation of arteries, with or without endothelium, from both normotensive and spontaneously hypertensive (SH) rats in the absence and presence of MnSOD. SNP induced a greater degree of relaxation in normotensive than in SH rats. MnSOD antagonized SNPinduced relaxation and effect was greater in normotensive than hypertensive rats. However, MnSOD even potentiated SNP-induced relaxation in mesenteric arteries with endothelium from SH rats. Our results indicate that HNO/NO-mediated relaxation is more effective in mesenteric artery smooth muscle from SH rats than from normotensive rats and that vascular dysfunction in SH rats is not solely endothelium-derived but involves changes in vascular smooth muscl PB - Springer T2 - Pharmacological Report T1 - Different responses of mesenteric artery from normotensive and spontaneously hypertensive rats to nitric oxide and its redox congeners VL - 59 SP - 315 EP - 322 UR - https://hdl.handle.net/21.15107/rcub_cer_3938 ER -
@article{ author = "Oreščanin, Zorana and Milovanović, Slobodan R. and Spasić, Snežana and Jones, David and Spasić, Mihajlo", year = "2007", abstract = "The conversion of nitric oxide (NO ) into its congeners nitrosonium (NO ) and nitroxyl (HNO/NO) ions may have important consequences for signal transduction and physiological responses. Manganese-containing superoxide dismutase (MnSOD) may convert NO into its redox congeners. In our current work, we have examined the mechanism of sodium nitroprusside (SNP)-induced relaxation of arteries, with or without endothelium, from both normotensive and spontaneously hypertensive (SH) rats in the absence and presence of MnSOD. SNP induced a greater degree of relaxation in normotensive than in SH rats. MnSOD antagonized SNPinduced relaxation and effect was greater in normotensive than hypertensive rats. However, MnSOD even potentiated SNP-induced relaxation in mesenteric arteries with endothelium from SH rats. Our results indicate that HNO/NO-mediated relaxation is more effective in mesenteric artery smooth muscle from SH rats than from normotensive rats and that vascular dysfunction in SH rats is not solely endothelium-derived but involves changes in vascular smooth muscl", publisher = "Springer", journal = "Pharmacological Report", title = "Different responses of mesenteric artery from normotensive and spontaneously hypertensive rats to nitric oxide and its redox congeners", volume = "59", pages = "315-322", url = "https://hdl.handle.net/21.15107/rcub_cer_3938" }
Oreščanin, Z., Milovanović, S. R., Spasić, S., Jones, D.,& Spasić, M.. (2007). Different responses of mesenteric artery from normotensive and spontaneously hypertensive rats to nitric oxide and its redox congeners. in Pharmacological Report Springer., 59, 315-322. https://hdl.handle.net/21.15107/rcub_cer_3938
Oreščanin Z, Milovanović SR, Spasić S, Jones D, Spasić M. Different responses of mesenteric artery from normotensive and spontaneously hypertensive rats to nitric oxide and its redox congeners. in Pharmacological Report. 2007;59:315-322. https://hdl.handle.net/21.15107/rcub_cer_3938 .
Oreščanin, Zorana, Milovanović, Slobodan R., Spasić, Snežana, Jones, David, Spasić, Mihajlo, "Different responses of mesenteric artery from normotensive and spontaneously hypertensive rats to nitric oxide and its redox congeners" in Pharmacological Report, 59 (2007):315-322, https://hdl.handle.net/21.15107/rcub_cer_3938 .