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Antitumor effects of a natural anthracycline analog (Aloin) involve altered activity of antioxidant enzymes in HeLaS3 cells

Authorized Users Only
2007
Authors
Niciforovic, Ana
Adžić, Miroslav
Spasić, Snežana
Radojcic, Marija B.
Article (Published version)
Metadata
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Abstract
The anti proliferative and cytotoxic potential of the natural anthracycline aloin from Aloe vera was tested on human uterine carcinoma HeLaS3 cells. Aloin showed a pronounced antiproliferative effect at physiological concentration (IC50 =97 mu M), caused cell cycle arrest in the S phase and markedly increased HeLaS3 cell apoptosis (to 24%). In the concentration range of 20-100 mu M, its action was accompanied by remarkable changes in the activity of almost all antioxidant enzymes: MnSOD activity was increased many fold, while CuZnSOD and iNOS activities were inhibited. Moreover, inhibition of CuZnSOD was shown to occur by direct aloin interaction with the enzyme. As catalase activity was not changed, it is suggested that such conditions were responsible for antiproliferative and cytotoxic effects owing to accumulation of H2O2. Aloin alone was a more potent proapoptotic agent than a 2 Gy fractional dose of ionizing radiation or a combination of the two. Compared to other currently used ...therapeutics, aloin, due to its less undesirable side effects and antimetastatic potential, may prove to be the agent of choice on which clinical protocols for the treatment of human cervical carcinoma should rely in future.

Keywords:
aloin / antioxidant enzymes / NF kappa B / HeLaS3 cells / cytotoxicity / cell cycle / proliferation / ionizing radiation
Source:
Cancer Biology & Therapy, 2007, 6, 8, 1200-1205
Publisher:
  • Taylor & Francis Inc, Philadelphia

ISSN: 1538-4047

PubMed: 17726368

WoS: 000252666800021

Scopus: 2-s2.0-39749084006
[ Google Scholar ]
45
33
Handle
https://hdl.handle.net/21.15107/rcub_cer_335
URI
https://cer.ihtm.bg.ac.rs/handle/123456789/335
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
IHTM
TY  - JOUR
AU  - Niciforovic, Ana
AU  - Adžić, Miroslav
AU  - Spasić, Snežana
AU  - Radojcic, Marija B.
PY  - 2007
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/335
AB  - The anti proliferative and cytotoxic potential of the natural anthracycline aloin from Aloe vera was tested on human uterine carcinoma HeLaS3 cells. Aloin showed a pronounced antiproliferative effect at physiological concentration (IC50 =97 mu M), caused cell cycle arrest in the S phase and markedly increased HeLaS3 cell apoptosis (to 24%). In the concentration range of 20-100 mu M, its action was accompanied by remarkable changes in the activity of almost all antioxidant enzymes: MnSOD activity was increased many fold, while CuZnSOD and iNOS activities were inhibited. Moreover, inhibition of CuZnSOD was shown to occur by direct aloin interaction with the enzyme. As catalase activity was not changed, it is suggested that such conditions were responsible for antiproliferative and cytotoxic effects owing to accumulation of H2O2. Aloin alone was a more potent proapoptotic agent than a 2 Gy fractional dose of ionizing radiation or a combination of the two. Compared to other currently used therapeutics, aloin, due to its less undesirable side effects and antimetastatic potential, may prove to be the agent of choice on which clinical protocols for the treatment of human cervical carcinoma should rely in future.
PB  - Taylor & Francis Inc, Philadelphia
T2  - Cancer Biology & Therapy
T1  - Antitumor effects of a natural anthracycline analog (Aloin) involve altered activity of antioxidant enzymes in HeLaS3 cells
VL  - 6
IS  - 8
SP  - 1200
EP  - 1205
UR  - https://hdl.handle.net/21.15107/rcub_cer_335
ER  - 
@article{
author = "Niciforovic, Ana and Adžić, Miroslav and Spasić, Snežana and Radojcic, Marija B.",
year = "2007",
abstract = "The anti proliferative and cytotoxic potential of the natural anthracycline aloin from Aloe vera was tested on human uterine carcinoma HeLaS3 cells. Aloin showed a pronounced antiproliferative effect at physiological concentration (IC50 =97 mu M), caused cell cycle arrest in the S phase and markedly increased HeLaS3 cell apoptosis (to 24%). In the concentration range of 20-100 mu M, its action was accompanied by remarkable changes in the activity of almost all antioxidant enzymes: MnSOD activity was increased many fold, while CuZnSOD and iNOS activities were inhibited. Moreover, inhibition of CuZnSOD was shown to occur by direct aloin interaction with the enzyme. As catalase activity was not changed, it is suggested that such conditions were responsible for antiproliferative and cytotoxic effects owing to accumulation of H2O2. Aloin alone was a more potent proapoptotic agent than a 2 Gy fractional dose of ionizing radiation or a combination of the two. Compared to other currently used therapeutics, aloin, due to its less undesirable side effects and antimetastatic potential, may prove to be the agent of choice on which clinical protocols for the treatment of human cervical carcinoma should rely in future.",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Cancer Biology & Therapy",
title = "Antitumor effects of a natural anthracycline analog (Aloin) involve altered activity of antioxidant enzymes in HeLaS3 cells",
volume = "6",
number = "8",
pages = "1200-1205",
url = "https://hdl.handle.net/21.15107/rcub_cer_335"
}
Niciforovic, A., Adžić, M., Spasić, S.,& Radojcic, M. B.. (2007). Antitumor effects of a natural anthracycline analog (Aloin) involve altered activity of antioxidant enzymes in HeLaS3 cells. in Cancer Biology & Therapy
Taylor & Francis Inc, Philadelphia., 6(8), 1200-1205.
https://hdl.handle.net/21.15107/rcub_cer_335
Niciforovic A, Adžić M, Spasić S, Radojcic MB. Antitumor effects of a natural anthracycline analog (Aloin) involve altered activity of antioxidant enzymes in HeLaS3 cells. in Cancer Biology & Therapy. 2007;6(8):1200-1205.
https://hdl.handle.net/21.15107/rcub_cer_335 .
Niciforovic, Ana, Adžić, Miroslav, Spasić, Snežana, Radojcic, Marija B., "Antitumor effects of a natural anthracycline analog (Aloin) involve altered activity of antioxidant enzymes in HeLaS3 cells" in Cancer Biology & Therapy, 6, no. 8 (2007):1200-1205,
https://hdl.handle.net/21.15107/rcub_cer_335 .

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