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Antitumor effects of a natural anthracycline analog (Aloin) involve altered activity of antioxidant enzymes in HeLaS3 cells

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2007
Authors
Niciforovic, Ana
Adžić, Miroslav
Spasić, Snežana
Radojcic, Marija B.
Article (Published version)
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Abstract
The anti proliferative and cytotoxic potential of the natural anthracycline aloin from Aloe vera was tested on human uterine carcinoma HeLaS3 cells. Aloin showed a pronounced antiproliferative effect at physiological concentration (IC50 =97 mu M), caused cell cycle arrest in the S phase and markedly increased HeLaS3 cell apoptosis (to 24%). In the concentration range of 20-100 mu M, its action was accompanied by remarkable changes in the activity of almost all antioxidant enzymes: MnSOD activity was increased many fold, while CuZnSOD and iNOS activities were inhibited. Moreover, inhibition of CuZnSOD was shown to occur by direct aloin interaction with the enzyme. As catalase activity was not changed, it is suggested that such conditions were responsible for antiproliferative and cytotoxic effects owing to accumulation of H2O2. Aloin alone was a more potent proapoptotic agent than a 2 Gy fractional dose of ionizing radiation or a combination of the two. Compared to other currently used ...therapeutics, aloin, due to its less undesirable side effects and antimetastatic potential, may prove to be the agent of choice on which clinical protocols for the treatment of human cervical carcinoma should rely in future.

Keywords:
aloin / antioxidant enzymes / NF kappa B / HeLaS3 cells / cytotoxicity / cell cycle / proliferation / ionizing radiation
Source:
Cancer Biology & Therapy, 2007, 6, 8, 1200-1205
Publisher:
  • Taylor & Francis Inc, Philadelphia

ISSN: 1538-4047

PubMed: 17726368

WoS: 000252666800021

Scopus: 2-s2.0-39749084006
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/335
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