Two new phenylpiperazines with atypical antipsychotic potential
Authorized Users Only
2007
Authors
Tomić, MirkoIgnjatović, D.
Tovilović, Gordana

Andrić, Deana

Roglić, Goran

Kostić Rajačić, Slađana

Article (Published version)

Metadata
Show full item recordAbstract
Two new series of substituted arylpiperazines with heterocyclic 3-propoxy-benzimidazole or 3-propoxy-benzimidazole-2-thione groups were synthesized and their in vitro binding affinities for the D2, 5-HT1A, 5-HT2A, and α1-adrenergic receptors determined. Among them, only two compounds with phenyl aryl-constituent (8a and 9a) showed 5-HT2A/D2 pKi binding ratios proposed for atypical neuroleptics. As to their behavioral screening on rodents, both compounds exhibited a non-cataleptic action in rats and antagonized d-amphetamine-induced hyperlocomotion in mice, suggesting their possible atypical antipsychotic potency.
Keywords:
Arylpiperazines / Atypical antipsychotics / Dopamine receptors / Serotonin receptorsSource:
Bioorganic and Medicinal Chemistry Letters, 2007, 17, 21, 5749-5753Publisher:
- Pergamon-Elsevier Science Ltd, Oxford
Projects:
- Biomedicinska ispitivanja i razvoj nekih novih psihotropnih supstanci (RS-143032)
- Sinteza i karakterizacija biološki aktivnih supstanci i kompjuterska simulacija bioloških sistema (RS-142009)
DOI: 10.1016/j.bmcl.2007.08.066
ISSN: 0960-894X
PubMed: 17870534