Two new series of substituted arylpiperazines with heterocyclic 3-propoxy-benzimidazole or 3-propoxy-benzimidazole-2-thione groups were synthesized and their in vitro binding affinities for the D2, 5-HT1A, 5-HT2A, and α1-adrenergic receptors determined. Among them, only two compounds with phenyl aryl-constituent (8a and 9a) showed 5-HT2A/D2 pKi binding ratios proposed for atypical neuroleptics. As to their behavioral screening on rodents, both compounds exhibited a non-cataleptic action in rats and antagonized d-amphetamine-induced hyperlocomotion in mice, suggesting their possible atypical antipsychotic potency.
TY - JOUR
AU - Tomić, Mirko
AU - Ignjatović, D.
AU - Tovilović, Gordana
AU - Andrić, Deana
AU - Roglić, Goran
AU - Kostić Rajačić, Slađana
PY - 2007
UR - http://cer.ihtm.bg.ac.rs/handle/123456789/354
AB - Two new series of substituted arylpiperazines with heterocyclic 3-propoxy-benzimidazole or 3-propoxy-benzimidazole-2-thione groups were synthesized and their in vitro binding affinities for the D2, 5-HT1A, 5-HT2A, and α1-adrenergic receptors determined. Among them, only two compounds with phenyl aryl-constituent (8a and 9a) showed 5-HT2A/D2 pKi binding ratios proposed for atypical neuroleptics. As to their behavioral screening on rodents, both compounds exhibited a non-cataleptic action in rats and antagonized d-amphetamine-induced hyperlocomotion in mice, suggesting their possible atypical antipsychotic potency.
PB - Pergamon-Elsevier Science Ltd, Oxford
T2 - Bioorganic and Medicinal Chemistry Letters
T1 - Two new phenylpiperazines with atypical antipsychotic potential
VL - 17
IS - 21
SP - 5749
EP - 5753
DO - 10.1016/j.bmcl.2007.08.066
ER -
@article{
author = "Tomić, Mirko and Ignjatović, D. and Tovilović, Gordana and Andrić, Deana and Roglić, Goran and Kostić Rajačić, Slađana",
year = "2007",
url = "http://cer.ihtm.bg.ac.rs/handle/123456789/354",
abstract = "Two new series of substituted arylpiperazines with heterocyclic 3-propoxy-benzimidazole or 3-propoxy-benzimidazole-2-thione groups were synthesized and their in vitro binding affinities for the D2, 5-HT1A, 5-HT2A, and α1-adrenergic receptors determined. Among them, only two compounds with phenyl aryl-constituent (8a and 9a) showed 5-HT2A/D2 pKi binding ratios proposed for atypical neuroleptics. As to their behavioral screening on rodents, both compounds exhibited a non-cataleptic action in rats and antagonized d-amphetamine-induced hyperlocomotion in mice, suggesting their possible atypical antipsychotic potency.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Bioorganic and Medicinal Chemistry Letters",
title = "Two new phenylpiperazines with atypical antipsychotic potential",
volume = "17",
number = "21",
pages = "5749-5753",
doi = "10.1016/j.bmcl.2007.08.066"
}
Tomić, M., Ignjatović, D., Tovilović, G., Andrić, D., Roglić, G.,& Kostić Rajačić, S. (2007). Two new phenylpiperazines with atypical antipsychotic potential.
Bioorganic and Medicinal Chemistry Letters
Pergamon-Elsevier Science Ltd, Oxford., 17(21), 5749-5753.
https://doi.org/10.1016/j.bmcl.2007.08.066
Tomić M, Ignjatović D, Tovilović G, Andrić D, Roglić G, Kostić Rajačić S. Two new phenylpiperazines with atypical antipsychotic potential. Bioorganic and Medicinal Chemistry Letters. 2007;17(21):5749-5753
Tomić Mirko, Ignjatović D., Tovilović Gordana, Andrić Deana, Roglić Goran, Kostić Rajačić Slađana, "Two new phenylpiperazines with atypical antipsychotic potential" Bioorganic and Medicinal Chemistry Letters, 17, no. 21 (2007):5749-5753,
https://doi.org/10.1016/j.bmcl.2007.08.066 .
