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Newly Synthesized Fluorinated Cinnamylpiperazines Possessing Low In Vitro MAO-B Binding
(MDPI, 2020)
Herein, we report on the synthesis and pharmacological evaluation of ten novel fluorinated cinnamylpiperazines as potential monoamine oxidase B (MAO-B) ligands. The designed derivatives consist of either cinnamyl or ...
In vitro and in vivo evaluation of fluorinated indanone derivatives as potential positron emission tomography agents for the imaging of monoamine oxidase B in the brain
(Elsevier, 2021)
Monoamine oxidases (MAOs) play a key role in the metabolism of major monoamine neurotransmitters. In particular, the upregulation of MAO-B in Parkinson's disease, Alzheimer's disease and cancer augmented the development ...
3D-QSAR, molecular docking and in silico ADMET studies of propiophenone derivatives with anti-HIV-1 protease activity
(Springer Nature, 2021)
HIV protease inhibitors are one of the most important agents for the treatment of HIV infection. In this work, molecular modeling studies combining 3D-QSAR, molecular docking, MESP, HOMO, and LUMO energy calculations were ...
How aromatic system size affects the sensitivities of highly energetic molecules?
(Royal Society of Chemistry, 2021)
Positive values of electrostatic potentials above the central regions of the molecular surface are strongly related to the high sensitivities of highly energetic molecules. The influence of aromatic system size on the ...
Turbulence recognition in free convective flow by thermal - video post -processing in the case of a thermal power plant mill
(Serbia : Serbian Society of Heat Transfer Engineers, 2021)
This paper presents a study of a free convection flow around the walls of a ventilation mill of the Thermal Power Plant “Kostolac B”, Kostolac, Serbia. A combined method consists of thermography and software post-processing, ...
Recombinant Bet v 1-BanLec chimera modulates functional characteristics of peritoneal murine macrophages by promoting IL-10 secretion
(Elsevier, 2021)
Allergen-specific immunotherapy (AIT) is a desensitizing treatment for allergic diseases that corrects the underlined pathological immune response to innocuous protein antigens, called allergens. Recombinant allergens ...
Intermittent Chaos in the CSTR Bray–Liebhafsky Oscillator-Specific Flow Rate Dependence
(Frontiers Media S.A., 2020)
Dynamic states with intermittent oscillations consist of a chaotic mixture of large
amplitude relaxation oscillations grouped in bursts, and between them, small-amplitude
sinusoidal oscillations, or even the quiescent ...
Biotransformation of Perrottetin F by Aspergillus niger: New Bioactive Secondary Metabolites
(Türkiye : ACG Publications, 2021)
Biotransformation of bis-bibenzyl perrottetin F (1), isolated from the liverwort Lunularia cruciata by Aspergillus niger, has been investigated. New metabolites (2-4) have been isolated using reversed phase semipreparative ...
Corrosion behaviour of AA2024 aluminium alloy in different tempers in NaCl solution and with the CeCl3 corrosion inhibitor
(Wiley - VCH Verlag GmbH & Co, 2020)
The paper analyses the corrosion behaviour of naturally and artificially aged
AA2024 alloy in NaCl solution and in the presence of an environment ‐ friendly
corrosion inhibitor, CeCl 3 . On the basis of the values of ...
Chelate coordination compounds as a new class of high-energy materials: The case of nitro-bis(acetylacetonato) complexes
(MDPI, 2021)
The existence of areas of strongly positive electrostatic potential in the central regions of the molecular surface of high-energy molecules is a strong indicator that these compounds are very sensitive towards detonation. ...