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Prikaz rezultata 1-10 od 31
Synthesis and pharmacological evaluation of novel cis and trans 3‑substituted anilidopiperidines
(Springer Nature, 2020)
Background 4-Anilidopiperidine class of synthetic opioid analgesics, with it’s representative fentanyl, are by far the most potent and clinically significant for the treatment of the severe chronic and surgical pain. ...
Complexes of Zn(II)–Triazoles with CO2 and H2O: Structures, Energetics, and Applications
(American Chemical Society (ACS), 2019)
Using a first-principle methodology, we investigate the stable structures of the nonreactive and reactive clusters formed between Zn2+–triazoles ([Zn2+-Tz]) clusters and CO2 and/or H2O. In sum, we characterized two modes ...
Chemo- and biocatalytic esterification of marchantin A and cytotoxic activity of ester derivatives
(Elsevier, 2020)
Chemical and biocatalytic synthesis of seven previously undescribed marchantin A ester derivatives has been presented. Chemical synthesis afforded three peresterified bisbibenzyl products (TE1-TE3), while enzymatic method, ...
Edaravone May Prevent Ferroptosis in ALS
(Bentham Science, 2020)
Radicava™ (Edaravone) was approved the Food and Drug Administration (FDA) as a new treatment for amyotrophic lateral sclerosis (ALS). Edaravone is a synthetic antioxidant that specifically targets oxidative damage interacting ...
Increased yield of enzymatic synthesis by chromatographic selection of different N-glycoforms of yeast invertase
(Wiley, 2020)
Invertases are glycosidases applied for synthesis of alkyl glycosides that are important and effective surfactants. Stability of invertases in the environment with increased content of organic solvent is crucial for increase ...
Novel derivatives of aroylacrylic acid phenylamides as inducers of apoptosis through the ROS-mediated pathway in several cancer cell lines
(Elsevier, 2022)
In the present work, the α, β-double bond of the aroylacrylic acid phenylamides was suitably modified to optimize the toxicity–antiproliferative activity ratio of the resulting compounds 1 –5 . The phenylamides were modified ...
Bisaurones-enzymatic production and biological evaluation
(Royal Society of Chemistry, 2020)
The Trametes versicolor laccase catalyzed oxidation of chalcone butein afforded four dimers of aurone sulfuretin (i.e. two regioisomeric pairs of diasteromers, 1-4) as the major products. The formation of the dimers was ...
Multi-disciplinary Shape Optimization of Missile Fin Configuration Subject to Aerodynamic Heating
(American Institute of Aeronautics and Astronautics, 2020)
The main goal of this paper is to expand previously conducted study and consequently to upgrade the proposed multimodular numerical framework developed for fluid–structure interaction simulation (FSI) and multidisciplinary ...
Modulating Excited Charge-Transfer States of G‑Quartet Self- Assemblies by Earth Alkaline Cations and Hydration
(American Chemical Society (ACS), 2020)
Guanine self-assemblies are promising supramolecularplatforms for optoelectronic applications. The study (Hua et al., J. Phys. Chem. C 2012, 116, 14,682−14,689) reported that alkaline cations cannot modulate the electronic ...
Synthesis, X-ray structures and magnetic properties of Ni(II) complexes of heteroaromatic hydrazone
(Elsevier, 2020)
Two binuclear double end-on azido bridged Ni(II) complexes, [Ni2L2(μ-1,1-N3)2(N3)2]⋅2H2O (1a), and [Ni2L2(μ-1,1-N3)2(N3)2]⋅4H2O (1b) having the same inner sphere, where L=((E)-N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl) ...