Edaravone May Prevent Ferroptosis in ALS
Authors
Spasić, Snežana
Nikolić-Kokić, Aleksandra

Miletić, Srđan

Oreščanin-Dušić, Zorana

Spasić, Mihajlo

Blagojević, Duško

Stević, Zorica

Article (Accepted Version)
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Radicava™ (Edaravone) was approved the Food and Drug Administration (FDA) as a new treatment for amyotrophic lateral sclerosis (ALS). Edaravone is a synthetic antioxidant that specifically targets oxidative damage interacting with lipid radicals in the cell. In ALS disease the multiple cell types are involved in devastating loss of motor neurons. Mutations and biochemical changes in various cell types jointly contribute to motor neuron death, disease onset, and disease progression. The overall mechanism of neurodegeneration in ALS is still not completely understood. Dying motor neurons have been reported to exhibit features of apoptosis. However, non-apoptotic features of dying motor neurons have also been reported such as ferroptosis. The role of Edaravone in the prevention of ferroptosis in parallel with other therapeutic approaches to ALS therapy is discussed.
Keywords:
Edaravone / amyotrophic lateral sclerosis (ALS) / ferroptosis / therapy / neurons / neurodegenerationSource:
Current Drug Targets, 2020, 21, 8, 776-780Publisher:
- Bentham Science
Funding / projects:
Note:
- This is the peer-reviewed version of the article: Spasic, Snezana; Nikolic-Kokic, Aleksandra; Miletic, Srdan; Orescanin-Dusic, Zorana; Spasic, Mihajlo B; Blagojevic, Dusko; Stevic, Zorica. Curr Drug Targets ; 21(8): 776-780, 2020, doi: https://doi.org/10.2174/1389450121666200220123305
DOI: 10.2174/1389450121666200220123305
ISSN: 1389-4501
WoS: 000542986600002
Scopus: 2-s2.0-85087096289
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IHTMTY - JOUR AU - Spasić, Snežana AU - Nikolić-Kokić, Aleksandra AU - Miletić, Srđan AU - Oreščanin-Dušić, Zorana AU - Spasić, Mihajlo AU - Blagojević, Duško AU - Stević, Zorica PY - 2020 UR - https://www.eurekaselect.com/179582/article UR - https://cer.ihtm.bg.ac.rs/handle/123456789/3966 AB - Radicava™ (Edaravone) was approved the Food and Drug Administration (FDA) as a new treatment for amyotrophic lateral sclerosis (ALS). Edaravone is a synthetic antioxidant that specifically targets oxidative damage interacting with lipid radicals in the cell. In ALS disease the multiple cell types are involved in devastating loss of motor neurons. Mutations and biochemical changes in various cell types jointly contribute to motor neuron death, disease onset, and disease progression. The overall mechanism of neurodegeneration in ALS is still not completely understood. Dying motor neurons have been reported to exhibit features of apoptosis. However, non-apoptotic features of dying motor neurons have also been reported such as ferroptosis. The role of Edaravone in the prevention of ferroptosis in parallel with other therapeutic approaches to ALS therapy is discussed. PB - Bentham Science T2 - Current Drug Targets T1 - Edaravone May Prevent Ferroptosis in ALS VL - 21 IS - 8 SP - 776 EP - 780 DO - 10.2174/1389450121666200220123305 ER -
@article{ author = "Spasić, Snežana and Nikolić-Kokić, Aleksandra and Miletić, Srđan and Oreščanin-Dušić, Zorana and Spasić, Mihajlo and Blagojević, Duško and Stević, Zorica", year = "2020", abstract = "Radicava™ (Edaravone) was approved the Food and Drug Administration (FDA) as a new treatment for amyotrophic lateral sclerosis (ALS). Edaravone is a synthetic antioxidant that specifically targets oxidative damage interacting with lipid radicals in the cell. In ALS disease the multiple cell types are involved in devastating loss of motor neurons. Mutations and biochemical changes in various cell types jointly contribute to motor neuron death, disease onset, and disease progression. The overall mechanism of neurodegeneration in ALS is still not completely understood. Dying motor neurons have been reported to exhibit features of apoptosis. However, non-apoptotic features of dying motor neurons have also been reported such as ferroptosis. The role of Edaravone in the prevention of ferroptosis in parallel with other therapeutic approaches to ALS therapy is discussed.", publisher = "Bentham Science", journal = "Current Drug Targets", title = "Edaravone May Prevent Ferroptosis in ALS", volume = "21", number = "8", pages = "776-780", doi = "10.2174/1389450121666200220123305" }
Spasić, S., Nikolić-Kokić, A., Miletić, S., Oreščanin-Dušić, Z., Spasić, M., Blagojević, D.,& Stević, Z.. (2020). Edaravone May Prevent Ferroptosis in ALS. in Current Drug Targets Bentham Science., 21(8), 776-780. https://doi.org/10.2174/1389450121666200220123305
Spasić S, Nikolić-Kokić A, Miletić S, Oreščanin-Dušić Z, Spasić M, Blagojević D, Stević Z. Edaravone May Prevent Ferroptosis in ALS. in Current Drug Targets. 2020;21(8):776-780. doi:10.2174/1389450121666200220123305 .
Spasić, Snežana, Nikolić-Kokić, Aleksandra, Miletić, Srđan, Oreščanin-Dušić, Zorana, Spasić, Mihajlo, Blagojević, Duško, Stević, Zorica, "Edaravone May Prevent Ferroptosis in ALS" in Current Drug Targets, 21, no. 8 (2020):776-780, https://doi.org/10.2174/1389450121666200220123305 . .