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Deoxycholic acid-derived tetraoxane antimalarials and antiproliferatives
(American Chemical Society (ACS), 2007)
The synthesis of deoxycholic acid (DCA)- and cholic acid (CA)-derived mixed tetraoxanes revealed that N-(2-dimethylamino)ethyl derivatives are potent antimalarials in vitro and in vivo. The tetraoxanes presented in this ...
On the specific surface area of nanoporous materials
(Oxford : Pergamon-Elsevier Science Ltd, 2011)
A proper quantification of the specific surface area of nanoporous materials is necessary for a better understanding of the properties that are affected by the high surface-area-to-volume ratio of nanoporous metals, ...
Photodegradation of thiacloprid using Fe/TiO2 as a heterogeneous photo-Fenton catalyst
(Elsevier, 2011)
Three Fe/TiO2 photocatalysts with different content of Fe (1.9, 7.2 and 13.9%, w/w) were synthesized by a simple deposition-precipitation method and characterized by XRD, SEM, N-2 physisorption at 77K and Mossbauer ...
Immobilization of Cell Wall Invertase Modified with Glutaraldehyde for Continuous Production of Invert Sugar
(American Chemical Society (ACS), 2010)
Yeast cell wall invertase (CWI) was modified with dimethyl suberimidate, glutaraldehyde, formaldehyde, and sodium periodate. Retained activity after modification was 45% for CWI modified with formaldehyde, 77% for CWI ...
Influence of thermal treatment on phenolic compounds and antioxidant properties of oak acorns from Serbia
(Elsevier, 2007)
The aim of the present work was to investigate and compare phenolic compounds and antioxidant activity of methanol extracts of Quercus robur and Quercus cerris acorn kernels obtained before and after thermal treatment. ...
A refined pharmacophore identifies potent 4-amino-7-chloroquinoline-based inhibitors of the botulinum neurotoxin serotype A metalloprotease
(American Chemical Society (ACS), 2007)
We previously identified structurally diverse small molecule (non-peptidic) inhibitors (SMNPIs) of the botulinum neurotoxin serotype A (BoNT/A) light chain (LC). Of these, several (including antimalarial drugs) contained ...
Supramolecular Route to Well-Ordered Metal Nanofoams
(American Chemical Society (ACS), 2011)
Metal nanofoams with a porosity above 50% v/v have recently attracted great. Interest In materials science due to their interesting properties.. We.. demonstrate a new straightforward route to prepare such nanofoams using ...
Novel 4-aminoquinolines active against chloroquine-resistant and sensitive P. falciparum strains that also inhibit botulinum serotype A
(American Chemical Society (ACS), 2008)
We report on the initial result of the coupling of 4-amino-7- chloroquinoline with steroidal and adamantane constituents to provide small molecules with excellent in vitro antimalarial activities (IC90 (W2) down to 6.74 ...
New chimeric antimalarials with 4-aminoquinoline moiety linked to a tetraoxane skeleton
(American Chemical Society (ACS), 2008)
The synthesis of the chimeric molecules consisting of two pharmacophores, tetraoxane and 7-chloro-4-aminoquinoline, is reported. The tetraoxanes 2, 4, and 8 show relatively potent in vitro antimalarial activities, with ...
Synthesis and antioxidant properties of fullero-steroidal covalent conjugates
(Oxford : Pergamon-Elsevier Science Ltd, 2007)
Four new fullero-steroids were synthesized starting from gamma-aminobutyric acid (GABA)-incorporated fulleropyrrolidine and corresponding sterols. The synthesis, characterization, preliminary study on in vitro antioxidant ...