Deoxycholic acid-derived tetraoxane antimalarials and antiproliferatives
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2007
Authors
Terzić-Jovanović, Nataša
Opsenica, Dejan

Milić, Dragana

Tinant, Bernard
Smith, K. S.
Milhous, Wilbur K.
Šolaja, Bogdan

Article (Published version)

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The synthesis of deoxycholic acid (DCA)- and cholic acid (CA)-derived mixed tetraoxanes revealed that N-(2-dimethylamino)ethyl derivatives are potent antimalarials in vitro and in vivo. The tetraoxanes presented in this paper are dual inhibitors: besides curing mice in vivo without observed toxic effects, they kill cancer cell lines at very low concentrations. For example, DCA and CA derivatives 16 and 25 cured 3/5 (160 mg/kg/day) and 2/5 (40 mg/kg/day, MTD >960 mg/kg), respectively, and they were extremely active against melanoma LOX IMVI cancer, LC50 = 22 nM and 69 nM, respectively.
Source:
Journal of Medicinal Chemistry, 2007, 50, 21, 5118-5127Publisher:
- American Chemical Society (ACS)
Funding / projects:
DOI: 10.1021/jm070684m
ISSN: 0022-2623
PubMed: 17887664
WoS: 000250110700009
Scopus: 2-s2.0-35348910826
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IHTMTY - JOUR AU - Terzić-Jovanović, Nataša AU - Opsenica, Dejan AU - Milić, Dragana AU - Tinant, Bernard AU - Smith, K. S. AU - Milhous, Wilbur K. AU - Šolaja, Bogdan PY - 2007 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/350 AB - The synthesis of deoxycholic acid (DCA)- and cholic acid (CA)-derived mixed tetraoxanes revealed that N-(2-dimethylamino)ethyl derivatives are potent antimalarials in vitro and in vivo. The tetraoxanes presented in this paper are dual inhibitors: besides curing mice in vivo without observed toxic effects, they kill cancer cell lines at very low concentrations. For example, DCA and CA derivatives 16 and 25 cured 3/5 (160 mg/kg/day) and 2/5 (40 mg/kg/day, MTD >960 mg/kg), respectively, and they were extremely active against melanoma LOX IMVI cancer, LC50 = 22 nM and 69 nM, respectively. PB - American Chemical Society (ACS) T2 - Journal of Medicinal Chemistry T1 - Deoxycholic acid-derived tetraoxane antimalarials and antiproliferatives VL - 50 IS - 21 SP - 5118 EP - 5127 DO - 10.1021/jm070684m ER -
@article{ author = "Terzić-Jovanović, Nataša and Opsenica, Dejan and Milić, Dragana and Tinant, Bernard and Smith, K. S. and Milhous, Wilbur K. and Šolaja, Bogdan", year = "2007", abstract = "The synthesis of deoxycholic acid (DCA)- and cholic acid (CA)-derived mixed tetraoxanes revealed that N-(2-dimethylamino)ethyl derivatives are potent antimalarials in vitro and in vivo. The tetraoxanes presented in this paper are dual inhibitors: besides curing mice in vivo without observed toxic effects, they kill cancer cell lines at very low concentrations. For example, DCA and CA derivatives 16 and 25 cured 3/5 (160 mg/kg/day) and 2/5 (40 mg/kg/day, MTD >960 mg/kg), respectively, and they were extremely active against melanoma LOX IMVI cancer, LC50 = 22 nM and 69 nM, respectively.", publisher = "American Chemical Society (ACS)", journal = "Journal of Medicinal Chemistry", title = "Deoxycholic acid-derived tetraoxane antimalarials and antiproliferatives", volume = "50", number = "21", pages = "5118-5127", doi = "10.1021/jm070684m" }
Terzić-Jovanović, N., Opsenica, D., Milić, D., Tinant, B., Smith, K. S., Milhous, W. K.,& Šolaja, B.. (2007). Deoxycholic acid-derived tetraoxane antimalarials and antiproliferatives. in Journal of Medicinal Chemistry American Chemical Society (ACS)., 50(21), 5118-5127. https://doi.org/10.1021/jm070684m
Terzić-Jovanović N, Opsenica D, Milić D, Tinant B, Smith KS, Milhous WK, Šolaja B. Deoxycholic acid-derived tetraoxane antimalarials and antiproliferatives. in Journal of Medicinal Chemistry. 2007;50(21):5118-5127. doi:10.1021/jm070684m .
Terzić-Jovanović, Nataša, Opsenica, Dejan, Milić, Dragana, Tinant, Bernard, Smith, K. S., Milhous, Wilbur K., Šolaja, Bogdan, "Deoxycholic acid-derived tetraoxane antimalarials and antiproliferatives" in Journal of Medicinal Chemistry, 50, no. 21 (2007):5118-5127, https://doi.org/10.1021/jm070684m . .