The synthesis of deoxycholic acid (DCA)- and cholic acid (CA)-derived mixed tetraoxanes revealed that N-(2-dimethylamino)ethyl derivatives are potent antimalarials in vitro and in vivo. The tetraoxanes presented in this paper are dual inhibitors: besides curing mice in vivo without observed toxic effects, they kill cancer cell lines at very low concentrations. For example, DCA and CA derivatives 16 and 25 cured 3/5 (160 mg/kg/day) and 2/5 (40 mg/kg/day, MTD >960 mg/kg), respectively, and they were extremely active against melanoma LOX IMVI cancer, LC50 = 22 nM and 69 nM, respectively.
Source:
Journal of Medicinal Chemistry, 2007, 50, 21, 5118-5127
TY - JOUR
AU - Terzić-Jovanović, Nataša
AU - Opsenica, Dejan
AU - Milić, Dragana
AU - Tinant, Bernard
AU - Smith, K. S.
AU - Milhous, Wilbur K.
AU - Šolaja, Bogdan
PY - 2007
UR - http://cer.ihtm.bg.ac.rs/handle/123456789/350
AB - The synthesis of deoxycholic acid (DCA)- and cholic acid (CA)-derived mixed tetraoxanes revealed that N-(2-dimethylamino)ethyl derivatives are potent antimalarials in vitro and in vivo. The tetraoxanes presented in this paper are dual inhibitors: besides curing mice in vivo without observed toxic effects, they kill cancer cell lines at very low concentrations. For example, DCA and CA derivatives 16 and 25 cured 3/5 (160 mg/kg/day) and 2/5 (40 mg/kg/day, MTD >960 mg/kg), respectively, and they were extremely active against melanoma LOX IMVI cancer, LC50 = 22 nM and 69 nM, respectively.
PB - American Chemical Society (ACS)
T2 - Journal of Medicinal Chemistry
T1 - Deoxycholic acid-derived tetraoxane antimalarials and antiproliferatives
VL - 50
IS - 21
SP - 5118
EP - 5127
DO - 10.1021/jm070684m
ER -
@article{
author = "Terzić-Jovanović, Nataša and Opsenica, Dejan and Milić, Dragana and Tinant, Bernard and Smith, K. S. and Milhous, Wilbur K. and Šolaja, Bogdan",
year = "2007",
url = "http://cer.ihtm.bg.ac.rs/handle/123456789/350",
abstract = "The synthesis of deoxycholic acid (DCA)- and cholic acid (CA)-derived mixed tetraoxanes revealed that N-(2-dimethylamino)ethyl derivatives are potent antimalarials in vitro and in vivo. The tetraoxanes presented in this paper are dual inhibitors: besides curing mice in vivo without observed toxic effects, they kill cancer cell lines at very low concentrations. For example, DCA and CA derivatives 16 and 25 cured 3/5 (160 mg/kg/day) and 2/5 (40 mg/kg/day, MTD >960 mg/kg), respectively, and they were extremely active against melanoma LOX IMVI cancer, LC50 = 22 nM and 69 nM, respectively.",
publisher = "American Chemical Society (ACS)",
journal = "Journal of Medicinal Chemistry",
title = "Deoxycholic acid-derived tetraoxane antimalarials and antiproliferatives",
volume = "50",
number = "21",
pages = "5118-5127",
doi = "10.1021/jm070684m"
}
Terzić-Jovanović, N., Opsenica, D., Milić, D., Tinant, B., Smith, K. S., Milhous, W. K.,& Šolaja, B. (2007). Deoxycholic acid-derived tetraoxane antimalarials and antiproliferatives.
Journal of Medicinal Chemistry
American Chemical Society (ACS)., 50(21), 5118-5127.
https://doi.org/10.1021/jm070684m
Terzić-Jovanović N, Opsenica D, Milić D, Tinant B, Smith KS, Milhous WK, Šolaja B. Deoxycholic acid-derived tetraoxane antimalarials and antiproliferatives. Journal of Medicinal Chemistry. 2007;50(21):5118-5127
Terzić-Jovanović Nataša, Opsenica Dejan, Milić Dragana, Tinant Bernard, Smith K. S., Milhous Wilbur K., Šolaja Bogdan, "Deoxycholic acid-derived tetraoxane antimalarials and antiproliferatives" Journal of Medicinal Chemistry, 50, no. 21 (2007):5118-5127,
https://doi.org/10.1021/jm070684m .
