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A thermodynamic insight into viral infections: do viruses in a lytic cycle hijack cell metabolism due to their low Gibbs energy?
(Elsevier, 2020)
After adsorption and penetration, a virus hijacks a cell's metabolic machinery and uses it as a medium for its reproduction and growth through multiplication. Growth is competitive, since the same precursors and machinery ...
Food Antioxidants and Their Interaction with Human Proteins
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)
Common to all biological systems and living organisms are molecular interactions, which
may lead to specific physiological events. Most often, a cascade of events occurs, establishing an
equilibrium between possibly ...
Atom counting method for determining elemental composition of viruses and its applications in biothermodynamics and environmental science
(Elsevier, 2022)
Quantitative physicochemical perspective on life processes has been a great asset, in bioengineering and biotechnology. The quantitative physicochemical approach can be applied to practically all organisms, including ...
Thermodynamic insight into viral infections 2: empirical formulas, molecular compositions and thermodynamic properties of SARS, MERS and SARS-CoV-2 (COVID-19) viruses
(Elsevier, 2020)
The current situation with the SARS-CoV-2 pandemic indicates the importance of new approaches in vaccine design. In order to design new attenuated vaccines, to decrease virulence of virus wild types, it is important to ...
Ligand binding to fibrinogen influences its structure and function
(University of Novi Sad - Faculty of Sciences, Department of Biology, 2021)
Fibrinogen is a plasma protein that is highly susceptible to oxidation. Because of this chemical modification, fibrinogen acquires thrombogenic characteristics under different pathophysiological conditions. Increased ...
Elemental composition, heat capacity from 2 to 300 K and derived thermodynamic functions of 5 microorganism species
(Elsevier, 2021)
Detailed elemental analysis and low-temperature calorimetric measurement results are reported for the first time for Gram-positive bacteria, Gram-negative bacteria and mold fungi. Microorganism unit carbon formulas (empirical ...
Strain Wars: Competitive interactions between SARS-CoV-2 strains are explained by Gibbs energy of antigen-receptor binding
(Elsevier, 2022)
Since the beginning of the COVID-19 pandemic, SARS-CoV-2 has mutated several times into new strains, with an increased infectivity. Infectivity of SARS-CoV-2 strains depends on binding affinity of the virus to its host ...
Thermodynamic properties of human tissues
(Society of Thermal Engineers of Serbia, 2020)
This paper reports empirical formulas, enthalpies of formation, molar entropies, Gibbs energies of formation, and molar heat capacities at 25°C and 37°C for human soft tissues. The results show that Gibbs energy, except ...
Omicron BA.2.75 Sublineage (Centaurus) Follows the Expectations of the Evolution Theory: Less Negative Gibbs Energy of Biosynthesis Indicates Decreased Pathogenicity
(MDPI, 2022)
SARS-CoV-2 belongs to the group of RNA viruses with a pronounced tendency to mutate. Omicron BA.2.75 is a subvariant believed to be able to suppress the currently dominant BA.5 and cause a new winter wave of the COVID-19 ...
Omicron BA.2.75 subvariant of SARS-CoV-2 is expected to have the greatest infectivity compared with the competing BA.2 and BA.5, due to most negative Gibbs energy of binding.
(MDPI, 2022)
Omicron BA.2.75 may become the next globally dominant strain of COVID-19 in 2022. The BA.2.75 sub-variant has acquired more mutations (9) in spike protein and other genes of SARS-CoV-2 than any other variant. Thus, its ...