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Different responses of mesenteric artery from normotensive and spontaneously hypertensive rats to nitric oxide and its redox congeners
dc.creator | Oreščanin, Zorana | |
dc.creator | Milovanović, Slobodan R. | |
dc.creator | Spasić, Snežana | |
dc.creator | Jones, David | |
dc.creator | Spasić, Mihajlo | |
dc.date.accessioned | 2020-12-02T12:00:08Z | |
dc.date.available | 2020-12-02T12:00:08Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 1734-1140 | |
dc.identifier.issn | 2299-5684 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/3938 | |
dc.description.abstract | The conversion of nitric oxide (NO ) into its congeners nitrosonium (NO ) and nitroxyl (HNO/NO) ions may have important consequences for signal transduction and physiological responses. Manganese-containing superoxide dismutase (MnSOD) may convert NO into its redox congeners. In our current work, we have examined the mechanism of sodium nitroprusside (SNP)-induced relaxation of arteries, with or without endothelium, from both normotensive and spontaneously hypertensive (SH) rats in the absence and presence of MnSOD. SNP induced a greater degree of relaxation in normotensive than in SH rats. MnSOD antagonized SNPinduced relaxation and effect was greater in normotensive than hypertensive rats. However, MnSOD even potentiated SNP-induced relaxation in mesenteric arteries with endothelium from SH rats. Our results indicate that HNO/NO-mediated relaxation is more effective in mesenteric artery smooth muscle from SH rats than from normotensive rats and that vascular dysfunction in SH rats is not solely endothelium-derived but involves changes in vascular smooth muscl | en |
dc.language.iso | en | sr |
dc.publisher | Springer | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/143034/RS// | sr |
dc.rights | restrictedAccess | sr |
dc.source | Pharmacological Report | sr |
dc.subject | Endothelium | sr |
dc.subject | Hypertension | sr |
dc.subject | Mesenteric artery | sr |
dc.subject | MnSOD | sr |
dc.subject | Sodium nitroprusside | sr |
dc.title | Different responses of mesenteric artery from normotensive and spontaneously hypertensive rats to nitric oxide and its redox congeners | en |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dcterms.abstract | Спасић, Снежана; Орешчанин, Зорана; Спасић, Михајло; Јонес, Давид; Миловановић, Слободан Р.; | |
dc.rights.holder | Springer | sr |
dc.citation.volume | 59 | |
dc.citation.spage | 315 | |
dc.citation.epage | 322 | |
dc.citation.rank | M22 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_cer_3938 | |
dc.identifier.scopus | 2-s2.0-34548131592 | |
dc.identifier.wos | 000248614800009 | |
dc.type.version | publishedVersion | sr |