Претраживање
Приказ резултата 1-5 од 5
Two new jatrophane diterpenes from the roots of Euphorbia nicaeensis / Два нова јатрофанска дитерпена из корена Euphorbia nicaeensis
(Serbian Chemical Society, 2021)
In the previous study fifteen jatrophane diterpenes were isolated from the Euphorbia nicaeensis latex. Fourteen of them have been shown to be potent P-glycoprotein (P-gp) inhibitor in two MDR cancer cells (NCI-H460/R and ...
Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines
(Oxford : Pergamon-Elsevier Science Ltd, 2013)
Thirteen jatrophane diterpenoids (1-10, 13-15), three previously isolated (11, 12, 16) and a known tigliane (17) were isolated from the latex of Euphorbia dendroides. The structures and relative configurations of compounds ...
Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis
(Oxford : Pergamon-Elsevier Science Ltd, 2018)
Seven previously undescribed jatrophane diterpenoids, nicaeenin A-G, with eight known jatrophane diterpenoids, namely euphodendrophanes A-C, F, N, O, Q S, were isolated from latex of Euphorbia nicaeensis collected in Serbia. ...
Molecular and cytogenetic changes in multi-drug resistant cancer cells and their influence on new compounds testing
(Springer, New York, 2013)
Multi-drug resistance (MDR) is a major obstacle to successful cancer treatment. Therefore, in vitro models are necessary for the investigation of the phenotypic changes provoked by cytotoxic agents and more importantly for ...
Novel hybrids of sclareol and 1,2,4-triazolo[1,5-a]pyrimidine show collateral sensitivity in multidrug-resistant glioblastoma cells
(Elsevier, 2023)
The synthesis of 24 hybrid molecules, consisting of naturally occurring sclareol (SCL) and synthetic 1,2,4-triazolo[1,5-a]pyrimidines (TPs), is described. New compounds were designed with the aim of improving the cytotoxic ...