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Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines

Authorized Users Only
2013
Authors
Jadranin, Milka
Pešić, Milica
Aljančić, Ivana
Milosavljević, Slobodan
Todorović, Nina
Podolski-Renic, Ana
Bankovic, Jasna
Tanic, Nikola
Markovic, Ivanka
Vajs, Vlatka
Tešević, Vele
Article (Published version)
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Abstract
Thirteen jatrophane diterpenoids (1-10, 13-15), three previously isolated (11, 12, 16) and a known tigliane (17) were isolated from the latex of Euphorbia dendroides. The structures and relative configurations of compounds were elucidated by spectroscopic techniques. The P-glycoprotein (P-gp) inhibiting activities of the representative set of jatrophanes (1-6 and 11-16) have been assessed. Jatrophanes 2 and 5 demonstrated the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).
Keywords:
Euphorbia dendroides / Euphorbiaceae / Isolation / Jatrophanes / Euphodendrophanes G-S / P-glycoprotein / Multi-drug resistance
Source:
Phytochemistry, 2013, 86, 208-217
Publisher:
  • Oxford : Pergamon-Elsevier Science Ltd
Funding / projects:
  • Natural products of wild, cultivated and edible plants: structure and bioactivity determination (RS-172053)
  • Identification of predictive molecular markers for cancer progression, response to therapy and disease outcome (RS-41031)

DOI: 10.1016/j.phytochem.2012.09.003

ISSN: 0031-9422

PubMed: 23079764

WoS: 000315017100024

Scopus: 2-s2.0-84872042428
[ Google Scholar ]
37
30
URI
https://cer.ihtm.bg.ac.rs/handle/123456789/1278
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
IHTM
TY  - JOUR
AU  - Jadranin, Milka
AU  - Pešić, Milica
AU  - Aljančić, Ivana
AU  - Milosavljević, Slobodan
AU  - Todorović, Nina
AU  - Podolski-Renic, Ana
AU  - Bankovic, Jasna
AU  - Tanic, Nikola
AU  - Markovic, Ivanka
AU  - Vajs, Vlatka
AU  - Tešević, Vele
PY  - 2013
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1278
AB  - Thirteen jatrophane diterpenoids (1-10, 13-15), three previously isolated (11, 12, 16) and a known tigliane (17) were isolated from the latex of Euphorbia dendroides. The structures and relative configurations of compounds were elucidated by spectroscopic techniques. The P-glycoprotein (P-gp) inhibiting activities of the representative set of jatrophanes (1-6 and 11-16) have been assessed. Jatrophanes 2 and 5 demonstrated the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).
PB  - Oxford : Pergamon-Elsevier Science Ltd
T2  - Phytochemistry
T1  - Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines
VL  - 86
SP  - 208
EP  - 217
DO  - 10.1016/j.phytochem.2012.09.003
ER  - 
@article{
author = "Jadranin, Milka and Pešić, Milica and Aljančić, Ivana and Milosavljević, Slobodan and Todorović, Nina and Podolski-Renic, Ana and Bankovic, Jasna and Tanic, Nikola and Markovic, Ivanka and Vajs, Vlatka and Tešević, Vele",
year = "2013",
abstract = "Thirteen jatrophane diterpenoids (1-10, 13-15), three previously isolated (11, 12, 16) and a known tigliane (17) were isolated from the latex of Euphorbia dendroides. The structures and relative configurations of compounds were elucidated by spectroscopic techniques. The P-glycoprotein (P-gp) inhibiting activities of the representative set of jatrophanes (1-6 and 11-16) have been assessed. Jatrophanes 2 and 5 demonstrated the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "Phytochemistry",
title = "Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines",
volume = "86",
pages = "208-217",
doi = "10.1016/j.phytochem.2012.09.003"
}
Jadranin, M., Pešić, M., Aljančić, I., Milosavljević, S., Todorović, N., Podolski-Renic, A., Bankovic, J., Tanic, N., Markovic, I., Vajs, V.,& Tešević, V.. (2013). Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines. in Phytochemistry
Oxford : Pergamon-Elsevier Science Ltd., 86, 208-217.
https://doi.org/10.1016/j.phytochem.2012.09.003
Jadranin M, Pešić M, Aljančić I, Milosavljević S, Todorović N, Podolski-Renic A, Bankovic J, Tanic N, Markovic I, Vajs V, Tešević V. Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines. in Phytochemistry. 2013;86:208-217.
doi:10.1016/j.phytochem.2012.09.003 .
Jadranin, Milka, Pešić, Milica, Aljančić, Ivana, Milosavljević, Slobodan, Todorović, Nina, Podolski-Renic, Ana, Bankovic, Jasna, Tanic, Nikola, Markovic, Ivanka, Vajs, Vlatka, Tešević, Vele, "Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines" in Phytochemistry, 86 (2013):208-217,
https://doi.org/10.1016/j.phytochem.2012.09.003 . .

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