Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines
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2013
Authors
Jadranin, Milka
Pešić, Milica

Aljančić, Ivana
Milosavljević, Slobodan

Todorović, Nina

Podolski-Renic, Ana

Bankovic, Jasna
Tanic, Nikola
Markovic, Ivanka

Vajs, Vlatka
Tešević, Vele

Article (Published version)

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Show full item recordAbstract
Thirteen jatrophane diterpenoids (1-10, 13-15), three previously isolated (11, 12, 16) and a known tigliane (17) were isolated from the latex of Euphorbia dendroides. The structures and relative configurations of compounds were elucidated by spectroscopic techniques. The P-glycoprotein (P-gp) inhibiting activities of the representative set of jatrophanes (1-6 and 11-16) have been assessed. Jatrophanes 2 and 5 demonstrated the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).
Keywords:
Euphorbia dendroides / Euphorbiaceae / Isolation / Jatrophanes / Euphodendrophanes G-S / P-glycoprotein / Multi-drug resistanceSource:
Phytochemistry, 2013, 86, 208-217Publisher:
- Pergamon-Elsevier Science Ltd, Oxford
Projects:
- Natural products of wild, cultivated and edible plants: structure and bioactivity determination (RS-172053)
- Identification of predictive molecular markers for cancer progression, response to therapy and disease outcome (RS-41031)
DOI: 10.1016/j.phytochem.2012.09.003
ISSN: 0031-9422
PubMed: 23079764