Thirteen jatrophane diterpenoids (1-10, 13-15), three previously isolated (11, 12, 16) and a known tigliane (17) were isolated from the latex of Euphorbia dendroides. The structures and relative configurations of compounds were elucidated by spectroscopic techniques. The P-glycoprotein (P-gp) inhibiting activities of the representative set of jatrophanes (1-6 and 11-16) have been assessed. Jatrophanes 2 and 5 demonstrated the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).
TY - JOUR
AU - Jadranin, Milka
AU - Pešić, Milica
AU - Aljančić, Ivana
AU - Milosavljević, Slobodan
AU - Todorović, Nina
AU - Podolski-Renic, Ana
AU - Bankovic, Jasna
AU - Tanic, Nikola
AU - Markovic, Ivanka
AU - Vajs, Vlatka
AU - Tešević, Vele
PY - 2013
UR - http://cer.ihtm.bg.ac.rs/handle/123456789/1278
AB - Thirteen jatrophane diterpenoids (1-10, 13-15), three previously isolated (11, 12, 16) and a known tigliane (17) were isolated from the latex of Euphorbia dendroides. The structures and relative configurations of compounds were elucidated by spectroscopic techniques. The P-glycoprotein (P-gp) inhibiting activities of the representative set of jatrophanes (1-6 and 11-16) have been assessed. Jatrophanes 2 and 5 demonstrated the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).
PB - Pergamon-Elsevier Science Ltd, Oxford
T2 - Phytochemistry
T1 - Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines
VL - 86
SP - 208
EP - 217
DO - 10.1016/j.phytochem.2012.09.003
ER -
@article{
author = "Jadranin, Milka and Pešić, Milica and Aljančić, Ivana and Milosavljević, Slobodan and Todorović, Nina and Podolski-Renic, Ana and Bankovic, Jasna and Tanic, Nikola and Markovic, Ivanka and Vajs, Vlatka and Tešević, Vele",
year = "2013",
url = "http://cer.ihtm.bg.ac.rs/handle/123456789/1278",
abstract = "Thirteen jatrophane diterpenoids (1-10, 13-15), three previously isolated (11, 12, 16) and a known tigliane (17) were isolated from the latex of Euphorbia dendroides. The structures and relative configurations of compounds were elucidated by spectroscopic techniques. The P-glycoprotein (P-gp) inhibiting activities of the representative set of jatrophanes (1-6 and 11-16) have been assessed. Jatrophanes 2 and 5 demonstrated the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Phytochemistry",
title = "Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines",
volume = "86",
pages = "208-217",
doi = "10.1016/j.phytochem.2012.09.003"
}
Jadranin, M., Pešić, M., Aljančić, I., Milosavljević, S., Todorović, N., Podolski-Renic, A., Bankovic, J., Tanic, N., Markovic, I., Vajs, V.,& Tešević, V. (2013). Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines.
Phytochemistry
Pergamon-Elsevier Science Ltd, Oxford., 86, 208-217.
https://doi.org/10.1016/j.phytochem.2012.09.003
Jadranin M, Pešić M, Aljančić I, Milosavljević S, Todorović N, Podolski-Renic A, Bankovic J, Tanic N, Markovic I, Vajs V, Tešević V. Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines. Phytochemistry. 2013;86:208-217
Jadranin Milka, Pešić Milica, Aljančić Ivana, Milosavljević Slobodan, Todorović Nina, Podolski-Renic Ana, Bankovic Jasna, Tanic Nikola, Markovic Ivanka, Vajs Vlatka, Tešević Vele, "Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines" Phytochemistry, 86 (2013):208-217,
https://doi.org/10.1016/j.phytochem.2012.09.003 .
