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Synthesis, biology, and modeling of a C-4 carbonyl C,D-seco-taxoid
(Oxford : Pergamon-Elsevier Science Ltd, 2006)
A C,D-seco-paclitaxel derivative 26 was prepared from taxine and tested for biological activity. Chemical reactivity of the seco-compounds proved to be substantially modified, with respects to taxoids. The corresponding ...
Synthesis, biological evaluation, and modeling of a C,D-seco-taxoid
(Oxford : Pergamon-Elsevier Science Ltd, 2005)
A C,D-seco-paclitaxel derivative 12 was prepared and tested for biological activity. The key step in the synthesis was a free radical fragmentation of the bicyclic tertiary alcohol 7 under the conditions of the hypobromite ...