Synthesis, biology, and modeling of a C-4 carbonyl C,D-seco-taxoid
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2006
Authors
Ferjančić, Zorana
Matović, Radomir
Čeković, Živorad
Jiang, Yi
Snyder, James P.
Trajković, Vladimir
Saičić, Radomir N.
Article (Published version)
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Show full item recordAbstract
A C,D-seco-paclitaxel derivative 26 was prepared from taxine and tested for biological activity. Chemical reactivity of the seco-compounds proved to be substantially modified, with respects to taxoids. The corresponding C,D-seco-taxoid does not show tubulin stabilizing activity or cytotoxicity. Explanation of these observations based on molecular modeling is provided. (c) 2006 Elsevier Ltd. All rights reserved.
Keywords:
taxane antitumor agents / radicals and radical reactions / medium sized rings / natural products / molecular modelingSource:
Tetrahedron, 2006, 62, 36, 8503-8514Publisher:
- Pergamon-Elsevier Science Ltd, Oxford
DOI: 10.1016/j.tet.2006.06.080
ISSN: 0040-4020
WoS: 000240125700010
Scopus: 2-s2.0-33746306276
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