CER - Central Repository
Institute of Chemistry, Technology and Metallurgy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrilic)
    • Serbian (Latin)
  • Login
View Item 
  •   Central Repository
  • IHTM
  • Radovi istraživača / Researchers' publications
  • View Item
  •   Central Repository
  • IHTM
  • Radovi istraživača / Researchers' publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Synthesis, biology, and modeling of a C-4 carbonyl C,D-seco-taxoid

Authorized Users Only
2006
Authors
Ferjančić, Zorana
Matović, Radomir
Čeković, Živorad
Jiang, Yi
Snyder, James P.
Trajković, Vladimir
Saičić, Radomir N.
Article (Published version)
Metadata
Show full item record
Abstract
A C,D-seco-paclitaxel derivative 26 was prepared from taxine and tested for biological activity. Chemical reactivity of the seco-compounds proved to be substantially modified, with respects to taxoids. The corresponding C,D-seco-taxoid does not show tubulin stabilizing activity or cytotoxicity. Explanation of these observations based on molecular modeling is provided. (c) 2006 Elsevier Ltd. All rights reserved.
Keywords:
taxane antitumor agents / radicals and radical reactions / medium sized rings / natural products / molecular modeling
Source:
Tetrahedron, 2006, 62, 36, 8503-8514
Publisher:
  • Pergamon-Elsevier Science Ltd, Oxford

DOI: 10.1016/j.tet.2006.06.080

ISSN: 0040-4020

WoS: 000240125700010

Scopus: 2-s2.0-33746306276
[ Google Scholar ]
14
13
URI
http://cer.ihtm.bg.ac.rs/handle/123456789/2772
Collections
  • Radovi istraživača / Researchers' publications
Institution
IHTM

DSpace software copyright © 2002-2015  DuraSpace
About CeR – Central Repository | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceInstitutionsAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About CeR – Central Repository | Send Feedback

OpenAIRERCUB