TY  - JOUR
AU  - Mojović, Miloš
AU  - Dakovic, Marko
AU  - Omerasevic, Mia
AU  - Mojović, Zorica
AU  - Banković, Predrag
AU  - Milutinović Nikolić, Aleksandra
AU  - Jovanović, Dušan M.
PY  - 2010
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/648
AB  - The increased use of imaging techniques in diagnostic studies, such as MRI, has contributed to the development of the wide range of new materials which could be successfully used as image improving agents. However, there is a lack of such substances in the area of gastrointestinal tract MRI. Many of the traditionally popular relaxation altering agents show poor results and disadvantages provoking black bowel, side effects of diarrhea and the presence of artifacts arising from clumping. Paramagnetic species seem to be potentially suitable agents for these studies, but contrast opacification has been reported and less than 60% of the gastrointestinal tract magnetic resonance scans showed improved delineation of abdominal pathologies. The new solution has been proposed as zeolites or smectite clays (hectorite and montmorillonite) enclosing of paramagnetic metal ions obtained by ion-exchange methods. However, such materials have problems of leakage of paramagnetic ions causing the appearance of the various side-effects. In this study we show that Co(+2) and Dy(+3) paramagnetic-pillared bentonites could be successfully used as MRI digestive tract non-leaching contrast agents, altering the longitudinal and transverse relaxation times of fluids in contact with the clay minerals.
PB  - World Scientific Publ Co Pte Ltd, Singapore
T2  - International Journal of Modern Physics B
T1  - The paramagnetic pillared bentonites as digestive tract mri contrast agents
VL  - 24
IS  - 6-7
SP  - 780
EP  - 787
DO  - 10.1142/S0217979210064411
ER  - 

@article{
author = "Mojović, Miloš and Dakovic, Marko and Omerasevic, Mia and Mojović, Zorica and Banković, Predrag and Milutinović Nikolić, Aleksandra and Jovanović, Dušan M.",
year = "2010",
abstract = "The increased use of imaging techniques in diagnostic studies, such as MRI, has contributed to the development of the wide range of new materials which could be successfully used as image improving agents. However, there is a lack of such substances in the area of gastrointestinal tract MRI. Many of the traditionally popular relaxation altering agents show poor results and disadvantages provoking black bowel, side effects of diarrhea and the presence of artifacts arising from clumping. Paramagnetic species seem to be potentially suitable agents for these studies, but contrast opacification has been reported and less than 60% of the gastrointestinal tract magnetic resonance scans showed improved delineation of abdominal pathologies. The new solution has been proposed as zeolites or smectite clays (hectorite and montmorillonite) enclosing of paramagnetic metal ions obtained by ion-exchange methods. However, such materials have problems of leakage of paramagnetic ions causing the appearance of the various side-effects. In this study we show that Co(+2) and Dy(+3) paramagnetic-pillared bentonites could be successfully used as MRI digestive tract non-leaching contrast agents, altering the longitudinal and transverse relaxation times of fluids in contact with the clay minerals.",
publisher = "World Scientific Publ Co Pte Ltd, Singapore",
journal = "International Journal of Modern Physics B",
title = "The paramagnetic pillared bentonites as digestive tract mri contrast agents",
volume = "24",
number = "6-7",
pages = "780-787",
doi = "10.1142/S0217979210064411"
}

Mojović, M., Dakovic, M., Omerasevic, M., Mojović, Z., Banković, P., Milutinović Nikolić, A.,& Jovanović, D. M.. (2010). The paramagnetic pillared bentonites as digestive tract mri contrast agents. in International Journal of Modern Physics B
World Scientific Publ Co Pte Ltd, Singapore., 24(6-7), 780-787.
https://doi.org/10.1142/S0217979210064411

Mojović M, Dakovic M, Omerasevic M, Mojović Z, Banković P, Milutinović Nikolić A, Jovanović DM. The paramagnetic pillared bentonites as digestive tract mri contrast agents. in International Journal of Modern Physics B. 2010;24(6-7):780-787.
doi:10.1142/S0217979210064411 .

Mojović, Miloš, Dakovic, Marko, Omerasevic, Mia, Mojović, Zorica, Banković, Predrag, Milutinović Nikolić, Aleksandra, Jovanović, Dušan M., "The paramagnetic pillared bentonites as digestive tract mri contrast agents" in International Journal of Modern Physics B, 24, no. 6-7 (2010):780-787,
https://doi.org/10.1142/S0217979210064411 . .

TY  - JOUR
AU  - Mojović, Miloš
AU  - Dakovic, Marko
AU  - Banković, Predrag
AU  - Mojović, Zorica
PY  - 2010
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/652
AB  - The availability of sophisticated diagnostic methods such as MRI has contributed to the increased use of imaging technologies in therapy and diagnostic studies. However, gastrointestinal tract MRI generally shows poor results because of the lack of suitable contrast agents. The iron oxide is traditionally popular material for MRI gastrointestinal studies because of its well-known superparamagnetic properties. On the other hand, it has many disadvantages which include black bowel, side effects of diarrhea and, from an important analytical standpoint, the presence of artifacts arising from clumping. When paramagnetic iron concentrates, it may become ferromagnetic, drastically altering its imaging properties. Other paramagnetic species, represented by gadolinium, also seem to be potentially suitable agents for these studies. Nevertheless, this metal itself cannot be used in humans because of its toxic properties. Therefore, there is clearly a need for orally effective, well tolerated agents that can be used in humans for digestive imaging studies. This MRI contrast should be useful for visualizing the anatomy of the digestive tract and particularly to differentiate between normal and pathological states, such as tumors. The solution has been proposed as zeolites or smectites (hectorite and montmorillonite) enclosing of paramagnetic metal ions obtained by ion-exchange methods. However, such materials could have problems of leakage of paramagnetic ions causing the appearance of the number side-effects. We propose the usage of the pillaring method for paramagnetic metal encapsulation in bentonites. By that way, paramagnetic cations like Fe(+3), Mn(+2) and Gd(+3) are introduced between clay mineral layers as polyoxo cations. After calcination, these polyoxo cations grow to be pillars (oxides of these metals) which are incorporated into the clay mineral matrix which prevents ion-leaching and dangerous side-effects. In this study we show that paramagnetic-pillared bentonites could be successfully used as MRI digestive tract non-leaching contrast agents, altering the longitudinal relaxation times of fluids in contact with the clay minerals.
PB  - Elsevier
T2  - Applied Clay Science
T1  - Paramagnetic pillared bentonites - The new digestive tract MRI contrast agents
VL  - 48
IS  - 1-2
SP  - 191
EP  - 194
DO  - 10.1016/j.clay.2009.11.041
ER  - 

@article{
author = "Mojović, Miloš and Dakovic, Marko and Banković, Predrag and Mojović, Zorica",
year = "2010",
abstract = "The availability of sophisticated diagnostic methods such as MRI has contributed to the increased use of imaging technologies in therapy and diagnostic studies. However, gastrointestinal tract MRI generally shows poor results because of the lack of suitable contrast agents. The iron oxide is traditionally popular material for MRI gastrointestinal studies because of its well-known superparamagnetic properties. On the other hand, it has many disadvantages which include black bowel, side effects of diarrhea and, from an important analytical standpoint, the presence of artifacts arising from clumping. When paramagnetic iron concentrates, it may become ferromagnetic, drastically altering its imaging properties. Other paramagnetic species, represented by gadolinium, also seem to be potentially suitable agents for these studies. Nevertheless, this metal itself cannot be used in humans because of its toxic properties. Therefore, there is clearly a need for orally effective, well tolerated agents that can be used in humans for digestive imaging studies. This MRI contrast should be useful for visualizing the anatomy of the digestive tract and particularly to differentiate between normal and pathological states, such as tumors. The solution has been proposed as zeolites or smectites (hectorite and montmorillonite) enclosing of paramagnetic metal ions obtained by ion-exchange methods. However, such materials could have problems of leakage of paramagnetic ions causing the appearance of the number side-effects. We propose the usage of the pillaring method for paramagnetic metal encapsulation in bentonites. By that way, paramagnetic cations like Fe(+3), Mn(+2) and Gd(+3) are introduced between clay mineral layers as polyoxo cations. After calcination, these polyoxo cations grow to be pillars (oxides of these metals) which are incorporated into the clay mineral matrix which prevents ion-leaching and dangerous side-effects. In this study we show that paramagnetic-pillared bentonites could be successfully used as MRI digestive tract non-leaching contrast agents, altering the longitudinal relaxation times of fluids in contact with the clay minerals.",
publisher = "Elsevier",
journal = "Applied Clay Science",
title = "Paramagnetic pillared bentonites - The new digestive tract MRI contrast agents",
volume = "48",
number = "1-2",
pages = "191-194",
doi = "10.1016/j.clay.2009.11.041"
}

Mojović, M., Dakovic, M., Banković, P.,& Mojović, Z.. (2010). Paramagnetic pillared bentonites - The new digestive tract MRI contrast agents. in Applied Clay Science
Elsevier., 48(1-2), 191-194.
https://doi.org/10.1016/j.clay.2009.11.041

Mojović M, Dakovic M, Banković P, Mojović Z. Paramagnetic pillared bentonites - The new digestive tract MRI contrast agents. in Applied Clay Science. 2010;48(1-2):191-194.
doi:10.1016/j.clay.2009.11.041 .

Mojović, Miloš, Dakovic, Marko, Banković, Predrag, Mojović, Zorica, "Paramagnetic pillared bentonites - The new digestive tract MRI contrast agents" in Applied Clay Science, 48, no. 1-2 (2010):191-194,
https://doi.org/10.1016/j.clay.2009.11.041 . .

TY  - JOUR
AU  - Spasojević, Ivan
AU  - Mojović, Miloš
AU  - Stević, Zorica
AU  - Spasić, Snežana
AU  - Jones, David R.
AU  - Morina, Arian
AU  - Spasić, Mihajlo
PY  - 2010
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/738
AB  - A breakdown in homeostasis of redox-active metals represents an important factor for neurodegeneration. We have used EPR spectroscopy and BMPO spin-trap to investigate the catalytic properties and ligand modulation of redox activity of copper and iron in human cerebrospinal fluid (CSF). In contrast to iron, copper supplementation provoked a statistically significant increase in hydroxyl free radical generation in CSF treated with H(2)O(2). However, in a binary copper/iron containing Fenton system, iron catalytically activated copper. The chelator EDTA, which represents a model of physiological metal ligands, completely prevented copper's redox activity in CSF, while iron chelation led to a significant increase in hydroxyl radical generation, indicating that copper and iron do not only have diverse catalytic properties in the CSF but also that their redox activities are differently modulated by ligands. The application of DDC reduced hydroxyl radical generation in the CSF containing catalytically active metals (free Cu(2+) or Fe(3+)-EDTA complex). We conclude that chelators, such as DDC, are capable of preventing the pro-oxidative activity of both metals and may be suitable for reducing hydroxyl radical formation in certain pathophysiological settings.
PB  - Taylor & Francis Group
T2  - Redox Report
T1  - Bioavailability and catalytic properties of copper and iron for Fenton chemistry in human cerebrospinal fluid
VL  - 15
IS  - 1
SP  - 29
EP  - 35
DO  - 10.1179/174329210X12650506623087
ER  - 

@article{
author = "Spasojević, Ivan and Mojović, Miloš and Stević, Zorica and Spasić, Snežana and Jones, David R. and Morina, Arian and Spasić, Mihajlo",
year = "2010",
abstract = "A breakdown in homeostasis of redox-active metals represents an important factor for neurodegeneration. We have used EPR spectroscopy and BMPO spin-trap to investigate the catalytic properties and ligand modulation of redox activity of copper and iron in human cerebrospinal fluid (CSF). In contrast to iron, copper supplementation provoked a statistically significant increase in hydroxyl free radical generation in CSF treated with H(2)O(2). However, in a binary copper/iron containing Fenton system, iron catalytically activated copper. The chelator EDTA, which represents a model of physiological metal ligands, completely prevented copper's redox activity in CSF, while iron chelation led to a significant increase in hydroxyl radical generation, indicating that copper and iron do not only have diverse catalytic properties in the CSF but also that their redox activities are differently modulated by ligands. The application of DDC reduced hydroxyl radical generation in the CSF containing catalytically active metals (free Cu(2+) or Fe(3+)-EDTA complex). We conclude that chelators, such as DDC, are capable of preventing the pro-oxidative activity of both metals and may be suitable for reducing hydroxyl radical formation in certain pathophysiological settings.",
publisher = "Taylor & Francis Group",
journal = "Redox Report",
title = "Bioavailability and catalytic properties of copper and iron for Fenton chemistry in human cerebrospinal fluid",
volume = "15",
number = "1",
pages = "29-35",
doi = "10.1179/174329210X12650506623087"
}

Spasojević, I., Mojović, M., Stević, Z., Spasić, S., Jones, D. R., Morina, A.,& Spasić, M.. (2010). Bioavailability and catalytic properties of copper and iron for Fenton chemistry in human cerebrospinal fluid. in Redox Report
Taylor & Francis Group., 15(1), 29-35.
https://doi.org/10.1179/174329210X12650506623087

Spasojević I, Mojović M, Stević Z, Spasić S, Jones DR, Morina A, Spasić M. Bioavailability and catalytic properties of copper and iron for Fenton chemistry in human cerebrospinal fluid. in Redox Report. 2010;15(1):29-35.
doi:10.1179/174329210X12650506623087 .

Spasojević, Ivan, Mojović, Miloš, Stević, Zorica, Spasić, Snežana, Jones, David R., Morina, Arian, Spasić, Mihajlo, "Bioavailability and catalytic properties of copper and iron for Fenton chemistry in human cerebrospinal fluid" in Redox Report, 15, no. 1 (2010):29-35,
https://doi.org/10.1179/174329210X12650506623087 . .

TY  - JOUR
AU  - Živković, Jelena
AU  - Zeković, Z.
AU  - Mujić, I.
AU  - Gođevac, Dejan
AU  - Mojović, Miloš
AU  - Mujić, A.
AU  - Spasojević, Ivan
PY  - 2009
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/609
AB  - Electron paramagnetic resonance (EPR) spin-trapping and spin-probing techniques were applied to determine antioxidant activity of extracts of catkin, leaves, and spiny burs of Castanea sativa against physiologically relevant reactive species-superoxide and hydroxyl radical generated in simple chemical systems and hydrogen peroxide applied on erythrocytes. Efflux of K + was used as a marker of membrane integrity. Chemical composition of extracts was analyzed using HPLC/DAD and LC/MS. Extracts showed high antioxidative capacity against superoxide but lower activity against hydroxyl radical. They protected fluidity and integrity of membranes of erythrocytes exposed to hydrogen peroxide. Levels of derivatives of ellagitannins showed positive correlation with the antioxidative activity of extracts. Therefore, ellagitannins from chestnut extracts could represent easily accessible natural antioxidants and beneficial component of human diet in pathophysiological conditions related to oxidative stress. In conclusion, EPR spectroscopy represents a valuable tool for evaluation of antioxidant activity in both hydrophilic and lipophilic media.
T2  - Food Biophysics
T1  - EPR spin-trapping and spin-probing spectroscopy in assessing antioxidant properties: Example on extracts of catkin, leaves, and spiny burs of castanea sativa
VL  - 4
IS  - 2
SP  - 126
EP  - 133
DO  - 10.1007/s11483-009-9109-8
ER  - 

@article{
author = "Živković, Jelena and Zeković, Z. and Mujić, I. and Gođevac, Dejan and Mojović, Miloš and Mujić, A. and Spasojević, Ivan",
year = "2009",
abstract = "Electron paramagnetic resonance (EPR) spin-trapping and spin-probing techniques were applied to determine antioxidant activity of extracts of catkin, leaves, and spiny burs of Castanea sativa against physiologically relevant reactive species-superoxide and hydroxyl radical generated in simple chemical systems and hydrogen peroxide applied on erythrocytes. Efflux of K + was used as a marker of membrane integrity. Chemical composition of extracts was analyzed using HPLC/DAD and LC/MS. Extracts showed high antioxidative capacity against superoxide but lower activity against hydroxyl radical. They protected fluidity and integrity of membranes of erythrocytes exposed to hydrogen peroxide. Levels of derivatives of ellagitannins showed positive correlation with the antioxidative activity of extracts. Therefore, ellagitannins from chestnut extracts could represent easily accessible natural antioxidants and beneficial component of human diet in pathophysiological conditions related to oxidative stress. In conclusion, EPR spectroscopy represents a valuable tool for evaluation of antioxidant activity in both hydrophilic and lipophilic media.",
journal = "Food Biophysics",
title = "EPR spin-trapping and spin-probing spectroscopy in assessing antioxidant properties: Example on extracts of catkin, leaves, and spiny burs of castanea sativa",
volume = "4",
number = "2",
pages = "126-133",
doi = "10.1007/s11483-009-9109-8"
}

Živković, J., Zeković, Z., Mujić, I., Gođevac, D., Mojović, M., Mujić, A.,& Spasojević, I.. (2009). EPR spin-trapping and spin-probing spectroscopy in assessing antioxidant properties: Example on extracts of catkin, leaves, and spiny burs of castanea sativa. in Food Biophysics, 4(2), 126-133.
https://doi.org/10.1007/s11483-009-9109-8

Živković J, Zeković Z, Mujić I, Gođevac D, Mojović M, Mujić A, Spasojević I. EPR spin-trapping and spin-probing spectroscopy in assessing antioxidant properties: Example on extracts of catkin, leaves, and spiny burs of castanea sativa. in Food Biophysics. 2009;4(2):126-133.
doi:10.1007/s11483-009-9109-8 .

Živković, Jelena, Zeković, Z., Mujić, I., Gođevac, Dejan, Mojović, Miloš, Mujić, A., Spasojević, Ivan, "EPR spin-trapping and spin-probing spectroscopy in assessing antioxidant properties: Example on extracts of catkin, leaves, and spiny burs of castanea sativa" in Food Biophysics, 4, no. 2 (2009):126-133,
https://doi.org/10.1007/s11483-009-9109-8 . .

TY  - JOUR
AU  - Spasojević, Ivan
AU  - Mojović, Miloš
AU  - Blagojević, Duško
AU  - Spasić, Snežana
AU  - Jones, David
AU  - Nikolić-Kokić, Aleksandra
AU  - Spasić, Mihajlo
PY  - 2009
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3937
AB  - The hydroxyl radical (radical dotOH) has detrimental biological activity due to its very high reactivity. Our experiments were designed to determine the effects of equimolar concentrations of glucose, fructose and mannitol and three phosphorylated forms of fructose (fructose-1-phosphate (F1P); fructose-6-phosphate (F6P); and fructose-1,6-bis(phosphate) (F16BP)) on radical dotOH radical production via the Fenton reaction. EPR spectroscopy using spin-trap DEPMPO was applied to detect radical production. We found that the percentage inhibition of radical dotOH radical formation decreased in the order F16BP > F1P > F6P > fructose > mannitol = glucose. As ketoses can sequester redox-active iron thus preventing the Fenton reaction, the Haber–Weiss-like system was also employed to generate radical dotOH, so that the effect of iron sequestration could be distinguished from direct radical dotOH radical scavenging. In the latter system, the rank order of radical dotOH scavenging activity was F16BP > F1P > F6P > fructose = mannitol = glucose. Our results clearly demonstrate that intracellular phosphorylated forms of fructose have more scavenging properties than fructose or glucose, leading us to conclude that the acute administration of fructose could overcome the body’s reaction to exogenous antioxidants during appropriate therapy in certain pathophysiological conditions related to oxidative stress, such as sepsis, neurodegenerative diseases, atherosclerosis, malignancy, and some complications of pregnancy.
PB  - Elsevier
T2  - Carbohydrate Research
T1  - Relevance of the capacity of phosphorylated fructose to scavenge the hydroxyl radical
VL  - 344
IS  - 1
SP  - 80
EP  - 84
DO  - 10.1016/j.carres.2008.09.025
ER  - 

@article{
author = "Spasojević, Ivan and Mojović, Miloš and Blagojević, Duško and Spasić, Snežana and Jones, David and Nikolić-Kokić, Aleksandra and Spasić, Mihajlo",
year = "2009",
abstract = "The hydroxyl radical (radical dotOH) has detrimental biological activity due to its very high reactivity. Our experiments were designed to determine the effects of equimolar concentrations of glucose, fructose and mannitol and three phosphorylated forms of fructose (fructose-1-phosphate (F1P); fructose-6-phosphate (F6P); and fructose-1,6-bis(phosphate) (F16BP)) on radical dotOH radical production via the Fenton reaction. EPR spectroscopy using spin-trap DEPMPO was applied to detect radical production. We found that the percentage inhibition of radical dotOH radical formation decreased in the order F16BP > F1P > F6P > fructose > mannitol = glucose. As ketoses can sequester redox-active iron thus preventing the Fenton reaction, the Haber–Weiss-like system was also employed to generate radical dotOH, so that the effect of iron sequestration could be distinguished from direct radical dotOH radical scavenging. In the latter system, the rank order of radical dotOH scavenging activity was F16BP > F1P > F6P > fructose = mannitol = glucose. Our results clearly demonstrate that intracellular phosphorylated forms of fructose have more scavenging properties than fructose or glucose, leading us to conclude that the acute administration of fructose could overcome the body’s reaction to exogenous antioxidants during appropriate therapy in certain pathophysiological conditions related to oxidative stress, such as sepsis, neurodegenerative diseases, atherosclerosis, malignancy, and some complications of pregnancy.",
publisher = "Elsevier",
journal = "Carbohydrate Research",
title = "Relevance of the capacity of phosphorylated fructose to scavenge the hydroxyl radical",
volume = "344",
number = "1",
pages = "80-84",
doi = "10.1016/j.carres.2008.09.025"
}

Spasojević, I., Mojović, M., Blagojević, D., Spasić, S., Jones, D., Nikolić-Kokić, A.,& Spasić, M.. (2009). Relevance of the capacity of phosphorylated fructose to scavenge the hydroxyl radical. in Carbohydrate Research
Elsevier., 344(1), 80-84.
https://doi.org/10.1016/j.carres.2008.09.025

Spasojević I, Mojović M, Blagojević D, Spasić S, Jones D, Nikolić-Kokić A, Spasić M. Relevance of the capacity of phosphorylated fructose to scavenge the hydroxyl radical. in Carbohydrate Research. 2009;344(1):80-84.
doi:10.1016/j.carres.2008.09.025 .

Spasojević, Ivan, Mojović, Miloš, Blagojević, Duško, Spasić, Snežana, Jones, David, Nikolić-Kokić, Aleksandra, Spasić, Mihajlo, "Relevance of the capacity of phosphorylated fructose to scavenge the hydroxyl radical" in Carbohydrate Research, 344, no. 1 (2009):80-84,
https://doi.org/10.1016/j.carres.2008.09.025 . .

TY  - JOUR
AU  - Harhaji-Trajković, Ljubica
AU  - Mijatović, Sanja
AU  - Maksimović-Ivanić, Danijela D.
AU  - Stojanovic, I.D.
AU  - Momcilovic, M.B.
AU  - Tufegdžić, Srđan
AU  - Maksimović, Vesna M.
AU  - Marjanovi, Z.S.
AU  - Stosic-Grujicic, S.D.
PY  - 2009
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/616
AB  - Anticancer activities of various extracts of the medicinal mushroom, Ganoderma lucidum, have been widely demonstrated and are mainly associated with the presence of different bioactive polysaccharides and triterpenoids. We have evaluated and compared in vitro and in vivo the antitumor effects of two preparations from Ganoderma lucidum: a methanol extract containing total terpenoids (GLme) and a purified methanol extract containing mainly acidic terpenoids (GLpme). Both extracts inhibited tumor growth of B16 mouse melanoma cells inoculated subcutaneously into syngeneic C57BL/6 mice and reduced viability of B16 cells in vitro, whereby GLme exhibited stronger effect. Furthermore, anticancer activity of GLme was demonstrated for the first time against two other rodent tumor cell lines, L929-mouse fibrosarcoma and C6-rat astrocytoma. The mechanism of antitumor activity of GLme comprised inhibition of cell proliferation and induction of caspase-dependent apoptotic cell death mediated by upregulated p53 and inhibited Bcl-2 expression. Moreover, the antitumor effect of the GLme was associated with intensified production of reactive oxygen species, whereas their neutralization by the antioxidant, N-acetyl cysteine, resulted in partial recovery of cell viability. Thus, our results suggest that GLme might be a good candidate for treatment of diverse forms of cancers.
T2  - Nutrition and Cancer
T1  - Anticancer properties of ganoderma lucidum methanol extracts in vitro and in vivo
VL  - 61
IS  - 5
SP  - 696
EP  - 707
DO  - 10.1080/01635580902898743
ER  - 

@article{
author = "Harhaji-Trajković, Ljubica and Mijatović, Sanja and Maksimović-Ivanić, Danijela D. and Stojanovic, I.D. and Momcilovic, M.B. and Tufegdžić, Srđan and Maksimović, Vesna M. and Marjanovi, Z.S. and Stosic-Grujicic, S.D.",
year = "2009",
abstract = "Anticancer activities of various extracts of the medicinal mushroom, Ganoderma lucidum, have been widely demonstrated and are mainly associated with the presence of different bioactive polysaccharides and triterpenoids. We have evaluated and compared in vitro and in vivo the antitumor effects of two preparations from Ganoderma lucidum: a methanol extract containing total terpenoids (GLme) and a purified methanol extract containing mainly acidic terpenoids (GLpme). Both extracts inhibited tumor growth of B16 mouse melanoma cells inoculated subcutaneously into syngeneic C57BL/6 mice and reduced viability of B16 cells in vitro, whereby GLme exhibited stronger effect. Furthermore, anticancer activity of GLme was demonstrated for the first time against two other rodent tumor cell lines, L929-mouse fibrosarcoma and C6-rat astrocytoma. The mechanism of antitumor activity of GLme comprised inhibition of cell proliferation and induction of caspase-dependent apoptotic cell death mediated by upregulated p53 and inhibited Bcl-2 expression. Moreover, the antitumor effect of the GLme was associated with intensified production of reactive oxygen species, whereas their neutralization by the antioxidant, N-acetyl cysteine, resulted in partial recovery of cell viability. Thus, our results suggest that GLme might be a good candidate for treatment of diverse forms of cancers.",
journal = "Nutrition and Cancer",
title = "Anticancer properties of ganoderma lucidum methanol extracts in vitro and in vivo",
volume = "61",
number = "5",
pages = "696-707",
doi = "10.1080/01635580902898743"
}

Harhaji-Trajković, L., Mijatović, S., Maksimović-Ivanić, D. D., Stojanovic, I.D., Momcilovic, M.B., Tufegdžić, S., Maksimović, V. M., Marjanovi, Z.S.,& Stosic-Grujicic, S.D.. (2009). Anticancer properties of ganoderma lucidum methanol extracts in vitro and in vivo. in Nutrition and Cancer, 61(5), 696-707.
https://doi.org/10.1080/01635580902898743

Harhaji-Trajković L, Mijatović S, Maksimović-Ivanić DD, Stojanovic I, Momcilovic M, Tufegdžić S, Maksimović VM, Marjanovi Z, Stosic-Grujicic S. Anticancer properties of ganoderma lucidum methanol extracts in vitro and in vivo. in Nutrition and Cancer. 2009;61(5):696-707.
doi:10.1080/01635580902898743 .

Harhaji-Trajković, Ljubica, Mijatović, Sanja, Maksimović-Ivanić, Danijela D., Stojanovic, I.D., Momcilovic, M.B., Tufegdžić, Srđan, Maksimović, Vesna M., Marjanovi, Z.S., Stosic-Grujicic, S.D., "Anticancer properties of ganoderma lucidum methanol extracts in vitro and in vivo" in Nutrition and Cancer, 61, no. 5 (2009):696-707,
https://doi.org/10.1080/01635580902898743 . .

TY  - JOUR
AU  - Gođevac, Dejan
AU  - Vujisić, Ljubodrag V.
AU  - Mojović, Miloš
AU  - Ignjatović, Aleksandar
AU  - Spasojević, Ivan
AU  - Vajs, Vlatka
PY  - 2008
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/374
AB  - A total of 20 components were identified in Allium ursinum volatile oil (AUVO) by GC-MS, and 10 of them are found for the first time in this plant species. The antioxidant capacity of AUVO was examined by beta-carotene-linoleic acid bleaching, lipid peroxidation by Fenton reaction, EPR spin-probing assay using stable nitroxide radicals, DPPH., and ABTS(.+) scavenging assays. Reaction mechanism of the volatile oil components with nitroxide radicals, based on IR spectra analysis, is proposed. AUVO demonstrated poor scavenging ability against DPPH, and ABTS(.+) comparing to synthetic antioxidants BHT and trolox, while in beta-carotene-linoleic acid system AUVO showed an effect comparable to those for BHT. AUVO was also capable to scavenge stable nitroxide radicals such as water-soluble Tempone, and 7-DS and 12-DS, incorporated into the liposome membrane. Finally, AUVO increased membrane fluidity, which could be an important feature for further in vivo investigation of some disorders, such as hypertension and atherosclerosis.
PB  - Elsevier Sci Ltd, Oxford
T2  - Food Chemistry
T1  - Evaluation of antioxidant capacity of Allium ursinum L. volatile oil and its effect on membrane fluidity
VL  - 107
IS  - 4
SP  - 1692
EP  - 1700
DO  - 10.1016/j.foodchem.2007.10.017
ER  - 

@article{
author = "Gođevac, Dejan and Vujisić, Ljubodrag V. and Mojović, Miloš and Ignjatović, Aleksandar and Spasojević, Ivan and Vajs, Vlatka",
year = "2008",
abstract = "A total of 20 components were identified in Allium ursinum volatile oil (AUVO) by GC-MS, and 10 of them are found for the first time in this plant species. The antioxidant capacity of AUVO was examined by beta-carotene-linoleic acid bleaching, lipid peroxidation by Fenton reaction, EPR spin-probing assay using stable nitroxide radicals, DPPH., and ABTS(.+) scavenging assays. Reaction mechanism of the volatile oil components with nitroxide radicals, based on IR spectra analysis, is proposed. AUVO demonstrated poor scavenging ability against DPPH, and ABTS(.+) comparing to synthetic antioxidants BHT and trolox, while in beta-carotene-linoleic acid system AUVO showed an effect comparable to those for BHT. AUVO was also capable to scavenge stable nitroxide radicals such as water-soluble Tempone, and 7-DS and 12-DS, incorporated into the liposome membrane. Finally, AUVO increased membrane fluidity, which could be an important feature for further in vivo investigation of some disorders, such as hypertension and atherosclerosis.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Food Chemistry",
title = "Evaluation of antioxidant capacity of Allium ursinum L. volatile oil and its effect on membrane fluidity",
volume = "107",
number = "4",
pages = "1692-1700",
doi = "10.1016/j.foodchem.2007.10.017"
}

Gođevac, D., Vujisić, L. V., Mojović, M., Ignjatović, A., Spasojević, I.,& Vajs, V.. (2008). Evaluation of antioxidant capacity of Allium ursinum L. volatile oil and its effect on membrane fluidity. in Food Chemistry
Elsevier Sci Ltd, Oxford., 107(4), 1692-1700.
https://doi.org/10.1016/j.foodchem.2007.10.017

Gođevac D, Vujisić LV, Mojović M, Ignjatović A, Spasojević I, Vajs V. Evaluation of antioxidant capacity of Allium ursinum L. volatile oil and its effect on membrane fluidity. in Food Chemistry. 2008;107(4):1692-1700.
doi:10.1016/j.foodchem.2007.10.017 .

Gođevac, Dejan, Vujisić, Ljubodrag V., Mojović, Miloš, Ignjatović, Aleksandar, Spasojević, Ivan, Vajs, Vlatka, "Evaluation of antioxidant capacity of Allium ursinum L. volatile oil and its effect on membrane fluidity" in Food Chemistry, 107, no. 4 (2008):1692-1700,
https://doi.org/10.1016/j.foodchem.2007.10.017 . .