TY  - JOUR
AU  - Dostanić, Jasmina
AU  - Lončarević, Davor
AU  - Banković, Predrag
AU  - Cvetković, Olga
AU  - Jovanović, Dušan M.
AU  - Mijin, Dušan
PY  - 2011
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/920
AB  - Photocatalytic degradation of synthesized azo pyridone dye (5-(4-sulpho phenylazo)-6-hydroxy-4-methyl-3-cyano-2-pyridone), in aqueous solutions by simulated sunlight in the presence of commercial TiO2, Aeroxide P25, was studied. The reaction kinetics analysis showed that photodegradation exhibits pseudo first-order kinetics according to Langmuir-Hinshelwood model. The effects of various process parameters on the photocatalytic degradation were investigated. The optimal catalyst content and pH were determined. A decrease in the reaction rate was observed upon the increase of the initial dye concentration. Degradation of the dye was enhanced by hydrogen peroxide, but it was inhibited by ethanol. The influence of temperature was studied, and the energy of activation was determined. According to total organic carbon (TOC) analysis, 54% of TOC remained when 100% of the dye was decolorized. Although the intermediates were not determined in this study, the TOC results clearly indicate their presence during the reaction. In addition, photocatalytic degradation of simulated dyehouse effluents, containing tested azo pyridone dye and associated auxiliary chemicals was investigated.
PB  - Taylor and Francis Inc.
T2  - Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental En
T1  - Influence of process parameters on the photodegradation of synthesized azo pyridone dye in TiO2 water suspension under simulated sunlight
VL  - 46
IS  - 1
SP  - 70
EP  - 79
DO  - 10.1080/10934529.2011.526905
ER  - 

@article{
author = "Dostanić, Jasmina and Lončarević, Davor and Banković, Predrag and Cvetković, Olga and Jovanović, Dušan M. and Mijin, Dušan",
year = "2011",
abstract = "Photocatalytic degradation of synthesized azo pyridone dye (5-(4-sulpho phenylazo)-6-hydroxy-4-methyl-3-cyano-2-pyridone), in aqueous solutions by simulated sunlight in the presence of commercial TiO2, Aeroxide P25, was studied. The reaction kinetics analysis showed that photodegradation exhibits pseudo first-order kinetics according to Langmuir-Hinshelwood model. The effects of various process parameters on the photocatalytic degradation were investigated. The optimal catalyst content and pH were determined. A decrease in the reaction rate was observed upon the increase of the initial dye concentration. Degradation of the dye was enhanced by hydrogen peroxide, but it was inhibited by ethanol. The influence of temperature was studied, and the energy of activation was determined. According to total organic carbon (TOC) analysis, 54% of TOC remained when 100% of the dye was decolorized. Although the intermediates were not determined in this study, the TOC results clearly indicate their presence during the reaction. In addition, photocatalytic degradation of simulated dyehouse effluents, containing tested azo pyridone dye and associated auxiliary chemicals was investigated.",
publisher = "Taylor and Francis Inc.",
journal = "Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental En",
title = "Influence of process parameters on the photodegradation of synthesized azo pyridone dye in TiO2 water suspension under simulated sunlight",
volume = "46",
number = "1",
pages = "70-79",
doi = "10.1080/10934529.2011.526905"
}

Dostanić, J., Lončarević, D., Banković, P., Cvetković, O., Jovanović, D. M.,& Mijin, D.. (2011). Influence of process parameters on the photodegradation of synthesized azo pyridone dye in TiO2 water suspension under simulated sunlight. in Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental En
Taylor and Francis Inc.., 46(1), 70-79.
https://doi.org/10.1080/10934529.2011.526905

Dostanić J, Lončarević D, Banković P, Cvetković O, Jovanović DM, Mijin D. Influence of process parameters on the photodegradation of synthesized azo pyridone dye in TiO2 water suspension under simulated sunlight. in Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental En. 2011;46(1):70-79.
doi:10.1080/10934529.2011.526905 .

Dostanić, Jasmina, Lončarević, Davor, Banković, Predrag, Cvetković, Olga, Jovanović, Dušan M., Mijin, Dušan, "Influence of process parameters on the photodegradation of synthesized azo pyridone dye in TiO2 water suspension under simulated sunlight" in Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental En, 46, no. 1 (2011):70-79,
https://doi.org/10.1080/10934529.2011.526905 . .

TY  - JOUR
AU  - Drljevic-Djuric, K. M.
AU  - Jović, Vladimir D.
AU  - Lačnjevac, Uroš
AU  - Avramov Ivić, Milka
AU  - Petrović, Slobodan D.
AU  - Mijin, Dušan
AU  - Djordjevic, S. B.
PY  - 2010
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/684
AB  - The oxidative behavior of antibiotic roxithromycin standard was studied at a gold electrode in 0.05 M NaHCO3 using cyclic linear sweep voltammetry and differential pulse voltammetry. It was found that the value of the oxidative peak of pure roxithromycin at 0.81 V vs. SCE in 0.05 M NaHCO3 at a scan rate of 50 mV s(-1) is a linear function of the concentration in a range 0.10006-0.654 mg cm(-3). It was also found that peak current density at 0.75 V vs. SCE at a scan rate of 2 mVs(-1), pulse amplitude of 25 mV and pulse time of 0.1 s exhibits linear dependence on the concentration of roxithromycin from 0.1006 to 0.476 mg cm(-3). Roxithromycin as a content of solid dosage form and urine was quantitatively determined and the obtained results were checked by HPLC.
PB  - Oxford : Pergamon-Elsevier Science Ltd
T2  - Electrochimica Acta
T1  - Voltammetric and differential pulse determination of roxithromycin
VL  - 56
IS  - 1
SP  - 47
EP  - 52
DO  - 10.1016/j.electacta.2010.09.067
ER  - 

@article{
author = "Drljevic-Djuric, K. M. and Jović, Vladimir D. and Lačnjevac, Uroš and Avramov Ivić, Milka and Petrović, Slobodan D. and Mijin, Dušan and Djordjevic, S. B.",
year = "2010",
abstract = "The oxidative behavior of antibiotic roxithromycin standard was studied at a gold electrode in 0.05 M NaHCO3 using cyclic linear sweep voltammetry and differential pulse voltammetry. It was found that the value of the oxidative peak of pure roxithromycin at 0.81 V vs. SCE in 0.05 M NaHCO3 at a scan rate of 50 mV s(-1) is a linear function of the concentration in a range 0.10006-0.654 mg cm(-3). It was also found that peak current density at 0.75 V vs. SCE at a scan rate of 2 mVs(-1), pulse amplitude of 25 mV and pulse time of 0.1 s exhibits linear dependence on the concentration of roxithromycin from 0.1006 to 0.476 mg cm(-3). Roxithromycin as a content of solid dosage form and urine was quantitatively determined and the obtained results were checked by HPLC.",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "Electrochimica Acta",
title = "Voltammetric and differential pulse determination of roxithromycin",
volume = "56",
number = "1",
pages = "47-52",
doi = "10.1016/j.electacta.2010.09.067"
}

Drljevic-Djuric, K. M., Jović, V. D., Lačnjevac, U., Avramov Ivić, M., Petrović, S. D., Mijin, D.,& Djordjevic, S. B.. (2010). Voltammetric and differential pulse determination of roxithromycin. in Electrochimica Acta
Oxford : Pergamon-Elsevier Science Ltd., 56(1), 47-52.
https://doi.org/10.1016/j.electacta.2010.09.067

Drljevic-Djuric KM, Jović VD, Lačnjevac U, Avramov Ivić M, Petrović SD, Mijin D, Djordjevic SB. Voltammetric and differential pulse determination of roxithromycin. in Electrochimica Acta. 2010;56(1):47-52.
doi:10.1016/j.electacta.2010.09.067 .

Drljevic-Djuric, K. M., Jović, Vladimir D., Lačnjevac, Uroš, Avramov Ivić, Milka, Petrović, Slobodan D., Mijin, Dušan, Djordjevic, S. B., "Voltammetric and differential pulse determination of roxithromycin" in Electrochimica Acta, 56, no. 1 (2010):47-52,
https://doi.org/10.1016/j.electacta.2010.09.067 . .

TY  - JOUR
AU  - Avramov Ivić, Milka
AU  - Petrović, Slobodan D.
AU  - Živković, Predrag M.
AU  - Mijin, Dušan
AU  - Drljević, Katica M.
PY  - 2010
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/693
AB  - Using the cyclic voltammetry, it has been shown that hydrogen evolution at a gold electrode is necessary in the electrochemical activation of azithromycin dihydrate and erythromycin A. After four hours of the potential holding at -1.2 V vs. SCE, the pH of the electrolyte has been changed from 8.40 to 8.96; from 8.40 to 8.77 in the presence of erythromycin A, and from 8.40 to 9.18 in the presence of azithromycin, indicating the reaction of the hydrogen species with antibiotics. This effect has been confirmed by using the phenolphthalein indicator and by analysing colours of the solutions by UV-Vis, as well as by FTIR spectroscopy. Under the identical experimental conditions at the gold electrode, in contrast to azithromycin dihydrate and erythromycin A, roxithromycin and midecamycin electroactivity promotion has been obtained during the first forward sweep starting from the area of a double layer region.
AB  - Metodom ciklične voltametrije je pokazano da je izdvajanje vodonika na elektrodi od zlata neophodno za elektrohemijsku aktivaciju azitromicin-dihidrata i eritromicina A. Četiri sata držanja potencijala na vrednosti 1,2 V vs. SCE je rezultovalo u promeni pH elektrolita sa 8,40 na 8,96; sa 8,40 na 8,77 u prisustvu eritromicina A, i sa 8,40 na 9,18 u prisustvu azitromicina, ukazujući na reakciju čestica izdvojenog vodonika sa antibioticima. Efekat je potvrđen upotrebom fenolftalein indikatora i analizom boje elektrolita UV-Vis spektroskopijom, a molekula antibiotika FTIR spektroskopijom. Pod istim eksperimentalnim uslovima na elektrodi od zlata, u suprotnosti sa ponašanjem azitromicin-dihidrata i eritromicina A, elektroaktivnost roksitromicina i midekamicina je uočena počevši od oblasti formiranja dvojnog sloja, tj. bez ikakvog učešća čestica izdvojenog vodonika.
PB  - Association of the Chemical Engineers of Serbia
T2  - Chemical Industry and Chemical Engineering Quarterly / CICEQ
T1  - A study of the catalytic role of a gold electrode in the electrochemical activation of four macrolide antibiotics in sodium bicarbonate solution
T1  - Ispitivanje katalitičke uloge elektrode od zlata u elektrohemijskoj aktivaciji četiri makrolidna antibiotika u natrijum-bikarbonatnom elektrolitu
VL  - 16
IS  - 2
SP  - 111
EP  - 116
DO  - 10.2298/CICEQ091211017A
ER  - 

@article{
author = "Avramov Ivić, Milka and Petrović, Slobodan D. and Živković, Predrag M. and Mijin, Dušan and Drljević, Katica M.",
year = "2010",
abstract = "Using the cyclic voltammetry, it has been shown that hydrogen evolution at a gold electrode is necessary in the electrochemical activation of azithromycin dihydrate and erythromycin A. After four hours of the potential holding at -1.2 V vs. SCE, the pH of the electrolyte has been changed from 8.40 to 8.96; from 8.40 to 8.77 in the presence of erythromycin A, and from 8.40 to 9.18 in the presence of azithromycin, indicating the reaction of the hydrogen species with antibiotics. This effect has been confirmed by using the phenolphthalein indicator and by analysing colours of the solutions by UV-Vis, as well as by FTIR spectroscopy. Under the identical experimental conditions at the gold electrode, in contrast to azithromycin dihydrate and erythromycin A, roxithromycin and midecamycin electroactivity promotion has been obtained during the first forward sweep starting from the area of a double layer region., Metodom ciklične voltametrije je pokazano da je izdvajanje vodonika na elektrodi od zlata neophodno za elektrohemijsku aktivaciju azitromicin-dihidrata i eritromicina A. Četiri sata držanja potencijala na vrednosti 1,2 V vs. SCE je rezultovalo u promeni pH elektrolita sa 8,40 na 8,96; sa 8,40 na 8,77 u prisustvu eritromicina A, i sa 8,40 na 9,18 u prisustvu azitromicina, ukazujući na reakciju čestica izdvojenog vodonika sa antibioticima. Efekat je potvrđen upotrebom fenolftalein indikatora i analizom boje elektrolita UV-Vis spektroskopijom, a molekula antibiotika FTIR spektroskopijom. Pod istim eksperimentalnim uslovima na elektrodi od zlata, u suprotnosti sa ponašanjem azitromicin-dihidrata i eritromicina A, elektroaktivnost roksitromicina i midekamicina je uočena počevši od oblasti formiranja dvojnog sloja, tj. bez ikakvog učešća čestica izdvojenog vodonika.",
publisher = "Association of the Chemical Engineers of Serbia",
journal = "Chemical Industry and Chemical Engineering Quarterly / CICEQ",
title = "A study of the catalytic role of a gold electrode in the electrochemical activation of four macrolide antibiotics in sodium bicarbonate solution, Ispitivanje katalitičke uloge elektrode od zlata u elektrohemijskoj aktivaciji četiri makrolidna antibiotika u natrijum-bikarbonatnom elektrolitu",
volume = "16",
number = "2",
pages = "111-116",
doi = "10.2298/CICEQ091211017A"
}

Avramov Ivić, M., Petrović, S. D., Živković, P. M., Mijin, D.,& Drljević, K. M.. (2010). A study of the catalytic role of a gold electrode in the electrochemical activation of four macrolide antibiotics in sodium bicarbonate solution. in Chemical Industry and Chemical Engineering Quarterly / CICEQ
Association of the Chemical Engineers of Serbia., 16(2), 111-116.
https://doi.org/10.2298/CICEQ091211017A

Avramov Ivić M, Petrović SD, Živković PM, Mijin D, Drljević KM. A study of the catalytic role of a gold electrode in the electrochemical activation of four macrolide antibiotics in sodium bicarbonate solution. in Chemical Industry and Chemical Engineering Quarterly / CICEQ. 2010;16(2):111-116.
doi:10.2298/CICEQ091211017A .

Avramov Ivić, Milka, Petrović, Slobodan D., Živković, Predrag M., Mijin, Dušan, Drljević, Katica M., "A study of the catalytic role of a gold electrode in the electrochemical activation of four macrolide antibiotics in sodium bicarbonate solution" in Chemical Industry and Chemical Engineering Quarterly / CICEQ, 16, no. 2 (2010):111-116,
https://doi.org/10.2298/CICEQ091211017A . .

TY  - JOUR
AU  - Alimmari, Adel SA
AU  - Marinković, Aleksandar D.
AU  - Mijin, Dušan
AU  - Valentić, Nataša V.
AU  - Todorović, Nina
AU  - Ušćumlić, Gordana
PY  - 2010
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/712
AB  - A series of some new pyridone arylazo dyes was synthesized from the corresponding diazonium salts and 3-cyano-4,6-diphenyl-2-pyridone using the classical reaction for the synthesis of the azo compounds. The structures of these dyes were confirmed by UV-Vis, FT-IR and 1H-NMR spectroscopic techniques. The solvatochromism of the dyes was evaluated with respect to visible absorption properties in various solvents. The effects of solvent dipolarity/polarizability and solvent/solute hydrogen bonding interactions were analyzed by means of the linear solvation energy relationship concept proposed by Kamlet and Taft. The 2-pyridone/2-hydroxypiridine tautomeric equilibration was found to depend on the substituents as well as on the solvents.
AB  - Serija novih piridonskih arilazo boja je sintetisana reakcijom odgovarajućih diazonijum soli i 3-cijano-4,6-difenil-2-piridona primenom klasične sinteze azo jedinjenja. Struktura sintetisanih boja je potvrđena na osnovu podataka dobijenih iz UV, FT-IR i 1H-NMR spektara. Solvatohromna svojstva boja su procenjena u odnosu na njihovu apsorpciju u vidljivom delu spektra u različitim rastvračima. Efekti rastvarača, dipolarnost/polarizabilnost i vodonične interakcije rastvarač/rastvorak, su analizirane primenom linearne korelacije solvatohromnih efekata predložene od strane Kamlet-a i Taft-a. Tautomerna ravnoteža 2-piridon/2-hidroksipiridin zavisi kako od efekata supstituenta tako i od uticaja rastvarača.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Synthesis, structure and solvatochromic properties of 3-cyano-4,6-diphenyl-5-(3- and 4-substituted phenylazo)-2-pyridones
T1  - Sinteza, struktura i solvatohromna svojstva 3-cijano-4,6-difenil-5-(3- i 4-supstituisanih fenilazo)-2-piridona
VL  - 75
IS  - 8
SP  - 1019
EP  - 1032
DO  - 10.2298/JSC091009074A
ER  - 

@article{
author = "Alimmari, Adel SA and Marinković, Aleksandar D. and Mijin, Dušan and Valentić, Nataša V. and Todorović, Nina and Ušćumlić, Gordana",
year = "2010",
abstract = "A series of some new pyridone arylazo dyes was synthesized from the corresponding diazonium salts and 3-cyano-4,6-diphenyl-2-pyridone using the classical reaction for the synthesis of the azo compounds. The structures of these dyes were confirmed by UV-Vis, FT-IR and 1H-NMR spectroscopic techniques. The solvatochromism of the dyes was evaluated with respect to visible absorption properties in various solvents. The effects of solvent dipolarity/polarizability and solvent/solute hydrogen bonding interactions were analyzed by means of the linear solvation energy relationship concept proposed by Kamlet and Taft. The 2-pyridone/2-hydroxypiridine tautomeric equilibration was found to depend on the substituents as well as on the solvents., Serija novih piridonskih arilazo boja je sintetisana reakcijom odgovarajućih diazonijum soli i 3-cijano-4,6-difenil-2-piridona primenom klasične sinteze azo jedinjenja. Struktura sintetisanih boja je potvrđena na osnovu podataka dobijenih iz UV, FT-IR i 1H-NMR spektara. Solvatohromna svojstva boja su procenjena u odnosu na njihovu apsorpciju u vidljivom delu spektra u različitim rastvračima. Efekti rastvarača, dipolarnost/polarizabilnost i vodonične interakcije rastvarač/rastvorak, su analizirane primenom linearne korelacije solvatohromnih efekata predložene od strane Kamlet-a i Taft-a. Tautomerna ravnoteža 2-piridon/2-hidroksipiridin zavisi kako od efekata supstituenta tako i od uticaja rastvarača.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Synthesis, structure and solvatochromic properties of 3-cyano-4,6-diphenyl-5-(3- and 4-substituted phenylazo)-2-pyridones, Sinteza, struktura i solvatohromna svojstva 3-cijano-4,6-difenil-5-(3- i 4-supstituisanih fenilazo)-2-piridona",
volume = "75",
number = "8",
pages = "1019-1032",
doi = "10.2298/JSC091009074A"
}

Alimmari, A. S., Marinković, A. D., Mijin, D., Valentić, N. V., Todorović, N.,& Ušćumlić, G.. (2010). Synthesis, structure and solvatochromic properties of 3-cyano-4,6-diphenyl-5-(3- and 4-substituted phenylazo)-2-pyridones. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 75(8), 1019-1032.
https://doi.org/10.2298/JSC091009074A

Alimmari AS, Marinković AD, Mijin D, Valentić NV, Todorović N, Ušćumlić G. Synthesis, structure and solvatochromic properties of 3-cyano-4,6-diphenyl-5-(3- and 4-substituted phenylazo)-2-pyridones. in Journal of the Serbian Chemical Society. 2010;75(8):1019-1032.
doi:10.2298/JSC091009074A .

Alimmari, Adel SA, Marinković, Aleksandar D., Mijin, Dušan, Valentić, Nataša V., Todorović, Nina, Ušćumlić, Gordana, "Synthesis, structure and solvatochromic properties of 3-cyano-4,6-diphenyl-5-(3- and 4-substituted phenylazo)-2-pyridones" in Journal of the Serbian Chemical Society, 75, no. 8 (2010):1019-1032,
https://doi.org/10.2298/JSC091009074A . .

TY  - JOUR
AU  - Valentić, Nataša V.
AU  - Vitnik, Željko
AU  - Mijin, Dušan
AU  - Ušćumlić, Gordana
AU  - Todorović, Nina
AU  - Juranić, Ivan
PY  - 2009
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3994
AB  - The C-13 NMR chemical shifts of the C2 carbon atom in the heteroaromatic nuclei of seventeen 5-(3- and 4-substituted arylazo)-4,6-dimethyl-3-cyano-2-pyridones were determined in deuterated DMSO solution. For quantitative assessment of the substituent effects on the C-13 NMR chemical shifts simple and extended Hammett equations and Swain-Lupton equation were used. The mode of transmission of substituent effects have been discussed in a relation to the geometry of investigated molecules. The geometry data were obtained using semiempirical MNDO-PM6 energy calculations. The observed C-13 NMR substituent chemical shifts were correlated with literature C-13 NMR data for the corresponding 3- and 4-substituted- 2',6'-dimethylazobenzenes and 3- and 4-substituted azobenzenes. A good linear dependence obtained in this way, provided a basis to discuss the influence of the ortho-methyl groups on the degree of coplanarity of azobenzene and pyridone systems, and on the efficiency of transmission of electronic substituent effect from one ring to the other one.
PB  - Arkat USA Inc.
T2  - ARKIVOC - Online Journal of Organic Chemistry
T1  - Linear Free Energy Relationships of the C-13 NMR chemical shifts in 5-(3-and 4-substituted arylazo)-4,6-dimethyl-3-cyano-2-pyridones
VL  - 2009
IS  - 13
SP  - 227
EP  - 240
DO  - 10.3998/ark.5550190.0010.d20
ER  - 

@article{
author = "Valentić, Nataša V. and Vitnik, Željko and Mijin, Dušan and Ušćumlić, Gordana and Todorović, Nina and Juranić, Ivan",
year = "2009",
abstract = "The C-13 NMR chemical shifts of the C2 carbon atom in the heteroaromatic nuclei of seventeen 5-(3- and 4-substituted arylazo)-4,6-dimethyl-3-cyano-2-pyridones were determined in deuterated DMSO solution. For quantitative assessment of the substituent effects on the C-13 NMR chemical shifts simple and extended Hammett equations and Swain-Lupton equation were used. The mode of transmission of substituent effects have been discussed in a relation to the geometry of investigated molecules. The geometry data were obtained using semiempirical MNDO-PM6 energy calculations. The observed C-13 NMR substituent chemical shifts were correlated with literature C-13 NMR data for the corresponding 3- and 4-substituted- 2',6'-dimethylazobenzenes and 3- and 4-substituted azobenzenes. A good linear dependence obtained in this way, provided a basis to discuss the influence of the ortho-methyl groups on the degree of coplanarity of azobenzene and pyridone systems, and on the efficiency of transmission of electronic substituent effect from one ring to the other one.",
publisher = "Arkat USA Inc.",
journal = "ARKIVOC - Online Journal of Organic Chemistry",
title = "Linear Free Energy Relationships of the C-13 NMR chemical shifts in 5-(3-and 4-substituted arylazo)-4,6-dimethyl-3-cyano-2-pyridones",
volume = "2009",
number = "13",
pages = "227-240",
doi = "10.3998/ark.5550190.0010.d20"
}

Valentić, N. V., Vitnik, Ž., Mijin, D., Ušćumlić, G., Todorović, N.,& Juranić, I.. (2009). Linear Free Energy Relationships of the C-13 NMR chemical shifts in 5-(3-and 4-substituted arylazo)-4,6-dimethyl-3-cyano-2-pyridones. in ARKIVOC - Online Journal of Organic Chemistry
Arkat USA Inc.., 2009(13), 227-240.
https://doi.org/10.3998/ark.5550190.0010.d20

Valentić NV, Vitnik Ž, Mijin D, Ušćumlić G, Todorović N, Juranić I. Linear Free Energy Relationships of the C-13 NMR chemical shifts in 5-(3-and 4-substituted arylazo)-4,6-dimethyl-3-cyano-2-pyridones. in ARKIVOC - Online Journal of Organic Chemistry. 2009;2009(13):227-240.
doi:10.3998/ark.5550190.0010.d20 .

Valentić, Nataša V., Vitnik, Željko, Mijin, Dušan, Ušćumlić, Gordana, Todorović, Nina, Juranić, Ivan, "Linear Free Energy Relationships of the C-13 NMR chemical shifts in 5-(3-and 4-substituted arylazo)-4,6-dimethyl-3-cyano-2-pyridones" in ARKIVOC - Online Journal of Organic Chemistry, 2009, no. 13 (2009):227-240,
https://doi.org/10.3998/ark.5550190.0010.d20 . .

TY  - JOUR
AU  - Tomasević, Andjelka V.
AU  - Avramov Ivić, Milka
AU  - Petrović, Slobodan D.
AU  - Jovanović, Mica B.
AU  - Mijin, Dušan
PY  - 2009
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/534
AB  - A gold electrode was used for the qualitative and quantitative electrochemical determination of analytical methomyl in a neutral electrolyte (0.050 M NaHCO3) using cyclic linear sweep voltammetry. In the potential range from -800 mV vs. SCE to 1000 mV vs. SCE the analytical methomyl was quantitatively determined in the concentration range 4.0-16 mg L-1. In the potential range from -1300 mV vs. SCE to 1300 mV vs. SCE, methomyl was qualitatively determined by two anodic and four cathodic reactions. Cycling the potential in this range for 150 min caused the degradation of the molecule, which was confirmed by HPLC analysis. On the other hand, technical methomyl exhibited an inhibition of the gold electrode surface due to the impurities.
AB  - U radu su dati rezultati ispitivanja elektrohemijskog ponašanja aktivnosti metomila (analitičkog i tehničkog proizvoda) na elektrodi od zlata u neutralnom elektrolitu (0,050 M NaHCO3). HPLC je korišćena za analizu elektrolita u toku elektrohemijske reakcije. Maksimalna vrednost visine strujnog vrha oksidacije čistog metomila na 600 mV prema ZKE u 0,050 M NaHCO3 na 50 mV s-1 je linearna funkcija njegove koncentracije u opsegu 4-16 mg L-1 što je omogućilo razvijanje metode za njegovo kvantitativno određiva- nje. Analitički metomil je kvalitativno određen detekcijom reproduktivne četiri anodne i jedne katodne reakcije u opsegu potencijala od -1300 do 1300 mV prema ZKE. Potencijal je cikliziran 150 min u navedenom opsegu i analiza anodnih i katodnih reakcija na početku, u toku i na kraju cikliziranja potencijala je ukazala na degradaciju molekula metomila. Tokom cikliziranja potencijala, HPLC analiza elektrolita je pokazala smanjenje koncentracija metomila kao posledicu njegove degradacije. Tehnički metomil nije pogodan za ispitivanje pod navedenim uslovima jer prisutne nečistoće inhibiraju površinu elektrode.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - A study of the electrochemical behavior of methomyl on a gold electrode in a neutral electrolyte
T1  - Proučavanje elektrohemijskog ponašanja metomila na elektrodi od zlata u neutralnom elektrolitu
VL  - 74
IS  - 5
SP  - 573
EP  - 579
DO  - 10.2298/JSC0905573T
ER  - 

@article{
author = "Tomasević, Andjelka V. and Avramov Ivić, Milka and Petrović, Slobodan D. and Jovanović, Mica B. and Mijin, Dušan",
year = "2009",
abstract = "A gold electrode was used for the qualitative and quantitative electrochemical determination of analytical methomyl in a neutral electrolyte (0.050 M NaHCO3) using cyclic linear sweep voltammetry. In the potential range from -800 mV vs. SCE to 1000 mV vs. SCE the analytical methomyl was quantitatively determined in the concentration range 4.0-16 mg L-1. In the potential range from -1300 mV vs. SCE to 1300 mV vs. SCE, methomyl was qualitatively determined by two anodic and four cathodic reactions. Cycling the potential in this range for 150 min caused the degradation of the molecule, which was confirmed by HPLC analysis. On the other hand, technical methomyl exhibited an inhibition of the gold electrode surface due to the impurities., U radu su dati rezultati ispitivanja elektrohemijskog ponašanja aktivnosti metomila (analitičkog i tehničkog proizvoda) na elektrodi od zlata u neutralnom elektrolitu (0,050 M NaHCO3). HPLC je korišćena za analizu elektrolita u toku elektrohemijske reakcije. Maksimalna vrednost visine strujnog vrha oksidacije čistog metomila na 600 mV prema ZKE u 0,050 M NaHCO3 na 50 mV s-1 je linearna funkcija njegove koncentracije u opsegu 4-16 mg L-1 što je omogućilo razvijanje metode za njegovo kvantitativno određiva- nje. Analitički metomil je kvalitativno određen detekcijom reproduktivne četiri anodne i jedne katodne reakcije u opsegu potencijala od -1300 do 1300 mV prema ZKE. Potencijal je cikliziran 150 min u navedenom opsegu i analiza anodnih i katodnih reakcija na početku, u toku i na kraju cikliziranja potencijala je ukazala na degradaciju molekula metomila. Tokom cikliziranja potencijala, HPLC analiza elektrolita je pokazala smanjenje koncentracija metomila kao posledicu njegove degradacije. Tehnički metomil nije pogodan za ispitivanje pod navedenim uslovima jer prisutne nečistoće inhibiraju površinu elektrode.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "A study of the electrochemical behavior of methomyl on a gold electrode in a neutral electrolyte, Proučavanje elektrohemijskog ponašanja metomila na elektrodi od zlata u neutralnom elektrolitu",
volume = "74",
number = "5",
pages = "573-579",
doi = "10.2298/JSC0905573T"
}

Tomasević, A. V., Avramov Ivić, M., Petrović, S. D., Jovanović, M. B.,& Mijin, D.. (2009). A study of the electrochemical behavior of methomyl on a gold electrode in a neutral electrolyte. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 74(5), 573-579.
https://doi.org/10.2298/JSC0905573T

Tomasević AV, Avramov Ivić M, Petrović SD, Jovanović MB, Mijin D. A study of the electrochemical behavior of methomyl on a gold electrode in a neutral electrolyte. in Journal of the Serbian Chemical Society. 2009;74(5):573-579.
doi:10.2298/JSC0905573T .

Tomasević, Andjelka V., Avramov Ivić, Milka, Petrović, Slobodan D., Jovanović, Mica B., Mijin, Dušan, "A study of the electrochemical behavior of methomyl on a gold electrode in a neutral electrolyte" in Journal of the Serbian Chemical Society, 74, no. 5 (2009):573-579,
https://doi.org/10.2298/JSC0905573T . .

TY  - JOUR
AU  - Marinković, Aleksandar D.
AU  - Jovanović, Bratislav Ž.
AU  - Todorović, Nina
AU  - Juranić, Ivan
PY  - 2009
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/603
AB  - Linear free energy relationships (LFER) were applied to the 1H and 13C NMR chemical shifts in 3-cyano-4-(substituted phenyl)-6-phenyl-2(1H)pyridones. The correlation analysis for the substituent-induced chemical shifts (SCS) with inductive (σI), and various resonance (σR) parameters were carried out using SSP (single substituent parameter), DSP (dual substituent parameter), and DSP-NLR (dual substituent parameter non-linear resonance) methods, as well as by multiple regression analysis. The presented calculation accounts satisfactorily for the polar and resonance substituent effects operating at pyridone carbon atoms. Negative ρ values were found for several correlations (reverse substituent effect). The conformations of investigated compounds have been studied by the use of semi-empirical MO-PM6 method and B3LYP density functional (DFT) hybrid methods. The twist of the plane of 4-substituted phenyl ring (θ1) is determined by electronic substituent effects, while the angles θ2 are almost constant.
PB  - Elsevier
T2  - Journal of Molecular Structure
T1  - Linear free energy relationships of the 1H and 13C NMR chemical shifts in 3-cyano-4-(substituted phenyl)-6-phenyl-2(1H)pyridones
VL  - 920
IS  - 1-3
SP  - 90
EP  - 96
DO  - 10.1016/j.molstruc.2008.10.018
ER  - 

@article{
author = "Marinković, Aleksandar D. and Jovanović, Bratislav Ž. and Todorović, Nina and Juranić, Ivan",
year = "2009",
abstract = "Linear free energy relationships (LFER) were applied to the 1H and 13C NMR chemical shifts in 3-cyano-4-(substituted phenyl)-6-phenyl-2(1H)pyridones. The correlation analysis for the substituent-induced chemical shifts (SCS) with inductive (σI), and various resonance (σR) parameters were carried out using SSP (single substituent parameter), DSP (dual substituent parameter), and DSP-NLR (dual substituent parameter non-linear resonance) methods, as well as by multiple regression analysis. The presented calculation accounts satisfactorily for the polar and resonance substituent effects operating at pyridone carbon atoms. Negative ρ values were found for several correlations (reverse substituent effect). The conformations of investigated compounds have been studied by the use of semi-empirical MO-PM6 method and B3LYP density functional (DFT) hybrid methods. The twist of the plane of 4-substituted phenyl ring (θ1) is determined by electronic substituent effects, while the angles θ2 are almost constant.",
publisher = "Elsevier",
journal = "Journal of Molecular Structure",
title = "Linear free energy relationships of the 1H and 13C NMR chemical shifts in 3-cyano-4-(substituted phenyl)-6-phenyl-2(1H)pyridones",
volume = "920",
number = "1-3",
pages = "90-96",
doi = "10.1016/j.molstruc.2008.10.018"
}

Marinković, A. D., Jovanović, B. Ž., Todorović, N.,& Juranić, I.. (2009). Linear free energy relationships of the 1H and 13C NMR chemical shifts in 3-cyano-4-(substituted phenyl)-6-phenyl-2(1H)pyridones. in Journal of Molecular Structure
Elsevier., 920(1-3), 90-96.
https://doi.org/10.1016/j.molstruc.2008.10.018

Marinković AD, Jovanović BŽ, Todorović N, Juranić I. Linear free energy relationships of the 1H and 13C NMR chemical shifts in 3-cyano-4-(substituted phenyl)-6-phenyl-2(1H)pyridones. in Journal of Molecular Structure. 2009;920(1-3):90-96.
doi:10.1016/j.molstruc.2008.10.018 .

Marinković, Aleksandar D., Jovanović, Bratislav Ž., Todorović, Nina, Juranić, Ivan, "Linear free energy relationships of the 1H and 13C NMR chemical shifts in 3-cyano-4-(substituted phenyl)-6-phenyl-2(1H)pyridones" in Journal of Molecular Structure, 920, no. 1-3 (2009):90-96,
https://doi.org/10.1016/j.molstruc.2008.10.018 . .

TY  - JOUR
AU  - Avramov Ivić, Milka
AU  - Petrović, Slobodan D.
AU  - Mijin, Dušan
AU  - Vanmoos, F.
AU  - Orlovic, D. Z.
AU  - Marjanovic, D. Z.
AU  - Radovic, V. V.
PY  - 2008
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/375
AB  - The reactivity of erythromycin (pure) was investigated on a gold electrode in neutral electrolyte by cyclic voltammetry. The resulting structural changes were observed with HPLC and FTIR spectroscopy by analyzing the bulk electrolyte after the electrochemical reactions. The results were compared with those previously obtained for azithromycin and clarithromycin under the same experimental conditions. It was found that the electrochemical behavior of erythromycin A differs from that of azithromycin dihydrate. Comparison with the electrochemical activity of basic clarithromycin suggests that the electrochemical activity of erythromycin is similar but more pronounced than that of clarithromycin. HPLC analysis confirmed these observations and showed that during the electrochemical oxidation of erythromycin A, the amount of starting macrolide decreased while the amount of starting impurities increased. Also some new products were observed. FTIR spectroscopy confirmed that erythromycin A is more reactive than clarithromycin, although similar changes in their molecular structures were observed.
PB  - Oxford : Pergamon-Elsevier Science Ltd
T2  - Electrochimica Acta
T1  - The electrochemical behavior of erythromycin A on a gold electrode
VL  - 54
IS  - 2
SP  - 649
EP  - 654
DO  - 10.1016/j.electacta.2008.07.010
ER  - 

@article{
author = "Avramov Ivić, Milka and Petrović, Slobodan D. and Mijin, Dušan and Vanmoos, F. and Orlovic, D. Z. and Marjanovic, D. Z. and Radovic, V. V.",
year = "2008",
abstract = "The reactivity of erythromycin (pure) was investigated on a gold electrode in neutral electrolyte by cyclic voltammetry. The resulting structural changes were observed with HPLC and FTIR spectroscopy by analyzing the bulk electrolyte after the electrochemical reactions. The results were compared with those previously obtained for azithromycin and clarithromycin under the same experimental conditions. It was found that the electrochemical behavior of erythromycin A differs from that of azithromycin dihydrate. Comparison with the electrochemical activity of basic clarithromycin suggests that the electrochemical activity of erythromycin is similar but more pronounced than that of clarithromycin. HPLC analysis confirmed these observations and showed that during the electrochemical oxidation of erythromycin A, the amount of starting macrolide decreased while the amount of starting impurities increased. Also some new products were observed. FTIR spectroscopy confirmed that erythromycin A is more reactive than clarithromycin, although similar changes in their molecular structures were observed.",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "Electrochimica Acta",
title = "The electrochemical behavior of erythromycin A on a gold electrode",
volume = "54",
number = "2",
pages = "649-654",
doi = "10.1016/j.electacta.2008.07.010"
}

Avramov Ivić, M., Petrović, S. D., Mijin, D., Vanmoos, F., Orlovic, D. Z., Marjanovic, D. Z.,& Radovic, V. V.. (2008). The electrochemical behavior of erythromycin A on a gold electrode. in Electrochimica Acta
Oxford : Pergamon-Elsevier Science Ltd., 54(2), 649-654.
https://doi.org/10.1016/j.electacta.2008.07.010

Avramov Ivić M, Petrović SD, Mijin D, Vanmoos F, Orlovic DZ, Marjanovic DZ, Radovic VV. The electrochemical behavior of erythromycin A on a gold electrode. in Electrochimica Acta. 2008;54(2):649-654.
doi:10.1016/j.electacta.2008.07.010 .

Avramov Ivić, Milka, Petrović, Slobodan D., Mijin, Dušan, Vanmoos, F., Orlovic, D. Z., Marjanovic, D. Z., Radovic, V. V., "The electrochemical behavior of erythromycin A on a gold electrode" in Electrochimica Acta, 54, no. 2 (2008):649-654,
https://doi.org/10.1016/j.electacta.2008.07.010 . .

TY  - JOUR
AU  - Avramov Ivić, Milka
AU  - Petrović, Slobodan D.
AU  - Vonmoos, F.
AU  - Mijin, Dušan
AU  - Živković, Predrag M.
AU  - Drljevic, K. M.
PY  - 2008
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/377
AB  - The aim of the present study was to examine the behavior of commercial clarithromycin, Clathrocyn (R), comparing to the results previously obtained using pure clarithromycin under the same experimental conditions. The study was performed by cyclic linear sweep voltammetry and the bulk of electrolyte was analyzed by FTIR spectroscopy and HPLC. At gold electrode, in the range of -1.2 V to 1.0 V vs. SCE in 0.05 M NaHCO3, the electrochemical determination of pure clarithromycin was previously defined by four anodic and one cathodic reproductive peaks, and commercial clarithromycin is defined by reproductive one anodic peak which appears from 0.60 to 0.80 V vs. SCE. Previously, FTIR analysis of the bulk electrolyte showed the apparent changes in pure clarithromycin molecule structure: in the ester bond of the lactone and in ethers and acetal bonds. FTIR analysis of the bulk electrolyte also showed changes in the molecule structure in commercial-tablets form of clarithromycin: indicating disappearance of lactone structure and changes of carbonyl group at position 9.
PB  - Pleiades Publishing Inc, Moscow
T2  - Russian Journal of Electrochemistry
T1  - The electrochemical behavior of commercial clarithromycin and spectroscopic detection of its structural changes
VL  - 44
IS  - 8
SP  - 931
EP  - 936
DO  - 10.1134/S1023193508080089
ER  - 

@article{
author = "Avramov Ivić, Milka and Petrović, Slobodan D. and Vonmoos, F. and Mijin, Dušan and Živković, Predrag M. and Drljevic, K. M.",
year = "2008",
abstract = "The aim of the present study was to examine the behavior of commercial clarithromycin, Clathrocyn (R), comparing to the results previously obtained using pure clarithromycin under the same experimental conditions. The study was performed by cyclic linear sweep voltammetry and the bulk of electrolyte was analyzed by FTIR spectroscopy and HPLC. At gold electrode, in the range of -1.2 V to 1.0 V vs. SCE in 0.05 M NaHCO3, the electrochemical determination of pure clarithromycin was previously defined by four anodic and one cathodic reproductive peaks, and commercial clarithromycin is defined by reproductive one anodic peak which appears from 0.60 to 0.80 V vs. SCE. Previously, FTIR analysis of the bulk electrolyte showed the apparent changes in pure clarithromycin molecule structure: in the ester bond of the lactone and in ethers and acetal bonds. FTIR analysis of the bulk electrolyte also showed changes in the molecule structure in commercial-tablets form of clarithromycin: indicating disappearance of lactone structure and changes of carbonyl group at position 9.",
publisher = "Pleiades Publishing Inc, Moscow",
journal = "Russian Journal of Electrochemistry",
title = "The electrochemical behavior of commercial clarithromycin and spectroscopic detection of its structural changes",
volume = "44",
number = "8",
pages = "931-936",
doi = "10.1134/S1023193508080089"
}

Avramov Ivić, M., Petrović, S. D., Vonmoos, F., Mijin, D., Živković, P. M.,& Drljevic, K. M.. (2008). The electrochemical behavior of commercial clarithromycin and spectroscopic detection of its structural changes. in Russian Journal of Electrochemistry
Pleiades Publishing Inc, Moscow., 44(8), 931-936.
https://doi.org/10.1134/S1023193508080089

Avramov Ivić M, Petrović SD, Vonmoos F, Mijin D, Živković PM, Drljevic KM. The electrochemical behavior of commercial clarithromycin and spectroscopic detection of its structural changes. in Russian Journal of Electrochemistry. 2008;44(8):931-936.
doi:10.1134/S1023193508080089 .

Avramov Ivić, Milka, Petrović, Slobodan D., Vonmoos, F., Mijin, Dušan, Živković, Predrag M., Drljevic, K. M., "The electrochemical behavior of commercial clarithromycin and spectroscopic detection of its structural changes" in Russian Journal of Electrochemistry, 44, no. 8 (2008):931-936,
https://doi.org/10.1134/S1023193508080089 . .

TY  - JOUR
AU  - Avramov Ivić, Milka
AU  - Petrović, Slobodan D.
AU  - Vonmoos, F.
AU  - Mijin, Dušan
AU  - Živković, Predrag M.
AU  - Drljević, Katica M.
PY  - 2007
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4256
AB  - The aim of the present study was the qualitative determination of the pure clarithromycin using a gold electrode in neutral electrolyte by cyclic linear sweep voltammetry. It was shown that in the range of -1.2 V to 1.0 V vs. SCE in 0.05 M NaHCO3, a gold electrode is successfully employed for the qualitative determination of clarithromycin by detection of the reproductive four anodic and one cathodic peaks. After the potentiostatic measurements at the potential values corresponded to current peaks, the bulk electrolyte was analyzed by FTIR spectroscopy to show the changes in molecular structure of clarithromycin. FTIR analysis of the bulk electrolyte after 4 h of holding the potential at -0.61 V vs. SCE (cathodic peak) showed the apparent changes in clarithromycin molecule structure: in the ester bond of the lactone and in ethers and acetal bonds.
PB  - Elsevier
T2  - Electrochemistry Communications
T1  - The qualitative electrochemical determination of clarithromycin and spectroscopic detection of its structural changes at gold electrode
VL  - 9
IS  - 7
SP  - 1643
EP  - 1647
DO  - 10.1016/j.elecom.2007.03.011
ER  - 

@article{
author = "Avramov Ivić, Milka and Petrović, Slobodan D. and Vonmoos, F. and Mijin, Dušan and Živković, Predrag M. and Drljević, Katica M.",
year = "2007",
abstract = "The aim of the present study was the qualitative determination of the pure clarithromycin using a gold electrode in neutral electrolyte by cyclic linear sweep voltammetry. It was shown that in the range of -1.2 V to 1.0 V vs. SCE in 0.05 M NaHCO3, a gold electrode is successfully employed for the qualitative determination of clarithromycin by detection of the reproductive four anodic and one cathodic peaks. After the potentiostatic measurements at the potential values corresponded to current peaks, the bulk electrolyte was analyzed by FTIR spectroscopy to show the changes in molecular structure of clarithromycin. FTIR analysis of the bulk electrolyte after 4 h of holding the potential at -0.61 V vs. SCE (cathodic peak) showed the apparent changes in clarithromycin molecule structure: in the ester bond of the lactone and in ethers and acetal bonds.",
publisher = "Elsevier",
journal = "Electrochemistry Communications",
title = "The qualitative electrochemical determination of clarithromycin and spectroscopic detection of its structural changes at gold electrode",
volume = "9",
number = "7",
pages = "1643-1647",
doi = "10.1016/j.elecom.2007.03.011"
}

Avramov Ivić, M., Petrović, S. D., Vonmoos, F., Mijin, D., Živković, P. M.,& Drljević, K. M.. (2007). The qualitative electrochemical determination of clarithromycin and spectroscopic detection of its structural changes at gold electrode. in Electrochemistry Communications
Elsevier., 9(7), 1643-1647.
https://doi.org/10.1016/j.elecom.2007.03.011

Avramov Ivić M, Petrović SD, Vonmoos F, Mijin D, Živković PM, Drljević KM. The qualitative electrochemical determination of clarithromycin and spectroscopic detection of its structural changes at gold electrode. in Electrochemistry Communications. 2007;9(7):1643-1647.
doi:10.1016/j.elecom.2007.03.011 .

Avramov Ivić, Milka, Petrović, Slobodan D., Vonmoos, F., Mijin, Dušan, Živković, Predrag M., Drljević, Katica M., "The qualitative electrochemical determination of clarithromycin and spectroscopic detection of its structural changes at gold electrode" in Electrochemistry Communications, 9, no. 7 (2007):1643-1647,
https://doi.org/10.1016/j.elecom.2007.03.011 . .

TY  - JOUR
AU  - Avramov Ivić, Milka
AU  - Petrović, Slobodan D.
AU  - Mijin, Dušan
PY  - 2007
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/334
AB  - The aim of the present study is to present the different reactivity of azithromycin and clarithromycin (pure and commercial) at a gold electrode in neutral electrolyte using cyclic linear sweep voltammetry under the same experimental conditions. A gold electrode was successfully used for the electrochemical qualitative and quantitative determination of azithromycin dihydrate and azithromycin from capsules (Hemomycin®) and for the separation of azithromycin from one of the excipients, lactose monohydrate. The good catalytically activity of the gold electrode was employed only for the qualitative electrochemical determination of pure clarithromycin by appearance of one cathodic and four anodic reactions, which enabled structural changes in this molecule during electrochemical reactions to be studied. Commercial clarithromycin, Clathrocyn® was qualitative determined by one reproducible anodic reaction. The activity of one of the excipients, Avicel, observed as a cathodic peak at different potential from the cathodic peak obtained with pure clarithromicin was used for the determination of its presence in Clathrocyn® tablets. FTIR Analysis showed the apparent changes in structure of pure clarithromycin, as well as in the molecule of clarithromycin in Clathrocyn® tablets. HPLC Analysis showed a significant decrease in the concentration of azithromycin, Hemomycin® clarithromycin and Clathrocyn® after the electrochemical reactions.
AB  - U radu su prikazani rezultati ispitivanja elektrohemijske aktivnosti azitromicina i klaritromicina (čiste supstance i komercijalnog farmaceutskog proizvoda) na elektrodi od zlata u neutralnom elektrolitu. HPLC i FTIR spektroskopija su korišćene za analizu elektrolita posle elektrohemijske reakcije. Pokazano je da pod istim eksperimentalnim uslovima azitromicin i klaritromicin ispoljavaju potpuno različito elektrohemijsko ponašanje uslovljeno razlikama u strukturi makrolidnog prstena. Maksimalna vrednost visine jedinog strujnog vrha oksidacije čistog azitromicina i azitromicina u kapsuli Hemomicina® na 0,6 V u 0,05 M NaHCO3 pri 50 mV s-1 je linearna funkcija koncentracije u opsegu 0,235-0,588 mg cm-3 što je omogućilo razvijanje metode za njegovo kvalitativno i kvantitativno određivanje. Razvijena je i metoda za separaciju i kvantitativno određivanje ekscipienta, monohidrata laktoze. Kvalitativno je određen čist klaritromicin detekcijom reproduktivne četiri anodne i jedne katodne reakcije dok je klaritromicin u tableti, Clathrocyn®, kvalitativno određen jednom reproduktivnom anodnom reakcijom. FTIR analiza je pokazala uočljive promene u strukturi molekula klaritromicina. Takođe su uočene i strukturne promene posle ispitivanja klaritromicina u tableti Klatrocina®. HPLC analiza je ukazala na značajno smanjenje koncentracija azitromicina, Hemomicina®, klaritromicina i Klatrocina® u elektrolitu posle elektrohemijskih reakcija.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - A study of the electrochemical activity of some macrolide antibiotics on a gold electrode in a neutral electrolyte
T1  - Proučavanje elektrohemijske aktivnosti nekih makrolidnih antibiotika na elektrodi od zlata u neutralnom elektrolitu
VL  - 72
IS  - 12
SP  - 1427
EP  - 1436
DO  - 10.2298/JSC0712427A
ER  - 

@article{
author = "Avramov Ivić, Milka and Petrović, Slobodan D. and Mijin, Dušan",
year = "2007",
abstract = "The aim of the present study is to present the different reactivity of azithromycin and clarithromycin (pure and commercial) at a gold electrode in neutral electrolyte using cyclic linear sweep voltammetry under the same experimental conditions. A gold electrode was successfully used for the electrochemical qualitative and quantitative determination of azithromycin dihydrate and azithromycin from capsules (Hemomycin®) and for the separation of azithromycin from one of the excipients, lactose monohydrate. The good catalytically activity of the gold electrode was employed only for the qualitative electrochemical determination of pure clarithromycin by appearance of one cathodic and four anodic reactions, which enabled structural changes in this molecule during electrochemical reactions to be studied. Commercial clarithromycin, Clathrocyn® was qualitative determined by one reproducible anodic reaction. The activity of one of the excipients, Avicel, observed as a cathodic peak at different potential from the cathodic peak obtained with pure clarithromicin was used for the determination of its presence in Clathrocyn® tablets. FTIR Analysis showed the apparent changes in structure of pure clarithromycin, as well as in the molecule of clarithromycin in Clathrocyn® tablets. HPLC Analysis showed a significant decrease in the concentration of azithromycin, Hemomycin® clarithromycin and Clathrocyn® after the electrochemical reactions., U radu su prikazani rezultati ispitivanja elektrohemijske aktivnosti azitromicina i klaritromicina (čiste supstance i komercijalnog farmaceutskog proizvoda) na elektrodi od zlata u neutralnom elektrolitu. HPLC i FTIR spektroskopija su korišćene za analizu elektrolita posle elektrohemijske reakcije. Pokazano je da pod istim eksperimentalnim uslovima azitromicin i klaritromicin ispoljavaju potpuno različito elektrohemijsko ponašanje uslovljeno razlikama u strukturi makrolidnog prstena. Maksimalna vrednost visine jedinog strujnog vrha oksidacije čistog azitromicina i azitromicina u kapsuli Hemomicina® na 0,6 V u 0,05 M NaHCO3 pri 50 mV s-1 je linearna funkcija koncentracije u opsegu 0,235-0,588 mg cm-3 što je omogućilo razvijanje metode za njegovo kvalitativno i kvantitativno određivanje. Razvijena je i metoda za separaciju i kvantitativno određivanje ekscipienta, monohidrata laktoze. Kvalitativno je određen čist klaritromicin detekcijom reproduktivne četiri anodne i jedne katodne reakcije dok je klaritromicin u tableti, Clathrocyn®, kvalitativno određen jednom reproduktivnom anodnom reakcijom. FTIR analiza je pokazala uočljive promene u strukturi molekula klaritromicina. Takođe su uočene i strukturne promene posle ispitivanja klaritromicina u tableti Klatrocina®. HPLC analiza je ukazala na značajno smanjenje koncentracija azitromicina, Hemomicina®, klaritromicina i Klatrocina® u elektrolitu posle elektrohemijskih reakcija.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "A study of the electrochemical activity of some macrolide antibiotics on a gold electrode in a neutral electrolyte, Proučavanje elektrohemijske aktivnosti nekih makrolidnih antibiotika na elektrodi od zlata u neutralnom elektrolitu",
volume = "72",
number = "12",
pages = "1427-1436",
doi = "10.2298/JSC0712427A"
}

Avramov Ivić, M., Petrović, S. D.,& Mijin, D.. (2007). A study of the electrochemical activity of some macrolide antibiotics on a gold electrode in a neutral electrolyte. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 72(12), 1427-1436.
https://doi.org/10.2298/JSC0712427A

Avramov Ivić M, Petrović SD, Mijin D. A study of the electrochemical activity of some macrolide antibiotics on a gold electrode in a neutral electrolyte. in Journal of the Serbian Chemical Society. 2007;72(12):1427-1436.
doi:10.2298/JSC0712427A .

Avramov Ivić, Milka, Petrović, Slobodan D., Mijin, Dušan, "A study of the electrochemical activity of some macrolide antibiotics on a gold electrode in a neutral electrolyte" in Journal of the Serbian Chemical Society, 72, no. 12 (2007):1427-1436,
https://doi.org/10.2298/JSC0712427A . .