TY  - JOUR
AU  - Mišković, Jovana
AU  - Karaman, Maja A.
AU  - Rašeta, Milena J.
AU  - Krsmanović, Nenad
AU  - Berežni, Sanja
AU  - Jakovljević, Dragica
AU  - Piattoni, Federica
AU  - Zambonelli, Alessandra
AU  - Gargano, Maria Letizia
AU  - Venturella, Giuseppe
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4338
AB  - In recent years, fungi have been recognized as producers of acetylcholinesterase (AChE) inhibitors, agents important for the prevention of Alzheimer’s disease (AD). This study aimed to examine the AChE inhibitory, the antioxidative and antibacterial activity of two different Schizophyllum commune strains that originated from Serbia (SRB) and Italy (IT). Submerged cultivation of grown mycelia (M) and fermentation broth (F) of ethanol (EtOH) and polysaccharide (PSH) extracts lasted for 7, 14, 21 and 28 days. For AChE activity Ellman method was performed, while for antioxidative activity, sevendifferent assays were conducted: DPPH, ABTS, FRAP, SOA, OH, NO together with total phenolic content. Antimicrobial screen, LC–MS/MS technique and FTIR measurements were performed. Different isolates exhibited different AChE activity, with PSH being the strongest (SRB, M, 28 days IC90 79.73 ± 26.34 µg/mL), while in EtOH extracts, IT stood out (F, 14 days, IC50 0.8 ± 0.6 µg/mL). PSH extracts (7 days) exhibit significant antioxidative activity (AO), opposite to EtOH extracts where 14 and 21days periods stood out. Only tw extracts showed antibacterial activity. Following LC–MS/MS analysis p-hydroxybenzoic and gallic acids were the most abundant phenolics. PSH extracts demonstrated remarkable results, making this study debut and introducing S. commune as a valuable resource of AChE inhibitors.
PB  - MDPI
T2  - Journal of Fungi
T1  - Comparison of two schizophyllum commune strains in production of acetylcholinesterase inhibitors and antioxidants from submerged cultivation
VL  - 7
IS  - 2
SP  - 115
EP  - 17
DO  - 10.3390/jof7020115
ER  - 

@article{
author = "Mišković, Jovana and Karaman, Maja A. and Rašeta, Milena J. and Krsmanović, Nenad and Berežni, Sanja and Jakovljević, Dragica and Piattoni, Federica and Zambonelli, Alessandra and Gargano, Maria Letizia and Venturella, Giuseppe",
year = "2021",
abstract = "In recent years, fungi have been recognized as producers of acetylcholinesterase (AChE) inhibitors, agents important for the prevention of Alzheimer’s disease (AD). This study aimed to examine the AChE inhibitory, the antioxidative and antibacterial activity of two different Schizophyllum commune strains that originated from Serbia (SRB) and Italy (IT). Submerged cultivation of grown mycelia (M) and fermentation broth (F) of ethanol (EtOH) and polysaccharide (PSH) extracts lasted for 7, 14, 21 and 28 days. For AChE activity Ellman method was performed, while for antioxidative activity, sevendifferent assays were conducted: DPPH, ABTS, FRAP, SOA, OH, NO together with total phenolic content. Antimicrobial screen, LC–MS/MS technique and FTIR measurements were performed. Different isolates exhibited different AChE activity, with PSH being the strongest (SRB, M, 28 days IC90 79.73 ± 26.34 µg/mL), while in EtOH extracts, IT stood out (F, 14 days, IC50 0.8 ± 0.6 µg/mL). PSH extracts (7 days) exhibit significant antioxidative activity (AO), opposite to EtOH extracts where 14 and 21days periods stood out. Only tw extracts showed antibacterial activity. Following LC–MS/MS analysis p-hydroxybenzoic and gallic acids were the most abundant phenolics. PSH extracts demonstrated remarkable results, making this study debut and introducing S. commune as a valuable resource of AChE inhibitors.",
publisher = "MDPI",
journal = "Journal of Fungi",
title = "Comparison of two schizophyllum commune strains in production of acetylcholinesterase inhibitors and antioxidants from submerged cultivation",
volume = "7",
number = "2",
pages = "115-17",
doi = "10.3390/jof7020115"
}

Mišković, J., Karaman, M. A., Rašeta, M. J., Krsmanović, N., Berežni, S., Jakovljević, D., Piattoni, F., Zambonelli, A., Gargano, M. L.,& Venturella, G.. (2021). Comparison of two schizophyllum commune strains in production of acetylcholinesterase inhibitors and antioxidants from submerged cultivation. in Journal of Fungi
MDPI., 7(2), 115-17.
https://doi.org/10.3390/jof7020115

Mišković J, Karaman MA, Rašeta MJ, Krsmanović N, Berežni S, Jakovljević D, Piattoni F, Zambonelli A, Gargano ML, Venturella G. Comparison of two schizophyllum commune strains in production of acetylcholinesterase inhibitors and antioxidants from submerged cultivation. in Journal of Fungi. 2021;7(2):115-17.
doi:10.3390/jof7020115 .

Mišković, Jovana, Karaman, Maja A., Rašeta, Milena J., Krsmanović, Nenad, Berežni, Sanja, Jakovljević, Dragica, Piattoni, Federica, Zambonelli, Alessandra, Gargano, Maria Letizia, Venturella, Giuseppe, "Comparison of two schizophyllum commune strains in production of acetylcholinesterase inhibitors and antioxidants from submerged cultivation" in Journal of Fungi, 7, no. 2 (2021):115-17,
https://doi.org/10.3390/jof7020115 . .

TY  - CONF
AU  - Cvijanović, Dušanka
AU  - Damnjanović, Bojan
AU  - Novaković, Maja
AU  - Živković, Milica
AU  - Anđelković, Ana
AU  - Vesić, Aleksandra
AU  - Vukov, Dragana
AU  - Radulović, Snežana
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7051
AB  - Human-made aquatic habitats, such as gravel pit lakes could be alternative habitats and biodiversity refugia for aquatic biota. The aim of this study was to determine conservation value of gravel pit lakes in the Drina river floodplain using rarity and naturalness of aquatic macrohytes. Conservation value was calculated for 14 lakes. The obtained results showed that the analyzed gravel pits along the Drina River represent an optimal habitats for rare and endangered macrophytic flora.
PB  - Srpsko društvo za zaštitu voda
C3  - Zbornik radova - 47. godišnja konferenciježa o aktuelnim temama korišćenja i zaštite voda, VODA 2018, 12 - 14. Jun 2018 godine, Sokobanja, Srbija
T1  - Konzervacioni status makrofitske vegetacije u kopovima šljunka u plavnom području donjeg toka reke Drine
SP  - 111
EP  - 118
UR  - https://hdl.handle.net/21.15107/rcub_cer_7051
ER  - 

@conference{
author = "Cvijanović, Dušanka and Damnjanović, Bojan and Novaković, Maja and Živković, Milica and Anđelković, Ana and Vesić, Aleksandra and Vukov, Dragana and Radulović, Snežana",
year = "2018",
abstract = "Human-made aquatic habitats, such as gravel pit lakes could be alternative habitats and biodiversity refugia for aquatic biota. The aim of this study was to determine conservation value of gravel pit lakes in the Drina river floodplain using rarity and naturalness of aquatic macrohytes. Conservation value was calculated for 14 lakes. The obtained results showed that the analyzed gravel pits along the Drina River represent an optimal habitats for rare and endangered macrophytic flora.",
publisher = "Srpsko društvo za zaštitu voda",
journal = "Zbornik radova - 47. godišnja konferenciježa o aktuelnim temama korišćenja i zaštite voda, VODA 2018, 12 - 14. Jun 2018 godine, Sokobanja, Srbija",
title = "Konzervacioni status makrofitske vegetacije u kopovima šljunka u plavnom području donjeg toka reke Drine",
pages = "111-118",
url = "https://hdl.handle.net/21.15107/rcub_cer_7051"
}

Cvijanović, D., Damnjanović, B., Novaković, M., Živković, M., Anđelković, A., Vesić, A., Vukov, D.,& Radulović, S.. (2018). Konzervacioni status makrofitske vegetacije u kopovima šljunka u plavnom području donjeg toka reke Drine. in Zbornik radova - 47. godišnja konferenciježa o aktuelnim temama korišćenja i zaštite voda, VODA 2018, 12 - 14. Jun 2018 godine, Sokobanja, Srbija
Srpsko društvo za zaštitu voda., 111-118.
https://hdl.handle.net/21.15107/rcub_cer_7051

Cvijanović D, Damnjanović B, Novaković M, Živković M, Anđelković A, Vesić A, Vukov D, Radulović S. Konzervacioni status makrofitske vegetacije u kopovima šljunka u plavnom području donjeg toka reke Drine. in Zbornik radova - 47. godišnja konferenciježa o aktuelnim temama korišćenja i zaštite voda, VODA 2018, 12 - 14. Jun 2018 godine, Sokobanja, Srbija. 2018;:111-118.
https://hdl.handle.net/21.15107/rcub_cer_7051 .

Cvijanović, Dušanka, Damnjanović, Bojan, Novaković, Maja, Živković, Milica, Anđelković, Ana, Vesić, Aleksandra, Vukov, Dragana, Radulović, Snežana, "Konzervacioni status makrofitske vegetacije u kopovima šljunka u plavnom području donjeg toka reke Drine" in Zbornik radova - 47. godišnja konferenciježa o aktuelnim temama korišćenja i zaštite voda, VODA 2018, 12 - 14. Jun 2018 godine, Sokobanja, Srbija (2018):111-118,
https://hdl.handle.net/21.15107/rcub_cer_7051 .

TY  - JOUR
AU  - Damnjanović, B.
AU  - Novković, M.
AU  - Vesić, Aleksandra
AU  - Živković, M.
AU  - Radulović, Siniša
AU  - Vukov, D.
AU  - Anđelković, A.
AU  - Cvijanović, D.
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2387
AB  - Massive gravel excavation is one of the most destructive forces affecting riverine habitats in Europe. However, gravel pit lakes are also recognized as valuable wildlife refuge areas. Different hydromorphological characteristics of gravel pits may influence aquatic biota differently. Optimal selection of gravel excavation procedures may create favorable conditions for ecosystem diversity. The aim of this study was to correlate hydromorphological variables against macrophyte composition and metrics in gravel pit lakes along the lower course of the Drina River. Field research was carried out at 18 gravel pit lakes (60 survey sectors) and four fluvial lakes (13 survey sectors), during the summer months of 2015, 2016 and 2018. The role of hydromorphological variables in structuring macrophyte assemblages was tested using the partial Canonical Correspondence Analysis, while the Generalized Linear Model was performed to test the ability of selected hydromorphological attributes to predict macrophyte quantitative metrics. The results demonstrated high habitat quality and conservation value of the gravel pit lakes compared to natural sites. Hydromorphological predictors for different macrophyte assemblages were defined. General recommendation is that two pit types should be excavated within a single extraction field, with the minimal impact to the riparian and shore zones. The first type should be located up to 100 m from river main channel, having area < 1000 m2 and a relative depth ratio > 5%. The second type should be optimally located 300 m form river main channel, with maximum depth of 3–4 m, surface area of 10,000–20,000 m2, and a relative depth ratio < 5%.
PB  - Springer Netherlands
T2  - Wetlands Ecology and Management
T1  - Biodiversity-friendly designs for gravel pit lakes along the Drina River floodplain (the Middle Danube Basin, Serbia)
DO  - 10.1007/s11273-018-9641-8
ER  - 

@article{
author = "Damnjanović, B. and Novković, M. and Vesić, Aleksandra and Živković, M. and Radulović, Siniša and Vukov, D. and Anđelković, A. and Cvijanović, D.",
year = "2018",
abstract = "Massive gravel excavation is one of the most destructive forces affecting riverine habitats in Europe. However, gravel pit lakes are also recognized as valuable wildlife refuge areas. Different hydromorphological characteristics of gravel pits may influence aquatic biota differently. Optimal selection of gravel excavation procedures may create favorable conditions for ecosystem diversity. The aim of this study was to correlate hydromorphological variables against macrophyte composition and metrics in gravel pit lakes along the lower course of the Drina River. Field research was carried out at 18 gravel pit lakes (60 survey sectors) and four fluvial lakes (13 survey sectors), during the summer months of 2015, 2016 and 2018. The role of hydromorphological variables in structuring macrophyte assemblages was tested using the partial Canonical Correspondence Analysis, while the Generalized Linear Model was performed to test the ability of selected hydromorphological attributes to predict macrophyte quantitative metrics. The results demonstrated high habitat quality and conservation value of the gravel pit lakes compared to natural sites. Hydromorphological predictors for different macrophyte assemblages were defined. General recommendation is that two pit types should be excavated within a single extraction field, with the minimal impact to the riparian and shore zones. The first type should be located up to 100 m from river main channel, having area < 1000 m2 and a relative depth ratio > 5%. The second type should be optimally located 300 m form river main channel, with maximum depth of 3–4 m, surface area of 10,000–20,000 m2, and a relative depth ratio < 5%.",
publisher = "Springer Netherlands",
journal = "Wetlands Ecology and Management",
title = "Biodiversity-friendly designs for gravel pit lakes along the Drina River floodplain (the Middle Danube Basin, Serbia)",
doi = "10.1007/s11273-018-9641-8"
}

Damnjanović, B., Novković, M., Vesić, A., Živković, M., Radulović, S., Vukov, D., Anđelković, A.,& Cvijanović, D.. (2018). Biodiversity-friendly designs for gravel pit lakes along the Drina River floodplain (the Middle Danube Basin, Serbia). in Wetlands Ecology and Management
Springer Netherlands..
https://doi.org/10.1007/s11273-018-9641-8

Damnjanović B, Novković M, Vesić A, Živković M, Radulović S, Vukov D, Anđelković A, Cvijanović D. Biodiversity-friendly designs for gravel pit lakes along the Drina River floodplain (the Middle Danube Basin, Serbia). in Wetlands Ecology and Management. 2018;.
doi:10.1007/s11273-018-9641-8 .

Damnjanović, B., Novković, M., Vesić, Aleksandra, Živković, M., Radulović, Siniša, Vukov, D., Anđelković, A., Cvijanović, D., "Biodiversity-friendly designs for gravel pit lakes along the Drina River floodplain (the Middle Danube Basin, Serbia)" in Wetlands Ecology and Management (2018),
https://doi.org/10.1007/s11273-018-9641-8 . .

TY  - JOUR
AU  - Karaman, M.
AU  - Tesanovic, K.
AU  - Novakovic, A.
AU  - Jakovljević, Dragica
AU  - Janjusevic, L.
AU  - Sibul, F.
AU  - Pejin, Boris
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2388
AB  - In vitro acetylholinesterase (AChE) inhibitory activity of an autochthonous sample of the mushroom Coprinus comatus (encompassing fruiting body FB, mycelia M and filtrate F from the submerged cultivation) was the subject of this study. C. comatus F extract exhibited rather potent anti-AChE activity (73.0 ± 1.5%) at in liquid conditions, comparable to those of the conventional drug donepezil (80.6 ± 1.4%). Also, the same extract exhibited high anti-AChE activity (1 µg) in solid. While its FTIR spectrum indicated the presence of phenolic compounds, quercetin (28.1 µg g−1 d.w.) was found to affect the observed bioactivity (59.8 ± 0.9%). This is the first report of profound anti-AChE activity of any C. comatus extract, a medicinal mushroom that has been successfully cultivated in P.R. China, due to the demanding needs of food industry.
PB  - Taylor and Francis Ltd.
T2  - Natural Product Research
T1  - Coprinus comatus filtrate extract, a novel neuroprotective agent of natural origin
VL  - 34
IS  - 16
SP  - 2346
EP  - 2350
DO  - 10.1080/14786419.2018.1533831
ER  - 

@article{
author = "Karaman, M. and Tesanovic, K. and Novakovic, A. and Jakovljević, Dragica and Janjusevic, L. and Sibul, F. and Pejin, Boris",
year = "2018",
abstract = "In vitro acetylholinesterase (AChE) inhibitory activity of an autochthonous sample of the mushroom Coprinus comatus (encompassing fruiting body FB, mycelia M and filtrate F from the submerged cultivation) was the subject of this study. C. comatus F extract exhibited rather potent anti-AChE activity (73.0 ± 1.5%) at in liquid conditions, comparable to those of the conventional drug donepezil (80.6 ± 1.4%). Also, the same extract exhibited high anti-AChE activity (1 µg) in solid. While its FTIR spectrum indicated the presence of phenolic compounds, quercetin (28.1 µg g−1 d.w.) was found to affect the observed bioactivity (59.8 ± 0.9%). This is the first report of profound anti-AChE activity of any C. comatus extract, a medicinal mushroom that has been successfully cultivated in P.R. China, due to the demanding needs of food industry.",
publisher = "Taylor and Francis Ltd.",
journal = "Natural Product Research",
title = "Coprinus comatus filtrate extract, a novel neuroprotective agent of natural origin",
volume = "34",
number = "16",
pages = "2346-2350",
doi = "10.1080/14786419.2018.1533831"
}

Karaman, M., Tesanovic, K., Novakovic, A., Jakovljević, D., Janjusevic, L., Sibul, F.,& Pejin, B.. (2018). Coprinus comatus filtrate extract, a novel neuroprotective agent of natural origin. in Natural Product Research
Taylor and Francis Ltd.., 34(16), 2346-2350.
https://doi.org/10.1080/14786419.2018.1533831

Karaman M, Tesanovic K, Novakovic A, Jakovljević D, Janjusevic L, Sibul F, Pejin B. Coprinus comatus filtrate extract, a novel neuroprotective agent of natural origin. in Natural Product Research. 2018;34(16):2346-2350.
doi:10.1080/14786419.2018.1533831 .

Karaman, M., Tesanovic, K., Novakovic, A., Jakovljević, Dragica, Janjusevic, L., Sibul, F., Pejin, Boris, "Coprinus comatus filtrate extract, a novel neuroprotective agent of natural origin" in Natural Product Research, 34, no. 16 (2018):2346-2350,
https://doi.org/10.1080/14786419.2018.1533831 . .

TY  - JOUR
AU  - Karaman, M.
AU  - Janjušević, L.
AU  - Jakovljević, Dragica
AU  - Šibul, F.
AU  - Pejin, Boris
PY  - 2017
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2214
AB  - This study outlines antioxidant and anti-AChE activities of the polysaccharide (PSH) extract from the mushroom species Amanita strobiliformis. Both the presence of α and ß glucans within the aforementioned extract was recorded. PSH extract displayed a profound scavenging activity of OH radicals (IC50 value, 11.86 ± 0.59 μg/mL) and high potential for reduction of Fe3+ ions (174.11 ± 8.70 mg eq. AA/g d.w.) being almost 48- and 5-fold more effective than mannitol and butylated hydroxytoluene used as a positive control, respectively. Compared with galanthamine (0.001 μg), the same extract exhibited a moderate anti-AChE activity (10 μg) in solid. Since purified PSH extract exhibited higher bioactivity (IC50 value 7.27 ± 0.31 μg/mL, 197.68 ± 9.47 mg eq. AA/g d.w. and 0.1 μg, respectively), it can be predominantly ascribed to the polysaccharide compounds. A. strobiliformis PSH extract may be considered as a promising resource of potent bioactive polysaccharides of natural origin successfully addressing both oxidative stress and lack of acetylcholine.
PB  - Taylor and Francis Ltd.
T2  - Natural Product Research
T1  - Anti-hydroxyl radical activity, redox potential and anti-AChE activity of Amanita strobiliformis polysaccharide extract
SP  - 1
EP  - 5
DO  - 10.1080/14786419.2017.1422183
ER  - 

@article{
author = "Karaman, M. and Janjušević, L. and Jakovljević, Dragica and Šibul, F. and Pejin, Boris",
year = "2017",
abstract = "This study outlines antioxidant and anti-AChE activities of the polysaccharide (PSH) extract from the mushroom species Amanita strobiliformis. Both the presence of α and ß glucans within the aforementioned extract was recorded. PSH extract displayed a profound scavenging activity of OH radicals (IC50 value, 11.86 ± 0.59 μg/mL) and high potential for reduction of Fe3+ ions (174.11 ± 8.70 mg eq. AA/g d.w.) being almost 48- and 5-fold more effective than mannitol and butylated hydroxytoluene used as a positive control, respectively. Compared with galanthamine (0.001 μg), the same extract exhibited a moderate anti-AChE activity (10 μg) in solid. Since purified PSH extract exhibited higher bioactivity (IC50 value 7.27 ± 0.31 μg/mL, 197.68 ± 9.47 mg eq. AA/g d.w. and 0.1 μg, respectively), it can be predominantly ascribed to the polysaccharide compounds. A. strobiliformis PSH extract may be considered as a promising resource of potent bioactive polysaccharides of natural origin successfully addressing both oxidative stress and lack of acetylcholine.",
publisher = "Taylor and Francis Ltd.",
journal = "Natural Product Research",
title = "Anti-hydroxyl radical activity, redox potential and anti-AChE activity of Amanita strobiliformis polysaccharide extract",
pages = "1-5",
doi = "10.1080/14786419.2017.1422183"
}

Karaman, M., Janjušević, L., Jakovljević, D., Šibul, F.,& Pejin, B.. (2017). Anti-hydroxyl radical activity, redox potential and anti-AChE activity of Amanita strobiliformis polysaccharide extract. in Natural Product Research
Taylor and Francis Ltd.., 1-5.
https://doi.org/10.1080/14786419.2017.1422183

Karaman M, Janjušević L, Jakovljević D, Šibul F, Pejin B. Anti-hydroxyl radical activity, redox potential and anti-AChE activity of Amanita strobiliformis polysaccharide extract. in Natural Product Research. 2017;:1-5.
doi:10.1080/14786419.2017.1422183 .

Karaman, M., Janjušević, L., Jakovljević, Dragica, Šibul, F., Pejin, Boris, "Anti-hydroxyl radical activity, redox potential and anti-AChE activity of Amanita strobiliformis polysaccharide extract" in Natural Product Research (2017):1-5,
https://doi.org/10.1080/14786419.2017.1422183 . .