TY  - JOUR
AU  - Ivanović, Stefan
AU  - Gođevac, Dejan
AU  - Ristivojević, Petar
AU  - Zdunić, Gordana
AU  - Stojanović, Danilo
AU  - Šavikin, Katarina
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5648
AB  - Introduction: Chokeberry is a plant belonging to the family Rosaceae which has a long history of edible and medicinal use. The aims of this study are: i) to investigate of HPTLC profile of the berry samples using HPTLC technique based metabolomics approach, ii) to determine the botanical origin of investigated chokeberry adulterations iii) to identify the most important botanical markers responsible for classification. Methods: A simple, rapid, and high-throughput planar chromatography (HPTLC) method was applied in combination with multivariate techniques for differentiating chokeberry samples and identification of the main metabolites of chokeberry and four common adulterants. Images of HPTLC chromatograms obtained using two different detections i.e. visible light and derivatization with natural products reagent were used as a dataset for multivariate analysis. Results: Principal component analysis and Orthogonal Partial Least Squares Discriminant Analysis confirmed the discrimination of five botanically different samples and recognized their main markers such as responsible for differences between chokeberry and four common adulterants. Conclusion: The obtained results showed that the HPTLC-based metabolomics approach can be a very reliable technique for the detection of chokeberry adulteration.
PB  - Elsevier GmbH
T2  - Journal of Herbal Medicine
T1  - HPTLC-based metabolomics approach for the detection of chokeberry (Aronia melanocarpa (Michx.) Elliott) adulteration
VL  - 37
SP  - 100618
DO  - 10.1016/j.hermed.2022.100618
ER  - 

@article{
author = "Ivanović, Stefan and Gođevac, Dejan and Ristivojević, Petar and Zdunić, Gordana and Stojanović, Danilo and Šavikin, Katarina",
year = "2023",
abstract = "Introduction: Chokeberry is a plant belonging to the family Rosaceae which has a long history of edible and medicinal use. The aims of this study are: i) to investigate of HPTLC profile of the berry samples using HPTLC technique based metabolomics approach, ii) to determine the botanical origin of investigated chokeberry adulterations iii) to identify the most important botanical markers responsible for classification. Methods: A simple, rapid, and high-throughput planar chromatography (HPTLC) method was applied in combination with multivariate techniques for differentiating chokeberry samples and identification of the main metabolites of chokeberry and four common adulterants. Images of HPTLC chromatograms obtained using two different detections i.e. visible light and derivatization with natural products reagent were used as a dataset for multivariate analysis. Results: Principal component analysis and Orthogonal Partial Least Squares Discriminant Analysis confirmed the discrimination of five botanically different samples and recognized their main markers such as responsible for differences between chokeberry and four common adulterants. Conclusion: The obtained results showed that the HPTLC-based metabolomics approach can be a very reliable technique for the detection of chokeberry adulteration.",
publisher = "Elsevier GmbH",
journal = "Journal of Herbal Medicine",
title = "HPTLC-based metabolomics approach for the detection of chokeberry (Aronia melanocarpa (Michx.) Elliott) adulteration",
volume = "37",
pages = "100618",
doi = "10.1016/j.hermed.2022.100618"
}

Ivanović, S., Gođevac, D., Ristivojević, P., Zdunić, G., Stojanović, D.,& Šavikin, K.. (2023). HPTLC-based metabolomics approach for the detection of chokeberry (Aronia melanocarpa (Michx.) Elliott) adulteration. in Journal of Herbal Medicine
Elsevier GmbH., 37, 100618.
https://doi.org/10.1016/j.hermed.2022.100618

Ivanović S, Gođevac D, Ristivojević P, Zdunić G, Stojanović D, Šavikin K. HPTLC-based metabolomics approach for the detection of chokeberry (Aronia melanocarpa (Michx.) Elliott) adulteration. in Journal of Herbal Medicine. 2023;37:100618.
doi:10.1016/j.hermed.2022.100618 .

Ivanović, Stefan, Gođevac, Dejan, Ristivojević, Petar, Zdunić, Gordana, Stojanović, Danilo, Šavikin, Katarina, "HPTLC-based metabolomics approach for the detection of chokeberry (Aronia melanocarpa (Michx.) Elliott) adulteration" in Journal of Herbal Medicine, 37 (2023):100618,
https://doi.org/10.1016/j.hermed.2022.100618 . .

TY  - JOUR
AU  - Ortiz, Sergio
AU  - Šavikin, Katarina
AU  - Massicot, France
AU  - Olivier, Elodie
AU  - Dutot, Melody
AU  - Rat, Patrice
AU  - Deguin, Brigitte
AU  - Gođevac, Dejan
AU  - Menković, Nebojša
AU  - Živković, Jelena
AU  - Zdunić, Gordana
AU  - Boutefnouchet, Sabrina
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7218
AB  - Medicinal plants used in European folk medicine attached to Lamiales, Gentianales or Asterales orders are used to treat inflammatory disorders. Many targets have been identified but to date, implication of purinergic receptor P2X7 activation has not yet been investigated. We managed to evaluate the protective effect on P2X7 activation by plant extracts used as anti-inflammatory in European folk medicine by the YO-PRO-1 uptake dye in vitro bioassay. Results revealed that among our selected plants, species from Scrophularia and Plantago genus were able to decrease significantly P2X7 activation (>50 % at 0.1 and 1 μg/mL). UPLC/MS, dereplication and metabolomic analysis of Scrophularia extracts, allowed us to identify the cinnamoyl-iridoid harpagoside as putative inhibitor of P2X7 activation. These results open a new research field regarding the anti-inflammatory mechanism of cinnamoyl-iridoids bearing plants, which may involve the P2X7 receptor.
PB  - Wiley
T2  - Chemistry & Biodiversity
T1  - P2X7‐Receptor Pathway Involvement in the Anti‐Inflammatory Activity of Medicinal Plants
VL  - 20
IS  - 8
DO  - 10.1002/cbdv.202300427
ER  - 

@article{
author = "Ortiz, Sergio and Šavikin, Katarina and Massicot, France and Olivier, Elodie and Dutot, Melody and Rat, Patrice and Deguin, Brigitte and Gođevac, Dejan and Menković, Nebojša and Živković, Jelena and Zdunić, Gordana and Boutefnouchet, Sabrina",
year = "2023",
abstract = "Medicinal plants used in European folk medicine attached to Lamiales, Gentianales or Asterales orders are used to treat inflammatory disorders. Many targets have been identified but to date, implication of purinergic receptor P2X7 activation has not yet been investigated. We managed to evaluate the protective effect on P2X7 activation by plant extracts used as anti-inflammatory in European folk medicine by the YO-PRO-1 uptake dye in vitro bioassay. Results revealed that among our selected plants, species from Scrophularia and Plantago genus were able to decrease significantly P2X7 activation (>50 % at 0.1 and 1 μg/mL). UPLC/MS, dereplication and metabolomic analysis of Scrophularia extracts, allowed us to identify the cinnamoyl-iridoid harpagoside as putative inhibitor of P2X7 activation. These results open a new research field regarding the anti-inflammatory mechanism of cinnamoyl-iridoids bearing plants, which may involve the P2X7 receptor.",
publisher = "Wiley",
journal = "Chemistry & Biodiversity",
title = "P2X7‐Receptor Pathway Involvement in the Anti‐Inflammatory Activity of Medicinal Plants",
volume = "20",
number = "8",
doi = "10.1002/cbdv.202300427"
}

Ortiz, S., Šavikin, K., Massicot, F., Olivier, E., Dutot, M., Rat, P., Deguin, B., Gođevac, D., Menković, N., Živković, J., Zdunić, G.,& Boutefnouchet, S.. (2023). P2X7‐Receptor Pathway Involvement in the Anti‐Inflammatory Activity of Medicinal Plants. in Chemistry & Biodiversity
Wiley., 20(8).
https://doi.org/10.1002/cbdv.202300427

Ortiz S, Šavikin K, Massicot F, Olivier E, Dutot M, Rat P, Deguin B, Gođevac D, Menković N, Živković J, Zdunić G, Boutefnouchet S. P2X7‐Receptor Pathway Involvement in the Anti‐Inflammatory Activity of Medicinal Plants. in Chemistry & Biodiversity. 2023;20(8).
doi:10.1002/cbdv.202300427 .

Ortiz, Sergio, Šavikin, Katarina, Massicot, France, Olivier, Elodie, Dutot, Melody, Rat, Patrice, Deguin, Brigitte, Gođevac, Dejan, Menković, Nebojša, Živković, Jelena, Zdunić, Gordana, Boutefnouchet, Sabrina, "P2X7‐Receptor Pathway Involvement in the Anti‐Inflammatory Activity of Medicinal Plants" in Chemistry & Biodiversity, 20, no. 8 (2023),
https://doi.org/10.1002/cbdv.202300427 . .

TY  - CONF
AU  - Ivanović, Stefan
AU  - Ristivojević, Petar
AU  - Zdunić, Gordana
AU  - Stojanović, Danilo
AU  - Šavikin, Katarina
AU  - Gođevac, Dejan
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7537
AB  - Chokeberry is a plant belonging to the family Rosaceae which has a long history of edible and
medicinal use. The aims of this study are: i) to investigate of HPTLC profile of berries samples
using HPTLC technique based metabolomics approach, ii) to determine the botanical origin of
investigated chokeberry adulterations iii) to identify the most important botanical markers
responsible for classification.
A simple, rapid, and high-throughput planar chromatography (HPTLC) method was applied in
combination with multivariate techniques for differentiating chokeberry samples and identification
of the main metabolites of chokeberry and four common adulterants. Images of HPTLC
chromatograms obtained using two different detections i.e. visible light and derivatization with
natural products reagent were used as a dataset for multivariate analysis.
Principal component analysis and Orthogonal Partial Least Squares Discriminant Analysis
confirmed the discrimination of five botanically different samples and recognized their main
markers such as responsible for differences between chokeberry and four common adulterants.
The obtained results showed that the HPTLC-based metabolomics approach can be a very reliable technique for the detection of chokeberry adulteration
PB  - University of Belgrade
C3  - Unifood Conference, Program i zbornik radova, Beograd, 24 i 25 septembar 2021. / Unifood Conference, Programme & Book of Abstracts, Belgrade September 24-25 2021
T1  - Detection of chokeberry adulteration by HPTLS-based metabolomics
SP  - 136
EP  - 136
UR  - https://hdl.handle.net/21.15107/rcub_cer_7537
ER  - 

@conference{
author = "Ivanović, Stefan and Ristivojević, Petar and Zdunić, Gordana and Stojanović, Danilo and Šavikin, Katarina and Gođevac, Dejan",
year = "2021",
abstract = "Chokeberry is a plant belonging to the family Rosaceae which has a long history of edible and
medicinal use. The aims of this study are: i) to investigate of HPTLC profile of berries samples
using HPTLC technique based metabolomics approach, ii) to determine the botanical origin of
investigated chokeberry adulterations iii) to identify the most important botanical markers
responsible for classification.
A simple, rapid, and high-throughput planar chromatography (HPTLC) method was applied in
combination with multivariate techniques for differentiating chokeberry samples and identification
of the main metabolites of chokeberry and four common adulterants. Images of HPTLC
chromatograms obtained using two different detections i.e. visible light and derivatization with
natural products reagent were used as a dataset for multivariate analysis.
Principal component analysis and Orthogonal Partial Least Squares Discriminant Analysis
confirmed the discrimination of five botanically different samples and recognized their main
markers such as responsible for differences between chokeberry and four common adulterants.
The obtained results showed that the HPTLC-based metabolomics approach can be a very reliable technique for the detection of chokeberry adulteration",
publisher = "University of Belgrade",
journal = "Unifood Conference, Program i zbornik radova, Beograd, 24 i 25 septembar 2021. / Unifood Conference, Programme & Book of Abstracts, Belgrade September 24-25 2021",
title = "Detection of chokeberry adulteration by HPTLS-based metabolomics",
pages = "136-136",
url = "https://hdl.handle.net/21.15107/rcub_cer_7537"
}

Ivanović, S., Ristivojević, P., Zdunić, G., Stojanović, D., Šavikin, K.,& Gođevac, D.. (2021). Detection of chokeberry adulteration by HPTLS-based metabolomics. in Unifood Conference, Program i zbornik radova, Beograd, 24 i 25 septembar 2021. / Unifood Conference, Programme & Book of Abstracts, Belgrade September 24-25 2021
University of Belgrade., 136-136.
https://hdl.handle.net/21.15107/rcub_cer_7537

Ivanović S, Ristivojević P, Zdunić G, Stojanović D, Šavikin K, Gođevac D. Detection of chokeberry adulteration by HPTLS-based metabolomics. in Unifood Conference, Program i zbornik radova, Beograd, 24 i 25 septembar 2021. / Unifood Conference, Programme & Book of Abstracts, Belgrade September 24-25 2021. 2021;:136-136.
https://hdl.handle.net/21.15107/rcub_cer_7537 .

Ivanović, Stefan, Ristivojević, Petar, Zdunić, Gordana, Stojanović, Danilo, Šavikin, Katarina, Gođevac, Dejan, "Detection of chokeberry adulteration by HPTLS-based metabolomics" in Unifood Conference, Program i zbornik radova, Beograd, 24 i 25 septembar 2021. / Unifood Conference, Programme & Book of Abstracts, Belgrade September 24-25 2021 (2021):136-136,
https://hdl.handle.net/21.15107/rcub_cer_7537 .

TY  - JOUR
AU  - Mudrić, Jelena
AU  - Šavikin, Katarina
AU  - Đekić, Ljiljana
AU  - Pavlović, Stefan
AU  - Kurćubić, Ivana
AU  - Ibrić, Svetlana
AU  - Đuriš, Jelena
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4891
AB  - Gentian (Gentiana lutea L., Gentianaceae) root extract (GRE) is used for the treatment of gastrointestinal disorders. However, its bioactive potential is limited in conventional forms due to the low bioavailability and short elimination half-life of the dominant bioactive compound, gentiopicroside. The aim of study was to encapsulate GRE in the lipid-based gastroretentive delivery system that could provide high yield and encapsulation efficiency, as well as the biphasic release of gentiopicroside from the tablets obtained by direct compression. Solid lipid microparticles (SLM) loaded with GRE were prepared by freeze-drying double (W/O/W) emulsions, which were obtained by a multiple emulsion–melt dispersion technique, with GRE as the inner water phase, Gelucire® 39/01 or 43/01, as lipid components, with or without the addition of porous silica (Sylysia® 350) in the outer water phase. Formulated SLM powders were examined by SEM and mercury intrusion porosimetry, as well as by determination of yield, encapsulation efficiency, and flow properties. Furthermore, in vitro dissolution of gentiopicroside, the size of the dispersed systems, mechanical properties, and mucoadhesion of tablets obtained by direct compression were investigated. The results have revealed that SLM with the macroporous structure were formulated, and, consequently, the powders floated immediately in the acidic medium. Formulation with porous silica (Sylysia® 350) and Gelucire® 43/01 as a solid lipid was characterized with the high yield end encapsulation efficiency. Furthermore, the mucoadhesive properties of tablets obtained by direct compression of that formulation, as well as the biphasic release of gentiopicroside, presence of nanoassociates in dissolution medium, and optimal mechanical properties indicated that a promising lipid-based gastroretentive system for GRE was developed.
PB  - MDPI
T2  - Pharmaceutics
T1  - Development of Lipid-Based Gastroretentive Delivery System for Gentian Extract by Double Emulsion-Melt Dispersion Technique
VL  - 13
IS  - 12
SP  - 2095
DO  - 10.3390/pharmaceutics13122095
ER  - 

@article{
author = "Mudrić, Jelena and Šavikin, Katarina and Đekić, Ljiljana and Pavlović, Stefan and Kurćubić, Ivana and Ibrić, Svetlana and Đuriš, Jelena",
year = "2021",
abstract = "Gentian (Gentiana lutea L., Gentianaceae) root extract (GRE) is used for the treatment of gastrointestinal disorders. However, its bioactive potential is limited in conventional forms due to the low bioavailability and short elimination half-life of the dominant bioactive compound, gentiopicroside. The aim of study was to encapsulate GRE in the lipid-based gastroretentive delivery system that could provide high yield and encapsulation efficiency, as well as the biphasic release of gentiopicroside from the tablets obtained by direct compression. Solid lipid microparticles (SLM) loaded with GRE were prepared by freeze-drying double (W/O/W) emulsions, which were obtained by a multiple emulsion–melt dispersion technique, with GRE as the inner water phase, Gelucire® 39/01 or 43/01, as lipid components, with or without the addition of porous silica (Sylysia® 350) in the outer water phase. Formulated SLM powders were examined by SEM and mercury intrusion porosimetry, as well as by determination of yield, encapsulation efficiency, and flow properties. Furthermore, in vitro dissolution of gentiopicroside, the size of the dispersed systems, mechanical properties, and mucoadhesion of tablets obtained by direct compression were investigated. The results have revealed that SLM with the macroporous structure were formulated, and, consequently, the powders floated immediately in the acidic medium. Formulation with porous silica (Sylysia® 350) and Gelucire® 43/01 as a solid lipid was characterized with the high yield end encapsulation efficiency. Furthermore, the mucoadhesive properties of tablets obtained by direct compression of that formulation, as well as the biphasic release of gentiopicroside, presence of nanoassociates in dissolution medium, and optimal mechanical properties indicated that a promising lipid-based gastroretentive system for GRE was developed.",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "Development of Lipid-Based Gastroretentive Delivery System for Gentian Extract by Double Emulsion-Melt Dispersion Technique",
volume = "13",
number = "12",
pages = "2095",
doi = "10.3390/pharmaceutics13122095"
}

Mudrić, J., Šavikin, K., Đekić, L., Pavlović, S., Kurćubić, I., Ibrić, S.,& Đuriš, J.. (2021). Development of Lipid-Based Gastroretentive Delivery System for Gentian Extract by Double Emulsion-Melt Dispersion Technique. in Pharmaceutics
MDPI., 13(12), 2095.
https://doi.org/10.3390/pharmaceutics13122095

Mudrić J, Šavikin K, Đekić L, Pavlović S, Kurćubić I, Ibrić S, Đuriš J. Development of Lipid-Based Gastroretentive Delivery System for Gentian Extract by Double Emulsion-Melt Dispersion Technique. in Pharmaceutics. 2021;13(12):2095.
doi:10.3390/pharmaceutics13122095 .

Mudrić, Jelena, Šavikin, Katarina, Đekić, Ljiljana, Pavlović, Stefan, Kurćubić, Ivana, Ibrić, Svetlana, Đuriš, Jelena, "Development of Lipid-Based Gastroretentive Delivery System for Gentian Extract by Double Emulsion-Melt Dispersion Technique" in Pharmaceutics, 13, no. 12 (2021):2095,
https://doi.org/10.3390/pharmaceutics13122095 . .

TY  - JOUR
AU  - Zdunić, Gordana
AU  - Aradski, Ana Alimpić
AU  - Gođevac, Dejan
AU  - Živković, Jelena Č.
AU  - Laušević, Sonja Duletić
AU  - Milošević, Dijana Krstić
AU  - Šavikin, Katarina
PY  - 2020
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3446
AB  - Chokeberries (Aronia melanocarpa (Michx.) Elliot have recently become one of the most popular and widely used berry fruits, and there are numerous studies dealing with the investigation of their chemical composition and biological activities. Unlike berries, chokeberry leaves were far less investigated. Therefore, the aim of this study was to conduct a bioactivity-based analysis of chokeberry leaves collected after berries were harvested. Chemical analysis of hydroethanolic chokeberry extract and its ethyl acetate, n-butanol, and water fractions was performed. Antioxidant, hypoglycemic, and antineurodegenerative activities of the obtained samples were assessed by in vitro tests. The highest total phenolics content was found in n-butanol fraction (221.5 mg gallic acid equivalents/g dw). Fourteen compounds (six phenolic acids and eight flavonoids) were identified in the samples. Caffeoylquinic acid derivatives and quercetin glycosides were dominant phenolic compounds. The highest content of phenolic acids, as well as flavonoids, was recorded in n-butanol fraction (80.75 mg/g dw and 47.79 mg/g dw, respectively). This fraction was the most active in 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis (3-ethyl-benzothiazoline-6-sulfonic acid) (ABTS), and ferric reducing antioxidant power (FRAP) assays. Also, the n-butanol fraction was the most effective inhibitor of acetylcholinesterase (AChE) and tyrosinase (TYR) enzymes. All samples showed a better inhibitory effect on α-glucosidase enzyme with inhibition concentrations IC50 = 4.21 - 9.22 μg/mL, than α-amylase enzymes (IC50 = 14.36 - 88.61 μg/mL). Pearson’s correlation between the content of individual phenolics and the results of biological tests was performed. Thus, hyperoside and isoquercitrin showed a significant correlation with DPPH and ABTS tests, caffeoylquinic acids with FRAP test, quercetin 3-O-vicianoside with β-carotene assay, hyperoside and isoquercitrin with α-amylase inhibition activity, and isorhamnetin 3-O-rutinoside with α-glucosidase inhibition assay. Considering the obtained results, chokeberry leaves represent a valuable natural source of phenolic compounds with promising potential for the development of new products with beneficial effects on human health.
PB  - Elsevier
T2  - Industrial Crops and Products
T1  - In vitro hypoglycemic, antioxidant and antineurodegenerative activity of chokeberry (Aronia melanocarpa) leaves
VL  - 148
SP  - 112328
DO  - 10.1016/j.indcrop.2020.112328
ER  - 

@article{
author = "Zdunić, Gordana and Aradski, Ana Alimpić and Gođevac, Dejan and Živković, Jelena Č. and Laušević, Sonja Duletić and Milošević, Dijana Krstić and Šavikin, Katarina",
year = "2020",
abstract = "Chokeberries (Aronia melanocarpa (Michx.) Elliot have recently become one of the most popular and widely used berry fruits, and there are numerous studies dealing with the investigation of their chemical composition and biological activities. Unlike berries, chokeberry leaves were far less investigated. Therefore, the aim of this study was to conduct a bioactivity-based analysis of chokeberry leaves collected after berries were harvested. Chemical analysis of hydroethanolic chokeberry extract and its ethyl acetate, n-butanol, and water fractions was performed. Antioxidant, hypoglycemic, and antineurodegenerative activities of the obtained samples were assessed by in vitro tests. The highest total phenolics content was found in n-butanol fraction (221.5 mg gallic acid equivalents/g dw). Fourteen compounds (six phenolic acids and eight flavonoids) were identified in the samples. Caffeoylquinic acid derivatives and quercetin glycosides were dominant phenolic compounds. The highest content of phenolic acids, as well as flavonoids, was recorded in n-butanol fraction (80.75 mg/g dw and 47.79 mg/g dw, respectively). This fraction was the most active in 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis (3-ethyl-benzothiazoline-6-sulfonic acid) (ABTS), and ferric reducing antioxidant power (FRAP) assays. Also, the n-butanol fraction was the most effective inhibitor of acetylcholinesterase (AChE) and tyrosinase (TYR) enzymes. All samples showed a better inhibitory effect on α-glucosidase enzyme with inhibition concentrations IC50 = 4.21 - 9.22 μg/mL, than α-amylase enzymes (IC50 = 14.36 - 88.61 μg/mL). Pearson’s correlation between the content of individual phenolics and the results of biological tests was performed. Thus, hyperoside and isoquercitrin showed a significant correlation with DPPH and ABTS tests, caffeoylquinic acids with FRAP test, quercetin 3-O-vicianoside with β-carotene assay, hyperoside and isoquercitrin with α-amylase inhibition activity, and isorhamnetin 3-O-rutinoside with α-glucosidase inhibition assay. Considering the obtained results, chokeberry leaves represent a valuable natural source of phenolic compounds with promising potential for the development of new products with beneficial effects on human health.",
publisher = "Elsevier",
journal = "Industrial Crops and Products",
title = "In vitro hypoglycemic, antioxidant and antineurodegenerative activity of chokeberry (Aronia melanocarpa) leaves",
volume = "148",
pages = "112328",
doi = "10.1016/j.indcrop.2020.112328"
}

Zdunić, G., Aradski, A. A., Gođevac, D., Živković, J. Č., Laušević, S. D., Milošević, D. K.,& Šavikin, K.. (2020). In vitro hypoglycemic, antioxidant and antineurodegenerative activity of chokeberry (Aronia melanocarpa) leaves. in Industrial Crops and Products
Elsevier., 148, 112328.
https://doi.org/10.1016/j.indcrop.2020.112328

Zdunić G, Aradski AA, Gođevac D, Živković JČ, Laušević SD, Milošević DK, Šavikin K. In vitro hypoglycemic, antioxidant and antineurodegenerative activity of chokeberry (Aronia melanocarpa) leaves. in Industrial Crops and Products. 2020;148:112328.
doi:10.1016/j.indcrop.2020.112328 .

Zdunić, Gordana, Aradski, Ana Alimpić, Gođevac, Dejan, Živković, Jelena Č., Laušević, Sonja Duletić, Milošević, Dijana Krstić, Šavikin, Katarina, "In vitro hypoglycemic, antioxidant and antineurodegenerative activity of chokeberry (Aronia melanocarpa) leaves" in Industrial Crops and Products, 148 (2020):112328,
https://doi.org/10.1016/j.indcrop.2020.112328 . .

TY  - JOUR
AU  - Zdunić, Gordana
AU  - Gođevac, Dejan
AU  - Šavikin, Katarina
AU  - Krivokuća, Dragana
AU  - Mihailović, Milica
AU  - Pržić, Zoran
AU  - Marković, Nebojša
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2994
AB  - Grape pomace (grape skin, seeds, and stems) represents a valuable source of bioactive compounds, thus the interest in making use of these wine waste products is increasing. Prokupac is an autochthonous Serbian variety of black grape with a long tradition in production of red wine. Identification of the superficial polyphenolic compounds by LC/MS revealed presence of 19 compounds including hydroxybenzoic acid derivatives, ellagic acid derivatives, flavan‐3‐ol monomers, proanthocyanidins, and flavonols. Catechin and epicatechin together with proanthocyanidins were the most abundant compounds and the highest content of phenolic compounds was determined in Prokupac clones 43/1, 40/1, and 40/2. Grape seed oil consisted of dominantly UFA (87–95 %) where methyl linoleate was the most abundant in all samples (69–81 %). Palmitic (3–8 %) and stearic acid (2–4 %) methyl esters were dominant SFA. Prokupac clone 43/3 was the most abundant in UFA (95 %) with the lowest percentage of SFA (5 %), while clones 41/1 and 43/5 had the lowest percentage of UFA (87 %) and the highest content of SFA (13 %). Favorable chemical profile of Prokupac clone seeds implicates its potential to be used as a raw material in further processing and possibility to be included as one of the quality parameters in further selection of the most interesting Prokupac clone.
PB  - Wiley
T2  - Chemistry & Biodiversity
T1  - Grape Seed Polyphenols and Fatty Acids of Autochthonous Prokupac Vine Variety from Serbia
SP  - e1900053
DO  - 10.1002/cbdv.201900053
ER  - 

@article{
author = "Zdunić, Gordana and Gođevac, Dejan and Šavikin, Katarina and Krivokuća, Dragana and Mihailović, Milica and Pržić, Zoran and Marković, Nebojša",
year = "2019",
abstract = "Grape pomace (grape skin, seeds, and stems) represents a valuable source of bioactive compounds, thus the interest in making use of these wine waste products is increasing. Prokupac is an autochthonous Serbian variety of black grape with a long tradition in production of red wine. Identification of the superficial polyphenolic compounds by LC/MS revealed presence of 19 compounds including hydroxybenzoic acid derivatives, ellagic acid derivatives, flavan‐3‐ol monomers, proanthocyanidins, and flavonols. Catechin and epicatechin together with proanthocyanidins were the most abundant compounds and the highest content of phenolic compounds was determined in Prokupac clones 43/1, 40/1, and 40/2. Grape seed oil consisted of dominantly UFA (87–95 %) where methyl linoleate was the most abundant in all samples (69–81 %). Palmitic (3–8 %) and stearic acid (2–4 %) methyl esters were dominant SFA. Prokupac clone 43/3 was the most abundant in UFA (95 %) with the lowest percentage of SFA (5 %), while clones 41/1 and 43/5 had the lowest percentage of UFA (87 %) and the highest content of SFA (13 %). Favorable chemical profile of Prokupac clone seeds implicates its potential to be used as a raw material in further processing and possibility to be included as one of the quality parameters in further selection of the most interesting Prokupac clone.",
publisher = "Wiley",
journal = "Chemistry & Biodiversity",
title = "Grape Seed Polyphenols and Fatty Acids of Autochthonous Prokupac Vine Variety from Serbia",
pages = "e1900053",
doi = "10.1002/cbdv.201900053"
}

Zdunić, G., Gođevac, D., Šavikin, K., Krivokuća, D., Mihailović, M., Pržić, Z.,& Marković, N.. (2019). Grape Seed Polyphenols and Fatty Acids of Autochthonous Prokupac Vine Variety from Serbia. in Chemistry & Biodiversity
Wiley., e1900053.
https://doi.org/10.1002/cbdv.201900053

Zdunić G, Gođevac D, Šavikin K, Krivokuća D, Mihailović M, Pržić Z, Marković N. Grape Seed Polyphenols and Fatty Acids of Autochthonous Prokupac Vine Variety from Serbia. in Chemistry & Biodiversity. 2019;:e1900053.
doi:10.1002/cbdv.201900053 .

Zdunić, Gordana, Gođevac, Dejan, Šavikin, Katarina, Krivokuća, Dragana, Mihailović, Milica, Pržić, Zoran, Marković, Nebojša, "Grape Seed Polyphenols and Fatty Acids of Autochthonous Prokupac Vine Variety from Serbia" in Chemistry & Biodiversity (2019):e1900053,
https://doi.org/10.1002/cbdv.201900053 . .

TY  - CHAP
AU  - Šavikin, Katarina
AU  - Aljančić, Ivana
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan
AU  - Jadranin, Milka
AU  - Đorđević, Iris
AU  - Menković, Nebojša
PY  - 2015
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1835
AB  - The results are presented of phytochemical investigations, during the last decade, of some wild-growing species of the family Gentianaceae from Serbia and Montenegro. Some of the species investigated, members of the genera Gentiana, Gentianella, and Swertia, are endemic, and the emphasis in this report is on those exhibiting biological activities that could be regarded as a potential source of drugs. This review discusses more than fifty compounds, such as xanthones, secoiridoids, and C-glucoflavonoids.
PB  - Springer Berlin Heidelberg
T2  - The Gentianaceae - Volume 2: Biotechnology and Applications
T1  - Bioactive secondary metabolites in several genera of gentianaceae species from thè central regions of thè balkan peninsula
SP  - 319
EP  - 347
DO  - 10.1007/978-3-642-54102-5_14
ER  - 

@inbook{
author = "Šavikin, Katarina and Aljančić, Ivana and Vajs, Vlatka and Milosavljević, Slobodan and Jadranin, Milka and Đorđević, Iris and Menković, Nebojša",
year = "2015",
abstract = "The results are presented of phytochemical investigations, during the last decade, of some wild-growing species of the family Gentianaceae from Serbia and Montenegro. Some of the species investigated, members of the genera Gentiana, Gentianella, and Swertia, are endemic, and the emphasis in this report is on those exhibiting biological activities that could be regarded as a potential source of drugs. This review discusses more than fifty compounds, such as xanthones, secoiridoids, and C-glucoflavonoids.",
publisher = "Springer Berlin Heidelberg",
journal = "The Gentianaceae - Volume 2: Biotechnology and Applications",
booktitle = "Bioactive secondary metabolites in several genera of gentianaceae species from thè central regions of thè balkan peninsula",
pages = "319-347",
doi = "10.1007/978-3-642-54102-5_14"
}

Šavikin, K., Aljančić, I., Vajs, V., Milosavljević, S., Jadranin, M., Đorđević, I.,& Menković, N.. (2015). Bioactive secondary metabolites in several genera of gentianaceae species from thè central regions of thè balkan peninsula. in The Gentianaceae - Volume 2: Biotechnology and Applications
Springer Berlin Heidelberg., 319-347.
https://doi.org/10.1007/978-3-642-54102-5_14

Šavikin K, Aljančić I, Vajs V, Milosavljević S, Jadranin M, Đorđević I, Menković N. Bioactive secondary metabolites in several genera of gentianaceae species from thè central regions of thè balkan peninsula. in The Gentianaceae - Volume 2: Biotechnology and Applications. 2015;:319-347.
doi:10.1007/978-3-642-54102-5_14 .

Šavikin, Katarina, Aljančić, Ivana, Vajs, Vlatka, Milosavljević, Slobodan, Jadranin, Milka, Đorđević, Iris, Menković, Nebojša, "Bioactive secondary metabolites in several genera of gentianaceae species from thè central regions of thè balkan peninsula" in The Gentianaceae - Volume 2: Biotechnology and Applications (2015):319-347,
https://doi.org/10.1007/978-3-642-54102-5_14 . .

TY  - JOUR
AU  - Stević, Tatjana
AU  - Stanković, Slaviša
AU  - Šavikin, Katarina
AU  - Gođevac, Dejan
AU  - Dimkić, Ivica
AU  - Soković, Marina
AU  - Berić, Tanja
PY  - 2014
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1454
AB  - In recent years great attention was paid to biological control, the application of natural products in order to protect crops and medicinal plants against contamination with phytopathogenic and saprophytic fungi. Essential oils have been evaluated as a potentially safe replacement for chemicals used for that purpose. In this regard, antifungal potential of six essential oils was examined coupled with determination of the complete qualitative and quantitative chemical composition by GC-FID and GC-MS analysis. While essential oils of rosemary, sage, Spanish sage and black pepper were exclusively composed of monoterpenes, vetiver essential oil was entirely composed of sesquiterpenes. In essential oil of cinnamon dominates (E)-cinnamaldehyde. Applying the in vitro microdilution method, it was found that all essential oils were active in inhibiting the growth of all tested 21 pre- and post-harvest phytopathogenic and saprophytic fungi. MIC and MFC ranged from 1.2 mg ml-1 up to 22.6 mg ml-1 according to the test oil. Rosemary oil showed the best antifungal potential, followed by black pepper and cinnamon oil. Sage and Spanish sage oils also exhibited significant antifungal potential. Vetiver oil demonstrated the lowest antifungal activity. Essential oils that showed considerable antifungal potential are good candidates for further examination of their use in preventing and/or protection of medicinal plants, their seeds and dried drugs against fungal infections, both in the field and in warehouses.
AB  - Poslednjih godina velika pažnja poklanja se biološkoj kontroli to jest primeni prirodnih produkata u zaštiti, kako poljoprivrednih kultura, tako i lekovitog bilja od kontaminacije fitopatogenim i saprofitnim gljivama. U tom smislu, ispitivan je antifungalni potencijal šest etarskih ulja uz određivanje kompletnog kvalitativnog i kvantitativnog hemijskog sastava primenom GC-FID i GC-MS analiza. Dok se korišćeni uzorci etarskih ulja ruzmarina, žalfije, španske žalfije i crnog bibera isključivo sastoje od monoterpena, u ulju vetivera potpuno dominiraju seskviterpeni. U etarskom ulju cimeta najzastupljenija komponneta je bila (E)- cinemaldehid. Primenom in vitro mikrodilucione metode, utvrđeno je da su sva ulja bila aktivna u inhibiciji rasta 21 testirane, pre- i post-žetvene, fitopatogene i saprofitne gljive, sa razlikama u efikasnosti. MIC i MFC vrednosti su varirale u opsegu od 1,2 mg ml-1 do 22,6 mg ml-1, u zavisnosti od ispitivanog ulja. Najbolja antifungalna aktivnost utvrđena je za ulje ruzmarina, nešto slabija za ulja crnog bibera i cimeta, dok je ulje vetivera ispoljilo najslabiju aktivnost. Etarska ulja obe vrste žalfija ispoljila su značajan antifungalni potencijal. Etarska ulja koja poseduju značajan antifungalni potencijal su dobri kandidati za nastavak istraživanja u pravcu njihove primene u prevenciji i zaštiti useva lekovitog bilja, kao i njihovih semena i osušenih biljnih droga od gljivičnih infekcija, i u polju i u skladištima.
PB  - Institute for Medicinal Plants Research "Dr. Josif Pancic"
T2  - Lekovite sirovine
T1  - Chemical composition and inhibitory activity of selected essential oils against fungi isolated from medicinal plants
T1  - Hemijski sastav i inhibitorna aktivnost odabranih etarskih ulja na gljive izolovane sa lekovitog bilja
VL  - 34
IS  - 34
SP  - 69
EP  - 80
DO  - 10.5937/leksir1434069S
ER  - 

@article{
author = "Stević, Tatjana and Stanković, Slaviša and Šavikin, Katarina and Gođevac, Dejan and Dimkić, Ivica and Soković, Marina and Berić, Tanja",
year = "2014",
abstract = "In recent years great attention was paid to biological control, the application of natural products in order to protect crops and medicinal plants against contamination with phytopathogenic and saprophytic fungi. Essential oils have been evaluated as a potentially safe replacement for chemicals used for that purpose. In this regard, antifungal potential of six essential oils was examined coupled with determination of the complete qualitative and quantitative chemical composition by GC-FID and GC-MS analysis. While essential oils of rosemary, sage, Spanish sage and black pepper were exclusively composed of monoterpenes, vetiver essential oil was entirely composed of sesquiterpenes. In essential oil of cinnamon dominates (E)-cinnamaldehyde. Applying the in vitro microdilution method, it was found that all essential oils were active in inhibiting the growth of all tested 21 pre- and post-harvest phytopathogenic and saprophytic fungi. MIC and MFC ranged from 1.2 mg ml-1 up to 22.6 mg ml-1 according to the test oil. Rosemary oil showed the best antifungal potential, followed by black pepper and cinnamon oil. Sage and Spanish sage oils also exhibited significant antifungal potential. Vetiver oil demonstrated the lowest antifungal activity. Essential oils that showed considerable antifungal potential are good candidates for further examination of their use in preventing and/or protection of medicinal plants, their seeds and dried drugs against fungal infections, both in the field and in warehouses., Poslednjih godina velika pažnja poklanja se biološkoj kontroli to jest primeni prirodnih produkata u zaštiti, kako poljoprivrednih kultura, tako i lekovitog bilja od kontaminacije fitopatogenim i saprofitnim gljivama. U tom smislu, ispitivan je antifungalni potencijal šest etarskih ulja uz određivanje kompletnog kvalitativnog i kvantitativnog hemijskog sastava primenom GC-FID i GC-MS analiza. Dok se korišćeni uzorci etarskih ulja ruzmarina, žalfije, španske žalfije i crnog bibera isključivo sastoje od monoterpena, u ulju vetivera potpuno dominiraju seskviterpeni. U etarskom ulju cimeta najzastupljenija komponneta je bila (E)- cinemaldehid. Primenom in vitro mikrodilucione metode, utvrđeno je da su sva ulja bila aktivna u inhibiciji rasta 21 testirane, pre- i post-žetvene, fitopatogene i saprofitne gljive, sa razlikama u efikasnosti. MIC i MFC vrednosti su varirale u opsegu od 1,2 mg ml-1 do 22,6 mg ml-1, u zavisnosti od ispitivanog ulja. Najbolja antifungalna aktivnost utvrđena je za ulje ruzmarina, nešto slabija za ulja crnog bibera i cimeta, dok je ulje vetivera ispoljilo najslabiju aktivnost. Etarska ulja obe vrste žalfija ispoljila su značajan antifungalni potencijal. Etarska ulja koja poseduju značajan antifungalni potencijal su dobri kandidati za nastavak istraživanja u pravcu njihove primene u prevenciji i zaštiti useva lekovitog bilja, kao i njihovih semena i osušenih biljnih droga od gljivičnih infekcija, i u polju i u skladištima.",
publisher = "Institute for Medicinal Plants Research "Dr. Josif Pancic"",
journal = "Lekovite sirovine",
title = "Chemical composition and inhibitory activity of selected essential oils against fungi isolated from medicinal plants, Hemijski sastav i inhibitorna aktivnost odabranih etarskih ulja na gljive izolovane sa lekovitog bilja",
volume = "34",
number = "34",
pages = "69-80",
doi = "10.5937/leksir1434069S"
}

Stević, T., Stanković, S., Šavikin, K., Gođevac, D., Dimkić, I., Soković, M.,& Berić, T.. (2014). Chemical composition and inhibitory activity of selected essential oils against fungi isolated from medicinal plants. in Lekovite sirovine
Institute for Medicinal Plants Research "Dr. Josif Pancic"., 34(34), 69-80.
https://doi.org/10.5937/leksir1434069S

Stević T, Stanković S, Šavikin K, Gođevac D, Dimkić I, Soković M, Berić T. Chemical composition and inhibitory activity of selected essential oils against fungi isolated from medicinal plants. in Lekovite sirovine. 2014;34(34):69-80.
doi:10.5937/leksir1434069S .

Stević, Tatjana, Stanković, Slaviša, Šavikin, Katarina, Gođevac, Dejan, Dimkić, Ivica, Soković, Marina, Berić, Tanja, "Chemical composition and inhibitory activity of selected essential oils against fungi isolated from medicinal plants" in Lekovite sirovine, 34, no. 34 (2014):69-80,
https://doi.org/10.5937/leksir1434069S . .

TY  - CHAP
AU  - Konić-Ristić, A.
AU  - Šavikin, Katarina
AU  - Zdunić, Gordana
AU  - Gođevac, Dejan
AU  - Janković, Teodora
AU  - Menković, Nebojša
PY  - 2013
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1387
AB  - The biological value of berries relies on their nutritive and non-nutritive constituents. They are good sources of vitamins (vitamin A, C, E, folic acid), pro-vitamins and related compounds (carotene and lutein), minerals (calcium and selenium) and phytosterols, but the proposed health benefit is usually connected with phenolics as the main biologically active compound of berries. Berry phenolics include anthocyanins, flavonols, flavanols, condensed tannins (proanthocyanidins), hidrolyzable tannins (ellagitannins and gallotannins) and phenolic acids. Berries are recognized as the best dietary sources of anthocyanins. Different berries are distinguished by the presence of different classes of phenolics or compounds within the same class, their content and chemical structure (substituents, glycosylation, conjugation), potentially influencing their physiological properties and health effects. Analytical assessment of the phytochemical content of berries, the effects of storage and processing and putative interaction with other dietary compounds is essential for evaluation of their health benefit. It is of great importance to emphasize the biodiversity in the context of different phytochemical content in wild versus cultivated species, different varieties of the same species, or influenced by different cultivating conditions. Beneficial effects of berries consumption in health promotion and prevention of chronic diseases, such as cancer or cardiovascular diseases are shown in numerous epidemiological studies. In in vitro and animals studies berry fruits, their extracts and isolated compounds showed antioxidant, anticancer, antidiabetic, hypoholesterolemic, anti-inflammatory, vasoprotective, cardioprotecive, antiplatelet, antitrombotic or antimicrobial effects. Some of these effects are also shown in clinical trials in humans. Phenolic compounds of berries and their extracts have strong antioxidant potential that is often used to explain their health-promoting properties. Recent studies postulated that their antioxidant potential, as a basic mechanism of biological activity, is compromised by their low bioavailability. Consequently further research in this area is targeted towards other mechanisms of action, the evaluation of main sites of action and further elucidation of potential of berry phenolic compounds as antioxidants, based on their structure or metabolism, both in vitro and within the human body.
PB  - Nova Science Publishers, Inc.
T2  - Phytochemicals: Occurrence in Nature, Health Effects and Antioxidant Properties
T1  - Phenolic compounds, health effects and antioxidant properties of berries
SP  - 69
EP  - 85
UR  - https://hdl.handle.net/21.15107/rcub_cer_1387
ER  - 

@inbook{
author = "Konić-Ristić, A. and Šavikin, Katarina and Zdunić, Gordana and Gođevac, Dejan and Janković, Teodora and Menković, Nebojša",
year = "2013",
abstract = "The biological value of berries relies on their nutritive and non-nutritive constituents. They are good sources of vitamins (vitamin A, C, E, folic acid), pro-vitamins and related compounds (carotene and lutein), minerals (calcium and selenium) and phytosterols, but the proposed health benefit is usually connected with phenolics as the main biologically active compound of berries. Berry phenolics include anthocyanins, flavonols, flavanols, condensed tannins (proanthocyanidins), hidrolyzable tannins (ellagitannins and gallotannins) and phenolic acids. Berries are recognized as the best dietary sources of anthocyanins. Different berries are distinguished by the presence of different classes of phenolics or compounds within the same class, their content and chemical structure (substituents, glycosylation, conjugation), potentially influencing their physiological properties and health effects. Analytical assessment of the phytochemical content of berries, the effects of storage and processing and putative interaction with other dietary compounds is essential for evaluation of their health benefit. It is of great importance to emphasize the biodiversity in the context of different phytochemical content in wild versus cultivated species, different varieties of the same species, or influenced by different cultivating conditions. Beneficial effects of berries consumption in health promotion and prevention of chronic diseases, such as cancer or cardiovascular diseases are shown in numerous epidemiological studies. In in vitro and animals studies berry fruits, their extracts and isolated compounds showed antioxidant, anticancer, antidiabetic, hypoholesterolemic, anti-inflammatory, vasoprotective, cardioprotecive, antiplatelet, antitrombotic or antimicrobial effects. Some of these effects are also shown in clinical trials in humans. Phenolic compounds of berries and their extracts have strong antioxidant potential that is often used to explain their health-promoting properties. Recent studies postulated that their antioxidant potential, as a basic mechanism of biological activity, is compromised by their low bioavailability. Consequently further research in this area is targeted towards other mechanisms of action, the evaluation of main sites of action and further elucidation of potential of berry phenolic compounds as antioxidants, based on their structure or metabolism, both in vitro and within the human body.",
publisher = "Nova Science Publishers, Inc.",
journal = "Phytochemicals: Occurrence in Nature, Health Effects and Antioxidant Properties",
booktitle = "Phenolic compounds, health effects and antioxidant properties of berries",
pages = "69-85",
url = "https://hdl.handle.net/21.15107/rcub_cer_1387"
}

Konić-Ristić, A., Šavikin, K., Zdunić, G., Gođevac, D., Janković, T.,& Menković, N.. (2013). Phenolic compounds, health effects and antioxidant properties of berries. in Phytochemicals: Occurrence in Nature, Health Effects and Antioxidant Properties
Nova Science Publishers, Inc.., 69-85.
https://hdl.handle.net/21.15107/rcub_cer_1387

Konić-Ristić A, Šavikin K, Zdunić G, Gođevac D, Janković T, Menković N. Phenolic compounds, health effects and antioxidant properties of berries. in Phytochemicals: Occurrence in Nature, Health Effects and Antioxidant Properties. 2013;:69-85.
https://hdl.handle.net/21.15107/rcub_cer_1387 .

Konić-Ristić, A., Šavikin, Katarina, Zdunić, Gordana, Gođevac, Dejan, Janković, Teodora, Menković, Nebojša, "Phenolic compounds, health effects and antioxidant properties of berries" in Phytochemicals: Occurrence in Nature, Health Effects and Antioxidant Properties (2013):69-85,
https://hdl.handle.net/21.15107/rcub_cer_1387 .

TY  - JOUR
AU  - Zdunić, Gordana
AU  - Gođevac, Dejan
AU  - Milenković, Marina
AU  - Vučićević, D.
AU  - Šavikin, Katarina
AU  - Menković, Nebojša
AU  - Petrović, S.
PY  - 2009
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/625
AB  - Oil extracts of Hypericum perforatum L. (Oleum Hyperici) were prepared in three different ways according to the prescriptions from traditional medicine. Variability of constituents and biological activity were evaluated in the obtained oil extracts. The carrageenan-induced rat paw edema test has been used for screening the antiinflammatory activity, while the indomethacin-induced rat gastric mucosa damage test was used for evaluation of gastroprotective activity. All examined oil extracts possessed antiinflammatory and gastroprotective activity. Among them, the oil extract prepared by maceration with 96% ethanol, followed by extraction with sunflower oil by heating on a water bath (extract 2), in a dose of 1.25 mL/kg p.o., exhibited the highest antiinflammatory effect (95.24 ± 11.66%) and gastroprotective activity (gastric damage score of 0.21 ± 0.12). The same oil extract had the highest content of quercetin and I3,II8-biapigenin (129 ± 9 μg/mL and 52 ± 4 μg/mL, respectively). Quercetin and I3,II8-biapigenin exhibited antiinflammatory activity similar to those of indomethacin as well as significant gastroprotective activity. The results provide evidence for the usage of Oleum Hyperici as an anti-inflammatory and gastroprotective agent, which has been based previously only on ethnopharmacological claims. Copyright
T2  - Phytotherapy Research
T1  - Evaluation of Hypericum perforatum oil extracts for an antiinflammatory and gastroprotective activity in rats
VL  - 23
IS  - 11
SP  - 1559
EP  - 1564
DO  - 10.1002/ptr.2809
ER  - 

@article{
author = "Zdunić, Gordana and Gođevac, Dejan and Milenković, Marina and Vučićević, D. and Šavikin, Katarina and Menković, Nebojša and Petrović, S.",
year = "2009",
abstract = "Oil extracts of Hypericum perforatum L. (Oleum Hyperici) were prepared in three different ways according to the prescriptions from traditional medicine. Variability of constituents and biological activity were evaluated in the obtained oil extracts. The carrageenan-induced rat paw edema test has been used for screening the antiinflammatory activity, while the indomethacin-induced rat gastric mucosa damage test was used for evaluation of gastroprotective activity. All examined oil extracts possessed antiinflammatory and gastroprotective activity. Among them, the oil extract prepared by maceration with 96% ethanol, followed by extraction with sunflower oil by heating on a water bath (extract 2), in a dose of 1.25 mL/kg p.o., exhibited the highest antiinflammatory effect (95.24 ± 11.66%) and gastroprotective activity (gastric damage score of 0.21 ± 0.12). The same oil extract had the highest content of quercetin and I3,II8-biapigenin (129 ± 9 μg/mL and 52 ± 4 μg/mL, respectively). Quercetin and I3,II8-biapigenin exhibited antiinflammatory activity similar to those of indomethacin as well as significant gastroprotective activity. The results provide evidence for the usage of Oleum Hyperici as an anti-inflammatory and gastroprotective agent, which has been based previously only on ethnopharmacological claims. Copyright",
journal = "Phytotherapy Research",
title = "Evaluation of Hypericum perforatum oil extracts for an antiinflammatory and gastroprotective activity in rats",
volume = "23",
number = "11",
pages = "1559-1564",
doi = "10.1002/ptr.2809"
}

Zdunić, G., Gođevac, D., Milenković, M., Vučićević, D., Šavikin, K., Menković, N.,& Petrović, S.. (2009). Evaluation of Hypericum perforatum oil extracts for an antiinflammatory and gastroprotective activity in rats. in Phytotherapy Research, 23(11), 1559-1564.
https://doi.org/10.1002/ptr.2809

Zdunić G, Gođevac D, Milenković M, Vučićević D, Šavikin K, Menković N, Petrović S. Evaluation of Hypericum perforatum oil extracts for an antiinflammatory and gastroprotective activity in rats. in Phytotherapy Research. 2009;23(11):1559-1564.
doi:10.1002/ptr.2809 .

Zdunić, Gordana, Gođevac, Dejan, Milenković, Marina, Vučićević, D., Šavikin, Katarina, Menković, Nebojša, Petrović, S., "Evaluation of Hypericum perforatum oil extracts for an antiinflammatory and gastroprotective activity in rats" in Phytotherapy Research, 23, no. 11 (2009):1559-1564,
https://doi.org/10.1002/ptr.2809 . .

TY  - JOUR
AU  - Menković, Nebojša
AU  - Šavikin, Katarina
AU  - Zdunić, Gordana
AU  - Gojgić-Cvijović, Gordana
PY  - 2009
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/598
AB  - Aerial parts of Physocaulis nodosus (L.) W.D.J.Koch. (Apiaceae) collected on Hajla mountain possessed an essential oil in 0.62% yield (expressed in g per 100 g of dried plant material). The oil was analyzed by GC and GC/MS. Among 21 compounds 16 were identified, representing 93.0% of total oil composition. Dominant compounds were sabinene (36.4%), limonene (27.7%) and β-pinene (9.8%). The oil possessed a limited antibacterial activity against Micrococcus luteus, Staphylococcus aureus and Bacillus subtilis.
T2  - Journal of Essential Oil Research
T1  - Chemical composition and antimicrobial activity of essential oil of physocaulis nodosus (L.) W.D.J.Koch
VL  - 21
IS  - 1
SP  - 89
EP  - 90
DO  - 10.1080/10412905.2009.9700119
ER  - 

@article{
author = "Menković, Nebojša and Šavikin, Katarina and Zdunić, Gordana and Gojgić-Cvijović, Gordana",
year = "2009",
abstract = "Aerial parts of Physocaulis nodosus (L.) W.D.J.Koch. (Apiaceae) collected on Hajla mountain possessed an essential oil in 0.62% yield (expressed in g per 100 g of dried plant material). The oil was analyzed by GC and GC/MS. Among 21 compounds 16 were identified, representing 93.0% of total oil composition. Dominant compounds were sabinene (36.4%), limonene (27.7%) and β-pinene (9.8%). The oil possessed a limited antibacterial activity against Micrococcus luteus, Staphylococcus aureus and Bacillus subtilis.",
journal = "Journal of Essential Oil Research",
title = "Chemical composition and antimicrobial activity of essential oil of physocaulis nodosus (L.) W.D.J.Koch",
volume = "21",
number = "1",
pages = "89-90",
doi = "10.1080/10412905.2009.9700119"
}

Menković, N., Šavikin, K., Zdunić, G.,& Gojgić-Cvijović, G.. (2009). Chemical composition and antimicrobial activity of essential oil of physocaulis nodosus (L.) W.D.J.Koch. in Journal of Essential Oil Research, 21(1), 89-90.
https://doi.org/10.1080/10412905.2009.9700119

Menković N, Šavikin K, Zdunić G, Gojgić-Cvijović G. Chemical composition and antimicrobial activity of essential oil of physocaulis nodosus (L.) W.D.J.Koch. in Journal of Essential Oil Research. 2009;21(1):89-90.
doi:10.1080/10412905.2009.9700119 .

Menković, Nebojša, Šavikin, Katarina, Zdunić, Gordana, Gojgić-Cvijović, Gordana, "Chemical composition and antimicrobial activity of essential oil of physocaulis nodosus (L.) W.D.J.Koch" in Journal of Essential Oil Research, 21, no. 1 (2009):89-90,
https://doi.org/10.1080/10412905.2009.9700119 . .

TY  - JOUR
AU  - Gođevac, Dejan
AU  - Pejin, Boris
AU  - Zdunić, Gordana
AU  - Šavikin, Katarina
AU  - Stešević, Danijela
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan
PY  - 2008
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/429
AB  - Rutin (1, main constituent) and two flavone C-glycosides, vitexin (2) and vitexin 2''-O-α-rhamnopyranoside (3) were isolated from the aerial parts of Onobrychis montana subsp. scardica. They were identified by 1H-NMR, 13C-NMR and UV-Vis spectroscopy (procedure with shift reagents), and high resolution ESI-MS. A relatively high content of 1 (5.27 mg/g of dry plant material), measured by HPLC, indicated O. montana subsp. scardica as a new natural source of this biologically active compound. The isolated flavonoid compounds might be of value as chemotaxonomic markers.
AB  - Iz nadzemnih delova Onobrychis montana subsp. scardica izolovani su rutin (1, glavni sastojak) i dva flavonoidna S-glikozida, viteksin (2) i njegov 2''-O-α-ramnopiranozid (3). Njihova struktura je određena primenom 1H-NMR, 13C-NMR i UV spektroskopije (procedura sa reagensima UV-pomeranja) i masene spektrometrije visokog razlaganja (HR-ESI-MS). Relativno visok sadržaj rutina (5.27 mg/g suvog materijala) određen pomoću tečne hromatografije (HPLC), ukazuje na O. montana subsp. scardica kao nov prirodni izvor ovog biološki aktivnog jedinjenja. Izolovana jedinjenja mogu biti i od vrednosti kao hemotaksonomski markeri.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Flavonoids from the aerial parts of Onobrychis montana subsp. scardica
T1  - Flavonoidi iz nadzemnih delova Onobrychis montana subsp. scardica
VL  - 73
IS  - 5
SP  - 525
EP  - 529
DO  - 10.2298/JSC0805525G
ER  - 

@article{
author = "Gođevac, Dejan and Pejin, Boris and Zdunić, Gordana and Šavikin, Katarina and Stešević, Danijela and Vajs, Vlatka and Milosavljević, Slobodan",
year = "2008",
abstract = "Rutin (1, main constituent) and two flavone C-glycosides, vitexin (2) and vitexin 2''-O-α-rhamnopyranoside (3) were isolated from the aerial parts of Onobrychis montana subsp. scardica. They were identified by 1H-NMR, 13C-NMR and UV-Vis spectroscopy (procedure with shift reagents), and high resolution ESI-MS. A relatively high content of 1 (5.27 mg/g of dry plant material), measured by HPLC, indicated O. montana subsp. scardica as a new natural source of this biologically active compound. The isolated flavonoid compounds might be of value as chemotaxonomic markers., Iz nadzemnih delova Onobrychis montana subsp. scardica izolovani su rutin (1, glavni sastojak) i dva flavonoidna S-glikozida, viteksin (2) i njegov 2''-O-α-ramnopiranozid (3). Njihova struktura je određena primenom 1H-NMR, 13C-NMR i UV spektroskopije (procedura sa reagensima UV-pomeranja) i masene spektrometrije visokog razlaganja (HR-ESI-MS). Relativno visok sadržaj rutina (5.27 mg/g suvog materijala) određen pomoću tečne hromatografije (HPLC), ukazuje na O. montana subsp. scardica kao nov prirodni izvor ovog biološki aktivnog jedinjenja. Izolovana jedinjenja mogu biti i od vrednosti kao hemotaksonomski markeri.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Flavonoids from the aerial parts of Onobrychis montana subsp. scardica, Flavonoidi iz nadzemnih delova Onobrychis montana subsp. scardica",
volume = "73",
number = "5",
pages = "525-529",
doi = "10.2298/JSC0805525G"
}

Gođevac, D., Pejin, B., Zdunić, G., Šavikin, K., Stešević, D., Vajs, V.,& Milosavljević, S.. (2008). Flavonoids from the aerial parts of Onobrychis montana subsp. scardica. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 73(5), 525-529.
https://doi.org/10.2298/JSC0805525G

Gođevac D, Pejin B, Zdunić G, Šavikin K, Stešević D, Vajs V, Milosavljević S. Flavonoids from the aerial parts of Onobrychis montana subsp. scardica. in Journal of the Serbian Chemical Society. 2008;73(5):525-529.
doi:10.2298/JSC0805525G .

Gođevac, Dejan, Pejin, Boris, Zdunić, Gordana, Šavikin, Katarina, Stešević, Danijela, Vajs, Vlatka, Milosavljević, Slobodan, "Flavonoids from the aerial parts of Onobrychis montana subsp. scardica" in Journal of the Serbian Chemical Society, 73, no. 5 (2008):525-529,
https://doi.org/10.2298/JSC0805525G . .

TY  - CONF
AU  - Zdunić, Gordana
AU  - Stević, Tatjana
AU  - Gođevac, Dejan
AU  - Šavikin, Katarina
AU  - Petrović, Silvana
PY  - 2006
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/232
PB  - Pharmaceutical Association of Serbia, Belgrade, Serbia
C3  - Arhiv za farmaciju
T1  - Investigation of antimicrobial and antioxidant activity of seven Hypericum species
T1  - Ispitivanje antimikrobne i antioksidantne aktivnosti sedam Hypericum vrsta
VL  - 56
IS  - 5
SP  - 946
EP  - 947
UR  - https://hdl.handle.net/21.15107/rcub_cer_232
ER  - 

@conference{
author = "Zdunić, Gordana and Stević, Tatjana and Gođevac, Dejan and Šavikin, Katarina and Petrović, Silvana",
year = "2006",
publisher = "Pharmaceutical Association of Serbia, Belgrade, Serbia",
journal = "Arhiv za farmaciju",
title = "Investigation of antimicrobial and antioxidant activity of seven Hypericum species, Ispitivanje antimikrobne i antioksidantne aktivnosti sedam Hypericum vrsta",
volume = "56",
number = "5",
pages = "946-947",
url = "https://hdl.handle.net/21.15107/rcub_cer_232"
}

Zdunić, G., Stević, T., Gođevac, D., Šavikin, K.,& Petrović, S.. (2006). Investigation of antimicrobial and antioxidant activity of seven Hypericum species. in Arhiv za farmaciju
Pharmaceutical Association of Serbia, Belgrade, Serbia., 56(5), 946-947.
https://hdl.handle.net/21.15107/rcub_cer_232

Zdunić G, Stević T, Gođevac D, Šavikin K, Petrović S. Investigation of antimicrobial and antioxidant activity of seven Hypericum species. in Arhiv za farmaciju. 2006;56(5):946-947.
https://hdl.handle.net/21.15107/rcub_cer_232 .

Zdunić, Gordana, Stević, Tatjana, Gođevac, Dejan, Šavikin, Katarina, Petrović, Silvana, "Investigation of antimicrobial and antioxidant activity of seven Hypericum species" in Arhiv za farmaciju, 56, no. 5 (2006):946-947,
https://hdl.handle.net/21.15107/rcub_cer_232 .