P2X7‐Receptor Pathway Involvement in the Anti‐Inflammatory Activity of Medicinal Plants
Само за регистроване кориснике
2023
Аутори
Ortiz, SergioŠavikin, Katarina
Massicot, France
Olivier, Elodie
Dutot, Melody
Rat, Patrice
Deguin, Brigitte
Gođevac, Dejan
Menković, Nebojša
Živković, Jelena
Zdunić, Gordana
Boutefnouchet, Sabrina
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Medicinal plants used in European folk medicine attached to Lamiales, Gentianales or Asterales orders are used to treat inflammatory disorders. Many targets have been identified but to date, implication of purinergic receptor P2X7 activation has not yet been investigated. We managed to evaluate the protective effect on P2X7 activation by plant extracts used as anti-inflammatory in European folk medicine by the YO-PRO-1 uptake dye in vitro bioassay. Results revealed that among our selected plants, species from Scrophularia and Plantago genus were able to decrease significantly P2X7 activation (>50 % at 0.1 and 1 μg/mL). UPLC/MS, dereplication and metabolomic analysis of Scrophularia extracts, allowed us to identify the cinnamoyl-iridoid harpagoside as putative inhibitor of P2X7 activation. These results open a new research field regarding the anti-inflammatory mechanism of cinnamoyl-iridoids bearing plants, which may involve the P2X7 receptor.
Кључне речи:
Medicinal plants / plant extractsИзвор:
Chemistry & Biodiversity, 2023, 20, 8Издавач:
- Wiley
DOI: 10.1002/cbdv.202300427
ISSN: 1612-1872; 1612-1880
Scopus: 2-s2.0-85165585306
Институција/група
IHTMTY - JOUR AU - Ortiz, Sergio AU - Šavikin, Katarina AU - Massicot, France AU - Olivier, Elodie AU - Dutot, Melody AU - Rat, Patrice AU - Deguin, Brigitte AU - Gođevac, Dejan AU - Menković, Nebojša AU - Živković, Jelena AU - Zdunić, Gordana AU - Boutefnouchet, Sabrina PY - 2023 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/7218 AB - Medicinal plants used in European folk medicine attached to Lamiales, Gentianales or Asterales orders are used to treat inflammatory disorders. Many targets have been identified but to date, implication of purinergic receptor P2X7 activation has not yet been investigated. We managed to evaluate the protective effect on P2X7 activation by plant extracts used as anti-inflammatory in European folk medicine by the YO-PRO-1 uptake dye in vitro bioassay. Results revealed that among our selected plants, species from Scrophularia and Plantago genus were able to decrease significantly P2X7 activation (>50 % at 0.1 and 1 μg/mL). UPLC/MS, dereplication and metabolomic analysis of Scrophularia extracts, allowed us to identify the cinnamoyl-iridoid harpagoside as putative inhibitor of P2X7 activation. These results open a new research field regarding the anti-inflammatory mechanism of cinnamoyl-iridoids bearing plants, which may involve the P2X7 receptor. PB - Wiley T2 - Chemistry & Biodiversity T1 - P2X7‐Receptor Pathway Involvement in the Anti‐Inflammatory Activity of Medicinal Plants VL - 20 IS - 8 DO - 10.1002/cbdv.202300427 ER -
@article{ author = "Ortiz, Sergio and Šavikin, Katarina and Massicot, France and Olivier, Elodie and Dutot, Melody and Rat, Patrice and Deguin, Brigitte and Gođevac, Dejan and Menković, Nebojša and Živković, Jelena and Zdunić, Gordana and Boutefnouchet, Sabrina", year = "2023", abstract = "Medicinal plants used in European folk medicine attached to Lamiales, Gentianales or Asterales orders are used to treat inflammatory disorders. Many targets have been identified but to date, implication of purinergic receptor P2X7 activation has not yet been investigated. We managed to evaluate the protective effect on P2X7 activation by plant extracts used as anti-inflammatory in European folk medicine by the YO-PRO-1 uptake dye in vitro bioassay. Results revealed that among our selected plants, species from Scrophularia and Plantago genus were able to decrease significantly P2X7 activation (>50 % at 0.1 and 1 μg/mL). UPLC/MS, dereplication and metabolomic analysis of Scrophularia extracts, allowed us to identify the cinnamoyl-iridoid harpagoside as putative inhibitor of P2X7 activation. These results open a new research field regarding the anti-inflammatory mechanism of cinnamoyl-iridoids bearing plants, which may involve the P2X7 receptor.", publisher = "Wiley", journal = "Chemistry & Biodiversity", title = "P2X7‐Receptor Pathway Involvement in the Anti‐Inflammatory Activity of Medicinal Plants", volume = "20", number = "8", doi = "10.1002/cbdv.202300427" }
Ortiz, S., Šavikin, K., Massicot, F., Olivier, E., Dutot, M., Rat, P., Deguin, B., Gođevac, D., Menković, N., Živković, J., Zdunić, G.,& Boutefnouchet, S.. (2023). P2X7‐Receptor Pathway Involvement in the Anti‐Inflammatory Activity of Medicinal Plants. in Chemistry & Biodiversity Wiley., 20(8). https://doi.org/10.1002/cbdv.202300427
Ortiz S, Šavikin K, Massicot F, Olivier E, Dutot M, Rat P, Deguin B, Gođevac D, Menković N, Živković J, Zdunić G, Boutefnouchet S. P2X7‐Receptor Pathway Involvement in the Anti‐Inflammatory Activity of Medicinal Plants. in Chemistry & Biodiversity. 2023;20(8). doi:10.1002/cbdv.202300427 .
Ortiz, Sergio, Šavikin, Katarina, Massicot, France, Olivier, Elodie, Dutot, Melody, Rat, Patrice, Deguin, Brigitte, Gođevac, Dejan, Menković, Nebojša, Živković, Jelena, Zdunić, Gordana, Boutefnouchet, Sabrina, "P2X7‐Receptor Pathway Involvement in the Anti‐Inflammatory Activity of Medicinal Plants" in Chemistry & Biodiversity, 20, no. 8 (2023), https://doi.org/10.1002/cbdv.202300427 . .