TY  - JOUR
AU  - Krstić, Gordana
AU  - Kostić, Ana
AU  - Jadranin, Milka
AU  - Pešić, Milica
AU  - Novaković, Miroslav
AU  - Aljančić, Ivana
AU  - Vajs, Vlatka
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4910
AB  - In the previous study fifteen jatrophane diterpenes were isolated from the Euphorbia nicaeensis latex. Fourteen of them have been shown to be potent P-glycoprotein (P-gp) inhibitor in two MDR cancer cells (NCI-H460/R and DLD1-TxR). The aim of this study was to determine whether and which jatro­phane diterpenes can be isolated from the root of the plant, and then to examine their inhibition power on P-glycoprotein of selected cancer cell lines (NCI-H460, DLD1, U87, NCI-H460/R, DLD1-TxR and U87-TxR). Two previously undes­cribed jatrophane diterpenes were isolated from the root of E. nicaeensis col­lected in Deliblato Sand (Serbia). The structures of the isolated compounds were determined using 1D and 2D NMR, as well as HRESIMS data. The results obtained by MTT assay showed different antitumor potential of these two jatrophanes. Compound 1 inhibited cell growth of non-small cell lung car­cinoma cell lines NCI-H460 and NCI-H460/R, as well as glioblastoma cell lines U87 and U87-TxR, while jatrophane 2 was almost completely inactive in the suppression of cancer cell growth in a given range of concentrations. The obtained results also showed that the isolated compounds have an inhibitory effect on P-glycoprotein, as well as that their inhibitory potential is similar.
AB  - У претходном истраживању, петнаест дитерпена јатрофанског типа изоловано је из латекса Euphorbia nicaeensis. Њих четрнаест показала су се као снажни инхибитори P-гликопротеина (P-gp) у две MDR ћелијске линије рака (NCI-H460/R и DLD1-TxR). Циљ ове студије био је да се утврди да ли је и које јатрофанске дитерпене могуће изо- ловати из корена биљке, а затим испитивање њихове инхибиторне моћи на P-гликопро- теину одабраних ћелијских линија рака (NCI-H460, DLD1, U87, NCI-H460/R, DLD1-TxR и U87-TxR). Два претходно непозната јатрофана изолованa су из корена E. nicaeensis прикупљеног у Делиблатској пешчари. Структуре изолованих једињења одређене су применом 1D и 2D NMR метода, као и HRESIMS експеримента. Резултати добијени МТТ тестом показали су различит антиканцерогени потенцијал ова два јатрофана. Једињење 1 је инхибирало раст ћелија ћелијских линија неситноћелијског карцинома плућа NCI-H460 и NCI-H460/R, као и ћелијских линија глиобластома U87 и U87-TxR, док је јатрофан 2 био готово потпуно неефикасан у сузбијању растa ћелија карцинома у датом концентрационом опсегу. Добијени резултати су такође показали да 1 и 2 имају инхибиторно дејство на P-гликопротеин, као и да је њихов инхибиторни потенцијал сличан.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Two new jatrophane diterpenes from the roots of Euphorbia nicaeensis
T1  - Два нова јатрофанска дитерпена из корена Euphorbia nicaeensis
IS  - 12
SP  - 1219
EP  - 1228
DO  - 10.2298/JSC210806085K
ER  - 

@article{
author = "Krstić, Gordana and Kostić, Ana and Jadranin, Milka and Pešić, Milica and Novaković, Miroslav and Aljančić, Ivana and Vajs, Vlatka",
year = "2021",
abstract = "In the previous study fifteen jatrophane diterpenes were isolated from the Euphorbia nicaeensis latex. Fourteen of them have been shown to be potent P-glycoprotein (P-gp) inhibitor in two MDR cancer cells (NCI-H460/R and DLD1-TxR). The aim of this study was to determine whether and which jatro­phane diterpenes can be isolated from the root of the plant, and then to examine their inhibition power on P-glycoprotein of selected cancer cell lines (NCI-H460, DLD1, U87, NCI-H460/R, DLD1-TxR and U87-TxR). Two previously undes­cribed jatrophane diterpenes were isolated from the root of E. nicaeensis col­lected in Deliblato Sand (Serbia). The structures of the isolated compounds were determined using 1D and 2D NMR, as well as HRESIMS data. The results obtained by MTT assay showed different antitumor potential of these two jatrophanes. Compound 1 inhibited cell growth of non-small cell lung car­cinoma cell lines NCI-H460 and NCI-H460/R, as well as glioblastoma cell lines U87 and U87-TxR, while jatrophane 2 was almost completely inactive in the suppression of cancer cell growth in a given range of concentrations. The obtained results also showed that the isolated compounds have an inhibitory effect on P-glycoprotein, as well as that their inhibitory potential is similar., У претходном истраживању, петнаест дитерпена јатрофанског типа изоловано је из латекса Euphorbia nicaeensis. Њих четрнаест показала су се као снажни инхибитори P-гликопротеина (P-gp) у две MDR ћелијске линије рака (NCI-H460/R и DLD1-TxR). Циљ ове студије био је да се утврди да ли је и које јатрофанске дитерпене могуће изо- ловати из корена биљке, а затим испитивање њихове инхибиторне моћи на P-гликопро- теину одабраних ћелијских линија рака (NCI-H460, DLD1, U87, NCI-H460/R, DLD1-TxR и U87-TxR). Два претходно непозната јатрофана изолованa су из корена E. nicaeensis прикупљеног у Делиблатској пешчари. Структуре изолованих једињења одређене су применом 1D и 2D NMR метода, као и HRESIMS експеримента. Резултати добијени МТТ тестом показали су различит антиканцерогени потенцијал ова два јатрофана. Једињење 1 је инхибирало раст ћелија ћелијских линија неситноћелијског карцинома плућа NCI-H460 и NCI-H460/R, као и ћелијских линија глиобластома U87 и U87-TxR, док је јатрофан 2 био готово потпуно неефикасан у сузбијању растa ћелија карцинома у датом концентрационом опсегу. Добијени резултати су такође показали да 1 и 2 имају инхибиторно дејство на P-гликопротеин, као и да је њихов инхибиторни потенцијал сличан.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Two new jatrophane diterpenes from the roots of Euphorbia nicaeensis, Два нова јатрофанска дитерпена из корена Euphorbia nicaeensis",
number = "12",
pages = "1219-1228",
doi = "10.2298/JSC210806085K"
}

Krstić, G., Kostić, A., Jadranin, M., Pešić, M., Novaković, M., Aljančić, I.,& Vajs, V.. (2021). Two new jatrophane diterpenes from the roots of Euphorbia nicaeensis. in Journal of the Serbian Chemical Society
Serbian Chemical Society.(12), 1219-1228.
https://doi.org/10.2298/JSC210806085K

Krstić G, Kostić A, Jadranin M, Pešić M, Novaković M, Aljančić I, Vajs V. Two new jatrophane diterpenes from the roots of Euphorbia nicaeensis. in Journal of the Serbian Chemical Society. 2021;(12):1219-1228.
doi:10.2298/JSC210806085K .

Krstić, Gordana, Kostić, Ana, Jadranin, Milka, Pešić, Milica, Novaković, Miroslav, Aljančić, Ivana, Vajs, Vlatka, "Two new jatrophane diterpenes from the roots of Euphorbia nicaeensis" in Journal of the Serbian Chemical Society, no. 12 (2021):1219-1228,
https://doi.org/10.2298/JSC210806085K . .

TY  - JOUR
AU  - Krstić, Gordana
AU  - Aljančić, Ivana
AU  - Stanković, Jovana
AU  - Cvetković, Mirjana
AU  - Marin, Petar D.
AU  - Janaćković, Peđa T.
AU  - Tešević, Vele
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2923
AB  - The presence of n-alkanes, free alcohols and free acids in leaf epicuticular wax extracts of 22 samples of 11 Euphorbia L. species belonging to the sections Paralias, Esula, Myrsiniteae and Helioscopia, 10 of which were never examined before, were analyzed by gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS), and n-alkane C27 was detected as the principal component of leaf epicuticular waxes in the majority of the examined species, while the most abundant free alcohol was C26. Three Euphorbia species belonging to section Helioscopia were characterized by a predominance of alcohol C28. Free acid (C16) was the major component in 21 investigated samples. The usefulness of n-alkanes and free alcohols and free acids as potential chemotaxonomic markers is briefly discussed.
T2  - Archives of Biological Sciences
T1  - Leaf epicuticular waxes of eleven Euphorbia species (Euphorbiaceae) from the central Balkans: Impact on chemotaxonomy
VL  - 71
IS  - 1
SP  - 21
EP  - 26
DO  - 10.2298/ABS180608041K
ER  - 

@article{
author = "Krstić, Gordana and Aljančić, Ivana and Stanković, Jovana and Cvetković, Mirjana and Marin, Petar D. and Janaćković, Peđa T. and Tešević, Vele",
year = "2019",
abstract = "The presence of n-alkanes, free alcohols and free acids in leaf epicuticular wax extracts of 22 samples of 11 Euphorbia L. species belonging to the sections Paralias, Esula, Myrsiniteae and Helioscopia, 10 of which were never examined before, were analyzed by gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS), and n-alkane C27 was detected as the principal component of leaf epicuticular waxes in the majority of the examined species, while the most abundant free alcohol was C26. Three Euphorbia species belonging to section Helioscopia were characterized by a predominance of alcohol C28. Free acid (C16) was the major component in 21 investigated samples. The usefulness of n-alkanes and free alcohols and free acids as potential chemotaxonomic markers is briefly discussed.",
journal = "Archives of Biological Sciences",
title = "Leaf epicuticular waxes of eleven Euphorbia species (Euphorbiaceae) from the central Balkans: Impact on chemotaxonomy",
volume = "71",
number = "1",
pages = "21-26",
doi = "10.2298/ABS180608041K"
}

Krstić, G., Aljančić, I., Stanković, J., Cvetković, M., Marin, P. D., Janaćković, P. T.,& Tešević, V.. (2019). Leaf epicuticular waxes of eleven Euphorbia species (Euphorbiaceae) from the central Balkans: Impact on chemotaxonomy. in Archives of Biological Sciences, 71(1), 21-26.
https://doi.org/10.2298/ABS180608041K

Krstić G, Aljančić I, Stanković J, Cvetković M, Marin PD, Janaćković PT, Tešević V. Leaf epicuticular waxes of eleven Euphorbia species (Euphorbiaceae) from the central Balkans: Impact on chemotaxonomy. in Archives of Biological Sciences. 2019;71(1):21-26.
doi:10.2298/ABS180608041K .

Krstić, Gordana, Aljančić, Ivana, Stanković, Jovana, Cvetković, Mirjana, Marin, Petar D., Janaćković, Peđa T., Tešević, Vele, "Leaf epicuticular waxes of eleven Euphorbia species (Euphorbiaceae) from the central Balkans: Impact on chemotaxonomy" in Archives of Biological Sciences, 71, no. 1 (2019):21-26,
https://doi.org/10.2298/ABS180608041K . .

TY  - JOUR
AU  - Krstić, Gordana
AU  - Jadranin, Milka
AU  - Stanković, Miroslava
AU  - Aljančić, Ivana
AU  - Vujisić, Ljubodrag V.
AU  - Mandić, Boris
AU  - Tešević, Vele
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3143
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3514
AB  - Two sets of structurally different jatrophanes (1-11 and 13-16), jatrophane 12, and latex extract of 2 Euphorbia species (17 and 18) were tested for in vitro protective effect against chromosome aberrations in peripheral human lymphocytes using the cytokinesis-block micronucleus (CBMN) assay. Jatrophanes 1-6 in minimal doses of 1 µg/mL prominently decreased micronuclei (MN) frequency in the range 44.86% to 34.29% and manifested considerable protective effect. From the other set of jatrophanes, 13 in the same minimal dose notably decreased MN frequency by 31.05%, while extracts 17 and 18 at a concentration of 4 µg/mL remarkably decreased the frequency of MN by 37.94% and 36.12%, respectively. Jatrophanes 12, 14, and 16 showed moderate protection, while 7-11 and 15 were less active than positive control. The structure-activity relationship (SAR) studies of the tested jatrophanes (1-16) indicated the favorable position of benzoate at C-8 or C-9 (3, 4, and 13) and a preference of isobutanoyloxy group at C-3 (1-3) rather than propanoyloxy at the same position (4-6) for pronounced protective effect on human lymphocytes DNA. In a previous SAR study on 11 jatrophanes (1, 3-8, and 13-16), the same structural features in 3, 4, and 13 influenced powerful inhibition of P-gp, while growth inhibition of cancer cells was more than doubled in 1 (isobutanoyloxy group at C-3) compared to 6 (propanoyloxy at C-3).
PB  - SAGE Journals
T2  - Natural Product Communications
T1  - Jatrophane Diterpenoids With Protective Effect on Human Lymphocytes DNA
VL  - 14
IS  - 5
DO  - 10.1177/1934578X19848168
ER  - 

@article{
author = "Krstić, Gordana and Jadranin, Milka and Stanković, Miroslava and Aljančić, Ivana and Vujisić, Ljubodrag V. and Mandić, Boris and Tešević, Vele",
year = "2019",
abstract = "Two sets of structurally different jatrophanes (1-11 and 13-16), jatrophane 12, and latex extract of 2 Euphorbia species (17 and 18) were tested for in vitro protective effect against chromosome aberrations in peripheral human lymphocytes using the cytokinesis-block micronucleus (CBMN) assay. Jatrophanes 1-6 in minimal doses of 1 µg/mL prominently decreased micronuclei (MN) frequency in the range 44.86% to 34.29% and manifested considerable protective effect. From the other set of jatrophanes, 13 in the same minimal dose notably decreased MN frequency by 31.05%, while extracts 17 and 18 at a concentration of 4 µg/mL remarkably decreased the frequency of MN by 37.94% and 36.12%, respectively. Jatrophanes 12, 14, and 16 showed moderate protection, while 7-11 and 15 were less active than positive control. The structure-activity relationship (SAR) studies of the tested jatrophanes (1-16) indicated the favorable position of benzoate at C-8 or C-9 (3, 4, and 13) and a preference of isobutanoyloxy group at C-3 (1-3) rather than propanoyloxy at the same position (4-6) for pronounced protective effect on human lymphocytes DNA. In a previous SAR study on 11 jatrophanes (1, 3-8, and 13-16), the same structural features in 3, 4, and 13 influenced powerful inhibition of P-gp, while growth inhibition of cancer cells was more than doubled in 1 (isobutanoyloxy group at C-3) compared to 6 (propanoyloxy at C-3).",
publisher = "SAGE Journals",
journal = "Natural Product Communications",
title = "Jatrophane Diterpenoids With Protective Effect on Human Lymphocytes DNA",
volume = "14",
number = "5",
doi = "10.1177/1934578X19848168"
}

Krstić, G., Jadranin, M., Stanković, M., Aljančić, I., Vujisić, L. V., Mandić, B.,& Tešević, V.. (2019). Jatrophane Diterpenoids With Protective Effect on Human Lymphocytes DNA. in Natural Product Communications
SAGE Journals., 14(5).
https://doi.org/10.1177/1934578X19848168

Krstić G, Jadranin M, Stanković M, Aljančić I, Vujisić LV, Mandić B, Tešević V. Jatrophane Diterpenoids With Protective Effect on Human Lymphocytes DNA. in Natural Product Communications. 2019;14(5).
doi:10.1177/1934578X19848168 .

Krstić, Gordana, Jadranin, Milka, Stanković, Miroslava, Aljančić, Ivana, Vujisić, Ljubodrag V., Mandić, Boris, Tešević, Vele, "Jatrophane Diterpenoids With Protective Effect on Human Lymphocytes DNA" in Natural Product Communications, 14, no. 5 (2019),
https://doi.org/10.1177/1934578X19848168 . .

TY  - JOUR
AU  - Krstić, Gordana
AU  - Jadranin, Milka
AU  - Todorović, Nina
AU  - Pešić, Milica
AU  - Stankovic, Tijana
AU  - Aljančić, Ivana
AU  - Tešević, Vele
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2319
AB  - Seven previously undescribed jatrophane diterpenoids, nicaeenin A-G, with eight known jatrophane diterpenoids, namely euphodendrophanes A-C, F, N, O, Q S, were isolated from latex of Euphorbia nicaeensis collected in Serbia. The chemical structures of the compounds were determined by spectro-scopic analysis including 1D and 2D NMR and HRESIMS experiments. All but one of the previously undescribed jatrophanes, showed significant potential to inhibit P-glycoprotein (P-gp) activity in two MDR cancer cells (NCI-H460/12 and DLD1-TxR). The most powerful were nicaeenin F and nicaeenin G. Moreover nicaeenin G significantly stronger sensitized NCI-H460/R cells to DOX than Dex-VER.
PB  - Oxford : Pergamon-Elsevier Science Ltd
T2  - Phytochemistry
T1  - Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis
VL  - 148
SP  - 104
EP  - 112
DO  - 10.1016/j.phytochem.2018.01.016
ER  - 

@article{
author = "Krstić, Gordana and Jadranin, Milka and Todorović, Nina and Pešić, Milica and Stankovic, Tijana and Aljančić, Ivana and Tešević, Vele",
year = "2018",
abstract = "Seven previously undescribed jatrophane diterpenoids, nicaeenin A-G, with eight known jatrophane diterpenoids, namely euphodendrophanes A-C, F, N, O, Q S, were isolated from latex of Euphorbia nicaeensis collected in Serbia. The chemical structures of the compounds were determined by spectro-scopic analysis including 1D and 2D NMR and HRESIMS experiments. All but one of the previously undescribed jatrophanes, showed significant potential to inhibit P-glycoprotein (P-gp) activity in two MDR cancer cells (NCI-H460/12 and DLD1-TxR). The most powerful were nicaeenin F and nicaeenin G. Moreover nicaeenin G significantly stronger sensitized NCI-H460/R cells to DOX than Dex-VER.",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "Phytochemistry",
title = "Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis",
volume = "148",
pages = "104-112",
doi = "10.1016/j.phytochem.2018.01.016"
}

Krstić, G., Jadranin, M., Todorović, N., Pešić, M., Stankovic, T., Aljančić, I.,& Tešević, V.. (2018). Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis. in Phytochemistry
Oxford : Pergamon-Elsevier Science Ltd., 148, 104-112.
https://doi.org/10.1016/j.phytochem.2018.01.016

Krstić G, Jadranin M, Todorović N, Pešić M, Stankovic T, Aljančić I, Tešević V. Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis. in Phytochemistry. 2018;148:104-112.
doi:10.1016/j.phytochem.2018.01.016 .

Krstić, Gordana, Jadranin, Milka, Todorović, Nina, Pešić, Milica, Stankovic, Tijana, Aljančić, Ivana, Tešević, Vele, "Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis" in Phytochemistry, 148 (2018):104-112,
https://doi.org/10.1016/j.phytochem.2018.01.016 . .

TY  - CHAP
AU  - Gođevac, Dejan
AU  - Jadranin, Milka
AU  - Aljančić, Ivana
AU  - Vajs, Vlatka
AU  - Tešević, Vele
AU  - Milosavljević, Slobodan
PY  - 2015
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4182
AB  - Through the selected examples of different classes of secondary metabolites two general approaches in the analysis of complex mixtures of natural products are presented. The first one involves isolation of the constituents using optimized semi-prep LC in combination with classical column chromatography (CC) and the second one represents direct (on-line) analysis of complex plant extracts prior to isolation of the constituents. Thus the isolation of mg-quantities of jatrophanes the bioactive constituents of Euphorbia dendroides, with their structure determination on the basis of spectroscopic data interpretation (IR, NMR, MS), is described. The direct analysis of the plant extracts is demonstrated by the characterization of antioxidative polyphenols, i.e. oligomeric proanthocynidins from the MeOH extracts of grape Vitis vinifera seeds by the application of hyphenated methods (LC/UV/MS) in combination with 13C NMR spectroscopy, as well as tandem mass spectrometry (MS/MS) and MSn in combination with and without LC for identification of oligomeric proanthocynidins from other sources. The potential of another hyphenated instrumentation, LC/UV/SPE-NMR is shown by on-line identification of the various constituents of the crude extract of Hypericum perforatum. The possibilities and limitations of the NMR technique named diffusion ordered spectroscopy (DOSY) for direct analysis of the complex mixture, such as e.g. methanolic extract of Gentiana lutea, is discussed.
PB  - Dordrecht : Springer Netherlands
T2  - Medicinal and Aromatic Plants of the World
T1  - Application of Spectroscopic Methods and Hyphenated Techniques to the Analysis of Complex Plant Extracts
VL  - 1
SP  - 61
EP  - 85
DO  - 10.1007/978-94-017-9810-5_4
ER  - 

@inbook{
author = "Gođevac, Dejan and Jadranin, Milka and Aljančić, Ivana and Vajs, Vlatka and Tešević, Vele and Milosavljević, Slobodan",
year = "2015",
abstract = "Through the selected examples of different classes of secondary metabolites two general approaches in the analysis of complex mixtures of natural products are presented. The first one involves isolation of the constituents using optimized semi-prep LC in combination with classical column chromatography (CC) and the second one represents direct (on-line) analysis of complex plant extracts prior to isolation of the constituents. Thus the isolation of mg-quantities of jatrophanes the bioactive constituents of Euphorbia dendroides, with their structure determination on the basis of spectroscopic data interpretation (IR, NMR, MS), is described. The direct analysis of the plant extracts is demonstrated by the characterization of antioxidative polyphenols, i.e. oligomeric proanthocynidins from the MeOH extracts of grape Vitis vinifera seeds by the application of hyphenated methods (LC/UV/MS) in combination with 13C NMR spectroscopy, as well as tandem mass spectrometry (MS/MS) and MSn in combination with and without LC for identification of oligomeric proanthocynidins from other sources. The potential of another hyphenated instrumentation, LC/UV/SPE-NMR is shown by on-line identification of the various constituents of the crude extract of Hypericum perforatum. The possibilities and limitations of the NMR technique named diffusion ordered spectroscopy (DOSY) for direct analysis of the complex mixture, such as e.g. methanolic extract of Gentiana lutea, is discussed.",
publisher = "Dordrecht : Springer Netherlands",
journal = "Medicinal and Aromatic Plants of the World",
booktitle = "Application of Spectroscopic Methods and Hyphenated Techniques to the Analysis of Complex Plant Extracts",
volume = "1",
pages = "61-85",
doi = "10.1007/978-94-017-9810-5_4"
}

Gođevac, D., Jadranin, M., Aljančić, I., Vajs, V., Tešević, V.,& Milosavljević, S.. (2015). Application of Spectroscopic Methods and Hyphenated Techniques to the Analysis of Complex Plant Extracts. in Medicinal and Aromatic Plants of the World
Dordrecht : Springer Netherlands., 1, 61-85.
https://doi.org/10.1007/978-94-017-9810-5_4

Gođevac D, Jadranin M, Aljančić I, Vajs V, Tešević V, Milosavljević S. Application of Spectroscopic Methods and Hyphenated Techniques to the Analysis of Complex Plant Extracts. in Medicinal and Aromatic Plants of the World. 2015;1:61-85.
doi:10.1007/978-94-017-9810-5_4 .

Gođevac, Dejan, Jadranin, Milka, Aljančić, Ivana, Vajs, Vlatka, Tešević, Vele, Milosavljević, Slobodan, "Application of Spectroscopic Methods and Hyphenated Techniques to the Analysis of Complex Plant Extracts" in Medicinal and Aromatic Plants of the World, 1 (2015):61-85,
https://doi.org/10.1007/978-94-017-9810-5_4 . .

TY  - CHAP
AU  - Šavikin, Katarina
AU  - Aljančić, Ivana
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan
AU  - Jadranin, Milka
AU  - Đorđević, Iris
AU  - Menković, Nebojša
PY  - 2015
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1835
AB  - The results are presented of phytochemical investigations, during the last decade, of some wild-growing species of the family Gentianaceae from Serbia and Montenegro. Some of the species investigated, members of the genera Gentiana, Gentianella, and Swertia, are endemic, and the emphasis in this report is on those exhibiting biological activities that could be regarded as a potential source of drugs. This review discusses more than fifty compounds, such as xanthones, secoiridoids, and C-glucoflavonoids.
PB  - Springer Berlin Heidelberg
T2  - The Gentianaceae - Volume 2: Biotechnology and Applications
T1  - Bioactive secondary metabolites in several genera of gentianaceae species from thè central regions of thè balkan peninsula
SP  - 319
EP  - 347
DO  - 10.1007/978-3-642-54102-5_14
ER  - 

@inbook{
author = "Šavikin, Katarina and Aljančić, Ivana and Vajs, Vlatka and Milosavljević, Slobodan and Jadranin, Milka and Đorđević, Iris and Menković, Nebojša",
year = "2015",
abstract = "The results are presented of phytochemical investigations, during the last decade, of some wild-growing species of the family Gentianaceae from Serbia and Montenegro. Some of the species investigated, members of the genera Gentiana, Gentianella, and Swertia, are endemic, and the emphasis in this report is on those exhibiting biological activities that could be regarded as a potential source of drugs. This review discusses more than fifty compounds, such as xanthones, secoiridoids, and C-glucoflavonoids.",
publisher = "Springer Berlin Heidelberg",
journal = "The Gentianaceae - Volume 2: Biotechnology and Applications",
booktitle = "Bioactive secondary metabolites in several genera of gentianaceae species from thè central regions of thè balkan peninsula",
pages = "319-347",
doi = "10.1007/978-3-642-54102-5_14"
}

Šavikin, K., Aljančić, I., Vajs, V., Milosavljević, S., Jadranin, M., Đorđević, I.,& Menković, N.. (2015). Bioactive secondary metabolites in several genera of gentianaceae species from thè central regions of thè balkan peninsula. in The Gentianaceae - Volume 2: Biotechnology and Applications
Springer Berlin Heidelberg., 319-347.
https://doi.org/10.1007/978-3-642-54102-5_14

Šavikin K, Aljančić I, Vajs V, Milosavljević S, Jadranin M, Đorđević I, Menković N. Bioactive secondary metabolites in several genera of gentianaceae species from thè central regions of thè balkan peninsula. in The Gentianaceae - Volume 2: Biotechnology and Applications. 2015;:319-347.
doi:10.1007/978-3-642-54102-5_14 .

Šavikin, Katarina, Aljančić, Ivana, Vajs, Vlatka, Milosavljević, Slobodan, Jadranin, Milka, Đorđević, Iris, Menković, Nebojša, "Bioactive secondary metabolites in several genera of gentianaceae species from thè central regions of thè balkan peninsula" in The Gentianaceae - Volume 2: Biotechnology and Applications (2015):319-347,
https://doi.org/10.1007/978-3-642-54102-5_14 . .

TY  - JOUR
AU  - Tešević, Vele
AU  - Aljančić, Ivana
AU  - Vajs, Vlatka
AU  - Živković, Marijana
AU  - Nikićević, Ninoslav
AU  - Urosevic, Ivan
AU  - Vujisić, Ljubodrag V.
PY  - 2014
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1489
AB  - An ultra-performance liquid chromatographic triple quadrupole mass spectrometric (UPLC-QqQ-MS/MS) method with a multiple reactions monitoring mode (MRM) was developed and validated for the quantification of vanillin and syringaldehyde in plum brandy. The method showed good linearity (0.05 to 10 mg L-1) and low limits of detection and quantification (the LOD and LOQ values were 11.6 and 38.2 mu g L-1 for vanillin, and 12.7 and 42.0 mu g L-1 for syringaldehyde, respectively). The overall intra-day and inter-day variations were less than 4.21 % and the overall recovery was over 93.0 %. The correlation coefficients (R-2) of the calibration curves were higher than 0.9999. In order to evaluate whether the method was suitable for use as a routine analytical tool, vanillin and syringaldehyde were determined in 31 samples of Serbian plum brandy.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Development and validation of an LC-MS/MS method with a multiple reactions monitoring mode for the quantification of vanillin and syringaldehyde in plum brandies
VL  - 79
IS  - 12
SP  - 1537
EP  - 1543
DO  - 10.2298/JSC140225079T
ER  - 

@article{
author = "Tešević, Vele and Aljančić, Ivana and Vajs, Vlatka and Živković, Marijana and Nikićević, Ninoslav and Urosevic, Ivan and Vujisić, Ljubodrag V.",
year = "2014",
abstract = "An ultra-performance liquid chromatographic triple quadrupole mass spectrometric (UPLC-QqQ-MS/MS) method with a multiple reactions monitoring mode (MRM) was developed and validated for the quantification of vanillin and syringaldehyde in plum brandy. The method showed good linearity (0.05 to 10 mg L-1) and low limits of detection and quantification (the LOD and LOQ values were 11.6 and 38.2 mu g L-1 for vanillin, and 12.7 and 42.0 mu g L-1 for syringaldehyde, respectively). The overall intra-day and inter-day variations were less than 4.21 % and the overall recovery was over 93.0 %. The correlation coefficients (R-2) of the calibration curves were higher than 0.9999. In order to evaluate whether the method was suitable for use as a routine analytical tool, vanillin and syringaldehyde were determined in 31 samples of Serbian plum brandy.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Development and validation of an LC-MS/MS method with a multiple reactions monitoring mode for the quantification of vanillin and syringaldehyde in plum brandies",
volume = "79",
number = "12",
pages = "1537-1543",
doi = "10.2298/JSC140225079T"
}

Tešević, V., Aljančić, I., Vajs, V., Živković, M., Nikićević, N., Urosevic, I.,& Vujisić, L. V.. (2014). Development and validation of an LC-MS/MS method with a multiple reactions monitoring mode for the quantification of vanillin and syringaldehyde in plum brandies. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 79(12), 1537-1543.
https://doi.org/10.2298/JSC140225079T

Tešević V, Aljančić I, Vajs V, Živković M, Nikićević N, Urosevic I, Vujisić LV. Development and validation of an LC-MS/MS method with a multiple reactions monitoring mode for the quantification of vanillin and syringaldehyde in plum brandies. in Journal of the Serbian Chemical Society. 2014;79(12):1537-1543.
doi:10.2298/JSC140225079T .

Tešević, Vele, Aljančić, Ivana, Vajs, Vlatka, Živković, Marijana, Nikićević, Ninoslav, Urosevic, Ivan, Vujisić, Ljubodrag V., "Development and validation of an LC-MS/MS method with a multiple reactions monitoring mode for the quantification of vanillin and syringaldehyde in plum brandies" in Journal of the Serbian Chemical Society, 79, no. 12 (2014):1537-1543,
https://doi.org/10.2298/JSC140225079T . .

TY  - JOUR
AU  - Aljančić, Ivana
AU  - Vučković, Ivan
AU  - Jadranin, Milka
AU  - Pešić, Milica
AU  - Đorđević, Iris
AU  - Podolski-Renic, Ana
AU  - Stojkovic, Sonja
AU  - Menković, Nebojša
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan
PY  - 2014
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1542
AB  - Dimers tomoroside A (1) and tomoroside B (2) of the co-occuring known chalcone monomer (3), along with the seven known flavonoid glucosides (4-10), were isolated from the aerial parts of Helichrysum zivojinii Cernjavski & Soska. The structures of the isolated compounds were elucidated by spectroscopic techniques. Compound 1 inhibited topo Ha and hif-1 alpha expression and stimulated doxorubicin anticancer effect, while 2 increased the expression of hif-1 alpha a, probably acting as antioxidant and redox status modulator. Notably, 2 synergized with Tipifarnib showing potential to improve the action of this new chemotherapeutic involved in the modulation of mitogene activated protein (MAP) kinase signaling pathway.
PB  - Oxford : Pergamon-Elsevier Science Ltd
T2  - Phytochemistry
T1  - Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines
VL  - 98
SP  - 190
EP  - 196
DO  - 10.1016/j.phytochem.2013.11.025
ER  - 

@article{
author = "Aljančić, Ivana and Vučković, Ivan and Jadranin, Milka and Pešić, Milica and Đorđević, Iris and Podolski-Renic, Ana and Stojkovic, Sonja and Menković, Nebojša and Vajs, Vlatka and Milosavljević, Slobodan",
year = "2014",
abstract = "Dimers tomoroside A (1) and tomoroside B (2) of the co-occuring known chalcone monomer (3), along with the seven known flavonoid glucosides (4-10), were isolated from the aerial parts of Helichrysum zivojinii Cernjavski & Soska. The structures of the isolated compounds were elucidated by spectroscopic techniques. Compound 1 inhibited topo Ha and hif-1 alpha expression and stimulated doxorubicin anticancer effect, while 2 increased the expression of hif-1 alpha a, probably acting as antioxidant and redox status modulator. Notably, 2 synergized with Tipifarnib showing potential to improve the action of this new chemotherapeutic involved in the modulation of mitogene activated protein (MAP) kinase signaling pathway.",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "Phytochemistry",
title = "Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines",
volume = "98",
pages = "190-196",
doi = "10.1016/j.phytochem.2013.11.025"
}

Aljančić, I., Vučković, I., Jadranin, M., Pešić, M., Đorđević, I., Podolski-Renic, A., Stojkovic, S., Menković, N., Vajs, V.,& Milosavljević, S.. (2014). Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines. in Phytochemistry
Oxford : Pergamon-Elsevier Science Ltd., 98, 190-196.
https://doi.org/10.1016/j.phytochem.2013.11.025

Aljančić I, Vučković I, Jadranin M, Pešić M, Đorđević I, Podolski-Renic A, Stojkovic S, Menković N, Vajs V, Milosavljević S. Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines. in Phytochemistry. 2014;98:190-196.
doi:10.1016/j.phytochem.2013.11.025 .

Aljančić, Ivana, Vučković, Ivan, Jadranin, Milka, Pešić, Milica, Đorđević, Iris, Podolski-Renic, Ana, Stojkovic, Sonja, Menković, Nebojša, Vajs, Vlatka, Milosavljević, Slobodan, "Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines" in Phytochemistry, 98 (2014):190-196,
https://doi.org/10.1016/j.phytochem.2013.11.025 . .

TY  - JOUR
AU  - Tešević, Vele
AU  - Aljančić, Ivana
AU  - Milosavljević, Slobodan
AU  - Vajs, Vlatka
AU  - Đorđević, Iris
AU  - Jadranin, Milka
AU  - Menković, Nebojša
AU  - Matevski, Vlado
PY  - 2014
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1478
AB  - The aerial parts of three endemic Centaurea L. species, namely C. tomorosii Micevski, C. soskae Hayek and C. galicicae Micevski, afforded the sesquiterpene lactone cnicin (1) and seven flavonoids: apigenin (2), isokaempferide (3), hispidulin (4), eupatorin (5), cirsimaritin (6), santoflavone (7) and salvigenin (8). The structures of the isolated compounds were determined by UV, H-1-NMR and C-13-NMR spectroscopy and HR-ESI-MS spectrometry. H-1-NMR spectroscopy was used as a method for the quantitative analysis of cnicin.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Secondary metabolites of three endemic Centaurea L. species
VL  - 79
IS  - 11
SP  - 1355
EP  - 1362
DO  - 10.2298/JSC140318048T
ER  - 

@article{
author = "Tešević, Vele and Aljančić, Ivana and Milosavljević, Slobodan and Vajs, Vlatka and Đorđević, Iris and Jadranin, Milka and Menković, Nebojša and Matevski, Vlado",
year = "2014",
abstract = "The aerial parts of three endemic Centaurea L. species, namely C. tomorosii Micevski, C. soskae Hayek and C. galicicae Micevski, afforded the sesquiterpene lactone cnicin (1) and seven flavonoids: apigenin (2), isokaempferide (3), hispidulin (4), eupatorin (5), cirsimaritin (6), santoflavone (7) and salvigenin (8). The structures of the isolated compounds were determined by UV, H-1-NMR and C-13-NMR spectroscopy and HR-ESI-MS spectrometry. H-1-NMR spectroscopy was used as a method for the quantitative analysis of cnicin.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Secondary metabolites of three endemic Centaurea L. species",
volume = "79",
number = "11",
pages = "1355-1362",
doi = "10.2298/JSC140318048T"
}

Tešević, V., Aljančić, I., Milosavljević, S., Vajs, V., Đorđević, I., Jadranin, M., Menković, N.,& Matevski, V.. (2014). Secondary metabolites of three endemic Centaurea L. species. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 79(11), 1355-1362.
https://doi.org/10.2298/JSC140318048T

Tešević V, Aljančić I, Milosavljević S, Vajs V, Đorđević I, Jadranin M, Menković N, Matevski V. Secondary metabolites of three endemic Centaurea L. species. in Journal of the Serbian Chemical Society. 2014;79(11):1355-1362.
doi:10.2298/JSC140318048T .

Tešević, Vele, Aljančić, Ivana, Milosavljević, Slobodan, Vajs, Vlatka, Đorđević, Iris, Jadranin, Milka, Menković, Nebojša, Matevski, Vlado, "Secondary metabolites of three endemic Centaurea L. species" in Journal of the Serbian Chemical Society, 79, no. 11 (2014):1355-1362,
https://doi.org/10.2298/JSC140318048T . .

TY  - JOUR
AU  - Matić, Ivana Z.
AU  - Aljančić, Ivana
AU  - Žižak, Željko
AU  - Vajs, Vlatka
AU  - Jadranin, Milka
AU  - Milosavljević, Slobodan
AU  - Juranić, Zorica
PY  - 2013
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1289
AB  - Background: The aim of this research was to determine the intensity and mechanisms of the cytotoxic actions of five extracts isolated from the endemic plant species Helichrysum zivojinii Cernjavski & Soska (family Asteraceae) against specific cancer cell lines. In order to evaluate the sensitivity of normal immunocompetent cells implicated in the antitumor immune response, the cytotoxicity of extracts was also tested against healthy peripheral blood mononuclear cells (PBMC). Methods: The aerial parts of the plants were air-dried, powdered, and successively extracted with solvents of increasing polarity to obtain hexane, dichloromethane, ethyl-acetate, n-butanol and methanol extracts. The cytotoxic activities of the extracts against human cervix adenocarcinoma HeLa, human melanoma Fem-x, human myelogenous leukemia K562, human breast adenocarcinoma MDA-MB-361 cells and PBMC were evaluated by the MTT test. The mode of HeLa cell death was investigated by morphological analysis. Changes in the cell cycle of HeLa cells treated with the extracts were analyzed by flow cytometry. The apoptotic mechanisms induced by the tested extracts were determined using specific caspase inhibitors. Results: The investigated Helichrysum zivojinii extracts exerted selective dose-dependent cytotoxic actions against selected cancer cell lines and healthy immunocompetent PBMC stimulated to proliferate, while the cytotoxic actions exerted on unstimulated PBMC were less pronounced. The tested extracts exhibited considerably stronger cytotoxic activities towards HeLa, Fem-x and K562 cells in comparison to resting and stimulated PBMC. It is worth noting that the cytotoxicity of the extracts was weaker against unstimulated PBMC in comparison to stimulated PBMC. Furthermore, each of the five extracts induced apoptosis in HeLa cells, through the activation of both intrinsic and extrinsic signaling pathways. Conclusion: Extracts obtained from the endemic plant Helichrysum zivojinii may represent an important source of novel potential antitumor agents due to their pronounced and selective cytotoxic actions towards malignant cells.
PB  - Biomed Central Ltd, London
T2  - Bmc Complementary and Alternative Medicine
T1  - In vitro antitumor actions of extracts from endemic plant Helichrysum zivojinii
VL  - 13
DO  - 10.1186/1472-6882-13-36
ER  - 

@article{
author = "Matić, Ivana Z. and Aljančić, Ivana and Žižak, Željko and Vajs, Vlatka and Jadranin, Milka and Milosavljević, Slobodan and Juranić, Zorica",
year = "2013",
abstract = "Background: The aim of this research was to determine the intensity and mechanisms of the cytotoxic actions of five extracts isolated from the endemic plant species Helichrysum zivojinii Cernjavski & Soska (family Asteraceae) against specific cancer cell lines. In order to evaluate the sensitivity of normal immunocompetent cells implicated in the antitumor immune response, the cytotoxicity of extracts was also tested against healthy peripheral blood mononuclear cells (PBMC). Methods: The aerial parts of the plants were air-dried, powdered, and successively extracted with solvents of increasing polarity to obtain hexane, dichloromethane, ethyl-acetate, n-butanol and methanol extracts. The cytotoxic activities of the extracts against human cervix adenocarcinoma HeLa, human melanoma Fem-x, human myelogenous leukemia K562, human breast adenocarcinoma MDA-MB-361 cells and PBMC were evaluated by the MTT test. The mode of HeLa cell death was investigated by morphological analysis. Changes in the cell cycle of HeLa cells treated with the extracts were analyzed by flow cytometry. The apoptotic mechanisms induced by the tested extracts were determined using specific caspase inhibitors. Results: The investigated Helichrysum zivojinii extracts exerted selective dose-dependent cytotoxic actions against selected cancer cell lines and healthy immunocompetent PBMC stimulated to proliferate, while the cytotoxic actions exerted on unstimulated PBMC were less pronounced. The tested extracts exhibited considerably stronger cytotoxic activities towards HeLa, Fem-x and K562 cells in comparison to resting and stimulated PBMC. It is worth noting that the cytotoxicity of the extracts was weaker against unstimulated PBMC in comparison to stimulated PBMC. Furthermore, each of the five extracts induced apoptosis in HeLa cells, through the activation of both intrinsic and extrinsic signaling pathways. Conclusion: Extracts obtained from the endemic plant Helichrysum zivojinii may represent an important source of novel potential antitumor agents due to their pronounced and selective cytotoxic actions towards malignant cells.",
publisher = "Biomed Central Ltd, London",
journal = "Bmc Complementary and Alternative Medicine",
title = "In vitro antitumor actions of extracts from endemic plant Helichrysum zivojinii",
volume = "13",
doi = "10.1186/1472-6882-13-36"
}

Matić, I. Z., Aljančić, I., Žižak, Ž., Vajs, V., Jadranin, M., Milosavljević, S.,& Juranić, Z.. (2013). In vitro antitumor actions of extracts from endemic plant Helichrysum zivojinii. in Bmc Complementary and Alternative Medicine
Biomed Central Ltd, London., 13.
https://doi.org/10.1186/1472-6882-13-36

Matić IZ, Aljančić I, Žižak Ž, Vajs V, Jadranin M, Milosavljević S, Juranić Z. In vitro antitumor actions of extracts from endemic plant Helichrysum zivojinii. in Bmc Complementary and Alternative Medicine. 2013;13.
doi:10.1186/1472-6882-13-36 .

Matić, Ivana Z., Aljančić, Ivana, Žižak, Željko, Vajs, Vlatka, Jadranin, Milka, Milosavljević, Slobodan, Juranić, Zorica, "In vitro antitumor actions of extracts from endemic plant Helichrysum zivojinii" in Bmc Complementary and Alternative Medicine, 13 (2013),
https://doi.org/10.1186/1472-6882-13-36 . .

TY  - JOUR
AU  - Matić, Ivana Z.
AU  - Aljančić, Ivana
AU  - Vajs, Vlatka
AU  - Jadranin, Milka
AU  - Gligorijević, Nevenka
AU  - Milosavljević, Slobodan
AU  - Juranić, Zorica
PY  - 2013
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1264
AB  - Helichrysum zivojinii Cernjavski & Soska is an endemic plant species that grows in the National Park Galicica in Macedonia. Five extracts were isolated as fractions from the aerial parts of the plant: a n-hexane extract (1), a dichloromethane extract (2), an ethyl-acetate extract (3), a n-butanol extract (4) and a methanol extract (5). A dose-dependent cytotoxic activity of the extracts on MDA-MB-231 and EA.hy926 cells was observed. Extracts exhibited more pronounced cytotoxic actions on MDA-MB-231 cells than on EA.hy926 cells. The n-hexane extract (1), at a non-toxic concentration, exhibited an inhibitory effect on the migration as well the invasiveness of MDA-MB-231 cells. The dichloromethane extract (2), at a non-toxic concentration, demonstrated inhibition of MDA-MB-231 cells invasion. Each of the five extracts applied at non-toxic concentrations inhibited migration of EA.hy926 cells. The prominent inhibitory effect of the n-hexane extract on EA.hy926 cells migration was associated with a notable anti-angiogenic action of this extract. The other four tested extracts demonstrated mild anti-angiogenic activity. Our data highlight the prominent anticancer potential of n-hexane (1) and dichloromethane (2) extracts, which could be attributed to their very pronounced and selective cytotoxic activities as well as their anti-invasive and anti-angiogenic properties.
PB  - Natural Products Inc, Westerville
T2  - Natural Product Communications
T1  - Cancer-Suppressive Potential of Extracts of Endemic Plant Helichrysum zivojinii: Effects on Cell Migration, Invasion and Angiogenesis
VL  - 8
IS  - 9
SP  - 1291
EP  - 1296
UR  - https://hdl.handle.net/21.15107/rcub_cherry_1435
ER  - 

@article{
author = "Matić, Ivana Z. and Aljančić, Ivana and Vajs, Vlatka and Jadranin, Milka and Gligorijević, Nevenka and Milosavljević, Slobodan and Juranić, Zorica",
year = "2013",
abstract = "Helichrysum zivojinii Cernjavski & Soska is an endemic plant species that grows in the National Park Galicica in Macedonia. Five extracts were isolated as fractions from the aerial parts of the plant: a n-hexane extract (1), a dichloromethane extract (2), an ethyl-acetate extract (3), a n-butanol extract (4) and a methanol extract (5). A dose-dependent cytotoxic activity of the extracts on MDA-MB-231 and EA.hy926 cells was observed. Extracts exhibited more pronounced cytotoxic actions on MDA-MB-231 cells than on EA.hy926 cells. The n-hexane extract (1), at a non-toxic concentration, exhibited an inhibitory effect on the migration as well the invasiveness of MDA-MB-231 cells. The dichloromethane extract (2), at a non-toxic concentration, demonstrated inhibition of MDA-MB-231 cells invasion. Each of the five extracts applied at non-toxic concentrations inhibited migration of EA.hy926 cells. The prominent inhibitory effect of the n-hexane extract on EA.hy926 cells migration was associated with a notable anti-angiogenic action of this extract. The other four tested extracts demonstrated mild anti-angiogenic activity. Our data highlight the prominent anticancer potential of n-hexane (1) and dichloromethane (2) extracts, which could be attributed to their very pronounced and selective cytotoxic activities as well as their anti-invasive and anti-angiogenic properties.",
publisher = "Natural Products Inc, Westerville",
journal = "Natural Product Communications",
title = "Cancer-Suppressive Potential of Extracts of Endemic Plant Helichrysum zivojinii: Effects on Cell Migration, Invasion and Angiogenesis",
volume = "8",
number = "9",
pages = "1291-1296",
url = "https://hdl.handle.net/21.15107/rcub_cherry_1435"
}

Matić, I. Z., Aljančić, I., Vajs, V., Jadranin, M., Gligorijević, N., Milosavljević, S.,& Juranić, Z.. (2013). Cancer-Suppressive Potential of Extracts of Endemic Plant Helichrysum zivojinii: Effects on Cell Migration, Invasion and Angiogenesis. in Natural Product Communications
Natural Products Inc, Westerville., 8(9), 1291-1296.
https://hdl.handle.net/21.15107/rcub_cherry_1435

Matić IZ, Aljančić I, Vajs V, Jadranin M, Gligorijević N, Milosavljević S, Juranić Z. Cancer-Suppressive Potential of Extracts of Endemic Plant Helichrysum zivojinii: Effects on Cell Migration, Invasion and Angiogenesis. in Natural Product Communications. 2013;8(9):1291-1296.
https://hdl.handle.net/21.15107/rcub_cherry_1435 .

Matić, Ivana Z., Aljančić, Ivana, Vajs, Vlatka, Jadranin, Milka, Gligorijević, Nevenka, Milosavljević, Slobodan, Juranić, Zorica, "Cancer-Suppressive Potential of Extracts of Endemic Plant Helichrysum zivojinii: Effects on Cell Migration, Invasion and Angiogenesis" in Natural Product Communications, 8, no. 9 (2013):1291-1296,
https://hdl.handle.net/21.15107/rcub_cherry_1435 .

TY  - JOUR
AU  - Jadranin, Milka
AU  - Pešić, Milica
AU  - Aljančić, Ivana
AU  - Milosavljević, Slobodan
AU  - Todorović, Nina
AU  - Podolski-Renic, Ana
AU  - Bankovic, Jasna
AU  - Tanic, Nikola
AU  - Markovic, Ivanka
AU  - Vajs, Vlatka
AU  - Tešević, Vele
PY  - 2013
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1278
AB  - Thirteen jatrophane diterpenoids (1-10, 13-15), three previously isolated (11, 12, 16) and a known tigliane (17) were isolated from the latex of Euphorbia dendroides. The structures and relative configurations of compounds were elucidated by spectroscopic techniques. The P-glycoprotein (P-gp) inhibiting activities of the representative set of jatrophanes (1-6 and 11-16) have been assessed. Jatrophanes 2 and 5 demonstrated the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).
PB  - Oxford : Pergamon-Elsevier Science Ltd
T2  - Phytochemistry
T1  - Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines
VL  - 86
SP  - 208
EP  - 217
DO  - 10.1016/j.phytochem.2012.09.003
ER  - 

@article{
author = "Jadranin, Milka and Pešić, Milica and Aljančić, Ivana and Milosavljević, Slobodan and Todorović, Nina and Podolski-Renic, Ana and Bankovic, Jasna and Tanic, Nikola and Markovic, Ivanka and Vajs, Vlatka and Tešević, Vele",
year = "2013",
abstract = "Thirteen jatrophane diterpenoids (1-10, 13-15), three previously isolated (11, 12, 16) and a known tigliane (17) were isolated from the latex of Euphorbia dendroides. The structures and relative configurations of compounds were elucidated by spectroscopic techniques. The P-glycoprotein (P-gp) inhibiting activities of the representative set of jatrophanes (1-6 and 11-16) have been assessed. Jatrophanes 2 and 5 demonstrated the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "Phytochemistry",
title = "Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines",
volume = "86",
pages = "208-217",
doi = "10.1016/j.phytochem.2012.09.003"
}

Jadranin, M., Pešić, M., Aljančić, I., Milosavljević, S., Todorović, N., Podolski-Renic, A., Bankovic, J., Tanic, N., Markovic, I., Vajs, V.,& Tešević, V.. (2013). Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines. in Phytochemistry
Oxford : Pergamon-Elsevier Science Ltd., 86, 208-217.
https://doi.org/10.1016/j.phytochem.2012.09.003

Jadranin M, Pešić M, Aljančić I, Milosavljević S, Todorović N, Podolski-Renic A, Bankovic J, Tanic N, Markovic I, Vajs V, Tešević V. Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines. in Phytochemistry. 2013;86:208-217.
doi:10.1016/j.phytochem.2012.09.003 .

Jadranin, Milka, Pešić, Milica, Aljančić, Ivana, Milosavljević, Slobodan, Todorović, Nina, Podolski-Renic, Ana, Bankovic, Jasna, Tanic, Nikola, Markovic, Ivanka, Vajs, Vlatka, Tešević, Vele, "Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines" in Phytochemistry, 86 (2013):208-217,
https://doi.org/10.1016/j.phytochem.2012.09.003 . .

TY  - JOUR
AU  - Podolski-Renic, Ana
AU  - Jadranin, Milka
AU  - Stankovic, Tijana
AU  - Bankovic, Jasna
AU  - Stojkovic, Sonja
AU  - Chiourea, Maria
AU  - Aljančić, Ivana
AU  - Vajs, Vlatka
AU  - Tešević, Vele
AU  - Ruzdijic, Sabera
AU  - Gagos, Sarantis
AU  - Tanic, Nikola
AU  - Pešić, Milica
PY  - 2013
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1176
AB  - Multi-drug resistance (MDR) is a major obstacle to successful cancer treatment. Therefore, in vitro models are necessary for the investigation of the phenotypic changes provoked by cytotoxic agents and more importantly for preclinical testing of new anticancer drugs. We analyzed chromosomal, numerical, and structural changes after development of MDR, alterations in p53 and PTEN, single nucleotide polymorphisms (SNPs) in the mdr1 gene and corresponding protein expression of P-glycoprotein (P-gp) in three human MDR cancer cell lines: non-small cell lung carcinoma NCI-H460/R, colorectal carcinoma DLD1-TxR, and glioma U87-TxR. In addition, we explored how these molecular and phenotypic alterations influence the anticancer effect of new drugs. Cytogenetic analysis showed polyploidy reduction after development of MDR in U87-TxR. Losses of 6q in all resistant cancer cell lines and inactivation of p53 in U87-TxR and PTEN in DLD1-TxR were also revealed. Overexpression of P-gp was observed in all MDR cancer cell lines. We evaluated the anticancer activities and MDR reversal potential of Akt inhibitor GSK690693, Ras inhibitor Tipifarnib, and two P-gp inhibitors (jatrophane diterpenoids). Their effects vary due to the cell-type differences, existence of MDR phenotype, presence of mdr1 SNP, and tumor suppressors' alterations. Tipifarnib and jatrophane diterpenoids significantly sensitized MDR cancer cells to paclitaxel. In conclusion, investigated MDR cancer cells obtained new molecular and cytogenetic characteristics that may serve as potential clinical prognostic markers. In addition, these MDR cancer cell lines present a valuable model for preclinical evaluation of new anticancer agents.
PB  - Springer, New York
T2  - Cancer Chemotherapy and Pharmacology
T1  - Molecular and cytogenetic changes in multi-drug resistant cancer cells and their influence on new compounds testing
VL  - 72
IS  - 3
SP  - 683
EP  - 697
DO  - 10.1007/s00280-013-2247-1
ER  - 

@article{
author = "Podolski-Renic, Ana and Jadranin, Milka and Stankovic, Tijana and Bankovic, Jasna and Stojkovic, Sonja and Chiourea, Maria and Aljančić, Ivana and Vajs, Vlatka and Tešević, Vele and Ruzdijic, Sabera and Gagos, Sarantis and Tanic, Nikola and Pešić, Milica",
year = "2013",
abstract = "Multi-drug resistance (MDR) is a major obstacle to successful cancer treatment. Therefore, in vitro models are necessary for the investigation of the phenotypic changes provoked by cytotoxic agents and more importantly for preclinical testing of new anticancer drugs. We analyzed chromosomal, numerical, and structural changes after development of MDR, alterations in p53 and PTEN, single nucleotide polymorphisms (SNPs) in the mdr1 gene and corresponding protein expression of P-glycoprotein (P-gp) in three human MDR cancer cell lines: non-small cell lung carcinoma NCI-H460/R, colorectal carcinoma DLD1-TxR, and glioma U87-TxR. In addition, we explored how these molecular and phenotypic alterations influence the anticancer effect of new drugs. Cytogenetic analysis showed polyploidy reduction after development of MDR in U87-TxR. Losses of 6q in all resistant cancer cell lines and inactivation of p53 in U87-TxR and PTEN in DLD1-TxR were also revealed. Overexpression of P-gp was observed in all MDR cancer cell lines. We evaluated the anticancer activities and MDR reversal potential of Akt inhibitor GSK690693, Ras inhibitor Tipifarnib, and two P-gp inhibitors (jatrophane diterpenoids). Their effects vary due to the cell-type differences, existence of MDR phenotype, presence of mdr1 SNP, and tumor suppressors' alterations. Tipifarnib and jatrophane diterpenoids significantly sensitized MDR cancer cells to paclitaxel. In conclusion, investigated MDR cancer cells obtained new molecular and cytogenetic characteristics that may serve as potential clinical prognostic markers. In addition, these MDR cancer cell lines present a valuable model for preclinical evaluation of new anticancer agents.",
publisher = "Springer, New York",
journal = "Cancer Chemotherapy and Pharmacology",
title = "Molecular and cytogenetic changes in multi-drug resistant cancer cells and their influence on new compounds testing",
volume = "72",
number = "3",
pages = "683-697",
doi = "10.1007/s00280-013-2247-1"
}

Podolski-Renic, A., Jadranin, M., Stankovic, T., Bankovic, J., Stojkovic, S., Chiourea, M., Aljančić, I., Vajs, V., Tešević, V., Ruzdijic, S., Gagos, S., Tanic, N.,& Pešić, M.. (2013). Molecular and cytogenetic changes in multi-drug resistant cancer cells and their influence on new compounds testing. in Cancer Chemotherapy and Pharmacology
Springer, New York., 72(3), 683-697.
https://doi.org/10.1007/s00280-013-2247-1

Podolski-Renic A, Jadranin M, Stankovic T, Bankovic J, Stojkovic S, Chiourea M, Aljančić I, Vajs V, Tešević V, Ruzdijic S, Gagos S, Tanic N, Pešić M. Molecular and cytogenetic changes in multi-drug resistant cancer cells and their influence on new compounds testing. in Cancer Chemotherapy and Pharmacology. 2013;72(3):683-697.
doi:10.1007/s00280-013-2247-1 .

Podolski-Renic, Ana, Jadranin, Milka, Stankovic, Tijana, Bankovic, Jasna, Stojkovic, Sonja, Chiourea, Maria, Aljančić, Ivana, Vajs, Vlatka, Tešević, Vele, Ruzdijic, Sabera, Gagos, Sarantis, Tanic, Nikola, Pešić, Milica, "Molecular and cytogenetic changes in multi-drug resistant cancer cells and their influence on new compounds testing" in Cancer Chemotherapy and Pharmacology, 72, no. 3 (2013):683-697,
https://doi.org/10.1007/s00280-013-2247-1 . .

TY  - JOUR
AU  - Pešić, Milica
AU  - Bankovic, Jasna
AU  - Aljančić, Ivana
AU  - Todorović, Nina
AU  - Jadranin, Milka
AU  - Vajs, Vlatka
AU  - Tešević, Vele
AU  - Vučković, Ivan
AU  - Momcilovic, Miljana
AU  - Markovic, Ivanka D.
AU  - Tanic, Nikola
AU  - Ruzdijic, Sabera
PY  - 2011
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/830
AB  - Jatrophane diterpenes were shown to be inhibitors of P-glycoprotein (P-gp). There are also evidences on their microtubule-interacting activity in cancer cells. We evaluated new anti-cancer characteristics of two jatrophane type compounds from Euphorbia dendroides. For that purpose, the model system of sensitive non-small cell lung cancer cell line (NCI-H460) and its resistant counterpart (NCI-H460/R) was used. Although both jatrophanes showed inhibitory effect on cancer cell growth, they were non-toxic for peripheral blood mononuclear cells (PBMC). We examined their effects in combination with paclitaxel (PTX), a well-known mitotic spindle interacting chemotherapeutic. Jatrophanes overcome PTX resistance in concentration-dependent manner in MDR cancer cell line (NCI-H460/R). We observed that this synergistic effect is not caused merely by P-gp inhibition. In combination with PTX, jatrophanes induce cell killing and change cell cycle distribution leading to G2/M arrest. Furthermore, they exert an anti-angiogenic effect by decreasing the vascular endothelial growth factor (VEGF) secretion. The reduction of the level of mdr1 mRNA expression in sensitive cells, suggests that these compounds could not contribute to the development of resistance. In conclusion, present study provides a rational basis for the new cancer treatment approach with jatrophanes that are non-toxic to normal cells and have new favorable anti-cancer characteristics.
PB  - Oxford : Pergamon-Elsevier Science Ltd
T2  - Food and Chemical Toxicology
T1  - New anti-cancer characteristics of jatrophane diterpenes from Euphorbia dendroides
VL  - 49
IS  - 12
SP  - 3165
EP  - 3173
DO  - 10.1016/j.fct.2011.09.035
ER  - 

@article{
author = "Pešić, Milica and Bankovic, Jasna and Aljančić, Ivana and Todorović, Nina and Jadranin, Milka and Vajs, Vlatka and Tešević, Vele and Vučković, Ivan and Momcilovic, Miljana and Markovic, Ivanka D. and Tanic, Nikola and Ruzdijic, Sabera",
year = "2011",
abstract = "Jatrophane diterpenes were shown to be inhibitors of P-glycoprotein (P-gp). There are also evidences on their microtubule-interacting activity in cancer cells. We evaluated new anti-cancer characteristics of two jatrophane type compounds from Euphorbia dendroides. For that purpose, the model system of sensitive non-small cell lung cancer cell line (NCI-H460) and its resistant counterpart (NCI-H460/R) was used. Although both jatrophanes showed inhibitory effect on cancer cell growth, they were non-toxic for peripheral blood mononuclear cells (PBMC). We examined their effects in combination with paclitaxel (PTX), a well-known mitotic spindle interacting chemotherapeutic. Jatrophanes overcome PTX resistance in concentration-dependent manner in MDR cancer cell line (NCI-H460/R). We observed that this synergistic effect is not caused merely by P-gp inhibition. In combination with PTX, jatrophanes induce cell killing and change cell cycle distribution leading to G2/M arrest. Furthermore, they exert an anti-angiogenic effect by decreasing the vascular endothelial growth factor (VEGF) secretion. The reduction of the level of mdr1 mRNA expression in sensitive cells, suggests that these compounds could not contribute to the development of resistance. In conclusion, present study provides a rational basis for the new cancer treatment approach with jatrophanes that are non-toxic to normal cells and have new favorable anti-cancer characteristics.",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "Food and Chemical Toxicology",
title = "New anti-cancer characteristics of jatrophane diterpenes from Euphorbia dendroides",
volume = "49",
number = "12",
pages = "3165-3173",
doi = "10.1016/j.fct.2011.09.035"
}

Pešić, M., Bankovic, J., Aljančić, I., Todorović, N., Jadranin, M., Vajs, V., Tešević, V., Vučković, I., Momcilovic, M., Markovic, I. D., Tanic, N.,& Ruzdijic, S.. (2011). New anti-cancer characteristics of jatrophane diterpenes from Euphorbia dendroides. in Food and Chemical Toxicology
Oxford : Pergamon-Elsevier Science Ltd., 49(12), 3165-3173.
https://doi.org/10.1016/j.fct.2011.09.035

Pešić M, Bankovic J, Aljančić I, Todorović N, Jadranin M, Vajs V, Tešević V, Vučković I, Momcilovic M, Markovic ID, Tanic N, Ruzdijic S. New anti-cancer characteristics of jatrophane diterpenes from Euphorbia dendroides. in Food and Chemical Toxicology. 2011;49(12):3165-3173.
doi:10.1016/j.fct.2011.09.035 .

Pešić, Milica, Bankovic, Jasna, Aljančić, Ivana, Todorović, Nina, Jadranin, Milka, Vajs, Vlatka, Tešević, Vele, Vučković, Ivan, Momcilovic, Miljana, Markovic, Ivanka D., Tanic, Nikola, Ruzdijic, Sabera, "New anti-cancer characteristics of jatrophane diterpenes from Euphorbia dendroides" in Food and Chemical Toxicology, 49, no. 12 (2011):3165-3173,
https://doi.org/10.1016/j.fct.2011.09.035 . .

TY  - JOUR
AU  - Aljančić, Ivana
AU  - Pešić, Milica
AU  - Milosavljević, Slobodan
AU  - Todorović, Nina
AU  - Jadranin, Milka
AU  - Miosavljevic, Goran
AU  - Povrenovic, Dragan
AU  - Bankovic, Jasna
AU  - Tanic, Nikola
AU  - Markovic, Ivanka D.
AU  - Ruzdijic, Sabera
AU  - Vajs, Vlatka
AU  - Tešević, Vele
PY  - 2011
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/883
AB  - From the Montenegrin spurge Euphorbia dendroides, seven new diterpenoids [jatrophanes (1-6) and a tigliane (7)] were isolated and their structures elucidated by spectroscopic techniques. The biological activity of the new compounds was studied against four human cancer cell lines. The most effective jatrophane-type compound (2) and its structurally closely related derivative (1) were evaluated for their interactions with paclitaxel and doxorubicin using a multidrug-resistant cancer cell line. Both compounds exerted a strong reversal potential resulting from inhibition of P-glycoprotein transport.
PB  - American Chemical Society (ACS)
T2  - Journal of Natural Products
T1  - Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides
VL  - 74
IS  - 7
SP  - 1613
EP  - 1620
DO  - 10.1021/np200241c
ER  - 

@article{
author = "Aljančić, Ivana and Pešić, Milica and Milosavljević, Slobodan and Todorović, Nina and Jadranin, Milka and Miosavljevic, Goran and Povrenovic, Dragan and Bankovic, Jasna and Tanic, Nikola and Markovic, Ivanka D. and Ruzdijic, Sabera and Vajs, Vlatka and Tešević, Vele",
year = "2011",
abstract = "From the Montenegrin spurge Euphorbia dendroides, seven new diterpenoids [jatrophanes (1-6) and a tigliane (7)] were isolated and their structures elucidated by spectroscopic techniques. The biological activity of the new compounds was studied against four human cancer cell lines. The most effective jatrophane-type compound (2) and its structurally closely related derivative (1) were evaluated for their interactions with paclitaxel and doxorubicin using a multidrug-resistant cancer cell line. Both compounds exerted a strong reversal potential resulting from inhibition of P-glycoprotein transport.",
publisher = "American Chemical Society (ACS)",
journal = "Journal of Natural Products",
title = "Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides",
volume = "74",
number = "7",
pages = "1613-1620",
doi = "10.1021/np200241c"
}

Aljančić, I., Pešić, M., Milosavljević, S., Todorović, N., Jadranin, M., Miosavljevic, G., Povrenovic, D., Bankovic, J., Tanic, N., Markovic, I. D., Ruzdijic, S., Vajs, V.,& Tešević, V.. (2011). Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides. in Journal of Natural Products
American Chemical Society (ACS)., 74(7), 1613-1620.
https://doi.org/10.1021/np200241c

Aljančić I, Pešić M, Milosavljević S, Todorović N, Jadranin M, Miosavljevic G, Povrenovic D, Bankovic J, Tanic N, Markovic ID, Ruzdijic S, Vajs V, Tešević V. Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides. in Journal of Natural Products. 2011;74(7):1613-1620.
doi:10.1021/np200241c .

Aljančić, Ivana, Pešić, Milica, Milosavljević, Slobodan, Todorović, Nina, Jadranin, Milka, Miosavljevic, Goran, Povrenovic, Dragan, Bankovic, Jasna, Tanic, Nikola, Markovic, Ivanka D., Ruzdijic, Sabera, Vajs, Vlatka, Tešević, Vele, "Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides" in Journal of Natural Products, 74, no. 7 (2011):1613-1620,
https://doi.org/10.1021/np200241c . .

TY  - JOUR
AU  - Aljančić, Ivana
AU  - Stanković, Miroslava
AU  - Tešević, Vele
AU  - Vujisić, Ljubodrag V.
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan
PY  - 2010
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2738
AB  - This study was conducted to elucidate the in vitro protective effect of five flavonoids [apigenin (1), apigenin-7-O-glucoside (2), centaureidin (3), jaceidin (4) and quercetin (5)] against chromosomal damage in mitogen-induced human lymphocytes. Using the Cytochalasin-B blocked micronucleus (CBMN) assay, in which the biomarker of chromosome breakage and/or chromosome loss is the elevated frequency of micronucleus (MN) in binucleated (BN) cells, the presence of flavonoid 2 in minimal concentration (3 mu g/mL) gave a 35.5% decrease M the frequency of MN when compared with control human lymphocytes. The same concentration of flavonoids 1, 3 and 4, reduced the MN frequency by 24.4%, 28.0% and 28.0%, respectively. Higher concentrations (6 mu g/mL and 10 mu g/mL) seemed less effective. Flavonoid 5 (3 mu g/mL.) induced a slight decrease in MN frequency (5%), while higher doses (6 mu g/mL and 10 mu g/mL) provoked an increase of DNA damage. The comparable values for the cytokinesis-block proliferation index (CBPI) of the tested flavonoids and positive control suggested an inhibitory effect on lymphocyte proliferation. In the DPPH scavenging assay, flavonoids 1-4 demonstrated modest activity, in a dose-dependent manner, compared with the synthetic antioxidants BHT and Trolox, while 5 exhibited comparably high antioxidative activity.
PB  - Natural Products Inc, Westerville
T2  - Natural Product Communications
T1  - Protective Effect on Human Lymphocytes of Some Flavonoids Isolated from Two Achillea Species
VL  - 5
IS  - 5
SP  - 729
EP  - 732
DO  - 10.1177/1934578X1000500511
ER  - 

@article{
author = "Aljančić, Ivana and Stanković, Miroslava and Tešević, Vele and Vujisić, Ljubodrag V. and Vajs, Vlatka and Milosavljević, Slobodan",
year = "2010",
abstract = "This study was conducted to elucidate the in vitro protective effect of five flavonoids [apigenin (1), apigenin-7-O-glucoside (2), centaureidin (3), jaceidin (4) and quercetin (5)] against chromosomal damage in mitogen-induced human lymphocytes. Using the Cytochalasin-B blocked micronucleus (CBMN) assay, in which the biomarker of chromosome breakage and/or chromosome loss is the elevated frequency of micronucleus (MN) in binucleated (BN) cells, the presence of flavonoid 2 in minimal concentration (3 mu g/mL) gave a 35.5% decrease M the frequency of MN when compared with control human lymphocytes. The same concentration of flavonoids 1, 3 and 4, reduced the MN frequency by 24.4%, 28.0% and 28.0%, respectively. Higher concentrations (6 mu g/mL and 10 mu g/mL) seemed less effective. Flavonoid 5 (3 mu g/mL.) induced a slight decrease in MN frequency (5%), while higher doses (6 mu g/mL and 10 mu g/mL) provoked an increase of DNA damage. The comparable values for the cytokinesis-block proliferation index (CBPI) of the tested flavonoids and positive control suggested an inhibitory effect on lymphocyte proliferation. In the DPPH scavenging assay, flavonoids 1-4 demonstrated modest activity, in a dose-dependent manner, compared with the synthetic antioxidants BHT and Trolox, while 5 exhibited comparably high antioxidative activity.",
publisher = "Natural Products Inc, Westerville",
journal = "Natural Product Communications",
title = "Protective Effect on Human Lymphocytes of Some Flavonoids Isolated from Two Achillea Species",
volume = "5",
number = "5",
pages = "729-732",
doi = "10.1177/1934578X1000500511"
}

Aljančić, I., Stanković, M., Tešević, V., Vujisić, L. V., Vajs, V.,& Milosavljević, S.. (2010). Protective Effect on Human Lymphocytes of Some Flavonoids Isolated from Two Achillea Species. in Natural Product Communications
Natural Products Inc, Westerville., 5(5), 729-732.
https://doi.org/10.1177/1934578X1000500511

Aljančić I, Stanković M, Tešević V, Vujisić LV, Vajs V, Milosavljević S. Protective Effect on Human Lymphocytes of Some Flavonoids Isolated from Two Achillea Species. in Natural Product Communications. 2010;5(5):729-732.
doi:10.1177/1934578X1000500511 .

Aljančić, Ivana, Stanković, Miroslava, Tešević, Vele, Vujisić, Ljubodrag V., Vajs, Vlatka, Milosavljević, Slobodan, "Protective Effect on Human Lymphocytes of Some Flavonoids Isolated from Two Achillea Species" in Natural Product Communications, 5, no. 5 (2010):729-732,
https://doi.org/10.1177/1934578X1000500511 . .

TY  - JOUR
AU  - Tadić, Vojin
AU  - Aljančić, Ivana
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan
AU  - Đoković, Dejan
AU  - Đorđević, Iris
PY  - 2010
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3265
AB  - The essential oil from aerial parts of Tanacetum larvatum (gris.) Kanitz, an endemic perennial herb collected at three various natural habitats in Montenegro (Planinica [Sample a ], Visitor [Sample b ] and Sinjajevina [Sample c ]), were analyzed using GC and GC/MS. Sixty-four components were identified, representing 83.1%, 96.6% and 89.4% of the total oils content in the Samples a, b and c , respectively. The major constituent in Samples a and b , was oxygenated monoterpene, trans-sabinyl acetate (38.1% and 55.8% respectively). Monoterpene hydrocarbons, β-pinene (13.5%) and santolinatriene (30.6%), were found to be the dominant components in Sample c . The toxic trans-sabinyl acetate was present only in traces in this sample. trans-Chrysanthenyl acetate, as one of major components in feverfew essential oil, has not been previously identified in the investigated essential oils.
PB  - Informa UK Limited
T2  - Journal of Essential Oil Research
T1  - Intraspecific Variation of Tanacetum larvatum Essential Oil
VL  - 22
IS  - 5
SP  - 394
EP  - 398
DO  - 10.1080/10412905.2010.9700355
ER  - 

@article{
author = "Tadić, Vojin and Aljančić, Ivana and Vajs, Vlatka and Milosavljević, Slobodan and Đoković, Dejan and Đorđević, Iris",
year = "2010",
abstract = "The essential oil from aerial parts of Tanacetum larvatum (gris.) Kanitz, an endemic perennial herb collected at three various natural habitats in Montenegro (Planinica [Sample a ], Visitor [Sample b ] and Sinjajevina [Sample c ]), were analyzed using GC and GC/MS. Sixty-four components were identified, representing 83.1%, 96.6% and 89.4% of the total oils content in the Samples a, b and c , respectively. The major constituent in Samples a and b , was oxygenated monoterpene, trans-sabinyl acetate (38.1% and 55.8% respectively). Monoterpene hydrocarbons, β-pinene (13.5%) and santolinatriene (30.6%), were found to be the dominant components in Sample c . The toxic trans-sabinyl acetate was present only in traces in this sample. trans-Chrysanthenyl acetate, as one of major components in feverfew essential oil, has not been previously identified in the investigated essential oils.",
publisher = "Informa UK Limited",
journal = "Journal of Essential Oil Research",
title = "Intraspecific Variation of Tanacetum larvatum Essential Oil",
volume = "22",
number = "5",
pages = "394-398",
doi = "10.1080/10412905.2010.9700355"
}

Tadić, V., Aljančić, I., Vajs, V., Milosavljević, S., Đoković, D.,& Đorđević, I.. (2010). Intraspecific Variation of Tanacetum larvatum Essential Oil. in Journal of Essential Oil Research
Informa UK Limited., 22(5), 394-398.
https://doi.org/10.1080/10412905.2010.9700355

Tadić V, Aljančić I, Vajs V, Milosavljević S, Đoković D, Đorđević I. Intraspecific Variation of Tanacetum larvatum Essential Oil. in Journal of Essential Oil Research. 2010;22(5):394-398.
doi:10.1080/10412905.2010.9700355 .

Tadić, Vojin, Aljančić, Ivana, Vajs, Vlatka, Milosavljević, Slobodan, Đoković, Dejan, Đorđević, Iris, "Intraspecific Variation of Tanacetum larvatum Essential Oil" in Journal of Essential Oil Research, 22, no. 5 (2010):394-398,
https://doi.org/10.1080/10412905.2010.9700355 . .

TY  - JOUR
AU  - Aljančić, Ivana
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan
AU  - Todorović, Nina
AU  - Menković, Nebojša
AU  - Gođevac, Dejan
AU  - Tadić, V. M.
PY  - 2010
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/683
PB  - Springer, New York
T2  - Chemistry of Natural Compounds
T1  - Comparative analysis of parthenolide content in tanacetum larvatum, an endemic species of montenegro, collected from three different locations
VL  - 46
IS  - 4
SP  - 658
EP  - 660
DO  - 10.1007/s10600-010-9706-2
ER  - 

@article{
author = "Aljančić, Ivana and Vajs, Vlatka and Milosavljević, Slobodan and Todorović, Nina and Menković, Nebojša and Gođevac, Dejan and Tadić, V. M.",
year = "2010",
publisher = "Springer, New York",
journal = "Chemistry of Natural Compounds",
title = "Comparative analysis of parthenolide content in tanacetum larvatum, an endemic species of montenegro, collected from three different locations",
volume = "46",
number = "4",
pages = "658-660",
doi = "10.1007/s10600-010-9706-2"
}

Aljančić, I., Vajs, V., Milosavljević, S., Todorović, N., Menković, N., Gođevac, D.,& Tadić, V. M.. (2010). Comparative analysis of parthenolide content in tanacetum larvatum, an endemic species of montenegro, collected from three different locations. in Chemistry of Natural Compounds
Springer, New York., 46(4), 658-660.
https://doi.org/10.1007/s10600-010-9706-2

Aljančić I, Vajs V, Milosavljević S, Todorović N, Menković N, Gođevac D, Tadić VM. Comparative analysis of parthenolide content in tanacetum larvatum, an endemic species of montenegro, collected from three different locations. in Chemistry of Natural Compounds. 2010;46(4):658-660.
doi:10.1007/s10600-010-9706-2 .

Aljančić, Ivana, Vajs, Vlatka, Milosavljević, Slobodan, Todorović, Nina, Menković, Nebojša, Gođevac, Dejan, Tadić, V. M., "Comparative analysis of parthenolide content in tanacetum larvatum, an endemic species of montenegro, collected from three different locations" in Chemistry of Natural Compounds, 46, no. 4 (2010):658-660,
https://doi.org/10.1007/s10600-010-9706-2 . .

TY  - JOUR
AU  - Bulatovic, Vanja
AU  - Vajs, Vlatka
AU  - Aljančić, Ivana
AU  - Milosavljević, Slobodan
AU  - Đoković, Dejan
AU  - Petrovic, Silvana
PY  - 2006
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3264
AB  - Tanacetum larvatum (Oris.) Kanitz. is an endemic perennial herb distributed on a rocky terrain in Serbia (Kosovo), Montenegro and Albania. The chemical composition of T. larvatum essential oil, obtained from two locations in Montenegro (Mt. Komovi [Sample I] and Mt. Prokletije [Sample II]) was investigated. The oils obtained by hydrodistillation were analyzed by GC and GC/MS, on the two different capillary columns. The aerial parts of T. larvatum yielded 0.3% and 0.2% of a yellowish oil (Sample I and Sample II, respectively). About 40 compounds were identified, representing ∼89% and 96% of the total oil content in the Samples I and II, respectively. trans-Sabinyl acetate was found to be the dominant component (51.2% and 69.7%). Among the rest of compounds β-pinene (7.7% and 4.3%) and camphor (6.3% and 4.3%) were the most abundant in both samples.
PB  - Informa UK Limited
T2  - Journal of Essential Oil Research
T1  - Chemical Composition of Tanacetum larvatum Essential Oil
VL  - 18
IS  - 2
SP  - 126
EP  - 128
DO  - 10.1080/10412905.2006.9699040
ER  - 

@article{
author = "Bulatovic, Vanja and Vajs, Vlatka and Aljančić, Ivana and Milosavljević, Slobodan and Đoković, Dejan and Petrovic, Silvana",
year = "2006",
abstract = "Tanacetum larvatum (Oris.) Kanitz. is an endemic perennial herb distributed on a rocky terrain in Serbia (Kosovo), Montenegro and Albania. The chemical composition of T. larvatum essential oil, obtained from two locations in Montenegro (Mt. Komovi [Sample I] and Mt. Prokletije [Sample II]) was investigated. The oils obtained by hydrodistillation were analyzed by GC and GC/MS, on the two different capillary columns. The aerial parts of T. larvatum yielded 0.3% and 0.2% of a yellowish oil (Sample I and Sample II, respectively). About 40 compounds were identified, representing ∼89% and 96% of the total oil content in the Samples I and II, respectively. trans-Sabinyl acetate was found to be the dominant component (51.2% and 69.7%). Among the rest of compounds β-pinene (7.7% and 4.3%) and camphor (6.3% and 4.3%) were the most abundant in both samples.",
publisher = "Informa UK Limited",
journal = "Journal of Essential Oil Research",
title = "Chemical Composition of Tanacetum larvatum Essential Oil",
volume = "18",
number = "2",
pages = "126-128",
doi = "10.1080/10412905.2006.9699040"
}

Bulatovic, V., Vajs, V., Aljančić, I., Milosavljević, S., Đoković, D.,& Petrovic, S.. (2006). Chemical Composition of Tanacetum larvatum Essential Oil. in Journal of Essential Oil Research
Informa UK Limited., 18(2), 126-128.
https://doi.org/10.1080/10412905.2006.9699040

Bulatovic V, Vajs V, Aljančić I, Milosavljević S, Đoković D, Petrovic S. Chemical Composition of Tanacetum larvatum Essential Oil. in Journal of Essential Oil Research. 2006;18(2):126-128.
doi:10.1080/10412905.2006.9699040 .

Bulatovic, Vanja, Vajs, Vlatka, Aljančić, Ivana, Milosavljević, Slobodan, Đoković, Dejan, Petrovic, Silvana, "Chemical Composition of Tanacetum larvatum Essential Oil" in Journal of Essential Oil Research, 18, no. 2 (2006):126-128,
https://doi.org/10.1080/10412905.2006.9699040 . .

TY  - JOUR
AU  - Savikin-Fodulovic, K
AU  - Aljančić, Ivana
AU  - Vajs, Vlatka
AU  - Menkonic, N
AU  - Macura, S
AU  - Gojgić-Cvijović, Gordana
AU  - Milosavljević, Slobodan
PY  - 2003
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4155
AB  - As shown by quantitative 1H NMR measurements, a lipophilic extract of the aerial parts of Hypericum atomarium ssp. degenii contained a high percentage (3.1% per weight of dried plant material) of a prenylated phloroglucinol (1). Compound 1, named hyperatomarin, occurring in two tautomeric forms (1a ⇆ 1b), was isolated by bioactivity-guided preparative TLC and was identified on the basis of spectral data interpretation. This isolated phloroglucinol exhibited activity against Gram-positive (Staphyloccocus aureus and Microccocus luteus) and Gram-positive spore-forming bacteria (Bacillus subtilis and B. IP 5832).
PB  - American Chemical Society (ACS)
T2  - Journal of Natural Products
T1  - Hyperatomarin, an antibacterial prenylated phloroglucinol from Hypericum atomarium ssp degenii
VL  - 66
IS  - 9
SP  - 1236
EP  - 1238
DO  - 10.1021/np030131o
ER  - 

@article{
author = "Savikin-Fodulovic, K and Aljančić, Ivana and Vajs, Vlatka and Menkonic, N and Macura, S and Gojgić-Cvijović, Gordana and Milosavljević, Slobodan",
year = "2003",
abstract = "As shown by quantitative 1H NMR measurements, a lipophilic extract of the aerial parts of Hypericum atomarium ssp. degenii contained a high percentage (3.1% per weight of dried plant material) of a prenylated phloroglucinol (1). Compound 1, named hyperatomarin, occurring in two tautomeric forms (1a ⇆ 1b), was isolated by bioactivity-guided preparative TLC and was identified on the basis of spectral data interpretation. This isolated phloroglucinol exhibited activity against Gram-positive (Staphyloccocus aureus and Microccocus luteus) and Gram-positive spore-forming bacteria (Bacillus subtilis and B. IP 5832).",
publisher = "American Chemical Society (ACS)",
journal = "Journal of Natural Products",
title = "Hyperatomarin, an antibacterial prenylated phloroglucinol from Hypericum atomarium ssp degenii",
volume = "66",
number = "9",
pages = "1236-1238",
doi = "10.1021/np030131o"
}

Savikin-Fodulovic, K., Aljančić, I., Vajs, V., Menkonic, N., Macura, S., Gojgić-Cvijović, G.,& Milosavljević, S.. (2003). Hyperatomarin, an antibacterial prenylated phloroglucinol from Hypericum atomarium ssp degenii. in Journal of Natural Products
American Chemical Society (ACS)., 66(9), 1236-1238.
https://doi.org/10.1021/np030131o

Savikin-Fodulovic K, Aljančić I, Vajs V, Menkonic N, Macura S, Gojgić-Cvijović G, Milosavljević S. Hyperatomarin, an antibacterial prenylated phloroglucinol from Hypericum atomarium ssp degenii. in Journal of Natural Products. 2003;66(9):1236-1238.
doi:10.1021/np030131o .

Savikin-Fodulovic, K, Aljančić, Ivana, Vajs, Vlatka, Menkonic, N, Macura, S, Gojgić-Cvijović, Gordana, Milosavljević, Slobodan, "Hyperatomarin, an antibacterial prenylated phloroglucinol from Hypericum atomarium ssp degenii" in Journal of Natural Products, 66, no. 9 (2003):1236-1238,
https://doi.org/10.1021/np030131o . .

TY  - JOUR
AU  - Milosavljević, Slobodan
AU  - Juranić, Ivan
AU  - Aljančić, Ivana
AU  - Vajs, Vlatka
AU  - Todorović, Nina
PY  - 2003
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/117
AB  - The conformations of the C-6 lactonized germacranolides 1–3 were calculated by applying the PM3 semi-empirical method. The low-temperature 1H-NMR spectra of parthenolide (1) were also measured. The relations between the calculated and the experimentally determined geometries were established using a modified Karplus equation. The applied quantum-chemical calculations proved to be an efficient and easy-to-use tool for the elucidation and prediction of the properties of germacranolide-type sesquiterpene lactones.
AB  - Konformacije germakranolida 1–3, laktonizovanih u položaju (6), izračunate su primenom PM3 semi-empirijske MO metode. Takođe su snimljeni protonski NMR spektri partenolida (1) na niskim temperaturama. Pomoću modifikovane Karplusove jednačine je uspostavljena korelacija između eksperimentalno utvrđenih i izračunatih najstabilnijih konformacija. Zaključeno je da primenjena kvantno-hemijska izračunavanja brzo i pouzdano mogu predvideti i objasniti osobine seskviterpenskih laktona tipa germakranolida.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Conformation analysis of three germacranolides by the PM3 semi-empirical method
T1  - Konformaciona analiza tri germakranolida PM3 semi-empirijskom metodom
VL  - 68
IS  - 4-5
SP  - 281
EP  - 289
DO  - 10.2298/JSC0305281M
ER  - 

@article{
author = "Milosavljević, Slobodan and Juranić, Ivan and Aljančić, Ivana and Vajs, Vlatka and Todorović, Nina",
year = "2003",
abstract = "The conformations of the C-6 lactonized germacranolides 1–3 were calculated by applying the PM3 semi-empirical method. The low-temperature 1H-NMR spectra of parthenolide (1) were also measured. The relations between the calculated and the experimentally determined geometries were established using a modified Karplus equation. The applied quantum-chemical calculations proved to be an efficient and easy-to-use tool for the elucidation and prediction of the properties of germacranolide-type sesquiterpene lactones., Konformacije germakranolida 1–3, laktonizovanih u položaju (6), izračunate su primenom PM3 semi-empirijske MO metode. Takođe su snimljeni protonski NMR spektri partenolida (1) na niskim temperaturama. Pomoću modifikovane Karplusove jednačine je uspostavljena korelacija između eksperimentalno utvrđenih i izračunatih najstabilnijih konformacija. Zaključeno je da primenjena kvantno-hemijska izračunavanja brzo i pouzdano mogu predvideti i objasniti osobine seskviterpenskih laktona tipa germakranolida.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Conformation analysis of three germacranolides by the PM3 semi-empirical method, Konformaciona analiza tri germakranolida PM3 semi-empirijskom metodom",
volume = "68",
number = "4-5",
pages = "281-289",
doi = "10.2298/JSC0305281M"
}

Milosavljević, S., Juranić, I., Aljančić, I., Vajs, V.,& Todorović, N.. (2003). Conformation analysis of three germacranolides by the PM3 semi-empirical method. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 68(4-5), 281-289.
https://doi.org/10.2298/JSC0305281M

Milosavljević S, Juranić I, Aljančić I, Vajs V, Todorović N. Conformation analysis of three germacranolides by the PM3 semi-empirical method. in Journal of the Serbian Chemical Society. 2003;68(4-5):281-289.
doi:10.2298/JSC0305281M .

Milosavljević, Slobodan, Juranić, Ivan, Aljančić, Ivana, Vajs, Vlatka, Todorović, Nina, "Conformation analysis of three germacranolides by the PM3 semi-empirical method" in Journal of the Serbian Chemical Society, 68, no. 4-5 (2003):281-289,
https://doi.org/10.2298/JSC0305281M . .

TY  - JOUR
AU  - Menkovic, N
AU  - Savikin-Fodulovic, K
AU  - Bulatović, V.
AU  - Aljančić, Ivana
AU  - Juranic, N
AU  - Macura, S
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan
PY  - 2002
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4151
AB  - Isolation of 1-O-primeverosyl-3,8-dihydroxy-5-methoxyxanthone and 1-O-gentiobiosyl- 3,7-dimethoxy-8-hydroxyxanthone, along with five known xanthones, isobellidifolin, methylbellidifolin, isoswertianin, methylswertianin and norswertianin-1-O-beta-D-glucoside, from the roots of Swertia punctata is reported. In the aerial parts four xanthones, bellidifolin, methylbellidifolin, swertianolin and mangiferin, and flavone-C-gluco side, isoorientin were identified. The chemotaxonomic and pharmacological significance of these results is discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.
PB  - Oxford : Pergamon-Elsevier Science Ltd.
T2  - Phytochemistry
T1  - Xanthones from Swertia punctata
VL  - 61
IS  - 4
SP  - 415
EP  - 420
DO  - 10.1016/S0031-9422(02)00231-5
ER  - 

@article{
author = "Menkovic, N and Savikin-Fodulovic, K and Bulatović, V. and Aljančić, Ivana and Juranic, N and Macura, S and Vajs, Vlatka and Milosavljević, Slobodan",
year = "2002",
abstract = "Isolation of 1-O-primeverosyl-3,8-dihydroxy-5-methoxyxanthone and 1-O-gentiobiosyl- 3,7-dimethoxy-8-hydroxyxanthone, along with five known xanthones, isobellidifolin, methylbellidifolin, isoswertianin, methylswertianin and norswertianin-1-O-beta-D-glucoside, from the roots of Swertia punctata is reported. In the aerial parts four xanthones, bellidifolin, methylbellidifolin, swertianolin and mangiferin, and flavone-C-gluco side, isoorientin were identified. The chemotaxonomic and pharmacological significance of these results is discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.",
publisher = "Oxford : Pergamon-Elsevier Science Ltd.",
journal = "Phytochemistry",
title = "Xanthones from Swertia punctata",
volume = "61",
number = "4",
pages = "415-420",
doi = "10.1016/S0031-9422(02)00231-5"
}

Menkovic, N., Savikin-Fodulovic, K., Bulatović, V., Aljančić, I., Juranic, N., Macura, S., Vajs, V.,& Milosavljević, S.. (2002). Xanthones from Swertia punctata. in Phytochemistry
Oxford : Pergamon-Elsevier Science Ltd.., 61(4), 415-420.
https://doi.org/10.1016/S0031-9422(02)00231-5

Menkovic N, Savikin-Fodulovic K, Bulatović V, Aljančić I, Juranic N, Macura S, Vajs V, Milosavljević S. Xanthones from Swertia punctata. in Phytochemistry. 2002;61(4):415-420.
doi:10.1016/S0031-9422(02)00231-5 .

Menkovic, N, Savikin-Fodulovic, K, Bulatović, V., Aljančić, Ivana, Juranic, N, Macura, S, Vajs, Vlatka, Milosavljević, Slobodan, "Xanthones from Swertia punctata" in Phytochemistry, 61, no. 4 (2002):415-420,
https://doi.org/10.1016/S0031-9422(02)00231-5 . .

TY  - JOUR
AU  - Aljančić, Ivana
AU  - Vajs, Vlatka
AU  - Bulatović, V.
AU  - Menkovic, N
AU  - Milosavljević, Slobodan
PY  - 2001
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4150
AB  - The genus Tanacetum L. comprises ca 150 species that commonly occur in Europe from the Mediterranean to Persia. Tanacetum larvatum (Gris.) Kanitz, the examination of which is reported, is distributed on elevated rocky terrains in Albania, Serbia (Kosovo) and Montenegro. Aerial parts of T. larvatum were collected in Montenegro on two locations: crop a on mountain Komovi (altitutude 1800 m, 12 July 1998) and crop b on mountain Babji Zub (altitude ca 1500 m, 30 June 1999).
PB  - Oxford : Pergamon-Elsevier Science Ltd
T2  - Biochemical Systematics and Ecology
T1  - Parthenolide from the aerial parts of Tanacetum larvatum
VL  - 29
IS  - 6
SP  - 655
EP  - 657
DO  - 10.1016/S0305-1978(00)00093-4
ER  - 

@article{
author = "Aljančić, Ivana and Vajs, Vlatka and Bulatović, V. and Menkovic, N and Milosavljević, Slobodan",
year = "2001",
abstract = "The genus Tanacetum L. comprises ca 150 species that commonly occur in Europe from the Mediterranean to Persia. Tanacetum larvatum (Gris.) Kanitz, the examination of which is reported, is distributed on elevated rocky terrains in Albania, Serbia (Kosovo) and Montenegro. Aerial parts of T. larvatum were collected in Montenegro on two locations: crop a on mountain Komovi (altitutude 1800 m, 12 July 1998) and crop b on mountain Babji Zub (altitude ca 1500 m, 30 June 1999).",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "Biochemical Systematics and Ecology",
title = "Parthenolide from the aerial parts of Tanacetum larvatum",
volume = "29",
number = "6",
pages = "655-657",
doi = "10.1016/S0305-1978(00)00093-4"
}

Aljančić, I., Vajs, V., Bulatović, V., Menkovic, N.,& Milosavljević, S.. (2001). Parthenolide from the aerial parts of Tanacetum larvatum. in Biochemical Systematics and Ecology
Oxford : Pergamon-Elsevier Science Ltd., 29(6), 655-657.
https://doi.org/10.1016/S0305-1978(00)00093-4

Aljančić I, Vajs V, Bulatović V, Menkovic N, Milosavljević S. Parthenolide from the aerial parts of Tanacetum larvatum. in Biochemical Systematics and Ecology. 2001;29(6):655-657.
doi:10.1016/S0305-1978(00)00093-4 .

Aljančić, Ivana, Vajs, Vlatka, Bulatović, V., Menkovic, N, Milosavljević, Slobodan, "Parthenolide from the aerial parts of Tanacetum larvatum" in Biochemical Systematics and Ecology, 29, no. 6 (2001):655-657,
https://doi.org/10.1016/S0305-1978(00)00093-4 . .

TY  - JOUR
AU  - Aljančić, Ivana
AU  - Vajs, Vlatka
AU  - Menković, Nebojša
AU  - Karadžić, Ivanka
AU  - Juranić, Nenad
AU  - Milosavljević, Slobodan
AU  - Macura, Slobodan
PY  - 1999
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2809
AB  - Four flavones (1-4) and nine sesquiterpene lactones (5-13), one of them (5) a new compound, were isolated from the aerial parts of Achillea atrata L. subsp, multifida. Although the crude extract demonstrated in vitro inhibitory activity against Candida albicans and Bacillus subtilis, all isolated flavones were active against B. subtilis. Flavones 1, 2, and 3 were also active against C. albicans, while 1 and 3 exhibited activity against E. coli, as well. None of the tested lactones (7, 9, 12, and 13) showed any antimicrobial activity.
PB  - American Chemical Society (ACS)
T2  - Journal of Natural Products
T1  - Flavones and sesquiterpene lactones from Achillea atrata subsp, multifida: Antimicrobial activity
VL  - 62
IS  - 6
SP  - 909
EP  - 911
DO  - 10.1021/np980536m
ER  - 

@article{
author = "Aljančić, Ivana and Vajs, Vlatka and Menković, Nebojša and Karadžić, Ivanka and Juranić, Nenad and Milosavljević, Slobodan and Macura, Slobodan",
year = "1999",
abstract = "Four flavones (1-4) and nine sesquiterpene lactones (5-13), one of them (5) a new compound, were isolated from the aerial parts of Achillea atrata L. subsp, multifida. Although the crude extract demonstrated in vitro inhibitory activity against Candida albicans and Bacillus subtilis, all isolated flavones were active against B. subtilis. Flavones 1, 2, and 3 were also active against C. albicans, while 1 and 3 exhibited activity against E. coli, as well. None of the tested lactones (7, 9, 12, and 13) showed any antimicrobial activity.",
publisher = "American Chemical Society (ACS)",
journal = "Journal of Natural Products",
title = "Flavones and sesquiterpene lactones from Achillea atrata subsp, multifida: Antimicrobial activity",
volume = "62",
number = "6",
pages = "909-911",
doi = "10.1021/np980536m"
}

Aljančić, I., Vajs, V., Menković, N., Karadžić, I., Juranić, N., Milosavljević, S.,& Macura, S.. (1999). Flavones and sesquiterpene lactones from Achillea atrata subsp, multifida: Antimicrobial activity. in Journal of Natural Products
American Chemical Society (ACS)., 62(6), 909-911.
https://doi.org/10.1021/np980536m

Aljančić I, Vajs V, Menković N, Karadžić I, Juranić N, Milosavljević S, Macura S. Flavones and sesquiterpene lactones from Achillea atrata subsp, multifida: Antimicrobial activity. in Journal of Natural Products. 1999;62(6):909-911.
doi:10.1021/np980536m .

Aljančić, Ivana, Vajs, Vlatka, Menković, Nebojša, Karadžić, Ivanka, Juranić, Nenad, Milosavljević, Slobodan, Macura, Slobodan, "Flavones and sesquiterpene lactones from Achillea atrata subsp, multifida: Antimicrobial activity" in Journal of Natural Products, 62, no. 6 (1999):909-911,
https://doi.org/10.1021/np980536m . .

TY  - JOUR
AU  - Milosavljević, Slobodan
AU  - Macura, Slobodan
AU  - Stefanović, Milutin
AU  - Aljančić, Ivana
AU  - Milinković, Darinka
PY  - 1994
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4375
AB  - The isolation of three highly oxygenated guaianolides, desacetyl-1α-4α- dihydroxybishopsolicepolide [1], its 4β-hydroxy epimer 2 (a new compound), and 1β,2β:3β,4β-diepoxy-8α,10α-dihydroxyguai-12(13)-en-12,6α-olide [3], from the aerial parts of Achillea crithmifolia is reported. Because lactone 3 was shown to be identical with rupin A, the initially proposed 1α,2α:3α,4α-diepoxy stereochemistry of rupin A should be revised.
PB  - American Chemical Society
T2  - Journal of Natural Products
T1  - Sesquiterpene lactones from Achillea crithmifolia
VL  - 57
IS  - 1
SP  - 64
EP  - 67
DO  - 10.1021/np50103a008
ER  - 

@article{
author = "Milosavljević, Slobodan and Macura, Slobodan and Stefanović, Milutin and Aljančić, Ivana and Milinković, Darinka",
year = "1994",
abstract = "The isolation of three highly oxygenated guaianolides, desacetyl-1α-4α- dihydroxybishopsolicepolide [1], its 4β-hydroxy epimer 2 (a new compound), and 1β,2β:3β,4β-diepoxy-8α,10α-dihydroxyguai-12(13)-en-12,6α-olide [3], from the aerial parts of Achillea crithmifolia is reported. Because lactone 3 was shown to be identical with rupin A, the initially proposed 1α,2α:3α,4α-diepoxy stereochemistry of rupin A should be revised.",
publisher = "American Chemical Society",
journal = "Journal of Natural Products",
title = "Sesquiterpene lactones from Achillea crithmifolia",
volume = "57",
number = "1",
pages = "64-67",
doi = "10.1021/np50103a008"
}

Milosavljević, S., Macura, S., Stefanović, M., Aljančić, I.,& Milinković, D.. (1994). Sesquiterpene lactones from Achillea crithmifolia. in Journal of Natural Products
American Chemical Society., 57(1), 64-67.
https://doi.org/10.1021/np50103a008

Milosavljević S, Macura S, Stefanović M, Aljančić I, Milinković D. Sesquiterpene lactones from Achillea crithmifolia. in Journal of Natural Products. 1994;57(1):64-67.
doi:10.1021/np50103a008 .

Milosavljević, Slobodan, Macura, Slobodan, Stefanović, Milutin, Aljančić, Ivana, Milinković, Darinka, "Sesquiterpene lactones from Achillea crithmifolia" in Journal of Natural Products, 57, no. 1 (1994):64-67,
https://doi.org/10.1021/np50103a008 . .