TY  - JOUR
AU  - Ivanović, Stefan
AU  - Gođevac, Dejan
AU  - Ristivojević, Petar
AU  - Zdunić, Gordana
AU  - Stojanović, Danilo
AU  - Šavikin, Katarina
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5648
AB  - Introduction: Chokeberry is a plant belonging to the family Rosaceae which has a long history of edible and medicinal use. The aims of this study are: i) to investigate of HPTLC profile of the berry samples using HPTLC technique based metabolomics approach, ii) to determine the botanical origin of investigated chokeberry adulterations iii) to identify the most important botanical markers responsible for classification. Methods: A simple, rapid, and high-throughput planar chromatography (HPTLC) method was applied in combination with multivariate techniques for differentiating chokeberry samples and identification of the main metabolites of chokeberry and four common adulterants. Images of HPTLC chromatograms obtained using two different detections i.e. visible light and derivatization with natural products reagent were used as a dataset for multivariate analysis. Results: Principal component analysis and Orthogonal Partial Least Squares Discriminant Analysis confirmed the discrimination of five botanically different samples and recognized their main markers such as responsible for differences between chokeberry and four common adulterants. Conclusion: The obtained results showed that the HPTLC-based metabolomics approach can be a very reliable technique for the detection of chokeberry adulteration.
PB  - Elsevier GmbH
T2  - Journal of Herbal Medicine
T1  - HPTLC-based metabolomics approach for the detection of chokeberry (Aronia melanocarpa (Michx.) Elliott) adulteration
VL  - 37
SP  - 100618
DO  - 10.1016/j.hermed.2022.100618
ER  - 

@article{
author = "Ivanović, Stefan and Gođevac, Dejan and Ristivojević, Petar and Zdunić, Gordana and Stojanović, Danilo and Šavikin, Katarina",
year = "2023",
abstract = "Introduction: Chokeberry is a plant belonging to the family Rosaceae which has a long history of edible and medicinal use. The aims of this study are: i) to investigate of HPTLC profile of the berry samples using HPTLC technique based metabolomics approach, ii) to determine the botanical origin of investigated chokeberry adulterations iii) to identify the most important botanical markers responsible for classification. Methods: A simple, rapid, and high-throughput planar chromatography (HPTLC) method was applied in combination with multivariate techniques for differentiating chokeberry samples and identification of the main metabolites of chokeberry and four common adulterants. Images of HPTLC chromatograms obtained using two different detections i.e. visible light and derivatization with natural products reagent were used as a dataset for multivariate analysis. Results: Principal component analysis and Orthogonal Partial Least Squares Discriminant Analysis confirmed the discrimination of five botanically different samples and recognized their main markers such as responsible for differences between chokeberry and four common adulterants. Conclusion: The obtained results showed that the HPTLC-based metabolomics approach can be a very reliable technique for the detection of chokeberry adulteration.",
publisher = "Elsevier GmbH",
journal = "Journal of Herbal Medicine",
title = "HPTLC-based metabolomics approach for the detection of chokeberry (Aronia melanocarpa (Michx.) Elliott) adulteration",
volume = "37",
pages = "100618",
doi = "10.1016/j.hermed.2022.100618"
}

Ivanović, S., Gođevac, D., Ristivojević, P., Zdunić, G., Stojanović, D.,& Šavikin, K.. (2023). HPTLC-based metabolomics approach for the detection of chokeberry (Aronia melanocarpa (Michx.) Elliott) adulteration. in Journal of Herbal Medicine
Elsevier GmbH., 37, 100618.
https://doi.org/10.1016/j.hermed.2022.100618

Ivanović S, Gođevac D, Ristivojević P, Zdunić G, Stojanović D, Šavikin K. HPTLC-based metabolomics approach for the detection of chokeberry (Aronia melanocarpa (Michx.) Elliott) adulteration. in Journal of Herbal Medicine. 2023;37:100618.
doi:10.1016/j.hermed.2022.100618 .

Ivanović, Stefan, Gođevac, Dejan, Ristivojević, Petar, Zdunić, Gordana, Stojanović, Danilo, Šavikin, Katarina, "HPTLC-based metabolomics approach for the detection of chokeberry (Aronia melanocarpa (Michx.) Elliott) adulteration" in Journal of Herbal Medicine, 37 (2023):100618,
https://doi.org/10.1016/j.hermed.2022.100618 . .

TY  - JOUR
AU  - Ortiz, Sergio
AU  - Šavikin, Katarina
AU  - Massicot, France
AU  - Olivier, Elodie
AU  - Dutot, Melody
AU  - Rat, Patrice
AU  - Deguin, Brigitte
AU  - Gođevac, Dejan
AU  - Menković, Nebojša
AU  - Živković, Jelena
AU  - Zdunić, Gordana
AU  - Boutefnouchet, Sabrina
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7218
AB  - Medicinal plants used in European folk medicine attached to Lamiales, Gentianales or Asterales orders are used to treat inflammatory disorders. Many targets have been identified but to date, implication of purinergic receptor P2X7 activation has not yet been investigated. We managed to evaluate the protective effect on P2X7 activation by plant extracts used as anti-inflammatory in European folk medicine by the YO-PRO-1 uptake dye in vitro bioassay. Results revealed that among our selected plants, species from Scrophularia and Plantago genus were able to decrease significantly P2X7 activation (>50 % at 0.1 and 1 μg/mL). UPLC/MS, dereplication and metabolomic analysis of Scrophularia extracts, allowed us to identify the cinnamoyl-iridoid harpagoside as putative inhibitor of P2X7 activation. These results open a new research field regarding the anti-inflammatory mechanism of cinnamoyl-iridoids bearing plants, which may involve the P2X7 receptor.
PB  - Wiley
T2  - Chemistry & Biodiversity
T1  - P2X7‐Receptor Pathway Involvement in the Anti‐Inflammatory Activity of Medicinal Plants
VL  - 20
IS  - 8
DO  - 10.1002/cbdv.202300427
ER  - 

@article{
author = "Ortiz, Sergio and Šavikin, Katarina and Massicot, France and Olivier, Elodie and Dutot, Melody and Rat, Patrice and Deguin, Brigitte and Gođevac, Dejan and Menković, Nebojša and Živković, Jelena and Zdunić, Gordana and Boutefnouchet, Sabrina",
year = "2023",
abstract = "Medicinal plants used in European folk medicine attached to Lamiales, Gentianales or Asterales orders are used to treat inflammatory disorders. Many targets have been identified but to date, implication of purinergic receptor P2X7 activation has not yet been investigated. We managed to evaluate the protective effect on P2X7 activation by plant extracts used as anti-inflammatory in European folk medicine by the YO-PRO-1 uptake dye in vitro bioassay. Results revealed that among our selected plants, species from Scrophularia and Plantago genus were able to decrease significantly P2X7 activation (>50 % at 0.1 and 1 μg/mL). UPLC/MS, dereplication and metabolomic analysis of Scrophularia extracts, allowed us to identify the cinnamoyl-iridoid harpagoside as putative inhibitor of P2X7 activation. These results open a new research field regarding the anti-inflammatory mechanism of cinnamoyl-iridoids bearing plants, which may involve the P2X7 receptor.",
publisher = "Wiley",
journal = "Chemistry & Biodiversity",
title = "P2X7‐Receptor Pathway Involvement in the Anti‐Inflammatory Activity of Medicinal Plants",
volume = "20",
number = "8",
doi = "10.1002/cbdv.202300427"
}

Ortiz, S., Šavikin, K., Massicot, F., Olivier, E., Dutot, M., Rat, P., Deguin, B., Gođevac, D., Menković, N., Živković, J., Zdunić, G.,& Boutefnouchet, S.. (2023). P2X7‐Receptor Pathway Involvement in the Anti‐Inflammatory Activity of Medicinal Plants. in Chemistry & Biodiversity
Wiley., 20(8).
https://doi.org/10.1002/cbdv.202300427

Ortiz S, Šavikin K, Massicot F, Olivier E, Dutot M, Rat P, Deguin B, Gođevac D, Menković N, Živković J, Zdunić G, Boutefnouchet S. P2X7‐Receptor Pathway Involvement in the Anti‐Inflammatory Activity of Medicinal Plants. in Chemistry & Biodiversity. 2023;20(8).
doi:10.1002/cbdv.202300427 .

Ortiz, Sergio, Šavikin, Katarina, Massicot, France, Olivier, Elodie, Dutot, Melody, Rat, Patrice, Deguin, Brigitte, Gođevac, Dejan, Menković, Nebojša, Živković, Jelena, Zdunić, Gordana, Boutefnouchet, Sabrina, "P2X7‐Receptor Pathway Involvement in the Anti‐Inflammatory Activity of Medicinal Plants" in Chemistry & Biodiversity, 20, no. 8 (2023),
https://doi.org/10.1002/cbdv.202300427 . .

TY  - CONF
AU  - Ivanović, Stefan
AU  - Ristivojević, Petar
AU  - Zdunić, Gordana
AU  - Stojanović, Danilo
AU  - Šavikin, Katarina
AU  - Gođevac, Dejan
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7537
AB  - Chokeberry is a plant belonging to the family Rosaceae which has a long history of edible and
medicinal use. The aims of this study are: i) to investigate of HPTLC profile of berries samples
using HPTLC technique based metabolomics approach, ii) to determine the botanical origin of
investigated chokeberry adulterations iii) to identify the most important botanical markers
responsible for classification.
A simple, rapid, and high-throughput planar chromatography (HPTLC) method was applied in
combination with multivariate techniques for differentiating chokeberry samples and identification
of the main metabolites of chokeberry and four common adulterants. Images of HPTLC
chromatograms obtained using two different detections i.e. visible light and derivatization with
natural products reagent were used as a dataset for multivariate analysis.
Principal component analysis and Orthogonal Partial Least Squares Discriminant Analysis
confirmed the discrimination of five botanically different samples and recognized their main
markers such as responsible for differences between chokeberry and four common adulterants.
The obtained results showed that the HPTLC-based metabolomics approach can be a very reliable technique for the detection of chokeberry adulteration
PB  - University of Belgrade
C3  - Unifood Conference, Program i zbornik radova, Beograd, 24 i 25 septembar 2021. / Unifood Conference, Programme & Book of Abstracts, Belgrade September 24-25 2021
T1  - Detection of chokeberry adulteration by HPTLS-based metabolomics
SP  - 136
EP  - 136
UR  - https://hdl.handle.net/21.15107/rcub_cer_7537
ER  - 

@conference{
author = "Ivanović, Stefan and Ristivojević, Petar and Zdunić, Gordana and Stojanović, Danilo and Šavikin, Katarina and Gođevac, Dejan",
year = "2021",
abstract = "Chokeberry is a plant belonging to the family Rosaceae which has a long history of edible and
medicinal use. The aims of this study are: i) to investigate of HPTLC profile of berries samples
using HPTLC technique based metabolomics approach, ii) to determine the botanical origin of
investigated chokeberry adulterations iii) to identify the most important botanical markers
responsible for classification.
A simple, rapid, and high-throughput planar chromatography (HPTLC) method was applied in
combination with multivariate techniques for differentiating chokeberry samples and identification
of the main metabolites of chokeberry and four common adulterants. Images of HPTLC
chromatograms obtained using two different detections i.e. visible light and derivatization with
natural products reagent were used as a dataset for multivariate analysis.
Principal component analysis and Orthogonal Partial Least Squares Discriminant Analysis
confirmed the discrimination of five botanically different samples and recognized their main
markers such as responsible for differences between chokeberry and four common adulterants.
The obtained results showed that the HPTLC-based metabolomics approach can be a very reliable technique for the detection of chokeberry adulteration",
publisher = "University of Belgrade",
journal = "Unifood Conference, Program i zbornik radova, Beograd, 24 i 25 septembar 2021. / Unifood Conference, Programme & Book of Abstracts, Belgrade September 24-25 2021",
title = "Detection of chokeberry adulteration by HPTLS-based metabolomics",
pages = "136-136",
url = "https://hdl.handle.net/21.15107/rcub_cer_7537"
}

Ivanović, S., Ristivojević, P., Zdunić, G., Stojanović, D., Šavikin, K.,& Gođevac, D.. (2021). Detection of chokeberry adulteration by HPTLS-based metabolomics. in Unifood Conference, Program i zbornik radova, Beograd, 24 i 25 septembar 2021. / Unifood Conference, Programme & Book of Abstracts, Belgrade September 24-25 2021
University of Belgrade., 136-136.
https://hdl.handle.net/21.15107/rcub_cer_7537

Ivanović S, Ristivojević P, Zdunić G, Stojanović D, Šavikin K, Gođevac D. Detection of chokeberry adulteration by HPTLS-based metabolomics. in Unifood Conference, Program i zbornik radova, Beograd, 24 i 25 septembar 2021. / Unifood Conference, Programme & Book of Abstracts, Belgrade September 24-25 2021. 2021;:136-136.
https://hdl.handle.net/21.15107/rcub_cer_7537 .

Ivanović, Stefan, Ristivojević, Petar, Zdunić, Gordana, Stojanović, Danilo, Šavikin, Katarina, Gođevac, Dejan, "Detection of chokeberry adulteration by HPTLS-based metabolomics" in Unifood Conference, Program i zbornik radova, Beograd, 24 i 25 septembar 2021. / Unifood Conference, Programme & Book of Abstracts, Belgrade September 24-25 2021 (2021):136-136,
https://hdl.handle.net/21.15107/rcub_cer_7537 .

TY  - JOUR
AU  - Zdunić, Gordana
AU  - Aradski, Ana Alimpić
AU  - Gođevac, Dejan
AU  - Živković, Jelena Č.
AU  - Laušević, Sonja Duletić
AU  - Milošević, Dijana Krstić
AU  - Šavikin, Katarina
PY  - 2020
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3446
AB  - Chokeberries (Aronia melanocarpa (Michx.) Elliot have recently become one of the most popular and widely used berry fruits, and there are numerous studies dealing with the investigation of their chemical composition and biological activities. Unlike berries, chokeberry leaves were far less investigated. Therefore, the aim of this study was to conduct a bioactivity-based analysis of chokeberry leaves collected after berries were harvested. Chemical analysis of hydroethanolic chokeberry extract and its ethyl acetate, n-butanol, and water fractions was performed. Antioxidant, hypoglycemic, and antineurodegenerative activities of the obtained samples were assessed by in vitro tests. The highest total phenolics content was found in n-butanol fraction (221.5 mg gallic acid equivalents/g dw). Fourteen compounds (six phenolic acids and eight flavonoids) were identified in the samples. Caffeoylquinic acid derivatives and quercetin glycosides were dominant phenolic compounds. The highest content of phenolic acids, as well as flavonoids, was recorded in n-butanol fraction (80.75 mg/g dw and 47.79 mg/g dw, respectively). This fraction was the most active in 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis (3-ethyl-benzothiazoline-6-sulfonic acid) (ABTS), and ferric reducing antioxidant power (FRAP) assays. Also, the n-butanol fraction was the most effective inhibitor of acetylcholinesterase (AChE) and tyrosinase (TYR) enzymes. All samples showed a better inhibitory effect on α-glucosidase enzyme with inhibition concentrations IC50 = 4.21 - 9.22 μg/mL, than α-amylase enzymes (IC50 = 14.36 - 88.61 μg/mL). Pearson’s correlation between the content of individual phenolics and the results of biological tests was performed. Thus, hyperoside and isoquercitrin showed a significant correlation with DPPH and ABTS tests, caffeoylquinic acids with FRAP test, quercetin 3-O-vicianoside with β-carotene assay, hyperoside and isoquercitrin with α-amylase inhibition activity, and isorhamnetin 3-O-rutinoside with α-glucosidase inhibition assay. Considering the obtained results, chokeberry leaves represent a valuable natural source of phenolic compounds with promising potential for the development of new products with beneficial effects on human health.
PB  - Elsevier
T2  - Industrial Crops and Products
T1  - In vitro hypoglycemic, antioxidant and antineurodegenerative activity of chokeberry (Aronia melanocarpa) leaves
VL  - 148
SP  - 112328
DO  - 10.1016/j.indcrop.2020.112328
ER  - 

@article{
author = "Zdunić, Gordana and Aradski, Ana Alimpić and Gođevac, Dejan and Živković, Jelena Č. and Laušević, Sonja Duletić and Milošević, Dijana Krstić and Šavikin, Katarina",
year = "2020",
abstract = "Chokeberries (Aronia melanocarpa (Michx.) Elliot have recently become one of the most popular and widely used berry fruits, and there are numerous studies dealing with the investigation of their chemical composition and biological activities. Unlike berries, chokeberry leaves were far less investigated. Therefore, the aim of this study was to conduct a bioactivity-based analysis of chokeberry leaves collected after berries were harvested. Chemical analysis of hydroethanolic chokeberry extract and its ethyl acetate, n-butanol, and water fractions was performed. Antioxidant, hypoglycemic, and antineurodegenerative activities of the obtained samples were assessed by in vitro tests. The highest total phenolics content was found in n-butanol fraction (221.5 mg gallic acid equivalents/g dw). Fourteen compounds (six phenolic acids and eight flavonoids) were identified in the samples. Caffeoylquinic acid derivatives and quercetin glycosides were dominant phenolic compounds. The highest content of phenolic acids, as well as flavonoids, was recorded in n-butanol fraction (80.75 mg/g dw and 47.79 mg/g dw, respectively). This fraction was the most active in 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis (3-ethyl-benzothiazoline-6-sulfonic acid) (ABTS), and ferric reducing antioxidant power (FRAP) assays. Also, the n-butanol fraction was the most effective inhibitor of acetylcholinesterase (AChE) and tyrosinase (TYR) enzymes. All samples showed a better inhibitory effect on α-glucosidase enzyme with inhibition concentrations IC50 = 4.21 - 9.22 μg/mL, than α-amylase enzymes (IC50 = 14.36 - 88.61 μg/mL). Pearson’s correlation between the content of individual phenolics and the results of biological tests was performed. Thus, hyperoside and isoquercitrin showed a significant correlation with DPPH and ABTS tests, caffeoylquinic acids with FRAP test, quercetin 3-O-vicianoside with β-carotene assay, hyperoside and isoquercitrin with α-amylase inhibition activity, and isorhamnetin 3-O-rutinoside with α-glucosidase inhibition assay. Considering the obtained results, chokeberry leaves represent a valuable natural source of phenolic compounds with promising potential for the development of new products with beneficial effects on human health.",
publisher = "Elsevier",
journal = "Industrial Crops and Products",
title = "In vitro hypoglycemic, antioxidant and antineurodegenerative activity of chokeberry (Aronia melanocarpa) leaves",
volume = "148",
pages = "112328",
doi = "10.1016/j.indcrop.2020.112328"
}

Zdunić, G., Aradski, A. A., Gođevac, D., Živković, J. Č., Laušević, S. D., Milošević, D. K.,& Šavikin, K.. (2020). In vitro hypoglycemic, antioxidant and antineurodegenerative activity of chokeberry (Aronia melanocarpa) leaves. in Industrial Crops and Products
Elsevier., 148, 112328.
https://doi.org/10.1016/j.indcrop.2020.112328

Zdunić G, Aradski AA, Gođevac D, Živković JČ, Laušević SD, Milošević DK, Šavikin K. In vitro hypoglycemic, antioxidant and antineurodegenerative activity of chokeberry (Aronia melanocarpa) leaves. in Industrial Crops and Products. 2020;148:112328.
doi:10.1016/j.indcrop.2020.112328 .

Zdunić, Gordana, Aradski, Ana Alimpić, Gođevac, Dejan, Živković, Jelena Č., Laušević, Sonja Duletić, Milošević, Dijana Krstić, Šavikin, Katarina, "In vitro hypoglycemic, antioxidant and antineurodegenerative activity of chokeberry (Aronia melanocarpa) leaves" in Industrial Crops and Products, 148 (2020):112328,
https://doi.org/10.1016/j.indcrop.2020.112328 . .

TY  - JOUR
AU  - Stanković, Jovana
AU  - Novaković, Miroslav
AU  - Tešević, Vele
AU  - Ćiric, Ana
AU  - Soković, Marina
AU  - Zdunić, Gordana
AU  - Dajić-Stevanović, Zora
AU  - Gođevac, Dejan
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3433
AB  - This study was performed to determine the main antibacterial compounds of the essential oil (ЕО) of saltmarsh plant Artemisia santonicum (Asteraceae). The combination of HPTLC and direct bioautography was used for the activity guided isolation of isogeranic acid as the main antibacterial constituent with remarkable antimicrobial activity, although it was the minor component of the EO, present only in 0.2 %, as calculated from GC/FID. Its structure was determined by 1D- and 2D-NMR and GC–MS techniques. Antibacterial activity of isogeranic acid against all tested bacteria was significantly higher than EO and even than both controls streptomycin and ampicillin. In further investigation of antibiofilm and antiquorum sensing activity EO exhibited the best inhibition of the biofilm formation at 1/8 minimal inhibitory concentration (MIC) and isogeranic acid at 1/2 MIC. Both EO and isogeranic acid possessed pyocyanin inhibitory activity showing the reduction of pigment at 60.6 and 62.8 %, respectively, at 1/2 MIC concentrations.
AB  - Ово истраживање је спроведено у циљу одређивања главних антибактеријских компоненти етарског уља слатинске биљне врсте Artemisia santonicum (Asteraceae). Комбинација HPTLC методе и методе директне биоаутографије је коришћена за активношћу вођено изоловање изогеранилне киселине као главне компоненте са значајном антимикробном, антибиофилм и антикворум активношћу иако је била присутна у етарском уљу са само 0,2 %, израчунато из GC/FID. Њена структура је одређена 1D и 2D NMR и GC–MS техникама. Антибактеријска активност изогеранилне киселине на све тестиране бактерије је била значајно боља од етарског уља, и од обе контроле, стрептомицина и ампицилина. Етарско уље је показало најбољу инхибицију формирања биофилма у концентрацији 1/8 минималне инфибиторске концнетрације (MIC вредности), а изогеранилна киселина у концентрацији 1/2 MIC вредности. И етарско уље и изогеранилна киселина су имале пиоцијанин инхибиторну активност показавши смањење пигмента на 60,6 и 62,8 %, у концентрацији 1/2 MIC вредности, редом.
PB  - Serbian Chemical Society: Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - HPTLC-direct bioautography-guided isolation of isogeranic acid as the main antibacterial constituent of Artemisia santonicum essential oil
T1  - HPTLC директно-биоаутографски вођено изоловање изогеранилне киселине као главне антибактеријске компоненте етарског уља
VL  - 84
IS  - 12
SP  - 1355
EP  - 1365
DO  - 10.2298/JSC190513106S
ER  - 

@article{
author = "Stanković, Jovana and Novaković, Miroslav and Tešević, Vele and Ćiric, Ana and Soković, Marina and Zdunić, Gordana and Dajić-Stevanović, Zora and Gođevac, Dejan",
year = "2019",
abstract = "This study was performed to determine the main antibacterial compounds of the essential oil (ЕО) of saltmarsh plant Artemisia santonicum (Asteraceae). The combination of HPTLC and direct bioautography was used for the activity guided isolation of isogeranic acid as the main antibacterial constituent with remarkable antimicrobial activity, although it was the minor component of the EO, present only in 0.2 %, as calculated from GC/FID. Its structure was determined by 1D- and 2D-NMR and GC–MS techniques. Antibacterial activity of isogeranic acid against all tested bacteria was significantly higher than EO and even than both controls streptomycin and ampicillin. In further investigation of antibiofilm and antiquorum sensing activity EO exhibited the best inhibition of the biofilm formation at 1/8 minimal inhibitory concentration (MIC) and isogeranic acid at 1/2 MIC. Both EO and isogeranic acid possessed pyocyanin inhibitory activity showing the reduction of pigment at 60.6 and 62.8 %, respectively, at 1/2 MIC concentrations., Ово истраживање је спроведено у циљу одређивања главних антибактеријских компоненти етарског уља слатинске биљне врсте Artemisia santonicum (Asteraceae). Комбинација HPTLC методе и методе директне биоаутографије је коришћена за активношћу вођено изоловање изогеранилне киселине као главне компоненте са значајном антимикробном, антибиофилм и антикворум активношћу иако је била присутна у етарском уљу са само 0,2 %, израчунато из GC/FID. Њена структура је одређена 1D и 2D NMR и GC–MS техникама. Антибактеријска активност изогеранилне киселине на све тестиране бактерије је била значајно боља од етарског уља, и од обе контроле, стрептомицина и ампицилина. Етарско уље је показало најбољу инхибицију формирања биофилма у концентрацији 1/8 минималне инфибиторске концнетрације (MIC вредности), а изогеранилна киселина у концентрацији 1/2 MIC вредности. И етарско уље и изогеранилна киселина су имале пиоцијанин инхибиторну активност показавши смањење пигмента на 60,6 и 62,8 %, у концентрацији 1/2 MIC вредности, редом.",
publisher = "Serbian Chemical Society: Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "HPTLC-direct bioautography-guided isolation of isogeranic acid as the main antibacterial constituent of Artemisia santonicum essential oil, HPTLC директно-биоаутографски вођено изоловање изогеранилне киселине као главне антибактеријске компоненте етарског уља",
volume = "84",
number = "12",
pages = "1355-1365",
doi = "10.2298/JSC190513106S"
}

Stanković, J., Novaković, M., Tešević, V., Ćiric, A., Soković, M., Zdunić, G., Dajić-Stevanović, Z.,& Gođevac, D.. (2019). HPTLC-direct bioautography-guided isolation of isogeranic acid as the main antibacterial constituent of Artemisia santonicum essential oil. in Journal of the Serbian Chemical Society
Serbian Chemical Society: Belgrade., 84(12), 1355-1365.
https://doi.org/10.2298/JSC190513106S

Stanković J, Novaković M, Tešević V, Ćiric A, Soković M, Zdunić G, Dajić-Stevanović Z, Gođevac D. HPTLC-direct bioautography-guided isolation of isogeranic acid as the main antibacterial constituent of Artemisia santonicum essential oil. in Journal of the Serbian Chemical Society. 2019;84(12):1355-1365.
doi:10.2298/JSC190513106S .

Stanković, Jovana, Novaković, Miroslav, Tešević, Vele, Ćiric, Ana, Soković, Marina, Zdunić, Gordana, Dajić-Stevanović, Zora, Gođevac, Dejan, "HPTLC-direct bioautography-guided isolation of isogeranic acid as the main antibacterial constituent of Artemisia santonicum essential oil" in Journal of the Serbian Chemical Society, 84, no. 12 (2019):1355-1365,
https://doi.org/10.2298/JSC190513106S . .

TY  - JOUR
AU  - Zdunić, Gordana
AU  - Gođevac, Dejan
AU  - Šavikin, Katarina
AU  - Krivokuća, Dragana
AU  - Mihailović, Milica
AU  - Pržić, Zoran
AU  - Marković, Nebojša
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2994
AB  - Grape pomace (grape skin, seeds, and stems) represents a valuable source of bioactive compounds, thus the interest in making use of these wine waste products is increasing. Prokupac is an autochthonous Serbian variety of black grape with a long tradition in production of red wine. Identification of the superficial polyphenolic compounds by LC/MS revealed presence of 19 compounds including hydroxybenzoic acid derivatives, ellagic acid derivatives, flavan‐3‐ol monomers, proanthocyanidins, and flavonols. Catechin and epicatechin together with proanthocyanidins were the most abundant compounds and the highest content of phenolic compounds was determined in Prokupac clones 43/1, 40/1, and 40/2. Grape seed oil consisted of dominantly UFA (87–95 %) where methyl linoleate was the most abundant in all samples (69–81 %). Palmitic (3–8 %) and stearic acid (2–4 %) methyl esters were dominant SFA. Prokupac clone 43/3 was the most abundant in UFA (95 %) with the lowest percentage of SFA (5 %), while clones 41/1 and 43/5 had the lowest percentage of UFA (87 %) and the highest content of SFA (13 %). Favorable chemical profile of Prokupac clone seeds implicates its potential to be used as a raw material in further processing and possibility to be included as one of the quality parameters in further selection of the most interesting Prokupac clone.
PB  - Wiley
T2  - Chemistry & Biodiversity
T1  - Grape Seed Polyphenols and Fatty Acids of Autochthonous Prokupac Vine Variety from Serbia
SP  - e1900053
DO  - 10.1002/cbdv.201900053
ER  - 

@article{
author = "Zdunić, Gordana and Gođevac, Dejan and Šavikin, Katarina and Krivokuća, Dragana and Mihailović, Milica and Pržić, Zoran and Marković, Nebojša",
year = "2019",
abstract = "Grape pomace (grape skin, seeds, and stems) represents a valuable source of bioactive compounds, thus the interest in making use of these wine waste products is increasing. Prokupac is an autochthonous Serbian variety of black grape with a long tradition in production of red wine. Identification of the superficial polyphenolic compounds by LC/MS revealed presence of 19 compounds including hydroxybenzoic acid derivatives, ellagic acid derivatives, flavan‐3‐ol monomers, proanthocyanidins, and flavonols. Catechin and epicatechin together with proanthocyanidins were the most abundant compounds and the highest content of phenolic compounds was determined in Prokupac clones 43/1, 40/1, and 40/2. Grape seed oil consisted of dominantly UFA (87–95 %) where methyl linoleate was the most abundant in all samples (69–81 %). Palmitic (3–8 %) and stearic acid (2–4 %) methyl esters were dominant SFA. Prokupac clone 43/3 was the most abundant in UFA (95 %) with the lowest percentage of SFA (5 %), while clones 41/1 and 43/5 had the lowest percentage of UFA (87 %) and the highest content of SFA (13 %). Favorable chemical profile of Prokupac clone seeds implicates its potential to be used as a raw material in further processing and possibility to be included as one of the quality parameters in further selection of the most interesting Prokupac clone.",
publisher = "Wiley",
journal = "Chemistry & Biodiversity",
title = "Grape Seed Polyphenols and Fatty Acids of Autochthonous Prokupac Vine Variety from Serbia",
pages = "e1900053",
doi = "10.1002/cbdv.201900053"
}

Zdunić, G., Gođevac, D., Šavikin, K., Krivokuća, D., Mihailović, M., Pržić, Z.,& Marković, N.. (2019). Grape Seed Polyphenols and Fatty Acids of Autochthonous Prokupac Vine Variety from Serbia. in Chemistry & Biodiversity
Wiley., e1900053.
https://doi.org/10.1002/cbdv.201900053

Zdunić G, Gođevac D, Šavikin K, Krivokuća D, Mihailović M, Pržić Z, Marković N. Grape Seed Polyphenols and Fatty Acids of Autochthonous Prokupac Vine Variety from Serbia. in Chemistry & Biodiversity. 2019;:e1900053.
doi:10.1002/cbdv.201900053 .

Zdunić, Gordana, Gođevac, Dejan, Šavikin, Katarina, Krivokuća, Dragana, Mihailović, Milica, Pržić, Zoran, Marković, Nebojša, "Grape Seed Polyphenols and Fatty Acids of Autochthonous Prokupac Vine Variety from Serbia" in Chemistry & Biodiversity (2019):e1900053,
https://doi.org/10.1002/cbdv.201900053 . .

TY  - JOUR
AU  - Gođevac, Dejan
AU  - Damjanovic, Ana
AU  - Stanojković, Tatjana
AU  - Anđelković, Boban D.
AU  - Zdunić, Gordana
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2464
AB  - Herein, we propose a H-1 NMR-based metabolomics method to reveal cytotoxic metabolites from Mahonia aquifolium stem-bark. Primary and secondary metabolites in the Mahonia aquifolium extracts were identified by thorough analysis of H-1 and 2D NMR spectra, without prior isolation. An OPLS multivariate analysis method was used to correlate the chemical composition of the plant extracts with the results of cytotoxic activity against Human cervical adenocarcinoma cell line. Protoberberine alkaloids berberine and palmatine, along with bisbenzylisoquinoline alkaloid berbamine were identified as the most influential in the OPLS model, with the highest cytotoxic activity.
PB  - Elsevier
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Identification of cytotoxic metabolites from Mahonia aquifolium using H-1 NMR-based metabolomics approach
VL  - 150
SP  - 9
EP  - 14
DO  - 10.1016/j.jpba.2017.11.075
ER  - 

@article{
author = "Gođevac, Dejan and Damjanovic, Ana and Stanojković, Tatjana and Anđelković, Boban D. and Zdunić, Gordana",
year = "2018",
abstract = "Herein, we propose a H-1 NMR-based metabolomics method to reveal cytotoxic metabolites from Mahonia aquifolium stem-bark. Primary and secondary metabolites in the Mahonia aquifolium extracts were identified by thorough analysis of H-1 and 2D NMR spectra, without prior isolation. An OPLS multivariate analysis method was used to correlate the chemical composition of the plant extracts with the results of cytotoxic activity against Human cervical adenocarcinoma cell line. Protoberberine alkaloids berberine and palmatine, along with bisbenzylisoquinoline alkaloid berbamine were identified as the most influential in the OPLS model, with the highest cytotoxic activity.",
publisher = "Elsevier",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Identification of cytotoxic metabolites from Mahonia aquifolium using H-1 NMR-based metabolomics approach",
volume = "150",
pages = "9-14",
doi = "10.1016/j.jpba.2017.11.075"
}

Gođevac, D., Damjanovic, A., Stanojković, T., Anđelković, B. D.,& Zdunić, G.. (2018). Identification of cytotoxic metabolites from Mahonia aquifolium using H-1 NMR-based metabolomics approach. in Journal of Pharmaceutical and Biomedical Analysis
Elsevier., 150, 9-14.
https://doi.org/10.1016/j.jpba.2017.11.075

Gođevac D, Damjanovic A, Stanojković T, Anđelković BD, Zdunić G. Identification of cytotoxic metabolites from Mahonia aquifolium using H-1 NMR-based metabolomics approach. in Journal of Pharmaceutical and Biomedical Analysis. 2018;150:9-14.
doi:10.1016/j.jpba.2017.11.075 .

Gođevac, Dejan, Damjanovic, Ana, Stanojković, Tatjana, Anđelković, Boban D., Zdunić, Gordana, "Identification of cytotoxic metabolites from Mahonia aquifolium using H-1 NMR-based metabolomics approach" in Journal of Pharmaceutical and Biomedical Analysis, 150 (2018):9-14,
https://doi.org/10.1016/j.jpba.2017.11.075 . .

TY  - JOUR
AU  - Jovanovic, Aleksandra A.
AU  - Dordevic, Verica B.
AU  - Zdunić, Gordana
AU  - Pljevljakusic, Dejan
AU  - Savikin, Katarina P.
AU  - Gođevac, Dejan
AU  - Bugarski, Branko
PY  - 2017
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2217
AB  - Despite the fact that Thymus serpyllum is well-known medicinal plant and its chemical profile and biological activity have been investigated, there is no detailed study regarding the influence of different techniques and conditions on the extraction of polyphenolic compounds from Serpylli herba. The aim of this study was optimization of the extraction parameters that improves the efficiency of polyphenols extraction from T. serpyllum: particle size, solid-to-solvent ratio, solvent type and extraction time, by using maceration, heat- and ultrasound-assisted extraction (HAE and UAE). The extraction efficiency was expressed via total polyphenol content (TPC) and total flavonoid content (TFC). The statistical analysis (one-way ANOVA and full factorial design) has revealed that the optimal conditions for achieving the best polyphenols yield were particle size of 0.3 mm, 1:30 solid-to-solvent ratio and 50% ethanol, as environmentally friendly extraction medium, while extraction time has not shown statistically significant influence on polyphenols concentration, in all procedures. Under these conditions, the measured TPC was 26.6 mg GAE/L in maceration, 29.8 mg GAE/L in HAE and 32.7 mg GAE/L in UAE, which was in agreement with the predicted values, while TFC was 143 mg CE/L, 12.4 mg CE/L and 16.7 mg CE/L for maceration, HAE and UAE, respectively. According to total polyphenols yield, the efficiency of the extraction methods for all variables was ranked by significance in the following order: UAE > HAE > maceration, whereas total flavonoids yield was the highest in UAE, although there was no statistically significant difference between maceration and HAE. According to our results, UAE could be selected as the most successful and suitable technique for extraction of bioactive polyphenolic compounds from Serpylli herba. Using LC/MS and HPLC analysis, 9 polyphenolic compounds were identified and quantified: 6,8-Di-C-glucosylapigenin, chlorogenic acid, 6-hydroxyluteolin 7-O-glucoside, caffeic acid, luteolin 7-O-glucuronide, apigenin glucuronide, salvianolic acid g isomer, rosmarinic acid and salvianolic acid I. This study was an initial step in production of polyphenols-rich wild thyme extracts aimed to be used for formulation of foodstuffs and medicines.
PB  - Elsevier
T2  - Separation and Purification Technology
T1  - Optimization of the extraction process of polyphenols from Thymus serpyllum L. herb using maceration, heat- and ultrasound-assisted techniques
VL  - 179
SP  - 369
EP  - 380
DO  - 10.1016/j.seppur.2017.01.055
ER  - 

@article{
author = "Jovanovic, Aleksandra A. and Dordevic, Verica B. and Zdunić, Gordana and Pljevljakusic, Dejan and Savikin, Katarina P. and Gođevac, Dejan and Bugarski, Branko",
year = "2017",
abstract = "Despite the fact that Thymus serpyllum is well-known medicinal plant and its chemical profile and biological activity have been investigated, there is no detailed study regarding the influence of different techniques and conditions on the extraction of polyphenolic compounds from Serpylli herba. The aim of this study was optimization of the extraction parameters that improves the efficiency of polyphenols extraction from T. serpyllum: particle size, solid-to-solvent ratio, solvent type and extraction time, by using maceration, heat- and ultrasound-assisted extraction (HAE and UAE). The extraction efficiency was expressed via total polyphenol content (TPC) and total flavonoid content (TFC). The statistical analysis (one-way ANOVA and full factorial design) has revealed that the optimal conditions for achieving the best polyphenols yield were particle size of 0.3 mm, 1:30 solid-to-solvent ratio and 50% ethanol, as environmentally friendly extraction medium, while extraction time has not shown statistically significant influence on polyphenols concentration, in all procedures. Under these conditions, the measured TPC was 26.6 mg GAE/L in maceration, 29.8 mg GAE/L in HAE and 32.7 mg GAE/L in UAE, which was in agreement with the predicted values, while TFC was 143 mg CE/L, 12.4 mg CE/L and 16.7 mg CE/L for maceration, HAE and UAE, respectively. According to total polyphenols yield, the efficiency of the extraction methods for all variables was ranked by significance in the following order: UAE > HAE > maceration, whereas total flavonoids yield was the highest in UAE, although there was no statistically significant difference between maceration and HAE. According to our results, UAE could be selected as the most successful and suitable technique for extraction of bioactive polyphenolic compounds from Serpylli herba. Using LC/MS and HPLC analysis, 9 polyphenolic compounds were identified and quantified: 6,8-Di-C-glucosylapigenin, chlorogenic acid, 6-hydroxyluteolin 7-O-glucoside, caffeic acid, luteolin 7-O-glucuronide, apigenin glucuronide, salvianolic acid g isomer, rosmarinic acid and salvianolic acid I. This study was an initial step in production of polyphenols-rich wild thyme extracts aimed to be used for formulation of foodstuffs and medicines.",
publisher = "Elsevier",
journal = "Separation and Purification Technology",
title = "Optimization of the extraction process of polyphenols from Thymus serpyllum L. herb using maceration, heat- and ultrasound-assisted techniques",
volume = "179",
pages = "369-380",
doi = "10.1016/j.seppur.2017.01.055"
}

Jovanovic, A. A., Dordevic, V. B., Zdunić, G., Pljevljakusic, D., Savikin, K. P., Gođevac, D.,& Bugarski, B.. (2017). Optimization of the extraction process of polyphenols from Thymus serpyllum L. herb using maceration, heat- and ultrasound-assisted techniques. in Separation and Purification Technology
Elsevier., 179, 369-380.
https://doi.org/10.1016/j.seppur.2017.01.055

Jovanovic AA, Dordevic VB, Zdunić G, Pljevljakusic D, Savikin KP, Gođevac D, Bugarski B. Optimization of the extraction process of polyphenols from Thymus serpyllum L. herb using maceration, heat- and ultrasound-assisted techniques. in Separation and Purification Technology. 2017;179:369-380.
doi:10.1016/j.seppur.2017.01.055 .

Jovanovic, Aleksandra A., Dordevic, Verica B., Zdunić, Gordana, Pljevljakusic, Dejan, Savikin, Katarina P., Gođevac, Dejan, Bugarski, Branko, "Optimization of the extraction process of polyphenols from Thymus serpyllum L. herb using maceration, heat- and ultrasound-assisted techniques" in Separation and Purification Technology, 179 (2017):369-380,
https://doi.org/10.1016/j.seppur.2017.01.055 . .

TY  - JOUR
AU  - Jovanovic, Aleksandra A.
AU  - Dordevic, Verica B.
AU  - Zdunić, Gordana
AU  - Pljevljakusic, Dejan
AU  - Savikin, Katarina P.
AU  - Gođevac, Dejan
AU  - Bugarski, Branko
PY  - 2017
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3005
AB  - Despite the fact that Thymus serpyllum is well-known medicinal plant and its chemical profile and biological activity have been investigated, there is no detailed study regarding the influence of different techniques and conditions on the extraction of polyphenolic compounds from Serpylli herba. The aim of this study was optimization of the extraction parameters that improves the efficiency of polyphenols extraction from T. serpyllum: particle size, solid-to-solvent ratio, solvent type and extraction time, by using maceration, heat- and ultrasound-assisted extraction (HAE and UAE). The extraction efficiency was expressed via total polyphenol content (TPC) and total flavonoid content (TFC). The statistical analysis (one-way ANOVA and full factorial design) has revealed that the optimal conditions for achieving the best polyphenols yield were particle size of 0.3 mm, 1:30 solid-to-solvent ratio and 50% ethanol, as environmentally friendly extraction medium, while extraction time has not shown statistically significant influence on polyphenols concentration, in all procedures. Under these conditions, the measured TPC was 26.6 mg GAE/L in maceration, 29.8 mg GAE/L in HAE and 32.7 mg GAE/L in UAE, which was in agreement with the predicted values, while TFC was 143 mg CE/L, 12.4 mg CE/L and 16.7 mg CE/L for maceration, HAE and UAE, respectively. According to total polyphenols yield, the efficiency of the extraction methods for all variables was ranked by significance in the following order: UAE > HAE > maceration, whereas total flavonoids yield was the highest in UAE, although there was no statistically significant difference between maceration and HAE. According to our results, UAE could be selected as the most successful and suitable technique for extraction of bioactive polyphenolic compounds from Serpylli herba. Using LC/MS and HPLC analysis, 9 polyphenolic compounds were identified and quantified: 6,8-Di-C-glucosylapigenin, chlorogenic acid, 6-hydroxyluteolin 7-O-glucoside, caffeic acid, luteolin 7-O-glucuronide, apigenin glucuronide, salvianolic acid g isomer, rosmarinic acid and salvianolic acid I. This study was an initial step in production of polyphenols-rich wild thyme extracts aimed to be used for formulation of foodstuffs and medicines.
PB  - Elsevier
T2  - Separation and Purification Technology
T1  - Optimization of the extraction process of polyphenols from Thymus serpyllum L. herb using maceration, heat- and ultrasound-assisted techniques
VL  - 179
SP  - 369
EP  - 380
DO  - 10.1016/j.seppur.2017.01.055
ER  - 

@article{
author = "Jovanovic, Aleksandra A. and Dordevic, Verica B. and Zdunić, Gordana and Pljevljakusic, Dejan and Savikin, Katarina P. and Gođevac, Dejan and Bugarski, Branko",
year = "2017",
abstract = "Despite the fact that Thymus serpyllum is well-known medicinal plant and its chemical profile and biological activity have been investigated, there is no detailed study regarding the influence of different techniques and conditions on the extraction of polyphenolic compounds from Serpylli herba. The aim of this study was optimization of the extraction parameters that improves the efficiency of polyphenols extraction from T. serpyllum: particle size, solid-to-solvent ratio, solvent type and extraction time, by using maceration, heat- and ultrasound-assisted extraction (HAE and UAE). The extraction efficiency was expressed via total polyphenol content (TPC) and total flavonoid content (TFC). The statistical analysis (one-way ANOVA and full factorial design) has revealed that the optimal conditions for achieving the best polyphenols yield were particle size of 0.3 mm, 1:30 solid-to-solvent ratio and 50% ethanol, as environmentally friendly extraction medium, while extraction time has not shown statistically significant influence on polyphenols concentration, in all procedures. Under these conditions, the measured TPC was 26.6 mg GAE/L in maceration, 29.8 mg GAE/L in HAE and 32.7 mg GAE/L in UAE, which was in agreement with the predicted values, while TFC was 143 mg CE/L, 12.4 mg CE/L and 16.7 mg CE/L for maceration, HAE and UAE, respectively. According to total polyphenols yield, the efficiency of the extraction methods for all variables was ranked by significance in the following order: UAE > HAE > maceration, whereas total flavonoids yield was the highest in UAE, although there was no statistically significant difference between maceration and HAE. According to our results, UAE could be selected as the most successful and suitable technique for extraction of bioactive polyphenolic compounds from Serpylli herba. Using LC/MS and HPLC analysis, 9 polyphenolic compounds were identified and quantified: 6,8-Di-C-glucosylapigenin, chlorogenic acid, 6-hydroxyluteolin 7-O-glucoside, caffeic acid, luteolin 7-O-glucuronide, apigenin glucuronide, salvianolic acid g isomer, rosmarinic acid and salvianolic acid I. This study was an initial step in production of polyphenols-rich wild thyme extracts aimed to be used for formulation of foodstuffs and medicines.",
publisher = "Elsevier",
journal = "Separation and Purification Technology",
title = "Optimization of the extraction process of polyphenols from Thymus serpyllum L. herb using maceration, heat- and ultrasound-assisted techniques",
volume = "179",
pages = "369-380",
doi = "10.1016/j.seppur.2017.01.055"
}

Jovanovic, A. A., Dordevic, V. B., Zdunić, G., Pljevljakusic, D., Savikin, K. P., Gođevac, D.,& Bugarski, B.. (2017). Optimization of the extraction process of polyphenols from Thymus serpyllum L. herb using maceration, heat- and ultrasound-assisted techniques. in Separation and Purification Technology
Elsevier., 179, 369-380.
https://doi.org/10.1016/j.seppur.2017.01.055

Jovanovic AA, Dordevic VB, Zdunić G, Pljevljakusic D, Savikin KP, Gođevac D, Bugarski B. Optimization of the extraction process of polyphenols from Thymus serpyllum L. herb using maceration, heat- and ultrasound-assisted techniques. in Separation and Purification Technology. 2017;179:369-380.
doi:10.1016/j.seppur.2017.01.055 .

Jovanovic, Aleksandra A., Dordevic, Verica B., Zdunić, Gordana, Pljevljakusic, Dejan, Savikin, Katarina P., Gođevac, Dejan, Bugarski, Branko, "Optimization of the extraction process of polyphenols from Thymus serpyllum L. herb using maceration, heat- and ultrasound-assisted techniques" in Separation and Purification Technology, 179 (2017):369-380,
https://doi.org/10.1016/j.seppur.2017.01.055 . .

TY  - JOUR
AU  - Zdunić, Gordana
AU  - Gođevac, Dejan
AU  - Savikin, Katarina
AU  - Petrovic, Silvana
PY  - 2017
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2118
AB  - A comparative analysis of the phenolic compounds in the 70% EtOH extracts of Hypericum acutum, H. androsaemum, H. barbatum, H hirsutum, H maculatum, and H richeri has been carried out using high-performance liquid chromatography coupled with photodiode array UV detection and high resolution TOF mass spectrometry. Quercetin, astilbin, I3,II8-biapigenin, orientin, 2"-O-acetylorientin, three phenolcarboxylic acids, and eight flavonols 3-O-glycosides were identified in the extracts on the basis of their on-line UV spectra, accurate mass spectral data, and in comparison of retention times with those from the standards. Fingerprint analysis of the extracts revealed significant differences in the qualitative and quantitative chemical composition of the studied species. Antioxidant assays with various reaction mechanisms were used including ferric reducing antioxidant power (FRAP) assay, DPPH, ABTS, superoxide anion radical scavenging capacity and inhibition of liposome peroxidation induced by Fe2+. The most potent were extracts of H acutum and H maculatum indicating this Hypericum species interesting for further research aimed as a potentially new source of biologically active compounds.
PB  - Natural Product Incorporation
T2  - Natural Product Communications
T1  - Comparative Analysis of Phenolic Compounds in Seven Hypericum Species and Their Antioxidant Properties
VL  - 12
IS  - 11
SP  - 1805
EP  - 1811
DO  - 10.1177/1934578X1701201140
ER  - 

@article{
author = "Zdunić, Gordana and Gođevac, Dejan and Savikin, Katarina and Petrovic, Silvana",
year = "2017",
abstract = "A comparative analysis of the phenolic compounds in the 70% EtOH extracts of Hypericum acutum, H. androsaemum, H. barbatum, H hirsutum, H maculatum, and H richeri has been carried out using high-performance liquid chromatography coupled with photodiode array UV detection and high resolution TOF mass spectrometry. Quercetin, astilbin, I3,II8-biapigenin, orientin, 2"-O-acetylorientin, three phenolcarboxylic acids, and eight flavonols 3-O-glycosides were identified in the extracts on the basis of their on-line UV spectra, accurate mass spectral data, and in comparison of retention times with those from the standards. Fingerprint analysis of the extracts revealed significant differences in the qualitative and quantitative chemical composition of the studied species. Antioxidant assays with various reaction mechanisms were used including ferric reducing antioxidant power (FRAP) assay, DPPH, ABTS, superoxide anion radical scavenging capacity and inhibition of liposome peroxidation induced by Fe2+. The most potent were extracts of H acutum and H maculatum indicating this Hypericum species interesting for further research aimed as a potentially new source of biologically active compounds.",
publisher = "Natural Product Incorporation",
journal = "Natural Product Communications",
title = "Comparative Analysis of Phenolic Compounds in Seven Hypericum Species and Their Antioxidant Properties",
volume = "12",
number = "11",
pages = "1805-1811",
doi = "10.1177/1934578X1701201140"
}

Zdunić, G., Gođevac, D., Savikin, K.,& Petrovic, S.. (2017). Comparative Analysis of Phenolic Compounds in Seven Hypericum Species and Their Antioxidant Properties. in Natural Product Communications
Natural Product Incorporation., 12(11), 1805-1811.
https://doi.org/10.1177/1934578X1701201140

Zdunić G, Gođevac D, Savikin K, Petrovic S. Comparative Analysis of Phenolic Compounds in Seven Hypericum Species and Their Antioxidant Properties. in Natural Product Communications. 2017;12(11):1805-1811.
doi:10.1177/1934578X1701201140 .

Zdunić, Gordana, Gođevac, Dejan, Savikin, Katarina, Petrovic, Silvana, "Comparative Analysis of Phenolic Compounds in Seven Hypericum Species and Their Antioxidant Properties" in Natural Product Communications, 12, no. 11 (2017):1805-1811,
https://doi.org/10.1177/1934578X1701201140 . .

TY  - JOUR
AU  - Damjanovic, Ana
AU  - Zdunić, Gordana
AU  - Savikin, Katarina
AU  - Mandić, Boris
AU  - Jadranin, Milka
AU  - Matić, Ivana Z.
AU  - Stanojković, Tatjana
PY  - 2016
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1901
AB  - The cytotoxicity of Mahonia aquifolium ethanol and water extracts was examined using MTT test. The morphological changes were analyzed by fluorescence microscopy. Cell cycle distribution and possible activation of caspase-dependent pathway of cell death were assessed by flow cytometry. The effects of ethanol and water extracts on migration of endothelial EA. hy926 cells were analyzed by in vitro scratch assay and inhibition of angiogenesis was detected using tube formation assay. Both extracts demonstrated cytotoxic effects on cancer cell lines with very high selectivity. Morphological evaluation indicated apoptosis. These results were confirmed with cell cycle analysis, where there was accumulation of cancer cells in the subG1 phase. Ethanol and water extracts induced a caspase-dependent apoptosis in HeLa cells through activation of caspase-3 and caspase-8. Both extracts showed the ability to inbibit the migration of EA. hy926 cells and initial steps of angiogenesis. In addition, ethanol extract exerted significant anti-angiogenic effect.
PB  - Bangladesh Pharmacological Soc, Shahbah
T2  - Bangladesh Journal of Pharmacology
T1  - Evaluation of the anti-cancer potential of Mahonia aquifolium extracts via apoptosis and anti-angiogenesis
VL  - 11
IS  - 3
SP  - 741
EP  - 749
DO  - 10.3329/bjp.v11i3.27103
ER  - 

@article{
author = "Damjanovic, Ana and Zdunić, Gordana and Savikin, Katarina and Mandić, Boris and Jadranin, Milka and Matić, Ivana Z. and Stanojković, Tatjana",
year = "2016",
abstract = "The cytotoxicity of Mahonia aquifolium ethanol and water extracts was examined using MTT test. The morphological changes were analyzed by fluorescence microscopy. Cell cycle distribution and possible activation of caspase-dependent pathway of cell death were assessed by flow cytometry. The effects of ethanol and water extracts on migration of endothelial EA. hy926 cells were analyzed by in vitro scratch assay and inhibition of angiogenesis was detected using tube formation assay. Both extracts demonstrated cytotoxic effects on cancer cell lines with very high selectivity. Morphological evaluation indicated apoptosis. These results were confirmed with cell cycle analysis, where there was accumulation of cancer cells in the subG1 phase. Ethanol and water extracts induced a caspase-dependent apoptosis in HeLa cells through activation of caspase-3 and caspase-8. Both extracts showed the ability to inbibit the migration of EA. hy926 cells and initial steps of angiogenesis. In addition, ethanol extract exerted significant anti-angiogenic effect.",
publisher = "Bangladesh Pharmacological Soc, Shahbah",
journal = "Bangladesh Journal of Pharmacology",
title = "Evaluation of the anti-cancer potential of Mahonia aquifolium extracts via apoptosis and anti-angiogenesis",
volume = "11",
number = "3",
pages = "741-749",
doi = "10.3329/bjp.v11i3.27103"
}

Damjanovic, A., Zdunić, G., Savikin, K., Mandić, B., Jadranin, M., Matić, I. Z.,& Stanojković, T.. (2016). Evaluation of the anti-cancer potential of Mahonia aquifolium extracts via apoptosis and anti-angiogenesis. in Bangladesh Journal of Pharmacology
Bangladesh Pharmacological Soc, Shahbah., 11(3), 741-749.
https://doi.org/10.3329/bjp.v11i3.27103

Damjanovic A, Zdunić G, Savikin K, Mandić B, Jadranin M, Matić IZ, Stanojković T. Evaluation of the anti-cancer potential of Mahonia aquifolium extracts via apoptosis and anti-angiogenesis. in Bangladesh Journal of Pharmacology. 2016;11(3):741-749.
doi:10.3329/bjp.v11i3.27103 .

Damjanovic, Ana, Zdunić, Gordana, Savikin, Katarina, Mandić, Boris, Jadranin, Milka, Matić, Ivana Z., Stanojković, Tatjana, "Evaluation of the anti-cancer potential of Mahonia aquifolium extracts via apoptosis and anti-angiogenesis" in Bangladesh Journal of Pharmacology, 11, no. 3 (2016):741-749,
https://doi.org/10.3329/bjp.v11i3.27103 . .

TY  - JOUR
AU  - Živković, Jelena Č.
AU  - Savikin, Katarina
AU  - Zdunić, Gordana
AU  - Dojčinović, Biljana
AU  - Menković, Nebojša
PY  - 2016
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1873
AB  - The aim of this study was the determination of phenolic compounds, and mineral nutrients in the pulp and peel obtained from Balkan indigenous apple and pear cultivars. The phenolic composition, assessed by HPLC-DAD and spectrophotometric methods varied significantly between the cultivars for both peel and pulp. Among the apples, the Mekica cultivar had the highest total phenolic content while Secerlija and Zlatna Parmenka had the lowest. In the case of the pear samples, the maximum total phenolic content was found in Crna Takisa while the minimum content was recorded for Bela Arapka. In most of the investigated samples, chlorogenic acid in apples and arbutin in pears were the major detected polyphenolic compounds. With regard to the mineral analysis, K was the most abundant followed by P, Mg, Ca and S. Iron was the dominant microelement in apple peel and pulp samples, while in pear samples the principal microelement was B. The obtained results provide detailed information on the chemical composition of the tested apple and pear cultivars and thereby, could encourage their wider cultivation and consumption.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Phenolic and mineral profile of Balkan indigenous apple and pear cultivars
VL  - 81
IS  - 6
SP  - 607
EP  - 621
DO  - 10.2298/JSC151026023Z
ER  - 

@article{
author = "Živković, Jelena Č. and Savikin, Katarina and Zdunić, Gordana and Dojčinović, Biljana and Menković, Nebojša",
year = "2016",
abstract = "The aim of this study was the determination of phenolic compounds, and mineral nutrients in the pulp and peel obtained from Balkan indigenous apple and pear cultivars. The phenolic composition, assessed by HPLC-DAD and spectrophotometric methods varied significantly between the cultivars for both peel and pulp. Among the apples, the Mekica cultivar had the highest total phenolic content while Secerlija and Zlatna Parmenka had the lowest. In the case of the pear samples, the maximum total phenolic content was found in Crna Takisa while the minimum content was recorded for Bela Arapka. In most of the investigated samples, chlorogenic acid in apples and arbutin in pears were the major detected polyphenolic compounds. With regard to the mineral analysis, K was the most abundant followed by P, Mg, Ca and S. Iron was the dominant microelement in apple peel and pulp samples, while in pear samples the principal microelement was B. The obtained results provide detailed information on the chemical composition of the tested apple and pear cultivars and thereby, could encourage their wider cultivation and consumption.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Phenolic and mineral profile of Balkan indigenous apple and pear cultivars",
volume = "81",
number = "6",
pages = "607-621",
doi = "10.2298/JSC151026023Z"
}

Živković, J. Č., Savikin, K., Zdunić, G., Dojčinović, B.,& Menković, N.. (2016). Phenolic and mineral profile of Balkan indigenous apple and pear cultivars. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 81(6), 607-621.
https://doi.org/10.2298/JSC151026023Z

Živković JČ, Savikin K, Zdunić G, Dojčinović B, Menković N. Phenolic and mineral profile of Balkan indigenous apple and pear cultivars. in Journal of the Serbian Chemical Society. 2016;81(6):607-621.
doi:10.2298/JSC151026023Z .

Živković, Jelena Č., Savikin, Katarina, Zdunić, Gordana, Dojčinović, Biljana, Menković, Nebojša, "Phenolic and mineral profile of Balkan indigenous apple and pear cultivars" in Journal of the Serbian Chemical Society, 81, no. 6 (2016):607-621,
https://doi.org/10.2298/JSC151026023Z . .

TY  - JOUR
AU  - Zdunić, Gordana
AU  - Menković, Nebojša
AU  - Jadranin, Milka
AU  - Novaković, Miroslav
AU  - Savikin, Katarina P.
AU  - Živković, Jelena Č.
PY  - 2016
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1894
AB  - Pumpkin fruit is used in a diet since ancient times especially in rural communities. The major contributory factors of nutritional and medicinal value of pumpkins are carotenoids, polysaccharides, vitamins, minerals, and phenolic compounds. Due to a very large fruit that it is not easy to consume a whole as well as short shelf-life of fresh-cut pumpkin, different ways of conserving and processing are performed. In our study, total carotenoids, total phenolics and individual phenolics in fresh pumpkin and pumpkin traditional products such as sweet in wine, jam and juice, which are typical for northern parts of Serbia, were studied. Total carotenoids ranged from 27.6 mu g/g of pumpkin sweet in wine to 86.3 mu g/g of fresh fruit, while the amount of total phenolics varied between 93.0 mu g GAE/g of pumpkin juice and 905.9 mu g GAE/g of fresh fruit. Eight phenolic compounds were identified in the investigated samples and among them phenolic acids dominated. Among flavonoids, flavanon glycoside hesperidin was detected.
PB  - Association of Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - Phenolic compounds and carotenoids in pumpkin fruit and related traditional products
VL  - 70
IS  - 4
SP  - 429
EP  - 433
DO  - 10.2298/HEMIND150219049Z
ER  - 

@article{
author = "Zdunić, Gordana and Menković, Nebojša and Jadranin, Milka and Novaković, Miroslav and Savikin, Katarina P. and Živković, Jelena Č.",
year = "2016",
abstract = "Pumpkin fruit is used in a diet since ancient times especially in rural communities. The major contributory factors of nutritional and medicinal value of pumpkins are carotenoids, polysaccharides, vitamins, minerals, and phenolic compounds. Due to a very large fruit that it is not easy to consume a whole as well as short shelf-life of fresh-cut pumpkin, different ways of conserving and processing are performed. In our study, total carotenoids, total phenolics and individual phenolics in fresh pumpkin and pumpkin traditional products such as sweet in wine, jam and juice, which are typical for northern parts of Serbia, were studied. Total carotenoids ranged from 27.6 mu g/g of pumpkin sweet in wine to 86.3 mu g/g of fresh fruit, while the amount of total phenolics varied between 93.0 mu g GAE/g of pumpkin juice and 905.9 mu g GAE/g of fresh fruit. Eight phenolic compounds were identified in the investigated samples and among them phenolic acids dominated. Among flavonoids, flavanon glycoside hesperidin was detected.",
publisher = "Association of Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "Phenolic compounds and carotenoids in pumpkin fruit and related traditional products",
volume = "70",
number = "4",
pages = "429-433",
doi = "10.2298/HEMIND150219049Z"
}

Zdunić, G., Menković, N., Jadranin, M., Novaković, M., Savikin, K. P.,& Živković, J. Č.. (2016). Phenolic compounds and carotenoids in pumpkin fruit and related traditional products. in Hemijska industrija
Association of Chemical Engineers of Serbia., 70(4), 429-433.
https://doi.org/10.2298/HEMIND150219049Z

Zdunić G, Menković N, Jadranin M, Novaković M, Savikin KP, Živković JČ. Phenolic compounds and carotenoids in pumpkin fruit and related traditional products. in Hemijska industrija. 2016;70(4):429-433.
doi:10.2298/HEMIND150219049Z .

Zdunić, Gordana, Menković, Nebojša, Jadranin, Milka, Novaković, Miroslav, Savikin, Katarina P., Živković, Jelena Č., "Phenolic compounds and carotenoids in pumpkin fruit and related traditional products" in Hemijska industrija, 70, no. 4 (2016):429-433,
https://doi.org/10.2298/HEMIND150219049Z . .

TY  - JOUR
AU  - Živković, Jelena Č.
AU  - Savikin, Katarina
AU  - Zdunić, Gordana
AU  - Gođevac, Dejan
AU  - Marković, Nebojsa
AU  - Pržić, Zoran
AU  - Menković, Nebojša
PY  - 2016
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1940
AB  - Wine quality depends mainly on the characteristics of the grape it is made of, and one of the attributes affecting wine composition is cluster and berry morphology. The aim of this study was to represent variability of the morphological characteristics between different clones of the autochthonous grape variety Prokupac and to perform chemical evaluation of wines obtained from them. Total phenolic content was generally low and it ranged from 33.0 to 114.5 mg GAE/100 mL. Six main anthocyanin compounds including malvidin as the main anthocyanidin were detected. Malvidin 3-O-glucoside was the most abundant anthocyanin with concentration of 59.8 to 101.7 mu g/mL. Clones 43/5 and 43/4 yielded highest quality wines. According to the results, clonal selection makes a significant difference in Prokupac wine quality. On the other hand, there is a minor dependance of wine quality parameters to variation in morphological attributes of clusters and berries (bunch weight, proportion of stem, berry and seed weight, skin, pulp and seed weight per berry).
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Influence of bunch morphology on quality of wines produced from clones of grape variety Prokupac
VL  - 81
IS  - 8
SP  - 883
EP  - 896
DO  - 10.2298/JSC151114033Z
ER  - 

@article{
author = "Živković, Jelena Č. and Savikin, Katarina and Zdunić, Gordana and Gođevac, Dejan and Marković, Nebojsa and Pržić, Zoran and Menković, Nebojša",
year = "2016",
abstract = "Wine quality depends mainly on the characteristics of the grape it is made of, and one of the attributes affecting wine composition is cluster and berry morphology. The aim of this study was to represent variability of the morphological characteristics between different clones of the autochthonous grape variety Prokupac and to perform chemical evaluation of wines obtained from them. Total phenolic content was generally low and it ranged from 33.0 to 114.5 mg GAE/100 mL. Six main anthocyanin compounds including malvidin as the main anthocyanidin were detected. Malvidin 3-O-glucoside was the most abundant anthocyanin with concentration of 59.8 to 101.7 mu g/mL. Clones 43/5 and 43/4 yielded highest quality wines. According to the results, clonal selection makes a significant difference in Prokupac wine quality. On the other hand, there is a minor dependance of wine quality parameters to variation in morphological attributes of clusters and berries (bunch weight, proportion of stem, berry and seed weight, skin, pulp and seed weight per berry).",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Influence of bunch morphology on quality of wines produced from clones of grape variety Prokupac",
volume = "81",
number = "8",
pages = "883-896",
doi = "10.2298/JSC151114033Z"
}

Živković, J. Č., Savikin, K., Zdunić, G., Gođevac, D., Marković, N., Pržić, Z.,& Menković, N.. (2016). Influence of bunch morphology on quality of wines produced from clones of grape variety Prokupac. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 81(8), 883-896.
https://doi.org/10.2298/JSC151114033Z

Živković JČ, Savikin K, Zdunić G, Gođevac D, Marković N, Pržić Z, Menković N. Influence of bunch morphology on quality of wines produced from clones of grape variety Prokupac. in Journal of the Serbian Chemical Society. 2016;81(8):883-896.
doi:10.2298/JSC151114033Z .

Živković, Jelena Č., Savikin, Katarina, Zdunić, Gordana, Gođevac, Dejan, Marković, Nebojsa, Pržić, Zoran, Menković, Nebojša, "Influence of bunch morphology on quality of wines produced from clones of grape variety Prokupac" in Journal of the Serbian Chemical Society, 81, no. 8 (2016):883-896,
https://doi.org/10.2298/JSC151114033Z . .

TY  - JOUR
AU  - Savikin, Katarina
AU  - Zdunić, Gordana
AU  - Janković, Teodora
AU  - Gođevac, Dejan
AU  - Stanojković, Tatjana
AU  - Pljevljakusic, Dejan
PY  - 2014
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1584
AB  - A detailed phenolic composition analysis of dry chokeberry, bilberry and black currant fruit teas prepared on the most common ways-decoction and infusion, was performed, together with evaluation of cytotoxic activity. The most abundant in phenolics were chokeberry teas, followed by bilberry and black currant teas, while the highest anthocyanin amount was determined in bilberry samples. LC/DAD/MS method was used for identification of 17 anthocyanins, 11 flavonoids and 4 hydroxycinnamic acid derivatives. Quantitative analysis of investigated teas was carried out by HPLC analysis, and major phenolic compounds in berry fruit teas were chlorogenic acids, quercetin glycosides and anthocyanin glycosides. Berry teas were investigated for cytotoxic activity against cervix carcinoma, melanoma, colon, and chronic myelogenous leukemia cell lines, and chokebeny decoction was the most effective against all cell lines. According to the results obtained in this study, pure chokeberry, bilberry and black currant teas could be valuable sources of flavonoids and anthocyanins.
PB  - Elsevier
T2  - Food Research International
T1  - Berry fruit teas: Phenolic composition and cytotoxic activity
VL  - 62
SP  - 677
EP  - 683
DO  - 10.1016/j.foodres.2014.04.017
ER  - 

@article{
author = "Savikin, Katarina and Zdunić, Gordana and Janković, Teodora and Gođevac, Dejan and Stanojković, Tatjana and Pljevljakusic, Dejan",
year = "2014",
abstract = "A detailed phenolic composition analysis of dry chokeberry, bilberry and black currant fruit teas prepared on the most common ways-decoction and infusion, was performed, together with evaluation of cytotoxic activity. The most abundant in phenolics were chokeberry teas, followed by bilberry and black currant teas, while the highest anthocyanin amount was determined in bilberry samples. LC/DAD/MS method was used for identification of 17 anthocyanins, 11 flavonoids and 4 hydroxycinnamic acid derivatives. Quantitative analysis of investigated teas was carried out by HPLC analysis, and major phenolic compounds in berry fruit teas were chlorogenic acids, quercetin glycosides and anthocyanin glycosides. Berry teas were investigated for cytotoxic activity against cervix carcinoma, melanoma, colon, and chronic myelogenous leukemia cell lines, and chokebeny decoction was the most effective against all cell lines. According to the results obtained in this study, pure chokeberry, bilberry and black currant teas could be valuable sources of flavonoids and anthocyanins.",
publisher = "Elsevier",
journal = "Food Research International",
title = "Berry fruit teas: Phenolic composition and cytotoxic activity",
volume = "62",
pages = "677-683",
doi = "10.1016/j.foodres.2014.04.017"
}

Savikin, K., Zdunić, G., Janković, T., Gođevac, D., Stanojković, T.,& Pljevljakusic, D.. (2014). Berry fruit teas: Phenolic composition and cytotoxic activity. in Food Research International
Elsevier., 62, 677-683.
https://doi.org/10.1016/j.foodres.2014.04.017

Savikin K, Zdunić G, Janković T, Gođevac D, Stanojković T, Pljevljakusic D. Berry fruit teas: Phenolic composition and cytotoxic activity. in Food Research International. 2014;62:677-683.
doi:10.1016/j.foodres.2014.04.017 .

Savikin, Katarina, Zdunić, Gordana, Janković, Teodora, Gođevac, Dejan, Stanojković, Tatjana, Pljevljakusic, Dejan, "Berry fruit teas: Phenolic composition and cytotoxic activity" in Food Research International, 62 (2014):677-683,
https://doi.org/10.1016/j.foodres.2014.04.017 . .

TY  - JOUR
AU  - Savikin, Katarina
AU  - Živković, Jelena Č.
AU  - Zdunić, Gordana
AU  - Gođevac, Dejan
AU  - Dordevic, Boban
AU  - Dojčinović, Biljana
AU  - Đorđević, Neda O.
PY  - 2014
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1396
AB  - Some primary and secondary metabolites, as well as mineral nutrients in pulp, peel and juice obtained from four Serbian indigenous apple cultivars (Kozara, Kolacara, Budimka and.Sumatovka) collected at two different developmental stages were studied. With advanced maturation soluble solids content, total and reducing sugars increased, while L-ascorbic acid content and titratable acidity decreased. Thirteen phenolic compounds were quantified using LC-MS/MS. The total phenolic content (TPC) ranged from 9.37 to 1440 mg/100 g fw, and 0.83 to 7.84 mg/100 g fw in peel and pulp samples, respectively. Quercetin derivatives were the major detected polyphenolic group. Majority of determined phenolic compounds were influenced by cultivar and the best sources were cultivars Kolgara and Budimka. The content of flavonols (with the exception of quercitrin) varied significantly depending on maturity at harvest. With regard to mineral analysis, K was the most abundant ranging from 104 to 158 mg/100 g fw in peel, 74.4 to 93.3 mg/100 g fw in pulp, and 77.1 to 91.5 mg/100 g fw in juice samples. Obtained results provide detailed information on nutritional potential and chemical composition of tested apple cultivars and thereby could encourage their wider cultivation and consumption
PB  - Academic Press Inc.
T2  - Journal of Food Composition and Analysis
T1  - Phenolic and mineral profiles of four Balkan indigenous apple cultivars monitored at two different maturity stages
VL  - 35
IS  - 2
SP  - 101
EP  - 111
DO  - 10.1016/j.jfca.2014.05.004
ER  - 

@article{
author = "Savikin, Katarina and Živković, Jelena Č. and Zdunić, Gordana and Gođevac, Dejan and Dordevic, Boban and Dojčinović, Biljana and Đorđević, Neda O.",
year = "2014",
abstract = "Some primary and secondary metabolites, as well as mineral nutrients in pulp, peel and juice obtained from four Serbian indigenous apple cultivars (Kozara, Kolacara, Budimka and.Sumatovka) collected at two different developmental stages were studied. With advanced maturation soluble solids content, total and reducing sugars increased, while L-ascorbic acid content and titratable acidity decreased. Thirteen phenolic compounds were quantified using LC-MS/MS. The total phenolic content (TPC) ranged from 9.37 to 1440 mg/100 g fw, and 0.83 to 7.84 mg/100 g fw in peel and pulp samples, respectively. Quercetin derivatives were the major detected polyphenolic group. Majority of determined phenolic compounds were influenced by cultivar and the best sources were cultivars Kolgara and Budimka. The content of flavonols (with the exception of quercitrin) varied significantly depending on maturity at harvest. With regard to mineral analysis, K was the most abundant ranging from 104 to 158 mg/100 g fw in peel, 74.4 to 93.3 mg/100 g fw in pulp, and 77.1 to 91.5 mg/100 g fw in juice samples. Obtained results provide detailed information on nutritional potential and chemical composition of tested apple cultivars and thereby could encourage their wider cultivation and consumption",
publisher = "Academic Press Inc.",
journal = "Journal of Food Composition and Analysis",
title = "Phenolic and mineral profiles of four Balkan indigenous apple cultivars monitored at two different maturity stages",
volume = "35",
number = "2",
pages = "101-111",
doi = "10.1016/j.jfca.2014.05.004"
}

Savikin, K., Živković, J. Č., Zdunić, G., Gođevac, D., Dordevic, B., Dojčinović, B.,& Đorđević, N. O.. (2014). Phenolic and mineral profiles of four Balkan indigenous apple cultivars monitored at two different maturity stages. in Journal of Food Composition and Analysis
Academic Press Inc.., 35(2), 101-111.
https://doi.org/10.1016/j.jfca.2014.05.004

Savikin K, Živković JČ, Zdunić G, Gođevac D, Dordevic B, Dojčinović B, Đorđević NO. Phenolic and mineral profiles of four Balkan indigenous apple cultivars monitored at two different maturity stages. in Journal of Food Composition and Analysis. 2014;35(2):101-111.
doi:10.1016/j.jfca.2014.05.004 .

Savikin, Katarina, Živković, Jelena Č., Zdunić, Gordana, Gođevac, Dejan, Dordevic, Boban, Dojčinović, Biljana, Đorđević, Neda O., "Phenolic and mineral profiles of four Balkan indigenous apple cultivars monitored at two different maturity stages" in Journal of Food Composition and Analysis, 35, no. 2 (2014):101-111,
https://doi.org/10.1016/j.jfca.2014.05.004 . .

TY  - JOUR
AU  - Menković, Nebojša
AU  - Živković, Jelena Č.
AU  - Savikin, Katarina
AU  - Gođevac, Dejan
AU  - Zdunić, Gordana
PY  - 2014
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1546
AB  - Phenolic compounds are very important quality parameters of wine because of their impact on colour, taste and health properties. The present study was aimed at evaluating the general phenolic composition and free radical scavenging activity of aqueous and organic fractions obtained using liquid liquid extraction of red wine produced from the Serbian autochthonous grape variety Prokupac. The total phenolic contents in the different fractions ranged from 48.22 to 289.12 mg GAE per g dry fraction. Phenolic acids (mainly hydroxycinnamic acids) and quercetin 3-O-glucuronide were the main components in the EtOAc fraction at pH 2.0; catechins, phenolic acids (mainly hydroxybenzoic acids) and quercetin were found in the EtOAc fraction at pH 7.0, while anthocyanins were identified in the aqueous residue after EtOAc extraction. The major anthocyanin extracted into the aqueous fraction was malvidin-3-glucoside, while the most abundant non-anthocyanin phenolic compounds in the organic fractions were ethyl gallate and trans-caftaric acid. The radical scavenging activities of the fraction differed significantly and the IC50 values were 138.58 mu g mL(-1) for the aqueous fraction, 17.83 and 3.47 ng mL(-1) for the EtOAc fractions at pH 2.0 and 7.0, respectively. As the EtOAc fractions were found to be more potent radical scavengers, it could be assumed that non-anthocyanin phenolic compounds were responsible for such activity in Prokupac wine.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Phenolic composition and free radical scavenging activity of wine produced from the Serbian autochthonous grape variety Prokupac - A model approach
VL  - 79
IS  - 1
SP  - 11
EP  - 24
DO  - 10.2298/JSC130511089M
ER  - 

@article{
author = "Menković, Nebojša and Živković, Jelena Č. and Savikin, Katarina and Gođevac, Dejan and Zdunić, Gordana",
year = "2014",
abstract = "Phenolic compounds are very important quality parameters of wine because of their impact on colour, taste and health properties. The present study was aimed at evaluating the general phenolic composition and free radical scavenging activity of aqueous and organic fractions obtained using liquid liquid extraction of red wine produced from the Serbian autochthonous grape variety Prokupac. The total phenolic contents in the different fractions ranged from 48.22 to 289.12 mg GAE per g dry fraction. Phenolic acids (mainly hydroxycinnamic acids) and quercetin 3-O-glucuronide were the main components in the EtOAc fraction at pH 2.0; catechins, phenolic acids (mainly hydroxybenzoic acids) and quercetin were found in the EtOAc fraction at pH 7.0, while anthocyanins were identified in the aqueous residue after EtOAc extraction. The major anthocyanin extracted into the aqueous fraction was malvidin-3-glucoside, while the most abundant non-anthocyanin phenolic compounds in the organic fractions were ethyl gallate and trans-caftaric acid. The radical scavenging activities of the fraction differed significantly and the IC50 values were 138.58 mu g mL(-1) for the aqueous fraction, 17.83 and 3.47 ng mL(-1) for the EtOAc fractions at pH 2.0 and 7.0, respectively. As the EtOAc fractions were found to be more potent radical scavengers, it could be assumed that non-anthocyanin phenolic compounds were responsible for such activity in Prokupac wine.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Phenolic composition and free radical scavenging activity of wine produced from the Serbian autochthonous grape variety Prokupac - A model approach",
volume = "79",
number = "1",
pages = "11-24",
doi = "10.2298/JSC130511089M"
}

Menković, N., Živković, J. Č., Savikin, K., Gođevac, D.,& Zdunić, G.. (2014). Phenolic composition and free radical scavenging activity of wine produced from the Serbian autochthonous grape variety Prokupac - A model approach. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 79(1), 11-24.
https://doi.org/10.2298/JSC130511089M

Menković N, Živković JČ, Savikin K, Gođevac D, Zdunić G. Phenolic composition and free radical scavenging activity of wine produced from the Serbian autochthonous grape variety Prokupac - A model approach. in Journal of the Serbian Chemical Society. 2014;79(1):11-24.
doi:10.2298/JSC130511089M .

Menković, Nebojša, Živković, Jelena Č., Savikin, Katarina, Gođevac, Dejan, Zdunić, Gordana, "Phenolic composition and free radical scavenging activity of wine produced from the Serbian autochthonous grape variety Prokupac - A model approach" in Journal of the Serbian Chemical Society, 79, no. 1 (2014):11-24,
https://doi.org/10.2298/JSC130511089M . .

TY  - JOUR
AU  - Matić, Ivana Z.
AU  - Juranić, Zorica
AU  - Savikin, Katarina
AU  - Zdunić, Gordana
AU  - Nadvinski, Neva
AU  - Gođevac, Dejan
PY  - 2013
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1338
AB  - With the aim to evaluate the selectivity in the antitumor action, the cytotoxic activity of chamomile and marigold tea was tested against various malignant cell lines and against healthy immunocompetent peripheral blood mononuclear cells (PBMC). Chemical profiles of chamomile and marigold infusions and decoctions were analyzed by liquid chromatography/mass spectrometry; their total phenolic content and radical scavenging activity were determined, too. Results from present research demonstrate that chamomile and marigold tea exert selective dose-dependent cytotoxic action against target cancer cells. It is noteworthy that cytotoxicity of tea prepared from Calendula officinalis is remarkably higher in comparison to that from Matricaria recutita tea. The cytotoxic effect of chamomile tea is very weak to healthy PBMC, while the effect of marigold tea on PBMC is more pronounced. Marigold tea exerts highly selective antitumor effect especially to melanoma Fem-x cells in comparison to the action to normal healthy PBMC. Chemical analyses show that dominant phenolic compounds in examined infusions and decoctions are flavonoid glycosides and hydroxycinnamic acid derivatives. There are no considerable differences in total phenolic content and antioxidant activity between examined infusions. Antitumor potential of chamomile and marigold tea should be further investigated.
PB  - Wiley, Hoboken
T2  - Phytotherapy Research
T1  - Chamomile and Marigold Tea: Chemical Characterization and Evaluation of Anticancer Activity
VL  - 27
IS  - 6
SP  - 852
EP  - 858
DO  - 10.1002/ptr.4807
ER  - 

@article{
author = "Matić, Ivana Z. and Juranić, Zorica and Savikin, Katarina and Zdunić, Gordana and Nadvinski, Neva and Gođevac, Dejan",
year = "2013",
abstract = "With the aim to evaluate the selectivity in the antitumor action, the cytotoxic activity of chamomile and marigold tea was tested against various malignant cell lines and against healthy immunocompetent peripheral blood mononuclear cells (PBMC). Chemical profiles of chamomile and marigold infusions and decoctions were analyzed by liquid chromatography/mass spectrometry; their total phenolic content and radical scavenging activity were determined, too. Results from present research demonstrate that chamomile and marigold tea exert selective dose-dependent cytotoxic action against target cancer cells. It is noteworthy that cytotoxicity of tea prepared from Calendula officinalis is remarkably higher in comparison to that from Matricaria recutita tea. The cytotoxic effect of chamomile tea is very weak to healthy PBMC, while the effect of marigold tea on PBMC is more pronounced. Marigold tea exerts highly selective antitumor effect especially to melanoma Fem-x cells in comparison to the action to normal healthy PBMC. Chemical analyses show that dominant phenolic compounds in examined infusions and decoctions are flavonoid glycosides and hydroxycinnamic acid derivatives. There are no considerable differences in total phenolic content and antioxidant activity between examined infusions. Antitumor potential of chamomile and marigold tea should be further investigated.",
publisher = "Wiley, Hoboken",
journal = "Phytotherapy Research",
title = "Chamomile and Marigold Tea: Chemical Characterization and Evaluation of Anticancer Activity",
volume = "27",
number = "6",
pages = "852-858",
doi = "10.1002/ptr.4807"
}

Matić, I. Z., Juranić, Z., Savikin, K., Zdunić, G., Nadvinski, N.,& Gođevac, D.. (2013). Chamomile and Marigold Tea: Chemical Characterization and Evaluation of Anticancer Activity. in Phytotherapy Research
Wiley, Hoboken., 27(6), 852-858.
https://doi.org/10.1002/ptr.4807

Matić IZ, Juranić Z, Savikin K, Zdunić G, Nadvinski N, Gođevac D. Chamomile and Marigold Tea: Chemical Characterization and Evaluation of Anticancer Activity. in Phytotherapy Research. 2013;27(6):852-858.
doi:10.1002/ptr.4807 .

Matić, Ivana Z., Juranić, Zorica, Savikin, Katarina, Zdunić, Gordana, Nadvinski, Neva, Gođevac, Dejan, "Chamomile and Marigold Tea: Chemical Characterization and Evaluation of Anticancer Activity" in Phytotherapy Research, 27, no. 6 (2013):852-858,
https://doi.org/10.1002/ptr.4807 . .

TY  - JOUR
AU  - Menković, Nebojša
AU  - Gođevac, Dejan
AU  - Savikin, Katarina
AU  - Zdunić, Gordana
AU  - Milosavljević, Slobodan
AU  - Bojadzi, Andon
AU  - Avramoski, Oliver
PY  - 2013
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1333
AB  - Collection of Sideritis raeseri subsp. raeseri has a long tradition in local communities in the Ohrid-Prespa region. The aim of the present study was the analysis of bioactive compounds especially those with anti-inflammatory activity. Combination of the UV and MS data allowed the characterization of 17 compounds, which could be classified into flavonoid glycosides or hydroxycynnamic acid derivatives. Six of them were isolated using preparative HPLC: isoscutellarein 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside, 4'-O-methylhypolaetin 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside, hypolaetin 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-6 ''-O-acetyl-beta-D-glucopyranoside, 4'-O-methylisoscutellarein 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside, isoscutellarein 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-6 ''-O-acetyl-beta-D-glucopyranoside and 4'-O-methylhypolaetin 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-6 ''-O-acetyl-beta-D-glucopyranoside. The presence of phenylpropanoid glycoside martynoside was reported for the first time in the wild growing S. raeseri subsp. raeseri. Hypolaetin derivatives, known for their antiinflammatory activity, dominated and were more abundant in S. raeseri subsp. raeseri grown in NPG in comparison with S. scardica grown nearby the NPG. The type of solvent affected distribution and the amount of bioactive compounds and the advantage was given to less polar extracts which were richer in hypolaetin derivatives.
PB  - ACG Publications
T2  - Records of Natural Products
T1  - Bioactive Compounds of Endemic Species Sideritis raeseri subsp raeseri Grown in National Park Galicica
VL  - 7
IS  - 3
SP  - 161
EP  - 168
UR  - https://hdl.handle.net/21.15107/rcub_cer_1333
ER  - 

@article{
author = "Menković, Nebojša and Gođevac, Dejan and Savikin, Katarina and Zdunić, Gordana and Milosavljević, Slobodan and Bojadzi, Andon and Avramoski, Oliver",
year = "2013",
abstract = "Collection of Sideritis raeseri subsp. raeseri has a long tradition in local communities in the Ohrid-Prespa region. The aim of the present study was the analysis of bioactive compounds especially those with anti-inflammatory activity. Combination of the UV and MS data allowed the characterization of 17 compounds, which could be classified into flavonoid glycosides or hydroxycynnamic acid derivatives. Six of them were isolated using preparative HPLC: isoscutellarein 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside, 4'-O-methylhypolaetin 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside, hypolaetin 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-6 ''-O-acetyl-beta-D-glucopyranoside, 4'-O-methylisoscutellarein 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside, isoscutellarein 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-6 ''-O-acetyl-beta-D-glucopyranoside and 4'-O-methylhypolaetin 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-6 ''-O-acetyl-beta-D-glucopyranoside. The presence of phenylpropanoid glycoside martynoside was reported for the first time in the wild growing S. raeseri subsp. raeseri. Hypolaetin derivatives, known for their antiinflammatory activity, dominated and were more abundant in S. raeseri subsp. raeseri grown in NPG in comparison with S. scardica grown nearby the NPG. The type of solvent affected distribution and the amount of bioactive compounds and the advantage was given to less polar extracts which were richer in hypolaetin derivatives.",
publisher = "ACG Publications",
journal = "Records of Natural Products",
title = "Bioactive Compounds of Endemic Species Sideritis raeseri subsp raeseri Grown in National Park Galicica",
volume = "7",
number = "3",
pages = "161-168",
url = "https://hdl.handle.net/21.15107/rcub_cer_1333"
}

Menković, N., Gođevac, D., Savikin, K., Zdunić, G., Milosavljević, S., Bojadzi, A.,& Avramoski, O.. (2013). Bioactive Compounds of Endemic Species Sideritis raeseri subsp raeseri Grown in National Park Galicica. in Records of Natural Products
ACG Publications., 7(3), 161-168.
https://hdl.handle.net/21.15107/rcub_cer_1333

Menković N, Gođevac D, Savikin K, Zdunić G, Milosavljević S, Bojadzi A, Avramoski O. Bioactive Compounds of Endemic Species Sideritis raeseri subsp raeseri Grown in National Park Galicica. in Records of Natural Products. 2013;7(3):161-168.
https://hdl.handle.net/21.15107/rcub_cer_1333 .

Menković, Nebojša, Gođevac, Dejan, Savikin, Katarina, Zdunić, Gordana, Milosavljević, Slobodan, Bojadzi, Andon, Avramoski, Oliver, "Bioactive Compounds of Endemic Species Sideritis raeseri subsp raeseri Grown in National Park Galicica" in Records of Natural Products, 7, no. 3 (2013):161-168,
https://hdl.handle.net/21.15107/rcub_cer_1333 .

TY  - CHAP
AU  - Konić-Ristić, A.
AU  - Šavikin, Katarina
AU  - Zdunić, Gordana
AU  - Gođevac, Dejan
AU  - Janković, Teodora
AU  - Menković, Nebojša
PY  - 2013
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1387
AB  - The biological value of berries relies on their nutritive and non-nutritive constituents. They are good sources of vitamins (vitamin A, C, E, folic acid), pro-vitamins and related compounds (carotene and lutein), minerals (calcium and selenium) and phytosterols, but the proposed health benefit is usually connected with phenolics as the main biologically active compound of berries. Berry phenolics include anthocyanins, flavonols, flavanols, condensed tannins (proanthocyanidins), hidrolyzable tannins (ellagitannins and gallotannins) and phenolic acids. Berries are recognized as the best dietary sources of anthocyanins. Different berries are distinguished by the presence of different classes of phenolics or compounds within the same class, their content and chemical structure (substituents, glycosylation, conjugation), potentially influencing their physiological properties and health effects. Analytical assessment of the phytochemical content of berries, the effects of storage and processing and putative interaction with other dietary compounds is essential for evaluation of their health benefit. It is of great importance to emphasize the biodiversity in the context of different phytochemical content in wild versus cultivated species, different varieties of the same species, or influenced by different cultivating conditions. Beneficial effects of berries consumption in health promotion and prevention of chronic diseases, such as cancer or cardiovascular diseases are shown in numerous epidemiological studies. In in vitro and animals studies berry fruits, their extracts and isolated compounds showed antioxidant, anticancer, antidiabetic, hypoholesterolemic, anti-inflammatory, vasoprotective, cardioprotecive, antiplatelet, antitrombotic or antimicrobial effects. Some of these effects are also shown in clinical trials in humans. Phenolic compounds of berries and their extracts have strong antioxidant potential that is often used to explain their health-promoting properties. Recent studies postulated that their antioxidant potential, as a basic mechanism of biological activity, is compromised by their low bioavailability. Consequently further research in this area is targeted towards other mechanisms of action, the evaluation of main sites of action and further elucidation of potential of berry phenolic compounds as antioxidants, based on their structure or metabolism, both in vitro and within the human body.
PB  - Nova Science Publishers, Inc.
T2  - Phytochemicals: Occurrence in Nature, Health Effects and Antioxidant Properties
T1  - Phenolic compounds, health effects and antioxidant properties of berries
SP  - 69
EP  - 85
UR  - https://hdl.handle.net/21.15107/rcub_cer_1387
ER  - 

@inbook{
author = "Konić-Ristić, A. and Šavikin, Katarina and Zdunić, Gordana and Gođevac, Dejan and Janković, Teodora and Menković, Nebojša",
year = "2013",
abstract = "The biological value of berries relies on their nutritive and non-nutritive constituents. They are good sources of vitamins (vitamin A, C, E, folic acid), pro-vitamins and related compounds (carotene and lutein), minerals (calcium and selenium) and phytosterols, but the proposed health benefit is usually connected with phenolics as the main biologically active compound of berries. Berry phenolics include anthocyanins, flavonols, flavanols, condensed tannins (proanthocyanidins), hidrolyzable tannins (ellagitannins and gallotannins) and phenolic acids. Berries are recognized as the best dietary sources of anthocyanins. Different berries are distinguished by the presence of different classes of phenolics or compounds within the same class, their content and chemical structure (substituents, glycosylation, conjugation), potentially influencing their physiological properties and health effects. Analytical assessment of the phytochemical content of berries, the effects of storage and processing and putative interaction with other dietary compounds is essential for evaluation of their health benefit. It is of great importance to emphasize the biodiversity in the context of different phytochemical content in wild versus cultivated species, different varieties of the same species, or influenced by different cultivating conditions. Beneficial effects of berries consumption in health promotion and prevention of chronic diseases, such as cancer or cardiovascular diseases are shown in numerous epidemiological studies. In in vitro and animals studies berry fruits, their extracts and isolated compounds showed antioxidant, anticancer, antidiabetic, hypoholesterolemic, anti-inflammatory, vasoprotective, cardioprotecive, antiplatelet, antitrombotic or antimicrobial effects. Some of these effects are also shown in clinical trials in humans. Phenolic compounds of berries and their extracts have strong antioxidant potential that is often used to explain their health-promoting properties. Recent studies postulated that their antioxidant potential, as a basic mechanism of biological activity, is compromised by their low bioavailability. Consequently further research in this area is targeted towards other mechanisms of action, the evaluation of main sites of action and further elucidation of potential of berry phenolic compounds as antioxidants, based on their structure or metabolism, both in vitro and within the human body.",
publisher = "Nova Science Publishers, Inc.",
journal = "Phytochemicals: Occurrence in Nature, Health Effects and Antioxidant Properties",
booktitle = "Phenolic compounds, health effects and antioxidant properties of berries",
pages = "69-85",
url = "https://hdl.handle.net/21.15107/rcub_cer_1387"
}

Konić-Ristić, A., Šavikin, K., Zdunić, G., Gođevac, D., Janković, T.,& Menković, N.. (2013). Phenolic compounds, health effects and antioxidant properties of berries. in Phytochemicals: Occurrence in Nature, Health Effects and Antioxidant Properties
Nova Science Publishers, Inc.., 69-85.
https://hdl.handle.net/21.15107/rcub_cer_1387

Konić-Ristić A, Šavikin K, Zdunić G, Gođevac D, Janković T, Menković N. Phenolic compounds, health effects and antioxidant properties of berries. in Phytochemicals: Occurrence in Nature, Health Effects and Antioxidant Properties. 2013;:69-85.
https://hdl.handle.net/21.15107/rcub_cer_1387 .

Konić-Ristić, A., Šavikin, Katarina, Zdunić, Gordana, Gođevac, Dejan, Janković, Teodora, Menković, Nebojša, "Phenolic compounds, health effects and antioxidant properties of berries" in Phytochemicals: Occurrence in Nature, Health Effects and Antioxidant Properties (2013):69-85,
https://hdl.handle.net/21.15107/rcub_cer_1387 .

TY  - JOUR
AU  - Gođevac, Dejan
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan
AU  - Zdunić, Gordana
AU  - Ordevic, Boban
AU  - Stanković, Miroslava
PY  - 2012
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/972
AB  - On the basis of LC/UV/MS analysis, 35 compounds from the extracts of seeds of black, red, and white currants (2 cultivars of each) were identified. Black currants cultivars contained protocatechuic acid and p-hydroxybenzoic acid, and traces of nitril containing phenolic acids. The presence of synapoyl glucoside was characteristic for cv. Malling Jewel. Sesquiterpenoid glycosides and carboxymethylindol glycosides were present mainly in white and red currant cultivars. Blackcurrant seeds contained higher amounts of flavonoids, especially rutin, isoquercetin, and taxifolin. The currant seed extracts were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The frequency of MN was scored in binucleated cells, and the cultivars of black currants showed the best antioxidant potential. At a concentration of only 0.17 mg/mL, extract of the seed cv. Malling Jewel effected a decrease in the frequency of MN of 60% compared with control cell cultures. Practical Application: Our results provide evidence of protective effects of currant seed extracts and isolated pure compounds on cytogenetic damages in human lymphocytes. Thus, currant seed extracts could exert beneficial effects in quite a few diseases, for many of the biological actions have been attributed to their antioxidant properties.
PB  - Wiley-Blackwell, Hoboken
T2  - Journal of Food Science
T1  - Chemical Composition of Currant Seed Extracts and Their Protective Effect on Human Lymphocytes DNA
VL  - 77
IS  - 7
DO  - 10.1111/j.1750-3841.2012.02756.x
ER  - 

@article{
author = "Gođevac, Dejan and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan and Zdunić, Gordana and Ordevic, Boban and Stanković, Miroslava",
year = "2012",
abstract = "On the basis of LC/UV/MS analysis, 35 compounds from the extracts of seeds of black, red, and white currants (2 cultivars of each) were identified. Black currants cultivars contained protocatechuic acid and p-hydroxybenzoic acid, and traces of nitril containing phenolic acids. The presence of synapoyl glucoside was characteristic for cv. Malling Jewel. Sesquiterpenoid glycosides and carboxymethylindol glycosides were present mainly in white and red currant cultivars. Blackcurrant seeds contained higher amounts of flavonoids, especially rutin, isoquercetin, and taxifolin. The currant seed extracts were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The frequency of MN was scored in binucleated cells, and the cultivars of black currants showed the best antioxidant potential. At a concentration of only 0.17 mg/mL, extract of the seed cv. Malling Jewel effected a decrease in the frequency of MN of 60% compared with control cell cultures. Practical Application: Our results provide evidence of protective effects of currant seed extracts and isolated pure compounds on cytogenetic damages in human lymphocytes. Thus, currant seed extracts could exert beneficial effects in quite a few diseases, for many of the biological actions have been attributed to their antioxidant properties.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Journal of Food Science",
title = "Chemical Composition of Currant Seed Extracts and Their Protective Effect on Human Lymphocytes DNA",
volume = "77",
number = "7",
doi = "10.1111/j.1750-3841.2012.02756.x"
}

Gođevac, D., Tešević, V., Vajs, V., Milosavljević, S., Zdunić, G., Ordevic, B.,& Stanković, M.. (2012). Chemical Composition of Currant Seed Extracts and Their Protective Effect on Human Lymphocytes DNA. in Journal of Food Science
Wiley-Blackwell, Hoboken., 77(7).
https://doi.org/10.1111/j.1750-3841.2012.02756.x

Gođevac D, Tešević V, Vajs V, Milosavljević S, Zdunić G, Ordevic B, Stanković M. Chemical Composition of Currant Seed Extracts and Their Protective Effect on Human Lymphocytes DNA. in Journal of Food Science. 2012;77(7).
doi:10.1111/j.1750-3841.2012.02756.x .

Gođevac, Dejan, Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan, Zdunić, Gordana, Ordevic, Boban, Stanković, Miroslava, "Chemical Composition of Currant Seed Extracts and Their Protective Effect on Human Lymphocytes DNA" in Journal of Food Science, 77, no. 7 (2012),
https://doi.org/10.1111/j.1750-3841.2012.02756.x . .

TY  - JOUR
AU  - Balijagic, Jasmina
AU  - Janković, Teodora
AU  - Zdunić, Gordana
AU  - Boskovic, Jelena
AU  - Savikin, Katarina
AU  - Gođevac, Dejan
AU  - Stanojković, Tatjana
AU  - Jovancevic, Miodrag
AU  - Menković, Nebojša
PY  - 2012
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1122
AB  - LC-ESI-MS and HPLC were used for the identification of the constituents from G. lutea leaves collected at different localities, as well as for quantification of the main compounds. Seven secoiridoids, five C-glucoflavones and three xanthones, were identified. Swertiamarin derivatives, namely eustornorusside (2), eustomoside (3) and septemfidoside (5), were detected in G. lutea for the first time. Concentrations of five constituents (swertiamarin, gentiopicrin, isovitexin, mangiferin and isogentisin) were determined. The relationship between concentrations of gamma-pyrones and altitude was observed with statistically significant correlation (r = 0.94). The extracts were also evaluated for their content of total phenolics, and antiradical and cytotoxic activities. The total phenolics content ranged from 7.7 to 12.7 mg GAE/g, and the IC50 values for DPPH radical scavenging activity varied between 0.45 to 2.02 mg/mL. The leaf extract exhibited moderate cytotoxic effects toward HeLa cells with an IC50 value of 41.1 mu g/mL, while gentiopicrin, mangiferin and isogentisin exerted strong activity against HeLa cells, with IC50 values ranging from 5.7 to 8.8 mu g/mL. The results confirm the traditional usage of G. lutea leaves and also suggest their possible utilization as hepatoprotective, hypoglycemic and anti-inflammatory agents.
PB  - Natural Products Inc, Westerville
T2  - Natural Product Communications
T1  - Chemical Profile, Radical Scavenging and Cytotoxic Activity of Yellow Gentian Leaves (Genitaneae luteae folium) Grown in Northern Regions of Montenegro
VL  - 7
IS  - 11
SP  - 1487
EP  - 1490
UR  - https://hdl.handle.net/21.15107/rcub_cer_1122
ER  - 

@article{
author = "Balijagic, Jasmina and Janković, Teodora and Zdunić, Gordana and Boskovic, Jelena and Savikin, Katarina and Gođevac, Dejan and Stanojković, Tatjana and Jovancevic, Miodrag and Menković, Nebojša",
year = "2012",
abstract = "LC-ESI-MS and HPLC were used for the identification of the constituents from G. lutea leaves collected at different localities, as well as for quantification of the main compounds. Seven secoiridoids, five C-glucoflavones and three xanthones, were identified. Swertiamarin derivatives, namely eustornorusside (2), eustomoside (3) and septemfidoside (5), were detected in G. lutea for the first time. Concentrations of five constituents (swertiamarin, gentiopicrin, isovitexin, mangiferin and isogentisin) were determined. The relationship between concentrations of gamma-pyrones and altitude was observed with statistically significant correlation (r = 0.94). The extracts were also evaluated for their content of total phenolics, and antiradical and cytotoxic activities. The total phenolics content ranged from 7.7 to 12.7 mg GAE/g, and the IC50 values for DPPH radical scavenging activity varied between 0.45 to 2.02 mg/mL. The leaf extract exhibited moderate cytotoxic effects toward HeLa cells with an IC50 value of 41.1 mu g/mL, while gentiopicrin, mangiferin and isogentisin exerted strong activity against HeLa cells, with IC50 values ranging from 5.7 to 8.8 mu g/mL. The results confirm the traditional usage of G. lutea leaves and also suggest their possible utilization as hepatoprotective, hypoglycemic and anti-inflammatory agents.",
publisher = "Natural Products Inc, Westerville",
journal = "Natural Product Communications",
title = "Chemical Profile, Radical Scavenging and Cytotoxic Activity of Yellow Gentian Leaves (Genitaneae luteae folium) Grown in Northern Regions of Montenegro",
volume = "7",
number = "11",
pages = "1487-1490",
url = "https://hdl.handle.net/21.15107/rcub_cer_1122"
}

Balijagic, J., Janković, T., Zdunić, G., Boskovic, J., Savikin, K., Gođevac, D., Stanojković, T., Jovancevic, M.,& Menković, N.. (2012). Chemical Profile, Radical Scavenging and Cytotoxic Activity of Yellow Gentian Leaves (Genitaneae luteae folium) Grown in Northern Regions of Montenegro. in Natural Product Communications
Natural Products Inc, Westerville., 7(11), 1487-1490.
https://hdl.handle.net/21.15107/rcub_cer_1122

Balijagic J, Janković T, Zdunić G, Boskovic J, Savikin K, Gođevac D, Stanojković T, Jovancevic M, Menković N. Chemical Profile, Radical Scavenging and Cytotoxic Activity of Yellow Gentian Leaves (Genitaneae luteae folium) Grown in Northern Regions of Montenegro. in Natural Product Communications. 2012;7(11):1487-1490.
https://hdl.handle.net/21.15107/rcub_cer_1122 .

Balijagic, Jasmina, Janković, Teodora, Zdunić, Gordana, Boskovic, Jelena, Savikin, Katarina, Gođevac, Dejan, Stanojković, Tatjana, Jovancevic, Miodrag, Menković, Nebojša, "Chemical Profile, Radical Scavenging and Cytotoxic Activity of Yellow Gentian Leaves (Genitaneae luteae folium) Grown in Northern Regions of Montenegro" in Natural Product Communications, 7, no. 11 (2012):1487-1490,
https://hdl.handle.net/21.15107/rcub_cer_1122 .

TY  - JOUR
AU  - Zdunić, Gordana
AU  - Gođevac, Dejan
AU  - Savikin, Katarina
AU  - Novaković, Miroslav
AU  - Milosavljević, Slobodan
AU  - Petrovic, Silvana
PY  - 2011
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/928
AB  - The chemical composition and free radical scavenging properties of the MeOH extract of Hypericum richeri and its subsequent CHCl3, n-BuOH, EtOAc and aqueous extracts were investigated. Four quercetin-3-O-glycosides, three myricetin-3-O-glycosides, 3-O- and 5-O-caffeoylquinic acid, quercetin, I3,II8-biapigenin, pseudohypericin and hypericin were identified. The constituents of the extracts were quantified using HPLC-DAD (high-performance liquid chromatography-diode array detector). Isolation of the compounds from n-BuOH and EtOAc extracts was conducted by column chromatography. Antioxidant capacity of the extracts was evaluated by superoxide radical and ABTS root+ scavenging assays and inhibition of lipid peroxidation. The EtOAc extract of H. richeri was the most potent antioxidant in all experiments. Free radical scavenging compounds were identified by HPLC-DPPH root (high-performance liquid chromatography-2,2-diphenyl-1-picrylhydrazyl) post-column derivatisation method, where all phenolic compounds except I3,II8-biapigenin exhibited radical scavenging properties. This is the first report of the presence of myricetin-3-O-rutinoside, myricetin-3-O-galactoside, myricetin-3-O-glucoside, 5-O-caffeoylquinic acid and I3,II8-biapigenin in H. richeri.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Isolation and identification of phenolic compounds from Hypericum richeri Vill. and their antioxidant capacity
VL  - 25
IS  - 3
SP  - 175
EP  - 187
DO  - 10.1080/14786410802401390
ER  - 

@article{
author = "Zdunić, Gordana and Gođevac, Dejan and Savikin, Katarina and Novaković, Miroslav and Milosavljević, Slobodan and Petrovic, Silvana",
year = "2011",
abstract = "The chemical composition and free radical scavenging properties of the MeOH extract of Hypericum richeri and its subsequent CHCl3, n-BuOH, EtOAc and aqueous extracts were investigated. Four quercetin-3-O-glycosides, three myricetin-3-O-glycosides, 3-O- and 5-O-caffeoylquinic acid, quercetin, I3,II8-biapigenin, pseudohypericin and hypericin were identified. The constituents of the extracts were quantified using HPLC-DAD (high-performance liquid chromatography-diode array detector). Isolation of the compounds from n-BuOH and EtOAc extracts was conducted by column chromatography. Antioxidant capacity of the extracts was evaluated by superoxide radical and ABTS root+ scavenging assays and inhibition of lipid peroxidation. The EtOAc extract of H. richeri was the most potent antioxidant in all experiments. Free radical scavenging compounds were identified by HPLC-DPPH root (high-performance liquid chromatography-2,2-diphenyl-1-picrylhydrazyl) post-column derivatisation method, where all phenolic compounds except I3,II8-biapigenin exhibited radical scavenging properties. This is the first report of the presence of myricetin-3-O-rutinoside, myricetin-3-O-galactoside, myricetin-3-O-glucoside, 5-O-caffeoylquinic acid and I3,II8-biapigenin in H. richeri.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Isolation and identification of phenolic compounds from Hypericum richeri Vill. and their antioxidant capacity",
volume = "25",
number = "3",
pages = "175-187",
doi = "10.1080/14786410802401390"
}

Zdunić, G., Gođevac, D., Savikin, K., Novaković, M., Milosavljević, S.,& Petrovic, S.. (2011). Isolation and identification of phenolic compounds from Hypericum richeri Vill. and their antioxidant capacity. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 25(3), 175-187.
https://doi.org/10.1080/14786410802401390

Zdunić G, Gođevac D, Savikin K, Novaković M, Milosavljević S, Petrovic S. Isolation and identification of phenolic compounds from Hypericum richeri Vill. and their antioxidant capacity. in Natural Product Research. 2011;25(3):175-187.
doi:10.1080/14786410802401390 .

Zdunić, Gordana, Gođevac, Dejan, Savikin, Katarina, Novaković, Miroslav, Milosavljević, Slobodan, Petrovic, Silvana, "Isolation and identification of phenolic compounds from Hypericum richeri Vill. and their antioxidant capacity" in Natural Product Research, 25, no. 3 (2011):175-187,
https://doi.org/10.1080/14786410802401390 . .

TY  - JOUR
AU  - Gođevac, Dejan
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan
AU  - Dordevic, Boban
AU  - Zdunić, Gordana
AU  - Tešević, Vele
PY  - 2011
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/816
AB  - From the seeds of white currant (Ribes rubrum, cv. White Champagne), a new sesquiterpenoid glycoside 1 was isolated, along with two known compounds: dihydrophaseic acid 3'-O-b-D-glucopyranoside (2), and 3-carboxymethyl-indole-1-N-b-D-glucopyranoside (3). The structure of the new compound was identified as dihydrophaseic acid 3'-O-b-gentiobioside, based on extensive NMR and MS spectral studies.
AB  - Iz semena bele ribizle (Ribes rubrum, cv. bela šampanjska) izolovan je novi seskviterpenski glukozid (1), zajedno sa dva poznata jedinjenja: 3'-O-b-D-glukopiranozidom dihidrofazeinske kiseline (2) i 3-karboksimetilindol-1-N-b-D-glukopiranozidom (3). Na osnovu detaljnih NMR i MS studija, struktura novog jedinjenja je određena kao 3'-O-b-genciobiozid dihidrofazeinske kiseline.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Chemical composition of white currant seed extract
T1  - Hemijski sastav ekstrakta semenki bele ribizle
VL  - 76
IS  - 11
SP  - 1465
EP  - 1470
DO  - 10.2298/JSC110617132G
ER  - 

@article{
author = "Gođevac, Dejan and Vajs, Vlatka and Milosavljević, Slobodan and Dordevic, Boban and Zdunić, Gordana and Tešević, Vele",
year = "2011",
abstract = "From the seeds of white currant (Ribes rubrum, cv. White Champagne), a new sesquiterpenoid glycoside 1 was isolated, along with two known compounds: dihydrophaseic acid 3'-O-b-D-glucopyranoside (2), and 3-carboxymethyl-indole-1-N-b-D-glucopyranoside (3). The structure of the new compound was identified as dihydrophaseic acid 3'-O-b-gentiobioside, based on extensive NMR and MS spectral studies., Iz semena bele ribizle (Ribes rubrum, cv. bela šampanjska) izolovan je novi seskviterpenski glukozid (1), zajedno sa dva poznata jedinjenja: 3'-O-b-D-glukopiranozidom dihidrofazeinske kiseline (2) i 3-karboksimetilindol-1-N-b-D-glukopiranozidom (3). Na osnovu detaljnih NMR i MS studija, struktura novog jedinjenja je određena kao 3'-O-b-genciobiozid dihidrofazeinske kiseline.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Chemical composition of white currant seed extract, Hemijski sastav ekstrakta semenki bele ribizle",
volume = "76",
number = "11",
pages = "1465-1470",
doi = "10.2298/JSC110617132G"
}

Gođevac, D., Vajs, V., Milosavljević, S., Dordevic, B., Zdunić, G.,& Tešević, V.. (2011). Chemical composition of white currant seed extract. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 76(11), 1465-1470.
https://doi.org/10.2298/JSC110617132G

Gođevac D, Vajs V, Milosavljević S, Dordevic B, Zdunić G, Tešević V. Chemical composition of white currant seed extract. in Journal of the Serbian Chemical Society. 2011;76(11):1465-1470.
doi:10.2298/JSC110617132G .

Gođevac, Dejan, Vajs, Vlatka, Milosavljević, Slobodan, Dordevic, Boban, Zdunić, Gordana, Tešević, Vele, "Chemical composition of white currant seed extract" in Journal of the Serbian Chemical Society, 76, no. 11 (2011):1465-1470,
https://doi.org/10.2298/JSC110617132G . .

TY  - JOUR
AU  - Pljevljakusic, Dejan
AU  - Savikin, Katarina
AU  - Janković, Teodora
AU  - Zdunić, Gordana
AU  - Ristic, Mihailo
AU  - Gođevac, Dejan
AU  - Konic-Ristic, Aleksandra
PY  - 2011
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/867
AB  - Phytochemical analyses of the cultivated Sideritis raeseri subsp. raeseri in four different stages of flower development were performed. Traditionally used infusion and decoction were also prepared from aerial parts in full flowering stage, and analyses of active compounds and radical scavenging capacity were performed. The highest yield of the essential oil, obtained by hydrodistillation, was noticed in the full flowering phase (0.11%), with sesquiterpene bicyclogermacrene as the main constituent (42.5%). All examined extracts contained phenolic compounds and their amounts varied from 15.3 to 34.1 mg GAE/g DW. The amounts of total phenolics in infusion and decoction were similar (46.5 and 43.9 mg GAE/100 ml, respectively). LC-ESI-MS analyses of all samples allowed the characterisation of 22 phenolic compounds. Two dominant flavone glycosides, 4'-O-methylhypolaetin-7-O-[6"'-O-acetyl-beta-D-allopyranosyl (1 -> 2)-beta-D-glucopyranoside (17) and 4'-O-methylisoscutellarein-7-O-[6"'-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside (19) were quantified using HPLC. Moreover, the mineral content and the percent of transportation were investigated.
PB  - Elsevier Sci Ltd, Oxford
T2  - Food Chemistry
T1  - Chemical properties of the cultivated Sideritis raeseri Boiss. & Heldr. subsp raeseri
VL  - 124
IS  - 1
SP  - 226
EP  - 233
DO  - 10.1016/j.foodchem.2010.06.023
ER  - 

@article{
author = "Pljevljakusic, Dejan and Savikin, Katarina and Janković, Teodora and Zdunić, Gordana and Ristic, Mihailo and Gođevac, Dejan and Konic-Ristic, Aleksandra",
year = "2011",
abstract = "Phytochemical analyses of the cultivated Sideritis raeseri subsp. raeseri in four different stages of flower development were performed. Traditionally used infusion and decoction were also prepared from aerial parts in full flowering stage, and analyses of active compounds and radical scavenging capacity were performed. The highest yield of the essential oil, obtained by hydrodistillation, was noticed in the full flowering phase (0.11%), with sesquiterpene bicyclogermacrene as the main constituent (42.5%). All examined extracts contained phenolic compounds and their amounts varied from 15.3 to 34.1 mg GAE/g DW. The amounts of total phenolics in infusion and decoction were similar (46.5 and 43.9 mg GAE/100 ml, respectively). LC-ESI-MS analyses of all samples allowed the characterisation of 22 phenolic compounds. Two dominant flavone glycosides, 4'-O-methylhypolaetin-7-O-[6"'-O-acetyl-beta-D-allopyranosyl (1 -> 2)-beta-D-glucopyranoside (17) and 4'-O-methylisoscutellarein-7-O-[6"'-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside (19) were quantified using HPLC. Moreover, the mineral content and the percent of transportation were investigated.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Food Chemistry",
title = "Chemical properties of the cultivated Sideritis raeseri Boiss. & Heldr. subsp raeseri",
volume = "124",
number = "1",
pages = "226-233",
doi = "10.1016/j.foodchem.2010.06.023"
}

Pljevljakusic, D., Savikin, K., Janković, T., Zdunić, G., Ristic, M., Gođevac, D.,& Konic-Ristic, A.. (2011). Chemical properties of the cultivated Sideritis raeseri Boiss. & Heldr. subsp raeseri. in Food Chemistry
Elsevier Sci Ltd, Oxford., 124(1), 226-233.
https://doi.org/10.1016/j.foodchem.2010.06.023

Pljevljakusic D, Savikin K, Janković T, Zdunić G, Ristic M, Gođevac D, Konic-Ristic A. Chemical properties of the cultivated Sideritis raeseri Boiss. & Heldr. subsp raeseri. in Food Chemistry. 2011;124(1):226-233.
doi:10.1016/j.foodchem.2010.06.023 .

Pljevljakusic, Dejan, Savikin, Katarina, Janković, Teodora, Zdunić, Gordana, Ristic, Mihailo, Gođevac, Dejan, Konic-Ristic, Aleksandra, "Chemical properties of the cultivated Sideritis raeseri Boiss. & Heldr. subsp raeseri" in Food Chemistry, 124, no. 1 (2011):226-233,
https://doi.org/10.1016/j.foodchem.2010.06.023 . .