TY  - JOUR
AU  - Mijatović, Aleksandar
AU  - Šeba, Tino
AU  - Gligorijević, Nevenka
AU  - Ćoćić, Dušan
AU  - Spasić, Snežana
AU  - Lolić, Aleksandar
AU  - Aranđelović, Sandra
AU  - Nikolić, Milan
AU  - Gabričević, Mario
AU  - Baošić, Rada
PY  - 2024
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7593
AB  - The molecular structures of six neutral copper(II) complexes with propylenediamine bridges and different terminal groups have been reported and evaluated. Different antioxidant tests were performed on these complexes. Additionally, the antibacterial and antifungal activities of the investigated compounds were assessed. The study was complemented with data on their interaction with human serum albumin (HSA) and evaluated using spectroscopic fluorescence techniques. The copper(II) complexes were found to bind to HSA at multiple sites (n = 0.82–1.72), displaying relatively high binding constants on the order of Ka = (4.8–8.8) × 104 M−1. Furthermore, binding constants calculated from microscale thermophoresis (MST) data were within the range of 1.27 × 104–1.13 × 105 M−1; these results correlated well with the above Ka values obtained by fluorimetry. Molecular docking simulations were employed to study the ability of the complexes to bind to target macromolecules, such as HSA and DNA. As a significant addition to understanding their biological behavior, an MTT assay was performed to investigate the cytotoxicity of the complexes. The antiproliferative activity of the investigated copper(II) complexes with propylenediamine ligands, along with cisplatin as a reference compound, was evaluated in two human cancer cell lines (LS-174 and MCF-7) and one normal cell line (MRC-5). The obtained results are discussed, providing the structure–activity relationship of the copper(II) complexes with Schiff base tetradentate ligands.
PB  - Royal Society of Chemistry
T2  - New Journal of Chemistry
T1  - Promising in vitro and in silico biological activity of tetradentate Schiff base copper(II) complexes with a propylenediamine bridge
VL  - 48
IS  - 13
SP  - 5959
DO  - 10.1039/D3NJ05270B
ER  - 

@article{
author = "Mijatović, Aleksandar and Šeba, Tino and Gligorijević, Nevenka and Ćoćić, Dušan and Spasić, Snežana and Lolić, Aleksandar and Aranđelović, Sandra and Nikolić, Milan and Gabričević, Mario and Baošić, Rada",
year = "2024",
abstract = "The molecular structures of six neutral copper(II) complexes with propylenediamine bridges and different terminal groups have been reported and evaluated. Different antioxidant tests were performed on these complexes. Additionally, the antibacterial and antifungal activities of the investigated compounds were assessed. The study was complemented with data on their interaction with human serum albumin (HSA) and evaluated using spectroscopic fluorescence techniques. The copper(II) complexes were found to bind to HSA at multiple sites (n = 0.82–1.72), displaying relatively high binding constants on the order of Ka = (4.8–8.8) × 104 M−1. Furthermore, binding constants calculated from microscale thermophoresis (MST) data were within the range of 1.27 × 104–1.13 × 105 M−1; these results correlated well with the above Ka values obtained by fluorimetry. Molecular docking simulations were employed to study the ability of the complexes to bind to target macromolecules, such as HSA and DNA. As a significant addition to understanding their biological behavior, an MTT assay was performed to investigate the cytotoxicity of the complexes. The antiproliferative activity of the investigated copper(II) complexes with propylenediamine ligands, along with cisplatin as a reference compound, was evaluated in two human cancer cell lines (LS-174 and MCF-7) and one normal cell line (MRC-5). The obtained results are discussed, providing the structure–activity relationship of the copper(II) complexes with Schiff base tetradentate ligands.",
publisher = "Royal Society of Chemistry",
journal = "New Journal of Chemistry",
title = "Promising in vitro and in silico biological activity of tetradentate Schiff base copper(II) complexes with a propylenediamine bridge",
volume = "48",
number = "13",
pages = "5959",
doi = "10.1039/D3NJ05270B"
}

Mijatović, A., Šeba, T., Gligorijević, N., Ćoćić, D., Spasić, S., Lolić, A., Aranđelović, S., Nikolić, M., Gabričević, M.,& Baošić, R.. (2024). Promising in vitro and in silico biological activity of tetradentate Schiff base copper(II) complexes with a propylenediamine bridge. in New Journal of Chemistry
Royal Society of Chemistry., 48(13), 5959.
https://doi.org/10.1039/D3NJ05270B

Mijatović A, Šeba T, Gligorijević N, Ćoćić D, Spasić S, Lolić A, Aranđelović S, Nikolić M, Gabričević M, Baošić R. Promising in vitro and in silico biological activity of tetradentate Schiff base copper(II) complexes with a propylenediamine bridge. in New Journal of Chemistry. 2024;48(13):5959.
doi:10.1039/D3NJ05270B .

Mijatović, Aleksandar, Šeba, Tino, Gligorijević, Nevenka, Ćoćić, Dušan, Spasić, Snežana, Lolić, Aleksandar, Aranđelović, Sandra, Nikolić, Milan, Gabričević, Mario, Baošić, Rada, "Promising in vitro and in silico biological activity of tetradentate Schiff base copper(II) complexes with a propylenediamine bridge" in New Journal of Chemistry, 48, no. 13 (2024):5959,
https://doi.org/10.1039/D3NJ05270B . .

TY  - JOUR
AU  - Mijatović, Aleksandar
AU  - Gligorijević, Nevenka
AU  - Ćoćić, Dušan
AU  - Spasić, Snežana
AU  - Lolić, Aleksandar
AU  - Aranđelović, Sandra
AU  - Nikolić, Milan
AU  - Baošić, Rada
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6777
AB  - The biological activity of six structurally similar tetradentate Schiff base copper(II) complexes, namely [Cu(ethylenediamine-bis-acetylacetonate)] (CuAA) and five derivatives where two methyl groups are replaced by phenyl, (CuPP), CF3 (CuTT) or by mixed groups CH3/CF3 (CuAT), Ph/CF3 (CuPT), and Ph/CH3 (CuAP) has been investigated. The set of antioxidant assays was performed, and the results were expressed as IC50 and EC50 values. The series of complexes showed interesting bioactivity and were investigated for the determination of antioxidant, antifungal, antimicrobial, and cytotoxic activity. A significant antioxidant behavior was exhibited by complex CuAA, greater than Trolox in the Oxygen Radical Absorbance Capacity (ORAC) assay. Antibacterial assay over Gram-positive and Gram-negative pathogenic bacterial strains and some fungal pathogens were studied. Antiproliferative activity of complexes in two human tumor cell lines, breast adenocarcinoma MCF-7, colon adenocarcinoma LS-174, and normal fibroblast cells-MRC-5, examined the effect on cell cycle progression. The significant cytotoxic potential, comparable to cisplatin cytotoxicity, was determined in human breast cancer cell line-MCF-7 with IC50 values being 17.53–31.40 μM and human colon cancer cell line-LS-174 with IC50 values being 15.22–23.92 μM. All tested compounds showed nearly twice more selectivity toward cancer cell lines than normal cells. The interactions of complexes with human serum albumin (HSA), the most prominent protein in plasma, were investigated using spectroscopic fluorescence techniques. The complexes bind to human serum albumin at multiple sites (n = 0.2–1.9), displaying a moderate binding constant Ka = 4.1–12.4 × 104 M−1. The molecular docking experiment effectively showed complex binding to HSA and DNA molecular fragments.
PB  - Elsevier
T2  - Journal of Inorganic Biochemistry
T1  - In vitro and in silico study of the biological activity of tetradentate Schiff base copper(II) complexes with ethylenediamine-bridge
VL  - 244
SP  - 112224
DO  - 10.1016/j.jinorgbio.2023.112224
ER  - 

@article{
author = "Mijatović, Aleksandar and Gligorijević, Nevenka and Ćoćić, Dušan and Spasić, Snežana and Lolić, Aleksandar and Aranđelović, Sandra and Nikolić, Milan and Baošić, Rada",
year = "2023",
abstract = "The biological activity of six structurally similar tetradentate Schiff base copper(II) complexes, namely [Cu(ethylenediamine-bis-acetylacetonate)] (CuAA) and five derivatives where two methyl groups are replaced by phenyl, (CuPP), CF3 (CuTT) or by mixed groups CH3/CF3 (CuAT), Ph/CF3 (CuPT), and Ph/CH3 (CuAP) has been investigated. The set of antioxidant assays was performed, and the results were expressed as IC50 and EC50 values. The series of complexes showed interesting bioactivity and were investigated for the determination of antioxidant, antifungal, antimicrobial, and cytotoxic activity. A significant antioxidant behavior was exhibited by complex CuAA, greater than Trolox in the Oxygen Radical Absorbance Capacity (ORAC) assay. Antibacterial assay over Gram-positive and Gram-negative pathogenic bacterial strains and some fungal pathogens were studied. Antiproliferative activity of complexes in two human tumor cell lines, breast adenocarcinoma MCF-7, colon adenocarcinoma LS-174, and normal fibroblast cells-MRC-5, examined the effect on cell cycle progression. The significant cytotoxic potential, comparable to cisplatin cytotoxicity, was determined in human breast cancer cell line-MCF-7 with IC50 values being 17.53–31.40 μM and human colon cancer cell line-LS-174 with IC50 values being 15.22–23.92 μM. All tested compounds showed nearly twice more selectivity toward cancer cell lines than normal cells. The interactions of complexes with human serum albumin (HSA), the most prominent protein in plasma, were investigated using spectroscopic fluorescence techniques. The complexes bind to human serum albumin at multiple sites (n = 0.2–1.9), displaying a moderate binding constant Ka = 4.1–12.4 × 104 M−1. The molecular docking experiment effectively showed complex binding to HSA and DNA molecular fragments.",
publisher = "Elsevier",
journal = "Journal of Inorganic Biochemistry",
title = "In vitro and in silico study of the biological activity of tetradentate Schiff base copper(II) complexes with ethylenediamine-bridge",
volume = "244",
pages = "112224",
doi = "10.1016/j.jinorgbio.2023.112224"
}

Mijatović, A., Gligorijević, N., Ćoćić, D., Spasić, S., Lolić, A., Aranđelović, S., Nikolić, M.,& Baošić, R.. (2023). In vitro and in silico study of the biological activity of tetradentate Schiff base copper(II) complexes with ethylenediamine-bridge. in Journal of Inorganic Biochemistry
Elsevier., 244, 112224.
https://doi.org/10.1016/j.jinorgbio.2023.112224

Mijatović A, Gligorijević N, Ćoćić D, Spasić S, Lolić A, Aranđelović S, Nikolić M, Baošić R. In vitro and in silico study of the biological activity of tetradentate Schiff base copper(II) complexes with ethylenediamine-bridge. in Journal of Inorganic Biochemistry. 2023;244:112224.
doi:10.1016/j.jinorgbio.2023.112224 .

Mijatović, Aleksandar, Gligorijević, Nevenka, Ćoćić, Dušan, Spasić, Snežana, Lolić, Aleksandar, Aranđelović, Sandra, Nikolić, Milan, Baošić, Rada, "In vitro and in silico study of the biological activity of tetradentate Schiff base copper(II) complexes with ethylenediamine-bridge" in Journal of Inorganic Biochemistry, 244 (2023):112224,
https://doi.org/10.1016/j.jinorgbio.2023.112224 . .

TY  - JOUR
AU  - Mijin, Nemanja
AU  - Milošević, Jelica
AU  - Stevanović, Sanja
AU  - Petrović, Predrag
AU  - Lolić, Aleksandar
AU  - Urbic, Tomaz
AU  - Polović, Natalija
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7189
AB  - The aggregation of proteins into fibrillar, amyloid-like aggregates generally results in an improved, positive effect on various techno-functional properties within food products, such as gelation, emulsification, and foam stabilization. These highly stable structures, characterized by their repetitive, β-sheet rich motifs, may develop as the result of the thermal treatment of protein-rich food products. Heavy metal ions can influence amyloid-like aggregation of food proteins. Lead(II) and cadmium(II) represent some of the most abundant and common environmental water and food pollutants. In this work, the influence of heavy metal ions, lead and cadmium on amyloid-like aggregation of ovalbumin at high temperatures (90 °C) and under acidic conditions (pH 2.0) was investigated. Ovalbumin is used as a general model for how heavy metals can affect amyloid-like aggregation of a food protein. Structural changes were monitored via Thioflavin T and 8-Anilino-1-naphthalenesulfonic acid fluorescence, Fourier-Transform infrared spectroscopy, atomic force microscopy, dynamic light scattering, as well as computational analyses. The obtained results indicate that the added heavy metal ions bind to different sites within ovalbumin prior to thermal treatment. Lead binding sites are closer to the hydrophobic regions of an protein, while cadmium ion binding sites are more exposed. This specific binding of metal ions affects the morphologies of amyloid-like aggregates, resulting in lead-induced branching of amyloid-like fibrils, or cadmium-induced tangling of fibrils into dense amyloid clusters. This additive effect of heavy metal ions is most evident in ovalbumin samples which contain a mixture of both heavy metal ions.
PB  - Elsevier B.V.
T2  - Food Hydrocolloids
T1  - Amyloid-like aggregation influenced by lead(II) and cadmium(II) ions in hen egg white ovalbumin
VL  - 136
SP  - 108292
DO  - 10.1016/j.foodhyd.2022.108292
ER  - 

@article{
author = "Mijin, Nemanja and Milošević, Jelica and Stevanović, Sanja and Petrović, Predrag and Lolić, Aleksandar and Urbic, Tomaz and Polović, Natalija",
year = "2023",
abstract = "The aggregation of proteins into fibrillar, amyloid-like aggregates generally results in an improved, positive effect on various techno-functional properties within food products, such as gelation, emulsification, and foam stabilization. These highly stable structures, characterized by their repetitive, β-sheet rich motifs, may develop as the result of the thermal treatment of protein-rich food products. Heavy metal ions can influence amyloid-like aggregation of food proteins. Lead(II) and cadmium(II) represent some of the most abundant and common environmental water and food pollutants. In this work, the influence of heavy metal ions, lead and cadmium on amyloid-like aggregation of ovalbumin at high temperatures (90 °C) and under acidic conditions (pH 2.0) was investigated. Ovalbumin is used as a general model for how heavy metals can affect amyloid-like aggregation of a food protein. Structural changes were monitored via Thioflavin T and 8-Anilino-1-naphthalenesulfonic acid fluorescence, Fourier-Transform infrared spectroscopy, atomic force microscopy, dynamic light scattering, as well as computational analyses. The obtained results indicate that the added heavy metal ions bind to different sites within ovalbumin prior to thermal treatment. Lead binding sites are closer to the hydrophobic regions of an protein, while cadmium ion binding sites are more exposed. This specific binding of metal ions affects the morphologies of amyloid-like aggregates, resulting in lead-induced branching of amyloid-like fibrils, or cadmium-induced tangling of fibrils into dense amyloid clusters. This additive effect of heavy metal ions is most evident in ovalbumin samples which contain a mixture of both heavy metal ions.",
publisher = "Elsevier B.V.",
journal = "Food Hydrocolloids",
title = "Amyloid-like aggregation influenced by lead(II) and cadmium(II) ions in hen egg white ovalbumin",
volume = "136",
pages = "108292",
doi = "10.1016/j.foodhyd.2022.108292"
}

Mijin, N., Milošević, J., Stevanović, S., Petrović, P., Lolić, A., Urbic, T.,& Polović, N.. (2023). Amyloid-like aggregation influenced by lead(II) and cadmium(II) ions in hen egg white ovalbumin. in Food Hydrocolloids
Elsevier B.V.., 136, 108292.
https://doi.org/10.1016/j.foodhyd.2022.108292

Mijin N, Milošević J, Stevanović S, Petrović P, Lolić A, Urbic T, Polović N. Amyloid-like aggregation influenced by lead(II) and cadmium(II) ions in hen egg white ovalbumin. in Food Hydrocolloids. 2023;136:108292.
doi:10.1016/j.foodhyd.2022.108292 .

Mijin, Nemanja, Milošević, Jelica, Stevanović, Sanja, Petrović, Predrag, Lolić, Aleksandar, Urbic, Tomaz, Polović, Natalija, "Amyloid-like aggregation influenced by lead(II) and cadmium(II) ions in hen egg white ovalbumin" in Food Hydrocolloids, 136 (2023):108292,
https://doi.org/10.1016/j.foodhyd.2022.108292 . .

TY  - CONF
AU  - Mijatović, A.
AU  - Nikolić, M.
AU  - Spasić, Snežana
AU  - Žerađanin, Aleksandra
AU  - Joksimović, Kristina
AU  - Lolić, Aleksandar
AU  - Baošić, Rada
PY  - 2020
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5176
AB  - Schiff bases, and their Cu(II) complexes, are known for their biological activity. In this work, antibacterial activity against Gram-negative strains of Escherichia coli, Pseudomonas aeruginosa and Staphylococcus pyogenes, as well as Gram-positive Staphylococcus pyogenes and Pseudomonas aeruginosa was studied, together with antifungal activity against Candida, Aspergillus, and Mucor strains. Also, technically simple, and rapid tests like ABTS, HORAC, and ORAC were used to investigate the antioxidant activity in order to compare obtained results with 
different type of tests.
PB  - Banja Luka : University of Banjaluka, Faculty of Technology
C3  - The Book of Abstracts - XIII Conference of Chemistry, Technologists, and Environmentalists of Republic of Srpska, Banja Luka, Republic of Srpska, Bosnia & Hercegovina; Oct 30, 2020
T1  - Antioxidant and Antimicrobial Activity of Some Tetradentate Schiff Bases and Their Cu(II) Complexes
SP  - 19
UR  - https://hdl.handle.net/21.15107/rcub_cer_5176
ER  - 

@conference{
author = "Mijatović, A. and Nikolić, M. and Spasić, Snežana and Žerađanin, Aleksandra and Joksimović, Kristina and Lolić, Aleksandar and Baošić, Rada",
year = "2020",
abstract = "Schiff bases, and their Cu(II) complexes, are known for their biological activity. In this work, antibacterial activity against Gram-negative strains of Escherichia coli, Pseudomonas aeruginosa and Staphylococcus pyogenes, as well as Gram-positive Staphylococcus pyogenes and Pseudomonas aeruginosa was studied, together with antifungal activity against Candida, Aspergillus, and Mucor strains. Also, technically simple, and rapid tests like ABTS, HORAC, and ORAC were used to investigate the antioxidant activity in order to compare obtained results with 
different type of tests.",
publisher = "Banja Luka : University of Banjaluka, Faculty of Technology",
journal = "The Book of Abstracts - XIII Conference of Chemistry, Technologists, and Environmentalists of Republic of Srpska, Banja Luka, Republic of Srpska, Bosnia & Hercegovina; Oct 30, 2020",
title = "Antioxidant and Antimicrobial Activity of Some Tetradentate Schiff Bases and Their Cu(II) Complexes",
pages = "19",
url = "https://hdl.handle.net/21.15107/rcub_cer_5176"
}

Mijatović, A., Nikolić, M., Spasić, S., Žerađanin, A., Joksimović, K., Lolić, A.,& Baošić, R.. (2020). Antioxidant and Antimicrobial Activity of Some Tetradentate Schiff Bases and Their Cu(II) Complexes. in The Book of Abstracts - XIII Conference of Chemistry, Technologists, and Environmentalists of Republic of Srpska, Banja Luka, Republic of Srpska, Bosnia & Hercegovina; Oct 30, 2020
Banja Luka : University of Banjaluka, Faculty of Technology., 19.
https://hdl.handle.net/21.15107/rcub_cer_5176

Mijatović A, Nikolić M, Spasić S, Žerađanin A, Joksimović K, Lolić A, Baošić R. Antioxidant and Antimicrobial Activity of Some Tetradentate Schiff Bases and Their Cu(II) Complexes. in The Book of Abstracts - XIII Conference of Chemistry, Technologists, and Environmentalists of Republic of Srpska, Banja Luka, Republic of Srpska, Bosnia & Hercegovina; Oct 30, 2020. 2020;:19.
https://hdl.handle.net/21.15107/rcub_cer_5176 .

Mijatović, A., Nikolić, M., Spasić, Snežana, Žerađanin, Aleksandra, Joksimović, Kristina, Lolić, Aleksandar, Baošić, Rada, "Antioxidant and Antimicrobial Activity of Some Tetradentate Schiff Bases and Their Cu(II) Complexes" in The Book of Abstracts - XIII Conference of Chemistry, Technologists, and Environmentalists of Republic of Srpska, Banja Luka, Republic of Srpska, Bosnia & Hercegovina; Oct 30, 2020 (2020):19,
https://hdl.handle.net/21.15107/rcub_cer_5176 .

TY  - JOUR
AU  - Elshaflu, Hana
AU  - Todorović, Tamara
AU  - Nikolić, Milan
AU  - Lolić, Aleksandar
AU  - Višnjevac, Aleksandar
AU  - Hagenow, Stefanie
AU  - Padrón, José M.
AU  - Garcia-Sosa, Alfonso T.
AU  - Đorđević, Ivana
AU  - Grubišić, Sonja
AU  - Stark, Holger
AU  - Filipovic, Nenad R.
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2443
AB  - The novel approach in the treatment of complex multifactorial diseases, such as neurodegenerative disorders and cancer, requires a development of efficient multi-targeting oriented drugs. Since oxidative stress significantly contributes to the pathogenesis of cancer and neurodegenerative disorders, potential drug candidates should possess good antioxidant properties Due to promising biological activities shown for structurally related (1,3-thiazol-2-yl)hydrazones, a focused library of 12 structurally related benzylidene-based (1,3-selenazol-2-yl)hydrazones was designed as potential multi-targeting compounds. Monoamine oxidases (MAO) A/B inhibition properties of this class of compounds have been investigated. Surprisingly, the p-nitrophenyl-substituted (1,3-selenazol-2-yl)hydrazone 4 showed MAO B inhibition in a nanomolar concentration range (IC50 = 73 nM). Excellent antioxidant properties were confirmed in a number of different in vitro assays. Antiproliferative activity screening on a panel of six human solid tumor cell lines showed that potencies of some of the investigated compounds was comparable or even better than that of the positive control 5-fluorouracil. In-silico calculations of ADME properties pointed to promising good pharmacokinetic profiles of investigated compounds. Docking studies suggest that some compounds, compared to positive controls, have the ability to strongly interact with targets relevant to cancer such as 5'-nucleotidase, and to neurodegenerative diseases such as the small conductance calcium-activated potassium channel protein 1, in addition to confirmation of inhibitory binding at MAO B.
PB  - Frontiers Media Sa, Lausanne
T2  - Frontiers in Chemistry
T1  - Selenazolyl-hydrazones as Novel Selective MAO Inhibitors With Antiproliferative and Antioxidant Activities: Experimental and In-silico Studies
VL  - 6
DO  - 10.3389/fchem.2018.00247
ER  - 

@article{
author = "Elshaflu, Hana and Todorović, Tamara and Nikolić, Milan and Lolić, Aleksandar and Višnjevac, Aleksandar and Hagenow, Stefanie and Padrón, José M. and Garcia-Sosa, Alfonso T. and Đorđević, Ivana and Grubišić, Sonja and Stark, Holger and Filipovic, Nenad R.",
year = "2018",
abstract = "The novel approach in the treatment of complex multifactorial diseases, such as neurodegenerative disorders and cancer, requires a development of efficient multi-targeting oriented drugs. Since oxidative stress significantly contributes to the pathogenesis of cancer and neurodegenerative disorders, potential drug candidates should possess good antioxidant properties Due to promising biological activities shown for structurally related (1,3-thiazol-2-yl)hydrazones, a focused library of 12 structurally related benzylidene-based (1,3-selenazol-2-yl)hydrazones was designed as potential multi-targeting compounds. Monoamine oxidases (MAO) A/B inhibition properties of this class of compounds have been investigated. Surprisingly, the p-nitrophenyl-substituted (1,3-selenazol-2-yl)hydrazone 4 showed MAO B inhibition in a nanomolar concentration range (IC50 = 73 nM). Excellent antioxidant properties were confirmed in a number of different in vitro assays. Antiproliferative activity screening on a panel of six human solid tumor cell lines showed that potencies of some of the investigated compounds was comparable or even better than that of the positive control 5-fluorouracil. In-silico calculations of ADME properties pointed to promising good pharmacokinetic profiles of investigated compounds. Docking studies suggest that some compounds, compared to positive controls, have the ability to strongly interact with targets relevant to cancer such as 5'-nucleotidase, and to neurodegenerative diseases such as the small conductance calcium-activated potassium channel protein 1, in addition to confirmation of inhibitory binding at MAO B.",
publisher = "Frontiers Media Sa, Lausanne",
journal = "Frontiers in Chemistry",
title = "Selenazolyl-hydrazones as Novel Selective MAO Inhibitors With Antiproliferative and Antioxidant Activities: Experimental and In-silico Studies",
volume = "6",
doi = "10.3389/fchem.2018.00247"
}

Elshaflu, H., Todorović, T., Nikolić, M., Lolić, A., Višnjevac, A., Hagenow, S., Padrón, J. M., Garcia-Sosa, A. T., Đorđević, I., Grubišić, S., Stark, H.,& Filipovic, N. R.. (2018). Selenazolyl-hydrazones as Novel Selective MAO Inhibitors With Antiproliferative and Antioxidant Activities: Experimental and In-silico Studies. in Frontiers in Chemistry
Frontiers Media Sa, Lausanne., 6.
https://doi.org/10.3389/fchem.2018.00247

Elshaflu H, Todorović T, Nikolić M, Lolić A, Višnjevac A, Hagenow S, Padrón JM, Garcia-Sosa AT, Đorđević I, Grubišić S, Stark H, Filipovic NR. Selenazolyl-hydrazones as Novel Selective MAO Inhibitors With Antiproliferative and Antioxidant Activities: Experimental and In-silico Studies. in Frontiers in Chemistry. 2018;6.
doi:10.3389/fchem.2018.00247 .

Elshaflu, Hana, Todorović, Tamara, Nikolić, Milan, Lolić, Aleksandar, Višnjevac, Aleksandar, Hagenow, Stefanie, Padrón, José M., Garcia-Sosa, Alfonso T., Đorđević, Ivana, Grubišić, Sonja, Stark, Holger, Filipovic, Nenad R., "Selenazolyl-hydrazones as Novel Selective MAO Inhibitors With Antiproliferative and Antioxidant Activities: Experimental and In-silico Studies" in Frontiers in Chemistry, 6 (2018),
https://doi.org/10.3389/fchem.2018.00247 . .

TY  - JOUR
AU  - Đorđević, Ivana
AU  - Vukasinovic, Jelena
AU  - Todorović, Tamara
AU  - Filipovic, Nenad R.
AU  - Rodić, Marko V.
AU  - Lolić, Aleksandar
AU  - Portalone, Gustavo
AU  - Zlatović, Mario
AU  - Grubišić, Sonja
PY  - 2017
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2166
AB  - Cobalt(III) complexes derived from thio-and selenosemicarbazone ligands have been studied to elucidate the nature and consequences of S to Se substitution on their possible biological activity. Solid state structures of cobalt(III) complexes with bis-tridentate coordinated 2-quinolinecarboxaldehyde thio-and selenosemicarbazone were determined by single crystal X-ray diffraction analysis. The complexes were also characterized by spectroscopic methods and cyclic voltammetry. Electronic properties of the complexes were studied using DFT and TD-DFT methods. Finally, evident in vitro antioxidant activity of the complexes was demonstrated.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Synthesis, structures and electronic properties of Co(III) complexes with 2-quinolinecarboxaldehyde thio- and selenosemicarbazone: A combined experimental and theoretical study
VL  - 82
IS  - 7-8
SP  - 825
EP  - 839
DO  - 10.2298/JSC170412062D
ER  - 

@article{
author = "Đorđević, Ivana and Vukasinovic, Jelena and Todorović, Tamara and Filipovic, Nenad R. and Rodić, Marko V. and Lolić, Aleksandar and Portalone, Gustavo and Zlatović, Mario and Grubišić, Sonja",
year = "2017",
abstract = "Cobalt(III) complexes derived from thio-and selenosemicarbazone ligands have been studied to elucidate the nature and consequences of S to Se substitution on their possible biological activity. Solid state structures of cobalt(III) complexes with bis-tridentate coordinated 2-quinolinecarboxaldehyde thio-and selenosemicarbazone were determined by single crystal X-ray diffraction analysis. The complexes were also characterized by spectroscopic methods and cyclic voltammetry. Electronic properties of the complexes were studied using DFT and TD-DFT methods. Finally, evident in vitro antioxidant activity of the complexes was demonstrated.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Synthesis, structures and electronic properties of Co(III) complexes with 2-quinolinecarboxaldehyde thio- and selenosemicarbazone: A combined experimental and theoretical study",
volume = "82",
number = "7-8",
pages = "825-839",
doi = "10.2298/JSC170412062D"
}

Đorđević, I., Vukasinovic, J., Todorović, T., Filipovic, N. R., Rodić, M. V., Lolić, A., Portalone, G., Zlatović, M.,& Grubišić, S.. (2017). Synthesis, structures and electronic properties of Co(III) complexes with 2-quinolinecarboxaldehyde thio- and selenosemicarbazone: A combined experimental and theoretical study. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 82(7-8), 825-839.
https://doi.org/10.2298/JSC170412062D

Đorđević I, Vukasinovic J, Todorović T, Filipovic NR, Rodić MV, Lolić A, Portalone G, Zlatović M, Grubišić S. Synthesis, structures and electronic properties of Co(III) complexes with 2-quinolinecarboxaldehyde thio- and selenosemicarbazone: A combined experimental and theoretical study. in Journal of the Serbian Chemical Society. 2017;82(7-8):825-839.
doi:10.2298/JSC170412062D .

Đorđević, Ivana, Vukasinovic, Jelena, Todorović, Tamara, Filipovic, Nenad R., Rodić, Marko V., Lolić, Aleksandar, Portalone, Gustavo, Zlatović, Mario, Grubišić, Sonja, "Synthesis, structures and electronic properties of Co(III) complexes with 2-quinolinecarboxaldehyde thio- and selenosemicarbazone: A combined experimental and theoretical study" in Journal of the Serbian Chemical Society, 82, no. 7-8 (2017):825-839,
https://doi.org/10.2298/JSC170412062D . .