Promising in vitro and in silico biological activity of tetradentate Schiff base copper(II) complexes with a propylenediamine bridge
Само за регистроване кориснике
2024
Аутори
Mijatović, AleksandarŠeba, Tino
Gligorijević, Nevenka
Ćoćić, Dušan
Spasić, Snežana
Lolić, Aleksandar
Aranđelović, Sandra
Nikolić, Milan
Gabričević, Mario
Baošić, Rada
Чланак у часопису (Објављена верзија)
,
New Journal of Chemistry
Метаподаци
Приказ свих података о документуАпстракт
The molecular structures of six neutral copper(II) complexes with propylenediamine bridges and different terminal groups have been reported and evaluated. Different antioxidant tests were performed on these complexes. Additionally, the antibacterial and antifungal activities of the investigated compounds were assessed. The study was complemented with data on their interaction with human serum albumin (HSA) and evaluated using spectroscopic fluorescence techniques. The copper(II) complexes were found to bind to HSA at multiple sites (n = 0.82–1.72), displaying relatively high binding constants on the order of Ka = (4.8–8.8) × 104 M−1. Furthermore, binding constants calculated from microscale thermophoresis (MST) data were within the range of 1.27 × 104–1.13 × 105 M−1; these results correlated well with the above Ka values obtained by fluorimetry. Molecular docking simulations were employed to study the ability of the complexes to bind to target macromolecules, such as HSA and DNA. As a ...significant addition to understanding their biological behavior, an MTT assay was performed to investigate the cytotoxicity of the complexes. The antiproliferative activity of the investigated copper(II) complexes with propylenediamine ligands, along with cisplatin as a reference compound, was evaluated in two human cancer cell lines (LS-174 and MCF-7) and one normal cell line (MRC-5). The obtained results are discussed, providing the structure–activity relationship of the copper(II) complexes with Schiff base tetradentate ligands.
Кључне речи:
copper(II) complexes / human serum albumin (HSA) / fluorescence / microscale thermophoresisИзвор:
New Journal of Chemistry, 2024, 48, 13, 5959-Издавач:
- Royal Society of Chemistry
Финансирање / пројекти:
- Croatian Science Foundation (grant numbers IP-2016-06-3672)
- Croatian Science Foundation (grant numbers UIP-2017-05-9537)
- European Structural and Investment Funds (KK.01.1.1.07.0055)
- European Regional Development Fund FarmInova (KK.01.1.1.02.0021)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200168 (Универзитет у Београду, Хемијски факултет) (RS-MESTD-inst-2020-200168)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200126 (Универзитет у Београду, Рударско-геолошки факултет) (RS-MESTD-inst-2020-200126)
Институција/група
IHTMTY - JOUR AU - Mijatović, Aleksandar AU - Šeba, Tino AU - Gligorijević, Nevenka AU - Ćoćić, Dušan AU - Spasić, Snežana AU - Lolić, Aleksandar AU - Aranđelović, Sandra AU - Nikolić, Milan AU - Gabričević, Mario AU - Baošić, Rada PY - 2024 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/7593 AB - The molecular structures of six neutral copper(II) complexes with propylenediamine bridges and different terminal groups have been reported and evaluated. Different antioxidant tests were performed on these complexes. Additionally, the antibacterial and antifungal activities of the investigated compounds were assessed. The study was complemented with data on their interaction with human serum albumin (HSA) and evaluated using spectroscopic fluorescence techniques. The copper(II) complexes were found to bind to HSA at multiple sites (n = 0.82–1.72), displaying relatively high binding constants on the order of Ka = (4.8–8.8) × 104 M−1. Furthermore, binding constants calculated from microscale thermophoresis (MST) data were within the range of 1.27 × 104–1.13 × 105 M−1; these results correlated well with the above Ka values obtained by fluorimetry. Molecular docking simulations were employed to study the ability of the complexes to bind to target macromolecules, such as HSA and DNA. As a significant addition to understanding their biological behavior, an MTT assay was performed to investigate the cytotoxicity of the complexes. The antiproliferative activity of the investigated copper(II) complexes with propylenediamine ligands, along with cisplatin as a reference compound, was evaluated in two human cancer cell lines (LS-174 and MCF-7) and one normal cell line (MRC-5). The obtained results are discussed, providing the structure–activity relationship of the copper(II) complexes with Schiff base tetradentate ligands. PB - Royal Society of Chemistry T2 - New Journal of Chemistry T1 - Promising in vitro and in silico biological activity of tetradentate Schiff base copper(II) complexes with a propylenediamine bridge VL - 48 IS - 13 SP - 5959 DO - 10.1039/D3NJ05270B ER -
@article{ author = "Mijatović, Aleksandar and Šeba, Tino and Gligorijević, Nevenka and Ćoćić, Dušan and Spasić, Snežana and Lolić, Aleksandar and Aranđelović, Sandra and Nikolić, Milan and Gabričević, Mario and Baošić, Rada", year = "2024", abstract = "The molecular structures of six neutral copper(II) complexes with propylenediamine bridges and different terminal groups have been reported and evaluated. Different antioxidant tests were performed on these complexes. Additionally, the antibacterial and antifungal activities of the investigated compounds were assessed. The study was complemented with data on their interaction with human serum albumin (HSA) and evaluated using spectroscopic fluorescence techniques. The copper(II) complexes were found to bind to HSA at multiple sites (n = 0.82–1.72), displaying relatively high binding constants on the order of Ka = (4.8–8.8) × 104 M−1. Furthermore, binding constants calculated from microscale thermophoresis (MST) data were within the range of 1.27 × 104–1.13 × 105 M−1; these results correlated well with the above Ka values obtained by fluorimetry. Molecular docking simulations were employed to study the ability of the complexes to bind to target macromolecules, such as HSA and DNA. As a significant addition to understanding their biological behavior, an MTT assay was performed to investigate the cytotoxicity of the complexes. The antiproliferative activity of the investigated copper(II) complexes with propylenediamine ligands, along with cisplatin as a reference compound, was evaluated in two human cancer cell lines (LS-174 and MCF-7) and one normal cell line (MRC-5). The obtained results are discussed, providing the structure–activity relationship of the copper(II) complexes with Schiff base tetradentate ligands.", publisher = "Royal Society of Chemistry", journal = "New Journal of Chemistry", title = "Promising in vitro and in silico biological activity of tetradentate Schiff base copper(II) complexes with a propylenediamine bridge", volume = "48", number = "13", pages = "5959", doi = "10.1039/D3NJ05270B" }
Mijatović, A., Šeba, T., Gligorijević, N., Ćoćić, D., Spasić, S., Lolić, A., Aranđelović, S., Nikolić, M., Gabričević, M.,& Baošić, R.. (2024). Promising in vitro and in silico biological activity of tetradentate Schiff base copper(II) complexes with a propylenediamine bridge. in New Journal of Chemistry Royal Society of Chemistry., 48(13), 5959. https://doi.org/10.1039/D3NJ05270B
Mijatović A, Šeba T, Gligorijević N, Ćoćić D, Spasić S, Lolić A, Aranđelović S, Nikolić M, Gabričević M, Baošić R. Promising in vitro and in silico biological activity of tetradentate Schiff base copper(II) complexes with a propylenediamine bridge. in New Journal of Chemistry. 2024;48(13):5959. doi:10.1039/D3NJ05270B .
Mijatović, Aleksandar, Šeba, Tino, Gligorijević, Nevenka, Ćoćić, Dušan, Spasić, Snežana, Lolić, Aleksandar, Aranđelović, Sandra, Nikolić, Milan, Gabričević, Mario, Baošić, Rada, "Promising in vitro and in silico biological activity of tetradentate Schiff base copper(II) complexes with a propylenediamine bridge" in New Journal of Chemistry, 48, no. 13 (2024):5959, https://doi.org/10.1039/D3NJ05270B . .