TY  - JOUR
AU  - Lović, Jelena
AU  - Bogdanović, Aleksandra
AU  - Tadić, Vanja
AU  - Mijin, Dušan
AU  - Vuković, Dragan
AU  - Petrović, Slobodan D.
AU  - Avramov -  Ivić, Milka
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5171
AB  - Duloxetine hydrochloride (DUL) is effective in treating depression, and was examined for electroanalytical purposes. The DUL
standard was investigated by cyclic voltammetry (CV) and determined using differential pulse voltammetry (DPV) via its electrooxidation
at the Au electrode in 0.05 M NaHCO3. DPV showed a linear dependency of the anodic peak currents vs DUL standard
concentrations in the range from 0.1 to 3.33 μg ml−1 with the values of the limit of detection (LOD) and the limit of quantification
(LOQ): 0.133 and 0.667 μg ml−1, respectively. Using the constructed and validated calibration curve, the values of unknown DUL
concentrations in both Taita® tablets and in human serum spiked with the standard were determined. The number of protons and
electrons transferred was calculated and possible reaction mechanisms taking place on the surface of both electrodes were
proposed. The Au electrode exhibited a better sensitivity and a wider range of current vs concentration linear dependency for DUL
quantitative determination than the GC electrode. The study of DUL degradation showed that at the Au and GC electrodes, after
4.5 h of potential cycling, degradation occurs, giving formaldehyde as a product, which was confirmed by high performance liquid
chromatography (HPLC)
PB  - The Electrochemical Society
T2  - Journal of The Electrochemical Society
T1  - Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation
DO  - 10.1149/1945-7111/ac7e74
ER  - 

@article{
author = "Lović, Jelena and Bogdanović, Aleksandra and Tadić, Vanja and Mijin, Dušan and Vuković, Dragan and Petrović, Slobodan D. and Avramov -  Ivić, Milka",
year = "2022",
abstract = "Duloxetine hydrochloride (DUL) is effective in treating depression, and was examined for electroanalytical purposes. The DUL
standard was investigated by cyclic voltammetry (CV) and determined using differential pulse voltammetry (DPV) via its electrooxidation
at the Au electrode in 0.05 M NaHCO3. DPV showed a linear dependency of the anodic peak currents vs DUL standard
concentrations in the range from 0.1 to 3.33 μg ml−1 with the values of the limit of detection (LOD) and the limit of quantification
(LOQ): 0.133 and 0.667 μg ml−1, respectively. Using the constructed and validated calibration curve, the values of unknown DUL
concentrations in both Taita® tablets and in human serum spiked with the standard were determined. The number of protons and
electrons transferred was calculated and possible reaction mechanisms taking place on the surface of both electrodes were
proposed. The Au electrode exhibited a better sensitivity and a wider range of current vs concentration linear dependency for DUL
quantitative determination than the GC electrode. The study of DUL degradation showed that at the Au and GC electrodes, after
4.5 h of potential cycling, degradation occurs, giving formaldehyde as a product, which was confirmed by high performance liquid
chromatography (HPLC)",
publisher = "The Electrochemical Society",
journal = "Journal of The Electrochemical Society",
title = "Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation",
doi = "10.1149/1945-7111/ac7e74"
}

Lović, J., Bogdanović, A., Tadić, V., Mijin, D., Vuković, D., Petrović, S. D.,& Avramov -  Ivić, M.. (2022). Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation. in Journal of The Electrochemical Society
The Electrochemical Society..
https://doi.org/10.1149/1945-7111/ac7e74

Lović J, Bogdanović A, Tadić V, Mijin D, Vuković D, Petrović SD, Avramov -  Ivić M. Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation. in Journal of The Electrochemical Society. 2022;.
doi:10.1149/1945-7111/ac7e74 .

Lović, Jelena, Bogdanović, Aleksandra, Tadić, Vanja, Mijin, Dušan, Vuković, Dragan, Petrović, Slobodan D., Avramov -  Ivić, Milka, "Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation" in Journal of The Electrochemical Society (2022),
https://doi.org/10.1149/1945-7111/ac7e74 . .

TY  - JOUR
AU  - Lović, Jelena
AU  - Lađarević, Jelena
AU  - Trišović, Nemanja
AU  - Andrić, Filip
AU  - Mladenović, Aleksandar R.
AU  - Mijin, Dušan
AU  - Vuković, Dragan
AU  - Petrović, Slobodan D.
AU  - Avramov Ivić, Milka
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4246
AB  - The electrochemical characterization of sertraline at gold electrode was examined by cyclic voltammetry measurements (CV) in pH 8.4 bicarbonate buffer. Then Au electrode was evaluated for the quantitative determination of sertraline using square wave voltammetry (SWV). To enhance the sensitivity during the drug determination, (2-hydroxypropyl)-β-cyclodextrin
(HPβCD) and β-cyclodextrin (βCD) inclusion complexes were employed. Using the proposed SWV technique, the anodic current peak was linear within a concentration range of 0.1–0.5 μM with a limit of detection (LOD) of 2.0 × 10–8 M and a limit of quantification (LOQ) of 6.7 × 10–8 M. In the case of inclusion complex of the sertraline with HPβCD, a good linearity range of 0.1–0.9 μM was obtained with a LOD of 2.6 × 10–8 M and a LOQ of 8.8 × 10–8 M. The gold electrode
revealed the same linearity range for inclusion complex of the sertraline with βCD with a LOD and a LOQ being 2.6 × 10–8 and 8.6 × 10–8 M, respectively. Comparing the regression equations, it can be concluded that the sensitivity in the presence of inclusion complex can be up to 5 times higher. The applicability of the developed method was confirmed by the analysis of this drug in pharmaceutical formulation and in human serum spiked with sertraline standard. The comparison to HPLC method was successfully performed.
PB  - Springer
T2  - Monatshefte für Chemie - Chemical Monthly
T1  - Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution
SP  - 185
EP  - 192
DO  - 10.1007/s00706-021-02745-3
ER  - 

@article{
author = "Lović, Jelena and Lađarević, Jelena and Trišović, Nemanja and Andrić, Filip and Mladenović, Aleksandar R. and Mijin, Dušan and Vuković, Dragan and Petrović, Slobodan D. and Avramov Ivić, Milka",
year = "2021",
abstract = "The electrochemical characterization of sertraline at gold electrode was examined by cyclic voltammetry measurements (CV) in pH 8.4 bicarbonate buffer. Then Au electrode was evaluated for the quantitative determination of sertraline using square wave voltammetry (SWV). To enhance the sensitivity during the drug determination, (2-hydroxypropyl)-β-cyclodextrin
(HPβCD) and β-cyclodextrin (βCD) inclusion complexes were employed. Using the proposed SWV technique, the anodic current peak was linear within a concentration range of 0.1–0.5 μM with a limit of detection (LOD) of 2.0 × 10–8 M and a limit of quantification (LOQ) of 6.7 × 10–8 M. In the case of inclusion complex of the sertraline with HPβCD, a good linearity range of 0.1–0.9 μM was obtained with a LOD of 2.6 × 10–8 M and a LOQ of 8.8 × 10–8 M. The gold electrode
revealed the same linearity range for inclusion complex of the sertraline with βCD with a LOD and a LOQ being 2.6 × 10–8 and 8.6 × 10–8 M, respectively. Comparing the regression equations, it can be concluded that the sensitivity in the presence of inclusion complex can be up to 5 times higher. The applicability of the developed method was confirmed by the analysis of this drug in pharmaceutical formulation and in human serum spiked with sertraline standard. The comparison to HPLC method was successfully performed.",
publisher = "Springer",
journal = "Monatshefte für Chemie - Chemical Monthly",
title = "Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution",
pages = "185-192",
doi = "10.1007/s00706-021-02745-3"
}

Lović, J., Lađarević, J., Trišović, N., Andrić, F., Mladenović, A. R., Mijin, D., Vuković, D., Petrović, S. D.,& Avramov Ivić, M.. (2021). Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution. in Monatshefte für Chemie - Chemical Monthly
Springer., 185-192.
https://doi.org/10.1007/s00706-021-02745-3

Lović J, Lađarević J, Trišović N, Andrić F, Mladenović AR, Mijin D, Vuković D, Petrović SD, Avramov Ivić M. Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution. in Monatshefte für Chemie - Chemical Monthly. 2021;:185-192.
doi:10.1007/s00706-021-02745-3 .

Lović, Jelena, Lađarević, Jelena, Trišović, Nemanja, Andrić, Filip, Mladenović, Aleksandar R., Mijin, Dušan, Vuković, Dragan, Petrović, Slobodan D., Avramov Ivić, Milka, "Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution" in Monatshefte für Chemie - Chemical Monthly (2021):185-192,
https://doi.org/10.1007/s00706-021-02745-3 . .

TY  - CONF
AU  - Marinković, Aleksandar D.
AU  - Milosavljević, Milutin
AU  - Kovačević, Tihomir M.
AU  - Kovačina, Jovanka
AU  - Milošević, Milena D.
AU  - Jovanović, Aleksandar
AU  - Petrović, Slobodan D.
PY  - 2020
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3687
AB  - Innovative technology has been developed for the production of gelcoat and materials of reduced flammability based on unsaturated polyester resins. These materials were synthesized from raw materials obtained from waste poly(ethylene terephthalate) (PET) and bio-renewable resources. The presented technologies respect the environmental legislative as well as the principles of green and circular economy. Resulting products can be applied in various industries (construction/building, mining, polymer processing etc.).
PB  - ООО «Центр «АЮМЭЛЬ»
C3  - Catalogue of XVI International Salon of Inventions and New Technologies "New Time", Sevastopol, the Russian Federation, 24-26.09.2020.
T1  - Eco-friendly technology for gel-coat and fireproofing material production using bio-renewable and waste materials
SP  - 179
EP  - 180
UR  - https://hdl.handle.net/21.15107/rcub_cer_3687
ER  - 

@conference{
author = "Marinković, Aleksandar D. and Milosavljević, Milutin and Kovačević, Tihomir M. and Kovačina, Jovanka and Milošević, Milena D. and Jovanović, Aleksandar and Petrović, Slobodan D.",
year = "2020",
abstract = "Innovative technology has been developed for the production of gelcoat and materials of reduced flammability based on unsaturated polyester resins. These materials were synthesized from raw materials obtained from waste poly(ethylene terephthalate) (PET) and bio-renewable resources. The presented technologies respect the environmental legislative as well as the principles of green and circular economy. Resulting products can be applied in various industries (construction/building, mining, polymer processing etc.).",
publisher = "ООО «Центр «АЮМЭЛЬ»",
journal = "Catalogue of XVI International Salon of Inventions and New Technologies "New Time", Sevastopol, the Russian Federation, 24-26.09.2020.",
title = "Eco-friendly technology for gel-coat and fireproofing material production using bio-renewable and waste materials",
pages = "179-180",
url = "https://hdl.handle.net/21.15107/rcub_cer_3687"
}

Marinković, A. D., Milosavljević, M., Kovačević, T. M., Kovačina, J., Milošević, M. D., Jovanović, A.,& Petrović, S. D.. (2020). Eco-friendly technology for gel-coat and fireproofing material production using bio-renewable and waste materials. in Catalogue of XVI International Salon of Inventions and New Technologies "New Time", Sevastopol, the Russian Federation, 24-26.09.2020.
ООО «Центр «АЮМЭЛЬ»., 179-180.
https://hdl.handle.net/21.15107/rcub_cer_3687

Marinković AD, Milosavljević M, Kovačević TM, Kovačina J, Milošević MD, Jovanović A, Petrović SD. Eco-friendly technology for gel-coat and fireproofing material production using bio-renewable and waste materials. in Catalogue of XVI International Salon of Inventions and New Technologies "New Time", Sevastopol, the Russian Federation, 24-26.09.2020.. 2020;:179-180.
https://hdl.handle.net/21.15107/rcub_cer_3687 .

Marinković, Aleksandar D., Milosavljević, Milutin, Kovačević, Tihomir M., Kovačina, Jovanka, Milošević, Milena D., Jovanović, Aleksandar, Petrović, Slobodan D., "Eco-friendly technology for gel-coat and fireproofing material production using bio-renewable and waste materials" in Catalogue of XVI International Salon of Inventions and New Technologies "New Time", Sevastopol, the Russian Federation, 24-26.09.2020. (2020):179-180,
https://hdl.handle.net/21.15107/rcub_cer_3687 .

TY  - JOUR
AU  - Vajdle, Olga
AU  - Šekuljica, Sanja
AU  - Guzsvány, Valéria
AU  - Nagy, László
AU  - Kónya, Zoltán
AU  - Avramov Ivić, Milka
AU  - Mijin, Dušan
AU  - Petrović, Slobodan D.
AU  - Anojčić, Jasmina
PY  - 2020
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3615
AB  - In this work, carbon paste electrode (CPE) and carbon paste electrode modified with gold nanoparticles (AuNPs/CPE) were employed with rapid direct anodic square wave voltammetry (SWV) for macrolide antibiotics erythromycin ethylsuccinate (EES), azithromycin (AZI), clarithromycin (CLA) and roxithromycin (ROX) determination. The surface
of working electrodes was morphologically characterized by scanning electron microscopic (SEM) measurements whereby the presence of randomly distributed AuNPs of 10 nmdiameter size on CPE surface was confirmed by energy dispersive 
 spectrometer (EDS). SWV determination of four macrolide antibiotics using CPE was performed in aqueous Britton-Robinson buffer solutions (pH 2.0 to 11.98) showing that oxidation signals strongly depend upon pH (at pH ≥ 6) and exhibited the most favorable characteristics at pH 8.0 in the case of EES and pH 11.98 in the case of AZI, CLA and ROX. Under optimized conditions, the SWV method using CPE enables determination of all investigated macrolide antibiotics in low μg mL−1 concentration ranges with relative standard deviations (RSDs) lower than 6%
and achieved detection limits (LODs) as 0.18, 0.045, 1.43 and 0.30 μgmL−1 for EES, AZI, CLA and ROX, respectively. In the case of AZI and ROX, it was demonstrated that the use of AuNPs/CPE as working electrode could additionally improve the results obtained with the SWV method concerning exhibited sensitivity, reproducibility and linear concentration
range, due to the electrocatalytic properties of synthesized AuNPs. The optimized experimental parameters with the use of SWV method and CPE or AuNPs/CPE were successfully applied for determination of ROX and AZI in their pharmaceutical preparations Runac® and Hemomycin®, respectively. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of HPLC-DAD measurements.
PB  - Elsevier
T2  - Journal of Electroanalytical Chemistry
T1  - Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations
VL  - 873
SP  - 114324
DO  - 10.1016/j.jelechem.2020.114324
ER  - 

@article{
author = "Vajdle, Olga and Šekuljica, Sanja and Guzsvány, Valéria and Nagy, László and Kónya, Zoltán and Avramov Ivić, Milka and Mijin, Dušan and Petrović, Slobodan D. and Anojčić, Jasmina",
year = "2020",
abstract = "In this work, carbon paste electrode (CPE) and carbon paste electrode modified with gold nanoparticles (AuNPs/CPE) were employed with rapid direct anodic square wave voltammetry (SWV) for macrolide antibiotics erythromycin ethylsuccinate (EES), azithromycin (AZI), clarithromycin (CLA) and roxithromycin (ROX) determination. The surface
of working electrodes was morphologically characterized by scanning electron microscopic (SEM) measurements whereby the presence of randomly distributed AuNPs of 10 nmdiameter size on CPE surface was confirmed by energy dispersive 
 spectrometer (EDS). SWV determination of four macrolide antibiotics using CPE was performed in aqueous Britton-Robinson buffer solutions (pH 2.0 to 11.98) showing that oxidation signals strongly depend upon pH (at pH ≥ 6) and exhibited the most favorable characteristics at pH 8.0 in the case of EES and pH 11.98 in the case of AZI, CLA and ROX. Under optimized conditions, the SWV method using CPE enables determination of all investigated macrolide antibiotics in low μg mL−1 concentration ranges with relative standard deviations (RSDs) lower than 6%
and achieved detection limits (LODs) as 0.18, 0.045, 1.43 and 0.30 μgmL−1 for EES, AZI, CLA and ROX, respectively. In the case of AZI and ROX, it was demonstrated that the use of AuNPs/CPE as working electrode could additionally improve the results obtained with the SWV method concerning exhibited sensitivity, reproducibility and linear concentration
range, due to the electrocatalytic properties of synthesized AuNPs. The optimized experimental parameters with the use of SWV method and CPE or AuNPs/CPE were successfully applied for determination of ROX and AZI in their pharmaceutical preparations Runac® and Hemomycin®, respectively. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of HPLC-DAD measurements.",
publisher = "Elsevier",
journal = "Journal of Electroanalytical Chemistry",
title = "Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations",
volume = "873",
pages = "114324",
doi = "10.1016/j.jelechem.2020.114324"
}

Vajdle, O., Šekuljica, S., Guzsvány, V., Nagy, L., Kónya, Z., Avramov Ivić, M., Mijin, D., Petrović, S. D.,& Anojčić, J.. (2020). Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations. in Journal of Electroanalytical Chemistry
Elsevier., 873, 114324.
https://doi.org/10.1016/j.jelechem.2020.114324

Vajdle O, Šekuljica S, Guzsvány V, Nagy L, Kónya Z, Avramov Ivić M, Mijin D, Petrović SD, Anojčić J. Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations. in Journal of Electroanalytical Chemistry. 2020;873:114324.
doi:10.1016/j.jelechem.2020.114324 .

Vajdle, Olga, Šekuljica, Sanja, Guzsvány, Valéria, Nagy, László, Kónya, Zoltán, Avramov Ivić, Milka, Mijin, Dušan, Petrović, Slobodan D., Anojčić, Jasmina, "Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations" in Journal of Electroanalytical Chemistry, 873 (2020):114324,
https://doi.org/10.1016/j.jelechem.2020.114324 . .

TY  - JOUR
AU  - Vajdle, Olga
AU  - Šekuljica, Sanja
AU  - Guzsvány, Valéria
AU  - Nagy, László
AU  - Kónya, Zoltán
AU  - Avramov Ivić, Milka
AU  - Mijin, Dušan
AU  - Petrović, Slobodan D.
AU  - Anojčić, Jasmina
PY  - 2020
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3619
AB  - In this work, carbon paste electrode (CPE) and carbon paste electrode modified with gold nanoparticles (AuNPs/CPE) were employed with rapid direct anodic square wave voltammetry (SWV) for macrolide antibiotics erythromycin ethylsuccinate (EES), azithromycin (AZI), clarithromycin (CLA) and roxithromycin (ROX) determination. The surfaceof working electrodes was morphologically characterized by scanning electron microscopic (SEM) measurements whereby the presence of randomly distributed AuNPs of 10 nmdiameter size on CPE surface was confirmed by energy dispersive  spectrometer (EDS). SWV determination of four macrolide antibiotics using CPE was performed in aqueous Britton-Robinson buffer solutions (pH 2.0 to 11.98) showing that oxidation signals strongly depend upon pH (at pH ≥ 6) and exhibited the most favorable characteristics at pH 8.0 in the case of EES and pH 11.98 in the case of AZI, CLA and ROX. Under optimized conditions, the SWV method using CPE enables determination of all investigated macrolide antibiotics in low μg mL−1 concentration ranges with relative standard deviations (RSDs) lower than 6%and achieved detection limits (LODs) as 0.18, 0.045, 1.43 and 0.30 μgmL−1 for EES, AZI, CLA and ROX, respectively. In the case of AZI and ROX, it was demonstrated that the use of AuNPs/CPE as working electrode could additionally improve the results obtained with the SWV method concerning exhibited sensitivity, reproducibility and linear concentrationrange, due to the electrocatalytic properties of synthesized AuNPs. The optimized experimental parameters with the use of SWV method and CPE or AuNPs/CPE were successfully applied for determination of ROX and AZI in their pharmaceutical preparations Runac® and Hemomycin®, respectively. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of HPLC-DAD measurements.
PB  - Elsevier
T2  - Journal of Electroanalytical Chemistry
T1  - Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations
VL  - 873
SP  - 114324
DO  - 10.1016/j.jelechem.2020.114324
ER  - 

@article{
author = "Vajdle, Olga and Šekuljica, Sanja and Guzsvány, Valéria and Nagy, László and Kónya, Zoltán and Avramov Ivić, Milka and Mijin, Dušan and Petrović, Slobodan D. and Anojčić, Jasmina",
year = "2020",
abstract = "In this work, carbon paste electrode (CPE) and carbon paste electrode modified with gold nanoparticles (AuNPs/CPE) were employed with rapid direct anodic square wave voltammetry (SWV) for macrolide antibiotics erythromycin ethylsuccinate (EES), azithromycin (AZI), clarithromycin (CLA) and roxithromycin (ROX) determination. The surfaceof working electrodes was morphologically characterized by scanning electron microscopic (SEM) measurements whereby the presence of randomly distributed AuNPs of 10 nmdiameter size on CPE surface was confirmed by energy dispersive  spectrometer (EDS). SWV determination of four macrolide antibiotics using CPE was performed in aqueous Britton-Robinson buffer solutions (pH 2.0 to 11.98) showing that oxidation signals strongly depend upon pH (at pH ≥ 6) and exhibited the most favorable characteristics at pH 8.0 in the case of EES and pH 11.98 in the case of AZI, CLA and ROX. Under optimized conditions, the SWV method using CPE enables determination of all investigated macrolide antibiotics in low μg mL−1 concentration ranges with relative standard deviations (RSDs) lower than 6%and achieved detection limits (LODs) as 0.18, 0.045, 1.43 and 0.30 μgmL−1 for EES, AZI, CLA and ROX, respectively. In the case of AZI and ROX, it was demonstrated that the use of AuNPs/CPE as working electrode could additionally improve the results obtained with the SWV method concerning exhibited sensitivity, reproducibility and linear concentrationrange, due to the electrocatalytic properties of synthesized AuNPs. The optimized experimental parameters with the use of SWV method and CPE or AuNPs/CPE were successfully applied for determination of ROX and AZI in their pharmaceutical preparations Runac® and Hemomycin®, respectively. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of HPLC-DAD measurements.",
publisher = "Elsevier",
journal = "Journal of Electroanalytical Chemistry",
title = "Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations",
volume = "873",
pages = "114324",
doi = "10.1016/j.jelechem.2020.114324"
}

Vajdle, O., Šekuljica, S., Guzsvány, V., Nagy, L., Kónya, Z., Avramov Ivić, M., Mijin, D., Petrović, S. D.,& Anojčić, J.. (2020). Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations. in Journal of Electroanalytical Chemistry
Elsevier., 873, 114324.
https://doi.org/10.1016/j.jelechem.2020.114324

Vajdle O, Šekuljica S, Guzsvány V, Nagy L, Kónya Z, Avramov Ivić M, Mijin D, Petrović SD, Anojčić J. Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations. in Journal of Electroanalytical Chemistry. 2020;873:114324.
doi:10.1016/j.jelechem.2020.114324 .

Vajdle, Olga, Šekuljica, Sanja, Guzsvány, Valéria, Nagy, László, Kónya, Zoltán, Avramov Ivić, Milka, Mijin, Dušan, Petrović, Slobodan D., Anojčić, Jasmina, "Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations" in Journal of Electroanalytical Chemistry, 873 (2020):114324,
https://doi.org/10.1016/j.jelechem.2020.114324 . .

TY  - JOUR
AU  - Avramov Ivić, Milka
AU  - Lović, Jelena
AU  - Stevanović, Sanja
AU  - Nikolić, Nebojša D.
AU  - Trišović, Nemanja
AU  - Lađarević, Jelena
AU  - Vuković, Dragan
AU  - Drmanić, Saša Ž.
AU  - Mladenović, Aleksandar R.
AU  - Jadranin, Milka
AU  - Petrović, Slobodan D.
AU  - Mijin, Dušan
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3062
AB  - Esomeprazole is the most effective of the proton-pump inhibitors for the acid-related diseases and at first was examined for the electroanalytical purposes. The drug standard and as a content of injection powder was investigated by cyclic voltammetry (CV) and quantitatively determined using square wave voltammetry (SWV) via its electrooxidation at Au electrode in 0.05 M NaHCO3. SWV showed a linear dependency of the anodic peak currents vs. esomeprazole standard concentrations in the range from 3.0 to 500 μg mL−1 with the values of limit of detection (LOD) and limit of quantification (LOQ): 1.4 and 4.6 μg mL−1, respectively. Using the constructed and validated calibration curve, the values of unknown esomeprazole concentrations in injection powder and in human serum spiked with standard were determined. Before the electrochemical oxidation, it was shown by atomic force microscopy (AFM) that the small esomeprazole islands formed inside holes were visible and their diameter was about 200 nm attributed to physico-chemical characteristics of esomeprazole. After the electrochemical oxidation, the morphology of esomeprazole standard on Au surface was completely changed and composed of spherical particles in a diameter between 200 and 600 nm. With esomeprazole suspended in human serum, the process of crystallization partly occurred in the form of spherical grains with the average size of these grains was about 4 μm. The analysis at the macro level done by the optical microscopy (OM) confirmed this opinion. The study of esomeprazole degradation showed that at Au electrode, after 3 h of cycling, a neglectable amount of the esomeprazole was changed. Using IrOx electrode under directed stress conditions, its almost complete degradation was realized after 3 h confirmed by high performance liquid chromatography (HPLC). Total organic carbon (TOC) analysis showed that 95% of esomeprazole was mineralized. The HPLC and Liquid chromatography-mass spectrometry (LC-MS) study revealed the formation of 4-hydroxy omeprazole sulphide, 4-hydroxy omeprazole sulphone, esomeprazole sulphone and methylated esomeprazole.
PB  - Elsevier
T2  - Journal of Electroanalytical Chemistry
T1  - Electrochemical behavior of esomeprazole: Its determination at Au electrode as standard and in injection powder combined with the study of its degradation
VL  - 848
SP  - 113303
DO  - 10.1016/j.jelechem.2019.113303
ER  - 

@article{
author = "Avramov Ivić, Milka and Lović, Jelena and Stevanović, Sanja and Nikolić, Nebojša D. and Trišović, Nemanja and Lađarević, Jelena and Vuković, Dragan and Drmanić, Saša Ž. and Mladenović, Aleksandar R. and Jadranin, Milka and Petrović, Slobodan D. and Mijin, Dušan",
year = "2019",
abstract = "Esomeprazole is the most effective of the proton-pump inhibitors for the acid-related diseases and at first was examined for the electroanalytical purposes. The drug standard and as a content of injection powder was investigated by cyclic voltammetry (CV) and quantitatively determined using square wave voltammetry (SWV) via its electrooxidation at Au electrode in 0.05 M NaHCO3. SWV showed a linear dependency of the anodic peak currents vs. esomeprazole standard concentrations in the range from 3.0 to 500 μg mL−1 with the values of limit of detection (LOD) and limit of quantification (LOQ): 1.4 and 4.6 μg mL−1, respectively. Using the constructed and validated calibration curve, the values of unknown esomeprazole concentrations in injection powder and in human serum spiked with standard were determined. Before the electrochemical oxidation, it was shown by atomic force microscopy (AFM) that the small esomeprazole islands formed inside holes were visible and their diameter was about 200 nm attributed to physico-chemical characteristics of esomeprazole. After the electrochemical oxidation, the morphology of esomeprazole standard on Au surface was completely changed and composed of spherical particles in a diameter between 200 and 600 nm. With esomeprazole suspended in human serum, the process of crystallization partly occurred in the form of spherical grains with the average size of these grains was about 4 μm. The analysis at the macro level done by the optical microscopy (OM) confirmed this opinion. The study of esomeprazole degradation showed that at Au electrode, after 3 h of cycling, a neglectable amount of the esomeprazole was changed. Using IrOx electrode under directed stress conditions, its almost complete degradation was realized after 3 h confirmed by high performance liquid chromatography (HPLC). Total organic carbon (TOC) analysis showed that 95% of esomeprazole was mineralized. The HPLC and Liquid chromatography-mass spectrometry (LC-MS) study revealed the formation of 4-hydroxy omeprazole sulphide, 4-hydroxy omeprazole sulphone, esomeprazole sulphone and methylated esomeprazole.",
publisher = "Elsevier",
journal = "Journal of Electroanalytical Chemistry",
title = "Electrochemical behavior of esomeprazole: Its determination at Au electrode as standard and in injection powder combined with the study of its degradation",
volume = "848",
pages = "113303",
doi = "10.1016/j.jelechem.2019.113303"
}

Avramov Ivić, M., Lović, J., Stevanović, S., Nikolić, N. D., Trišović, N., Lađarević, J., Vuković, D., Drmanić, S. Ž., Mladenović, A. R., Jadranin, M., Petrović, S. D.,& Mijin, D.. (2019). Electrochemical behavior of esomeprazole: Its determination at Au electrode as standard and in injection powder combined with the study of its degradation. in Journal of Electroanalytical Chemistry
Elsevier., 848, 113303.
https://doi.org/10.1016/j.jelechem.2019.113303

Avramov Ivić M, Lović J, Stevanović S, Nikolić ND, Trišović N, Lađarević J, Vuković D, Drmanić SŽ, Mladenović AR, Jadranin M, Petrović SD, Mijin D. Electrochemical behavior of esomeprazole: Its determination at Au electrode as standard and in injection powder combined with the study of its degradation. in Journal of Electroanalytical Chemistry. 2019;848:113303.
doi:10.1016/j.jelechem.2019.113303 .

Avramov Ivić, Milka, Lović, Jelena, Stevanović, Sanja, Nikolić, Nebojša D., Trišović, Nemanja, Lađarević, Jelena, Vuković, Dragan, Drmanić, Saša Ž., Mladenović, Aleksandar R., Jadranin, Milka, Petrović, Slobodan D., Mijin, Dušan, "Electrochemical behavior of esomeprazole: Its determination at Au electrode as standard and in injection powder combined with the study of its degradation" in Journal of Electroanalytical Chemistry, 848 (2019):113303,
https://doi.org/10.1016/j.jelechem.2019.113303 . .

TY  - JOUR
AU  - Lović, Jelena
AU  - Lađarević, Jelena
AU  - Mijin, Dušan
AU  - Jadranin, Milka
AU  - Petrović, Slobodan D.
AU  - Avramov Ivić, Milka
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3159
AB  - In this study the electrochemical behavior of metformin (MET), oral antihyperglycaemic agent, was assayed at three different electrodes. The drug standard was investigated by cyclic voltammetry (CV) and square wave volta-mmetry (SWV) via its electrooxidation at Au and glassy carbon (GC) electrode in 0.05 M NaHCO3. Under these conditions transformation of MET to corresponding N-carbonyl guanidine via oxime intermediate is suggested. The stability of MET was tested under directed stress conditions using IrOx elec-trode with sodium sulphate as an electrolyte and cyclic 4-amino-2-imino-1-me-thyl-1,2-dihydro-1,3,5-triazine (4,2,1-AIMT) appeared as the main end-product. The courses of the electrochemical processes at three electrodes are followed by UV spectroscopy and evaluated by total organic carbon (TOC) analysis.
AB  - У оквиру рада изучавано је електрохемијско понашање метформина, лека са антихипергликемијским дејством, на три различите електроде. Стандард лека испитан је
цикличном волтаметријом и волтаметријом са правоугаоним импулсима у 0,05 М
раствору NaHCO3 на елекроди од злата и електроди од стакластог угљеника. Под овим
условима, предложена је трансформација лека до одговарајућег N-карбонил гуанидина
преко оксима као интермедијера. Стабилност метформина тестирана је и под условима
електрохемијске оксидације на IrOx електроди у присуству натријум сулфата као
електолита. У овом случају, предложено је настајање цикличног 4-амино-2-имино-1-
метил-1,2-дихидро-1,3,5-триазина као главног производа. Ток електрохемијских процеса
на све три електроде праћен је УВ спектроскопијом. Степен минерализације утврђен је
анализом укупног органског угљеника.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes
T1  - Електрохемијска стабилност метформина у воденим растворима NaHCO3 И Na2SO4 на Au, GC и IrOx електродама
VL  - 84
IS  - 11
SP  - 1319
EP  - 1327
DO  - 10.2298/JSC190731091L
ER  - 

@article{
author = "Lović, Jelena and Lađarević, Jelena and Mijin, Dušan and Jadranin, Milka and Petrović, Slobodan D. and Avramov Ivić, Milka",
year = "2019",
abstract = "In this study the electrochemical behavior of metformin (MET), oral antihyperglycaemic agent, was assayed at three different electrodes. The drug standard was investigated by cyclic voltammetry (CV) and square wave volta-mmetry (SWV) via its electrooxidation at Au and glassy carbon (GC) electrode in 0.05 M NaHCO3. Under these conditions transformation of MET to corresponding N-carbonyl guanidine via oxime intermediate is suggested. The stability of MET was tested under directed stress conditions using IrOx elec-trode with sodium sulphate as an electrolyte and cyclic 4-amino-2-imino-1-me-thyl-1,2-dihydro-1,3,5-triazine (4,2,1-AIMT) appeared as the main end-product. The courses of the electrochemical processes at three electrodes are followed by UV spectroscopy and evaluated by total organic carbon (TOC) analysis., У оквиру рада изучавано је електрохемијско понашање метформина, лека са антихипергликемијским дејством, на три различите електроде. Стандард лека испитан је
цикличном волтаметријом и волтаметријом са правоугаоним импулсима у 0,05 М
раствору NaHCO3 на елекроди од злата и електроди од стакластог угљеника. Под овим
условима, предложена је трансформација лека до одговарајућег N-карбонил гуанидина
преко оксима као интермедијера. Стабилност метформина тестирана је и под условима
електрохемијске оксидације на IrOx електроди у присуству натријум сулфата као
електолита. У овом случају, предложено је настајање цикличног 4-амино-2-имино-1-
метил-1,2-дихидро-1,3,5-триазина као главног производа. Ток електрохемијских процеса
на све три електроде праћен је УВ спектроскопијом. Степен минерализације утврђен је
анализом укупног органског угљеника.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes, Електрохемијска стабилност метформина у воденим растворима NaHCO3 И Na2SO4 на Au, GC и IrOx електродама",
volume = "84",
number = "11",
pages = "1319-1327",
doi = "10.2298/JSC190731091L"
}

Lović, J., Lađarević, J., Mijin, D., Jadranin, M., Petrović, S. D.,& Avramov Ivić, M.. (2019). Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 84(11), 1319-1327.
https://doi.org/10.2298/JSC190731091L

Lović J, Lađarević J, Mijin D, Jadranin M, Petrović SD, Avramov Ivić M. Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes. in Journal of the Serbian Chemical Society. 2019;84(11):1319-1327.
doi:10.2298/JSC190731091L .

Lović, Jelena, Lađarević, Jelena, Mijin, Dušan, Jadranin, Milka, Petrović, Slobodan D., Avramov Ivić, Milka, "Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes" in Journal of the Serbian Chemical Society, 84, no. 11 (2019):1319-1327,
https://doi.org/10.2298/JSC190731091L . .

TY  - JOUR
AU  - Lović, Jelena
AU  - Lađarević, Jelena
AU  - Mijin, Dušan
AU  - Jadranin, Milka
AU  - Petrović, Slobodan D.
AU  - Avramov Ivić, Milka
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3383
AB  - In this study the electrochemical behavior of metformin (MET), oral antihyperglycaemic agent, was assayed at three different electrodes. The drug standard was investigated by cyclic voltammetry (CV) and square wave volta-mmetry (SWV) via its electrooxidation at Au and glassy carbon (GC) electrode in 0.05 M NaHCO3. Under these conditions transformation of MET to corresponding N-carbonyl guanidine via oxime intermediate is suggested. The stability of MET was tested under directed stress conditions using IrOx elec-trode with sodium sulphate as an electrolyte and cyclic 4-amino-2-imino-1-me-thyl-1,2-dihydro-1,3,5-triazine (4,2,1-AIMT) appeared as the main end-product. The courses of the electrochemical processes at three electrodes are followed by UV spectroscopy and evaluated by total organic carbon (TOC) analysis.
AB  - У оквиру рада изучавано је електрохемијско понашање метформина, лека са антихипергликемијским дејством, на три различите електроде. Стандард лека испитан јецикличном волтаметријом и волтаметријом са правоугаоним импулсима у 0,05 Мраствору NaHCO3 на елекроди од злата и електроди од стакластог угљеника. Под овимусловима, предложена је трансформација лека до одговарајућег N-карбонил гуанидинапреко оксима као интермедијера. Стабилност метформина тестирана је и под условимаелектрохемијске оксидације на IrOx електроди у присуству натријум сулфата каоелектолита. У овом случају, предложено је настајање цикличног 4-амино-2-имино-1-метил-1,2-дихидро-1,3,5-триазина као главног производа. Ток електрохемијских процесана све три електроде праћен је УВ спектроскопијом. Степен минерализације утврђен јеанализом укупног органског угљеника.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes
T1  - Електрохемијска стабилност метформина у воденим растворима NaHCO3 И Na2SO4 на Au, GC и IrOx електродама
VL  - 84
IS  - 11
SP  - 1319
EP  - 1327
DO  - 10.2298/JSC190731091L
ER  - 

@article{
author = "Lović, Jelena and Lađarević, Jelena and Mijin, Dušan and Jadranin, Milka and Petrović, Slobodan D. and Avramov Ivić, Milka",
year = "2019",
abstract = "In this study the electrochemical behavior of metformin (MET), oral antihyperglycaemic agent, was assayed at three different electrodes. The drug standard was investigated by cyclic voltammetry (CV) and square wave volta-mmetry (SWV) via its electrooxidation at Au and glassy carbon (GC) electrode in 0.05 M NaHCO3. Under these conditions transformation of MET to corresponding N-carbonyl guanidine via oxime intermediate is suggested. The stability of MET was tested under directed stress conditions using IrOx elec-trode with sodium sulphate as an electrolyte and cyclic 4-amino-2-imino-1-me-thyl-1,2-dihydro-1,3,5-triazine (4,2,1-AIMT) appeared as the main end-product. The courses of the electrochemical processes at three electrodes are followed by UV spectroscopy and evaluated by total organic carbon (TOC) analysis., У оквиру рада изучавано је електрохемијско понашање метформина, лека са антихипергликемијским дејством, на три различите електроде. Стандард лека испитан јецикличном волтаметријом и волтаметријом са правоугаоним импулсима у 0,05 Мраствору NaHCO3 на елекроди од злата и електроди од стакластог угљеника. Под овимусловима, предложена је трансформација лека до одговарајућег N-карбонил гуанидинапреко оксима као интермедијера. Стабилност метформина тестирана је и под условимаелектрохемијске оксидације на IrOx електроди у присуству натријум сулфата каоелектолита. У овом случају, предложено је настајање цикличног 4-амино-2-имино-1-метил-1,2-дихидро-1,3,5-триазина као главног производа. Ток електрохемијских процесана све три електроде праћен је УВ спектроскопијом. Степен минерализације утврђен јеанализом укупног органског угљеника.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes, Електрохемијска стабилност метформина у воденим растворима NaHCO3 И Na2SO4 на Au, GC и IrOx електродама",
volume = "84",
number = "11",
pages = "1319-1327",
doi = "10.2298/JSC190731091L"
}

Lović, J., Lađarević, J., Mijin, D., Jadranin, M., Petrović, S. D.,& Avramov Ivić, M.. (2019). Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 84(11), 1319-1327.
https://doi.org/10.2298/JSC190731091L

Lović J, Lađarević J, Mijin D, Jadranin M, Petrović SD, Avramov Ivić M. Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes. in Journal of the Serbian Chemical Society. 2019;84(11):1319-1327.
doi:10.2298/JSC190731091L .

Lović, Jelena, Lađarević, Jelena, Mijin, Dušan, Jadranin, Milka, Petrović, Slobodan D., Avramov Ivić, Milka, "Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes" in Journal of the Serbian Chemical Society, 84, no. 11 (2019):1319-1327,
https://doi.org/10.2298/JSC190731091L . .

TY  - JOUR
AU  - Radosavljevic, Kristina D.
AU  - Lović, Jelena
AU  - Mijin, Dušan
AU  - Petrović, Slobodan D.
AU  - Jadranin, Milka
AU  - Mladenović, Aleksandar R.
AU  - Avramov Ivić, Milka
PY  - 2017
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2233
AB  - The electrodegradation of azithromycin was studied by its indirect oxidation using dimensionally stable Ti/RuO2 anode as catalyst in the electrolyte containing methanol, 0.05 M NaHCO3, sodium chloride and deionized water. The optimal conditions for galvanostatic electrodegradation for the azithromycin concentration of 0.472 mg cm(-3) were found to be NaCl concentration of 7 mg cm(-3) and the applied current of 300 mA. The differential pulse voltammetry using glassy carbon electrode was performed for the first time in the above-mentioned content of electrolyte for the nine concentration of azithromycin (0.075-0.675 mg cm(-3)) giving the limits of azithromycin detection and of quantification as: LOD 0.044 mg cm(-3) and LOQ 0.145 mg cm(-3). The calibration curve was constructed enabling the electrolyte analysis during its electrodegradation process. The electrolyte was analyzed by high-performance liquid chromatography and electrospray ionization time-of-flight mass spectrometry. The electrooxidation products were identified and after 180 min there was no azithromycin in the electrolyte while TOC analysis showed that 79% of azithromycin was mineralized. The proposed degradation scheme is presented.
PB  - Versita, Warsaw
T2  - Chemical Papers
T1  - Degradation of azithromycin using Ti/RuO2 anode as catalyst followed by DPV, HPLC-UV and MS analysis
VL  - 71
IS  - 7
SP  - 1217
EP  - 1224
DO  - 10.1007/s11696-016-0115-2
ER  - 

@article{
author = "Radosavljevic, Kristina D. and Lović, Jelena and Mijin, Dušan and Petrović, Slobodan D. and Jadranin, Milka and Mladenović, Aleksandar R. and Avramov Ivić, Milka",
year = "2017",
abstract = "The electrodegradation of azithromycin was studied by its indirect oxidation using dimensionally stable Ti/RuO2 anode as catalyst in the electrolyte containing methanol, 0.05 M NaHCO3, sodium chloride and deionized water. The optimal conditions for galvanostatic electrodegradation for the azithromycin concentration of 0.472 mg cm(-3) were found to be NaCl concentration of 7 mg cm(-3) and the applied current of 300 mA. The differential pulse voltammetry using glassy carbon electrode was performed for the first time in the above-mentioned content of electrolyte for the nine concentration of azithromycin (0.075-0.675 mg cm(-3)) giving the limits of azithromycin detection and of quantification as: LOD 0.044 mg cm(-3) and LOQ 0.145 mg cm(-3). The calibration curve was constructed enabling the electrolyte analysis during its electrodegradation process. The electrolyte was analyzed by high-performance liquid chromatography and electrospray ionization time-of-flight mass spectrometry. The electrooxidation products were identified and after 180 min there was no azithromycin in the electrolyte while TOC analysis showed that 79% of azithromycin was mineralized. The proposed degradation scheme is presented.",
publisher = "Versita, Warsaw",
journal = "Chemical Papers",
title = "Degradation of azithromycin using Ti/RuO2 anode as catalyst followed by DPV, HPLC-UV and MS analysis",
volume = "71",
number = "7",
pages = "1217-1224",
doi = "10.1007/s11696-016-0115-2"
}

Radosavljevic, K. D., Lović, J., Mijin, D., Petrović, S. D., Jadranin, M., Mladenović, A. R.,& Avramov Ivić, M.. (2017). Degradation of azithromycin using Ti/RuO2 anode as catalyst followed by DPV, HPLC-UV and MS analysis. in Chemical Papers
Versita, Warsaw., 71(7), 1217-1224.
https://doi.org/10.1007/s11696-016-0115-2

Radosavljevic KD, Lović J, Mijin D, Petrović SD, Jadranin M, Mladenović AR, Avramov Ivić M. Degradation of azithromycin using Ti/RuO2 anode as catalyst followed by DPV, HPLC-UV and MS analysis. in Chemical Papers. 2017;71(7):1217-1224.
doi:10.1007/s11696-016-0115-2 .

Radosavljevic, Kristina D., Lović, Jelena, Mijin, Dušan, Petrović, Slobodan D., Jadranin, Milka, Mladenović, Aleksandar R., Avramov Ivić, Milka, "Degradation of azithromycin using Ti/RuO2 anode as catalyst followed by DPV, HPLC-UV and MS analysis" in Chemical Papers, 71, no. 7 (2017):1217-1224,
https://doi.org/10.1007/s11696-016-0115-2 . .

TY  - JOUR
AU  - Vajdle, Olga
AU  - Guzsvány, Valéria
AU  - Škorić, Dušan
AU  - Csanadi, Janos
AU  - Petkovic, Milos
AU  - Avramov Ivić, Milka
AU  - Kónya, Zoltán
AU  - Petrović, Slobodan D.
AU  - Bobrowski, Andrzej
PY  - 2017
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2187
AB  - The renewable silver-amalgam film electrode (Hg(Ag)FE) was applied for voltammetric characterization and determination of semi-synthetic macrolide antibiotics azithromycin (AZI), clarithromycin (CLA) and roxithromycin (ROX) in the Britton-Robinson buffer as supporting electrolyte ranging the pH from 4.0 to 11.9. All three macrolides showed reduction signals in fairly negative potential range. During direct cathodic square wave voltammetric (SWV) investigations conducted over the potential range from -0.75 V to -2.00V vs SCE, either one or two reduction peaks were obtained in the potential range from -1.5 to -1.9 V. The shapes and intensities of the signals depend on the applied pH values in wider pH ranges. For analytical purposes concerning the development of direct cathodic SWV and adsorptive stripping SWV (SW-AdSV) methods the neutral and slightly alkaline media were suitable as pH 7.2, pH 7.4 and pH 7.0 for AZI, CIA and ROX, respectively. Based on the cyclic voltammograms recorded at these pH values, adsorption-controlled electrode kinetics process can be proposed for all three macrolides. Furthermore, the water suppressed H-1 NMR measurements in the pH range between 6.0 and 10.5 indicated that the macrolide molecules at the optimal analytical conditions are predominantly in protonated form via their tertiary amino groups which supported in all three cases their adsorption on the appropriately polarized Hg(Ag)FE electrode. The optimized direct cathodic SWV methods showed good linearity in concentration ranges 4.81-23.3 mu gmL(-1), 1.96-28.6 mu gmL(-1) and 1.48-25.9 mu gmL(-1) for AZI, CIA and ROX, respectively. The development of the SW-AdSV methods resulted in the linear responses at lower concentration ranges as 1.0-2.46 mu gmL(-1), 0.05-0.99 mu gmL(-1) and 0.10-0.99 mu gmL(-1), for AZI, CIA and ROX, respectively. The relative standard deviation for all developed methods was not higher than 1.0% except the SWV method for AZI with 4.7%. In the case of all three investigated macrolide antibiotics the protonated form of the tertiary amino group(s) at appropriate accumulation potential and time favored the adsorption of the ionic form of the target molecules offering the opportunity for the development of SW-AdSV methods for their trace level analysis on Hg(Ag)FE. Optimized SW-AdSV method was applied for determination of ROX in pharmaceutical preparation Runac.
PB  - Oxford : Pergamon-Elsevier Science Ltd
T2  - Electrochimica Acta
T1  - Voltammetric behavior and determination of the macrolide antibiotics azithromycin, clarithromycin and roxithromycin at a renewable silver - amalgam film electrode
VL  - 229
SP  - 334
EP  - 344
DO  - 10.1016/j.electacta.2017.01.146
ER  - 

@article{
author = "Vajdle, Olga and Guzsvány, Valéria and Škorić, Dušan and Csanadi, Janos and Petkovic, Milos and Avramov Ivić, Milka and Kónya, Zoltán and Petrović, Slobodan D. and Bobrowski, Andrzej",
year = "2017",
abstract = "The renewable silver-amalgam film electrode (Hg(Ag)FE) was applied for voltammetric characterization and determination of semi-synthetic macrolide antibiotics azithromycin (AZI), clarithromycin (CLA) and roxithromycin (ROX) in the Britton-Robinson buffer as supporting electrolyte ranging the pH from 4.0 to 11.9. All three macrolides showed reduction signals in fairly negative potential range. During direct cathodic square wave voltammetric (SWV) investigations conducted over the potential range from -0.75 V to -2.00V vs SCE, either one or two reduction peaks were obtained in the potential range from -1.5 to -1.9 V. The shapes and intensities of the signals depend on the applied pH values in wider pH ranges. For analytical purposes concerning the development of direct cathodic SWV and adsorptive stripping SWV (SW-AdSV) methods the neutral and slightly alkaline media were suitable as pH 7.2, pH 7.4 and pH 7.0 for AZI, CIA and ROX, respectively. Based on the cyclic voltammograms recorded at these pH values, adsorption-controlled electrode kinetics process can be proposed for all three macrolides. Furthermore, the water suppressed H-1 NMR measurements in the pH range between 6.0 and 10.5 indicated that the macrolide molecules at the optimal analytical conditions are predominantly in protonated form via their tertiary amino groups which supported in all three cases their adsorption on the appropriately polarized Hg(Ag)FE electrode. The optimized direct cathodic SWV methods showed good linearity in concentration ranges 4.81-23.3 mu gmL(-1), 1.96-28.6 mu gmL(-1) and 1.48-25.9 mu gmL(-1) for AZI, CIA and ROX, respectively. The development of the SW-AdSV methods resulted in the linear responses at lower concentration ranges as 1.0-2.46 mu gmL(-1), 0.05-0.99 mu gmL(-1) and 0.10-0.99 mu gmL(-1), for AZI, CIA and ROX, respectively. The relative standard deviation for all developed methods was not higher than 1.0% except the SWV method for AZI with 4.7%. In the case of all three investigated macrolide antibiotics the protonated form of the tertiary amino group(s) at appropriate accumulation potential and time favored the adsorption of the ionic form of the target molecules offering the opportunity for the development of SW-AdSV methods for their trace level analysis on Hg(Ag)FE. Optimized SW-AdSV method was applied for determination of ROX in pharmaceutical preparation Runac.",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "Electrochimica Acta",
title = "Voltammetric behavior and determination of the macrolide antibiotics azithromycin, clarithromycin and roxithromycin at a renewable silver - amalgam film electrode",
volume = "229",
pages = "334-344",
doi = "10.1016/j.electacta.2017.01.146"
}

Vajdle, O., Guzsvány, V., Škorić, D., Csanadi, J., Petkovic, M., Avramov Ivić, M., Kónya, Z., Petrović, S. D.,& Bobrowski, A.. (2017). Voltammetric behavior and determination of the macrolide antibiotics azithromycin, clarithromycin and roxithromycin at a renewable silver - amalgam film electrode. in Electrochimica Acta
Oxford : Pergamon-Elsevier Science Ltd., 229, 334-344.
https://doi.org/10.1016/j.electacta.2017.01.146

Vajdle O, Guzsvány V, Škorić D, Csanadi J, Petkovic M, Avramov Ivić M, Kónya Z, Petrović SD, Bobrowski A. Voltammetric behavior and determination of the macrolide antibiotics azithromycin, clarithromycin and roxithromycin at a renewable silver - amalgam film electrode. in Electrochimica Acta. 2017;229:334-344.
doi:10.1016/j.electacta.2017.01.146 .

Vajdle, Olga, Guzsvány, Valéria, Škorić, Dušan, Csanadi, Janos, Petkovic, Milos, Avramov Ivić, Milka, Kónya, Zoltán, Petrović, Slobodan D., Bobrowski, Andrzej, "Voltammetric behavior and determination of the macrolide antibiotics azithromycin, clarithromycin and roxithromycin at a renewable silver - amalgam film electrode" in Electrochimica Acta, 229 (2017):334-344,
https://doi.org/10.1016/j.electacta.2017.01.146 . .

TY  - JOUR
AU  - Lović, Jelena
AU  - Trišović, Nemanja
AU  - Antanasijevic, Jelena
AU  - Nikolić, Nebojša D.
AU  - Stevanović, Sanja
AU  - Mijin, Dušan
AU  - Vukovic, Dragan
AU  - Mladenović, Aleksandar R.
AU  - Petrović, Slobodan D.
AU  - Avramov Ivić, Milka
PY  - 2016
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4310
AB  - Nonmedical use of sildenafil citrate (SC) requires new methods for drug determination in human serum and in tablets. SC as standard and in Sildena (R) tablets is determined by square wave voltammetry (SWV) in 0.1 M H2SO4 (harmful for human serum) at gold electrode in a range: (1 x 10(-3),1 x 10(-2), 0.1, 0.5,1) mu M and on cysteine (Cys) modified gold electrode (Au/Cys) in a range: (1 x 10(-3),1 x 10(-2), 0.05, 0.1) mu M. The presence of Cys causes two times larger peak currents and shifting of the incipient potential of the SC oxidation to 0.1 V in negative direction. A safe procedure for SC determination as standard and in Sildena (R) tablets spiked with human serum is developed by SWV at gold electrode in 0.05 M NaHCO3 (suitable for human liquids) in a range: (1 x 10(-3),1 x 10(-2), 0.1, 0.2, 03) mu M. Microscopic characterization of the surfaces morphology was also performed. The SC concentrations were checked by high performance liquid chromatography-ultraviolet spectroscopy (HPLC-UV) showing that electrochemical method is more sensitive and can be used for the measurements of very low concentrations of the analyte.
PB  - Elsevier
T2  - Journal of Electroanalytical Chemistry
T1  - Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode
VL  - 782
SP  - 103
EP  - 107
DO  - 10.1016/j.jelechem.2016.10.022
ER  - 

@article{
author = "Lović, Jelena and Trišović, Nemanja and Antanasijevic, Jelena and Nikolić, Nebojša D. and Stevanović, Sanja and Mijin, Dušan and Vukovic, Dragan and Mladenović, Aleksandar R. and Petrović, Slobodan D. and Avramov Ivić, Milka",
year = "2016",
abstract = "Nonmedical use of sildenafil citrate (SC) requires new methods for drug determination in human serum and in tablets. SC as standard and in Sildena (R) tablets is determined by square wave voltammetry (SWV) in 0.1 M H2SO4 (harmful for human serum) at gold electrode in a range: (1 x 10(-3),1 x 10(-2), 0.1, 0.5,1) mu M and on cysteine (Cys) modified gold electrode (Au/Cys) in a range: (1 x 10(-3),1 x 10(-2), 0.05, 0.1) mu M. The presence of Cys causes two times larger peak currents and shifting of the incipient potential of the SC oxidation to 0.1 V in negative direction. A safe procedure for SC determination as standard and in Sildena (R) tablets spiked with human serum is developed by SWV at gold electrode in 0.05 M NaHCO3 (suitable for human liquids) in a range: (1 x 10(-3),1 x 10(-2), 0.1, 0.2, 03) mu M. Microscopic characterization of the surfaces morphology was also performed. The SC concentrations were checked by high performance liquid chromatography-ultraviolet spectroscopy (HPLC-UV) showing that electrochemical method is more sensitive and can be used for the measurements of very low concentrations of the analyte.",
publisher = "Elsevier",
journal = "Journal of Electroanalytical Chemistry",
title = "Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode",
volume = "782",
pages = "103-107",
doi = "10.1016/j.jelechem.2016.10.022"
}

Lović, J., Trišović, N., Antanasijevic, J., Nikolić, N. D., Stevanović, S., Mijin, D., Vukovic, D., Mladenović, A. R., Petrović, S. D.,& Avramov Ivić, M.. (2016). Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode. in Journal of Electroanalytical Chemistry
Elsevier., 782, 103-107.
https://doi.org/10.1016/j.jelechem.2016.10.022

Lović J, Trišović N, Antanasijevic J, Nikolić ND, Stevanović S, Mijin D, Vukovic D, Mladenović AR, Petrović SD, Avramov Ivić M. Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode. in Journal of Electroanalytical Chemistry. 2016;782:103-107.
doi:10.1016/j.jelechem.2016.10.022 .

Lović, Jelena, Trišović, Nemanja, Antanasijevic, Jelena, Nikolić, Nebojša D., Stevanović, Sanja, Mijin, Dušan, Vukovic, Dragan, Mladenović, Aleksandar R., Petrović, Slobodan D., Avramov Ivić, Milka, "Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode" in Journal of Electroanalytical Chemistry, 782 (2016):103-107,
https://doi.org/10.1016/j.jelechem.2016.10.022 . .

TY  - CHAP
AU  - Avramov Ivić, Milka
AU  - Petrović, Slobodan D.
AU  - Mijin, Dušan
PY  - 2016
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3644
AB  - Electrochemistry is rapidly growing area with a number of possible applications in the pharmaceutical analysis. Modern electrochemical methods are selective, sensitive, rapid, and provide easy techniques applicable to analyses in the pharmaceutical fi eld. It is evident that the electroanalytical techniques at varying levels of sensitivity are required to solve analytical–pharmaceutical problems. The advantages of electrochemical methods are the simple procedures of the sample preparation and in most cases lack of interferences from excipients in the pharmaceutical dosage forms.
PB  - Springer Science and Business Media LLC
T2  - Modern Aspects of Electrochemistry
T1  - Contribution to the Recent Advances in Electrochemical Analysis of Pharmaceuticals
VL  - 60
SP  - 89
EP  - 195
DO  - 10.1007/978-3-319-31849-3_2
ER  - 

@inbook{
author = "Avramov Ivić, Milka and Petrović, Slobodan D. and Mijin, Dušan",
year = "2016",
abstract = "Electrochemistry is rapidly growing area with a number of possible applications in the pharmaceutical analysis. Modern electrochemical methods are selective, sensitive, rapid, and provide easy techniques applicable to analyses in the pharmaceutical fi eld. It is evident that the electroanalytical techniques at varying levels of sensitivity are required to solve analytical–pharmaceutical problems. The advantages of electrochemical methods are the simple procedures of the sample preparation and in most cases lack of interferences from excipients in the pharmaceutical dosage forms.",
publisher = "Springer Science and Business Media LLC",
journal = "Modern Aspects of Electrochemistry",
booktitle = "Contribution to the Recent Advances in Electrochemical Analysis of Pharmaceuticals",
volume = "60",
pages = "89-195",
doi = "10.1007/978-3-319-31849-3_2"
}

Avramov Ivić, M., Petrović, S. D.,& Mijin, D.. (2016). Contribution to the Recent Advances in Electrochemical Analysis of Pharmaceuticals. in Modern Aspects of Electrochemistry
Springer Science and Business Media LLC., 60, 89-195.
https://doi.org/10.1007/978-3-319-31849-3_2

Avramov Ivić M, Petrović SD, Mijin D. Contribution to the Recent Advances in Electrochemical Analysis of Pharmaceuticals. in Modern Aspects of Electrochemistry. 2016;60:89-195.
doi:10.1007/978-3-319-31849-3_2 .

Avramov Ivić, Milka, Petrović, Slobodan D., Mijin, Dušan, "Contribution to the Recent Advances in Electrochemical Analysis of Pharmaceuticals" in Modern Aspects of Electrochemistry, 60 (2016):89-195,
https://doi.org/10.1007/978-3-319-31849-3_2 . .

TY  - JOUR
AU  - Vajdle, Olga
AU  - Guzsvány, Valéria
AU  - Škorić, Dušan
AU  - Anojčić, Jasmina
AU  - Jovanov, Pavle
AU  - Avramov Ivić, Milka
AU  - Csanadi, Janos
AU  - Kónya, Zoltán
AU  - Petrović, Slobodan D.
AU  - Bobrowski, Andrzej
PY  - 2016
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4319
AB  - Erythromycin, a macrolide antibiotic, has similar antimicrobial spectrum to penicillin and it is widely used, especially in the treatment of patients who are allergic to penicillin. In this work, the application of a renewable silver-amalgam film electrode (Hg(Ag)FE) for the characterization and determination of erythromycin ethylsuccinate (EES), a widely used esterified form of this antibiotic, by means of cyclic voltammetry (CV) and square wave voltammetry (SWV) is presented. In the aqueous Britton-Robinson buffer (pH 5.0-9.0) that served as the supporting electrolyte, one reduction peak of EES was observed in the investigated potential range between -0.75 V and -1.80 V vs SCE, with peak potential maxima ranging from -1.59 V to -1.70 V, which strongly depended on the applied pH, as did the peak shape. For the analytical purposes the pH of 7.0 was selected, since in this electrolyte the EES peak was well-shaped and separated from the background current of the supporting electrolyte in both cases; in the direct cathodic SWV and in the case of square wave adsorptive stripping voltammetry (SW-AdSV). It was established, by the E-p-pH correlation, that protons strongly influenced the electrochemical reduction of EES. The CVs recorded between 0.025-0.50 V s (1) at pH 7.0 confirmed that the electrode reaction is adsorption-controlled. Based on the series of H-1 NMR measurements it is proved that the tertiary amino group of EES is mainly in its protonated form at pH 7.0 which may lead, at appropriate accumulation potential and time, to the favored adsorption of the target ionic form of the analyte improving on such way the sensitivity of the SW-AdSV method. The optimized procedures resulted in stable SWV responses with good linear correlation in the EES concentration range from 4.53 to 29.8 mu g mL (1) (LOD = 1.36 mu g mL (1)), and from 0.69 mu g mL (1) to 2.44 mu g mL (1) (LOD 0.21 mu g mL (1)) in the case of optimized SW-AdSV. The relative standard deviation is below 1.5%. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of HPLC-DAD measurements. The direct cathodic SWV method was successfully applied for the determination of EES in the pharmaceutical preparation Eritromicin (R), while SW-AdSV was applied in the case of the spiked urine sample. In both cases, the standard addition method was used.
PB  - Oxford : Pergamon-Elsevier Science Ltd
T2  - Electrochimica Acta
T1  - Voltammetric behavior of erythromycin ethylsuccinate at a renewable silver-amalgam film electrode and its determination in urine and in a pharmaceutical preparation
VL  - 191
SP  - 44
EP  - 54
DO  - 10.1016/j.electacta.2015.12.207
ER  - 

@article{
author = "Vajdle, Olga and Guzsvány, Valéria and Škorić, Dušan and Anojčić, Jasmina and Jovanov, Pavle and Avramov Ivić, Milka and Csanadi, Janos and Kónya, Zoltán and Petrović, Slobodan D. and Bobrowski, Andrzej",
year = "2016",
abstract = "Erythromycin, a macrolide antibiotic, has similar antimicrobial spectrum to penicillin and it is widely used, especially in the treatment of patients who are allergic to penicillin. In this work, the application of a renewable silver-amalgam film electrode (Hg(Ag)FE) for the characterization and determination of erythromycin ethylsuccinate (EES), a widely used esterified form of this antibiotic, by means of cyclic voltammetry (CV) and square wave voltammetry (SWV) is presented. In the aqueous Britton-Robinson buffer (pH 5.0-9.0) that served as the supporting electrolyte, one reduction peak of EES was observed in the investigated potential range between -0.75 V and -1.80 V vs SCE, with peak potential maxima ranging from -1.59 V to -1.70 V, which strongly depended on the applied pH, as did the peak shape. For the analytical purposes the pH of 7.0 was selected, since in this electrolyte the EES peak was well-shaped and separated from the background current of the supporting electrolyte in both cases; in the direct cathodic SWV and in the case of square wave adsorptive stripping voltammetry (SW-AdSV). It was established, by the E-p-pH correlation, that protons strongly influenced the electrochemical reduction of EES. The CVs recorded between 0.025-0.50 V s (1) at pH 7.0 confirmed that the electrode reaction is adsorption-controlled. Based on the series of H-1 NMR measurements it is proved that the tertiary amino group of EES is mainly in its protonated form at pH 7.0 which may lead, at appropriate accumulation potential and time, to the favored adsorption of the target ionic form of the analyte improving on such way the sensitivity of the SW-AdSV method. The optimized procedures resulted in stable SWV responses with good linear correlation in the EES concentration range from 4.53 to 29.8 mu g mL (1) (LOD = 1.36 mu g mL (1)), and from 0.69 mu g mL (1) to 2.44 mu g mL (1) (LOD 0.21 mu g mL (1)) in the case of optimized SW-AdSV. The relative standard deviation is below 1.5%. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of HPLC-DAD measurements. The direct cathodic SWV method was successfully applied for the determination of EES in the pharmaceutical preparation Eritromicin (R), while SW-AdSV was applied in the case of the spiked urine sample. In both cases, the standard addition method was used.",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "Electrochimica Acta",
title = "Voltammetric behavior of erythromycin ethylsuccinate at a renewable silver-amalgam film electrode and its determination in urine and in a pharmaceutical preparation",
volume = "191",
pages = "44-54",
doi = "10.1016/j.electacta.2015.12.207"
}

Vajdle, O., Guzsvány, V., Škorić, D., Anojčić, J., Jovanov, P., Avramov Ivić, M., Csanadi, J., Kónya, Z., Petrović, S. D.,& Bobrowski, A.. (2016). Voltammetric behavior of erythromycin ethylsuccinate at a renewable silver-amalgam film electrode and its determination in urine and in a pharmaceutical preparation. in Electrochimica Acta
Oxford : Pergamon-Elsevier Science Ltd., 191, 44-54.
https://doi.org/10.1016/j.electacta.2015.12.207

Vajdle O, Guzsvány V, Škorić D, Anojčić J, Jovanov P, Avramov Ivić M, Csanadi J, Kónya Z, Petrović SD, Bobrowski A. Voltammetric behavior of erythromycin ethylsuccinate at a renewable silver-amalgam film electrode and its determination in urine and in a pharmaceutical preparation. in Electrochimica Acta. 2016;191:44-54.
doi:10.1016/j.electacta.2015.12.207 .

Vajdle, Olga, Guzsvány, Valéria, Škorić, Dušan, Anojčić, Jasmina, Jovanov, Pavle, Avramov Ivić, Milka, Csanadi, Janos, Kónya, Zoltán, Petrović, Slobodan D., Bobrowski, Andrzej, "Voltammetric behavior of erythromycin ethylsuccinate at a renewable silver-amalgam film electrode and its determination in urine and in a pharmaceutical preparation" in Electrochimica Acta, 191 (2016):44-54,
https://doi.org/10.1016/j.electacta.2015.12.207 . .

TY  - JOUR
AU  - Vajdle, Olga
AU  - Guzsvány, Valéria
AU  - Škorić, Dušan
AU  - Anojčić, Jasmina
AU  - Jovanov, Pavle
AU  - Avramov Ivić, Milka
AU  - Csanadi, Janos
AU  - Kónya, Zoltán
AU  - Petrović, Slobodan D.
AU  - Bobrowski, Andrzej
PY  - 2016
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1964
AB  - Erythromycin, a macrolide antibiotic, has similar antimicrobial spectrum to penicillin and it is widely used, especially in the treatment of patients who are allergic to penicillin. In this work, the application of a renewable silver-amalgam film electrode (Hg(Ag)FE) for the characterization and determination of erythromycin ethylsuccinate (EES), a widely used esterified form of this antibiotic, by means of cyclic voltammetry (CV) and square wave voltammetry (SWV) is presented. In the aqueous Britton-Robinson buffer (pH 5.0-9.0) that served as the supporting electrolyte, one reduction peak of EES was observed in the investigated potential range between -0.75 V and -1.80 V vs SCE, with peak potential maxima ranging from -1.59 V to -1.70 V, which strongly depended on the applied pH, as did the peak shape. For the analytical purposes the pH of 7.0 was selected, since in this electrolyte the EES peak was well-shaped and separated from the background current of the supporting electrolyte in both cases; in the direct cathodic SWV and in the case of square wave adsorptive stripping voltammetry (SW-AdSV). It was established, by the E-p-pH correlation, that protons strongly influenced the electrochemical reduction of EES. The CVs recorded between 0.025-0.50 V s (1) at pH 7.0 confirmed that the electrode reaction is adsorption-controlled. Based on the series of H-1 NMR measurements it is proved that the tertiary amino group of EES is mainly in its protonated form at pH 7.0 which may lead, at appropriate accumulation potential and time, to the favored adsorption of the target ionic form of the analyte improving on such way the sensitivity of the SW-AdSV method. The optimized procedures resulted in stable SWV responses with good linear correlation in the EES concentration range from 4.53 to 29.8 mu g mL (1) (LOD = 1.36 mu g mL (1)), and from 0.69 mu g mL (1) to 2.44 mu g mL (1) (LOD 0.21 mu g mL (1)) in the case of optimized SW-AdSV. The relative standard deviation is below 1.5%. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of HPLC-DAD measurements. The direct cathodic SWV method was successfully applied for the determination of EES in the pharmaceutical preparation Eritromicin (R), while SW-AdSV was applied in the case of the spiked urine sample. In both cases, the standard addition method was used.
PB  - Oxford : Pergamon-Elsevier Science Ltd
T2  - Electrochimica Acta
T1  - Voltammetric behavior of erythromycin ethylsuccinate at a renewable silver-amalgam film electrode and its determination in urine and in a pharmaceutical preparation
VL  - 191
SP  - 44
EP  - 54
DO  - 10.1016/j.electacta.2015.12.207
ER  - 

@article{
author = "Vajdle, Olga and Guzsvány, Valéria and Škorić, Dušan and Anojčić, Jasmina and Jovanov, Pavle and Avramov Ivić, Milka and Csanadi, Janos and Kónya, Zoltán and Petrović, Slobodan D. and Bobrowski, Andrzej",
year = "2016",
abstract = "Erythromycin, a macrolide antibiotic, has similar antimicrobial spectrum to penicillin and it is widely used, especially in the treatment of patients who are allergic to penicillin. In this work, the application of a renewable silver-amalgam film electrode (Hg(Ag)FE) for the characterization and determination of erythromycin ethylsuccinate (EES), a widely used esterified form of this antibiotic, by means of cyclic voltammetry (CV) and square wave voltammetry (SWV) is presented. In the aqueous Britton-Robinson buffer (pH 5.0-9.0) that served as the supporting electrolyte, one reduction peak of EES was observed in the investigated potential range between -0.75 V and -1.80 V vs SCE, with peak potential maxima ranging from -1.59 V to -1.70 V, which strongly depended on the applied pH, as did the peak shape. For the analytical purposes the pH of 7.0 was selected, since in this electrolyte the EES peak was well-shaped and separated from the background current of the supporting electrolyte in both cases; in the direct cathodic SWV and in the case of square wave adsorptive stripping voltammetry (SW-AdSV). It was established, by the E-p-pH correlation, that protons strongly influenced the electrochemical reduction of EES. The CVs recorded between 0.025-0.50 V s (1) at pH 7.0 confirmed that the electrode reaction is adsorption-controlled. Based on the series of H-1 NMR measurements it is proved that the tertiary amino group of EES is mainly in its protonated form at pH 7.0 which may lead, at appropriate accumulation potential and time, to the favored adsorption of the target ionic form of the analyte improving on such way the sensitivity of the SW-AdSV method. The optimized procedures resulted in stable SWV responses with good linear correlation in the EES concentration range from 4.53 to 29.8 mu g mL (1) (LOD = 1.36 mu g mL (1)), and from 0.69 mu g mL (1) to 2.44 mu g mL (1) (LOD 0.21 mu g mL (1)) in the case of optimized SW-AdSV. The relative standard deviation is below 1.5%. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of HPLC-DAD measurements. The direct cathodic SWV method was successfully applied for the determination of EES in the pharmaceutical preparation Eritromicin (R), while SW-AdSV was applied in the case of the spiked urine sample. In both cases, the standard addition method was used.",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "Electrochimica Acta",
title = "Voltammetric behavior of erythromycin ethylsuccinate at a renewable silver-amalgam film electrode and its determination in urine and in a pharmaceutical preparation",
volume = "191",
pages = "44-54",
doi = "10.1016/j.electacta.2015.12.207"
}

Vajdle, O., Guzsvány, V., Škorić, D., Anojčić, J., Jovanov, P., Avramov Ivić, M., Csanadi, J., Kónya, Z., Petrović, S. D.,& Bobrowski, A.. (2016). Voltammetric behavior of erythromycin ethylsuccinate at a renewable silver-amalgam film electrode and its determination in urine and in a pharmaceutical preparation. in Electrochimica Acta
Oxford : Pergamon-Elsevier Science Ltd., 191, 44-54.
https://doi.org/10.1016/j.electacta.2015.12.207

Vajdle O, Guzsvány V, Škorić D, Anojčić J, Jovanov P, Avramov Ivić M, Csanadi J, Kónya Z, Petrović SD, Bobrowski A. Voltammetric behavior of erythromycin ethylsuccinate at a renewable silver-amalgam film electrode and its determination in urine and in a pharmaceutical preparation. in Electrochimica Acta. 2016;191:44-54.
doi:10.1016/j.electacta.2015.12.207 .

Vajdle, Olga, Guzsvány, Valéria, Škorić, Dušan, Anojčić, Jasmina, Jovanov, Pavle, Avramov Ivić, Milka, Csanadi, Janos, Kónya, Zoltán, Petrović, Slobodan D., Bobrowski, Andrzej, "Voltammetric behavior of erythromycin ethylsuccinate at a renewable silver-amalgam film electrode and its determination in urine and in a pharmaceutical preparation" in Electrochimica Acta, 191 (2016):44-54,
https://doi.org/10.1016/j.electacta.2015.12.207 . .

TY  - JOUR
AU  - Lović, Jelena
AU  - Mijin, Dušan
AU  - Jovanović, Mica B.
AU  - Glavaski, Olivera S
AU  - Zeremski, Tijana
AU  - Petrović, Slobodan D.
AU  - Avramov Ivić, Milka
PY  - 2016
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1944
AB  - Tebuconazole, a pesticide that presents risks for ecosystems, groundwater and human health, was degraded on a gold electrode as the catalyst in 0.05 M NaHCO3 using cyclic voltammetry (CV). First, tebuconazole was characterized on the gold electrode using CV and square wave voltammetry (SWV). The gold electrode, being highly sensitive, provided linear relationships (currents vs. concentrations) in the range: (0.076-0.76 mu mol dm(-3)). Based on the CV measurements, the investigated process is irreversible and diffusion controlled. The observed catalytic role of the Au electrode in the oxidation of tebuconazole and the data obtained from CV and SWV provided the experimental conditions for the degradation of tebuconazole. The degradation was performed by continuous cycling followed by gas chromatography mass spectroscopy (GC MS) analysis. This enabled the catalytic elimination of tebuconazole for 60 min, which promoted the use of a gold electrode as the catalyst for the degradation of environmental pollutants. The scheme of the possible mechanism of tebuconazole degradation is given.
PB  - Elsevier France-Editions Scientifiques Medicales Elsevier, Paris
T2  - Comptes Rendus Chimie
T1  - An investigation of tebuconazole degradation using a gold electrode
VL  - 19
IS  - 5
SP  - 639
EP  - 645
DO  - 10.1016/j.crci.2016.01.014
ER  - 

@article{
author = "Lović, Jelena and Mijin, Dušan and Jovanović, Mica B. and Glavaski, Olivera S and Zeremski, Tijana and Petrović, Slobodan D. and Avramov Ivić, Milka",
year = "2016",
abstract = "Tebuconazole, a pesticide that presents risks for ecosystems, groundwater and human health, was degraded on a gold electrode as the catalyst in 0.05 M NaHCO3 using cyclic voltammetry (CV). First, tebuconazole was characterized on the gold electrode using CV and square wave voltammetry (SWV). The gold electrode, being highly sensitive, provided linear relationships (currents vs. concentrations) in the range: (0.076-0.76 mu mol dm(-3)). Based on the CV measurements, the investigated process is irreversible and diffusion controlled. The observed catalytic role of the Au electrode in the oxidation of tebuconazole and the data obtained from CV and SWV provided the experimental conditions for the degradation of tebuconazole. The degradation was performed by continuous cycling followed by gas chromatography mass spectroscopy (GC MS) analysis. This enabled the catalytic elimination of tebuconazole for 60 min, which promoted the use of a gold electrode as the catalyst for the degradation of environmental pollutants. The scheme of the possible mechanism of tebuconazole degradation is given.",
publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Paris",
journal = "Comptes Rendus Chimie",
title = "An investigation of tebuconazole degradation using a gold electrode",
volume = "19",
number = "5",
pages = "639-645",
doi = "10.1016/j.crci.2016.01.014"
}

Lović, J., Mijin, D., Jovanović, M. B., Glavaski, O. S., Zeremski, T., Petrović, S. D.,& Avramov Ivić, M.. (2016). An investigation of tebuconazole degradation using a gold electrode. in Comptes Rendus Chimie
Elsevier France-Editions Scientifiques Medicales Elsevier, Paris., 19(5), 639-645.
https://doi.org/10.1016/j.crci.2016.01.014

Lović J, Mijin D, Jovanović MB, Glavaski OS, Zeremski T, Petrović SD, Avramov Ivić M. An investigation of tebuconazole degradation using a gold electrode. in Comptes Rendus Chimie. 2016;19(5):639-645.
doi:10.1016/j.crci.2016.01.014 .

Lović, Jelena, Mijin, Dušan, Jovanović, Mica B., Glavaski, Olivera S, Zeremski, Tijana, Petrović, Slobodan D., Avramov Ivić, Milka, "An investigation of tebuconazole degradation using a gold electrode" in Comptes Rendus Chimie, 19, no. 5 (2016):639-645,
https://doi.org/10.1016/j.crci.2016.01.014 . .

TY  - JOUR
AU  - Avramov Ivić, Milka
AU  - Antanasijevic, Jelena
AU  - Trišović, Nemanja
AU  - Antanasijevic, Davor
AU  - Lović, Jelena
AU  - Mijin, Dušan
AU  - Petrović, Slobodan D.
PY  - 2016
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1941
AB  - The electrochemical behavior of phenobarbital sodium (PBS), paracetamol (PCM) and their binary mixtures was investigated using cyclic voltammetry (CV) and square wave voltammetry (SWV) at a bare gold electrode in a 0.05 M bicarbonate solution. A calibration curve of PBS obtained by SWV had two linear ranges, from 1.0 to 3.0 mu M and from 5.0 to 35.0 mu M with a limit of quantification (LOQ) of 0.62 mu M and a limit of detection (LOD) of 0.19 mu M, while a calibration curve of PCM was determined within the range from 10.0 to 50.0 mu M with a LOQ of 8.53 mu M and a LOD of 2.56 mu M. Both drugs underwent oxidation by irreversible, diffusion controlled process. The SW voltammograms of the drug mixtures produced complex, overlapping profiles and a chemometric method was applied for their decomposition. Two different artificial neural network (ANN) architectures, namely back-propagation neural network (BPNN) and general regression neural network (GRNN) were employed for the simultaneous prediction of the concentrations of the drugs in a synthetic sample. The BPNN model had higher accuracy (mean absolute percentage error values were in the range of 3.6-8.4%) and thus it can be used for the simultaneous determination of PBS and PCM.
PB  - Esg, Belgrade
T2  - International Journal of Electrochemical Science
T1  - A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode
VL  - 11
IS  - 7
SP  - 5935
EP  - 5951
DO  - 10.20964/2016.07.48
ER  - 

@article{
author = "Avramov Ivić, Milka and Antanasijevic, Jelena and Trišović, Nemanja and Antanasijevic, Davor and Lović, Jelena and Mijin, Dušan and Petrović, Slobodan D.",
year = "2016",
abstract = "The electrochemical behavior of phenobarbital sodium (PBS), paracetamol (PCM) and their binary mixtures was investigated using cyclic voltammetry (CV) and square wave voltammetry (SWV) at a bare gold electrode in a 0.05 M bicarbonate solution. A calibration curve of PBS obtained by SWV had two linear ranges, from 1.0 to 3.0 mu M and from 5.0 to 35.0 mu M with a limit of quantification (LOQ) of 0.62 mu M and a limit of detection (LOD) of 0.19 mu M, while a calibration curve of PCM was determined within the range from 10.0 to 50.0 mu M with a LOQ of 8.53 mu M and a LOD of 2.56 mu M. Both drugs underwent oxidation by irreversible, diffusion controlled process. The SW voltammograms of the drug mixtures produced complex, overlapping profiles and a chemometric method was applied for their decomposition. Two different artificial neural network (ANN) architectures, namely back-propagation neural network (BPNN) and general regression neural network (GRNN) were employed for the simultaneous prediction of the concentrations of the drugs in a synthetic sample. The BPNN model had higher accuracy (mean absolute percentage error values were in the range of 3.6-8.4%) and thus it can be used for the simultaneous determination of PBS and PCM.",
publisher = "Esg, Belgrade",
journal = "International Journal of Electrochemical Science",
title = "A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode",
volume = "11",
number = "7",
pages = "5935-5951",
doi = "10.20964/2016.07.48"
}

Avramov Ivić, M., Antanasijevic, J., Trišović, N., Antanasijevic, D., Lović, J., Mijin, D.,& Petrović, S. D.. (2016). A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode. in International Journal of Electrochemical Science
Esg, Belgrade., 11(7), 5935-5951.
https://doi.org/10.20964/2016.07.48

Avramov Ivić M, Antanasijevic J, Trišović N, Antanasijevic D, Lović J, Mijin D, Petrović SD. A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode. in International Journal of Electrochemical Science. 2016;11(7):5935-5951.
doi:10.20964/2016.07.48 .

Avramov Ivić, Milka, Antanasijevic, Jelena, Trišović, Nemanja, Antanasijevic, Davor, Lović, Jelena, Mijin, Dušan, Petrović, Slobodan D., "A Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrode" in International Journal of Electrochemical Science, 11, no. 7 (2016):5935-5951,
https://doi.org/10.20964/2016.07.48 . .

TY  - JOUR
AU  - Lović, Jelena
AU  - Trišović, Nemanja
AU  - Antanasijevic, Jelena
AU  - Nikolić, Nebojša D.
AU  - Stevanović, Sanja
AU  - Mijin, Dušan
AU  - Vukovic, Dragan
AU  - Mladenović, Aleksandar R.
AU  - Petrović, Slobodan D.
AU  - Avramov Ivić, Milka
PY  - 2016
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1902
AB  - Nonmedical use of sildenafil citrate (SC) requires new methods for drug determination in human serum and in tablets. SC as standard and in Sildena (R) tablets is determined by square wave voltammetry (SWV) in 0.1 M H2SO4 (harmful for human serum) at gold electrode in a range: (1 x 10(-3),1 x 10(-2), 0.1, 0.5,1) mu M and on cysteine (Cys) modified gold electrode (Au/Cys) in a range: (1 x 10(-3),1 x 10(-2), 0.05, 0.1) mu M. The presence of Cys causes two times larger peak currents and shifting of the incipient potential of the SC oxidation to 0.1 V in negative direction. A safe procedure for SC determination as standard and in Sildena (R) tablets spiked with human serum is developed by SWV at gold electrode in 0.05 M NaHCO3 (suitable for human liquids) in a range: (1 x 10(-3),1 x 10(-2), 0.1, 0.2, 03) mu M. Microscopic characterization of the surfaces morphology was also performed. The SC concentrations were checked by high performance liquid chromatography-ultraviolet spectroscopy (HPLC-UV) showing that electrochemical method is more sensitive and can be used for the measurements of very low concentrations of the analyte.
PB  - Elsevier
T2  - Journal of Electroanalytical Chemistry
T1  - Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode
VL  - 782
SP  - 103
EP  - 107
DO  - 10.1016/j.jelechem.2016.10.022
ER  - 

@article{
author = "Lović, Jelena and Trišović, Nemanja and Antanasijevic, Jelena and Nikolić, Nebojša D. and Stevanović, Sanja and Mijin, Dušan and Vukovic, Dragan and Mladenović, Aleksandar R. and Petrović, Slobodan D. and Avramov Ivić, Milka",
year = "2016",
abstract = "Nonmedical use of sildenafil citrate (SC) requires new methods for drug determination in human serum and in tablets. SC as standard and in Sildena (R) tablets is determined by square wave voltammetry (SWV) in 0.1 M H2SO4 (harmful for human serum) at gold electrode in a range: (1 x 10(-3),1 x 10(-2), 0.1, 0.5,1) mu M and on cysteine (Cys) modified gold electrode (Au/Cys) in a range: (1 x 10(-3),1 x 10(-2), 0.05, 0.1) mu M. The presence of Cys causes two times larger peak currents and shifting of the incipient potential of the SC oxidation to 0.1 V in negative direction. A safe procedure for SC determination as standard and in Sildena (R) tablets spiked with human serum is developed by SWV at gold electrode in 0.05 M NaHCO3 (suitable for human liquids) in a range: (1 x 10(-3),1 x 10(-2), 0.1, 0.2, 03) mu M. Microscopic characterization of the surfaces morphology was also performed. The SC concentrations were checked by high performance liquid chromatography-ultraviolet spectroscopy (HPLC-UV) showing that electrochemical method is more sensitive and can be used for the measurements of very low concentrations of the analyte.",
publisher = "Elsevier",
journal = "Journal of Electroanalytical Chemistry",
title = "Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode",
volume = "782",
pages = "103-107",
doi = "10.1016/j.jelechem.2016.10.022"
}

Lović, J., Trišović, N., Antanasijevic, J., Nikolić, N. D., Stevanović, S., Mijin, D., Vukovic, D., Mladenović, A. R., Petrović, S. D.,& Avramov Ivić, M.. (2016). Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode. in Journal of Electroanalytical Chemistry
Elsevier., 782, 103-107.
https://doi.org/10.1016/j.jelechem.2016.10.022

Lović J, Trišović N, Antanasijevic J, Nikolić ND, Stevanović S, Mijin D, Vukovic D, Mladenović AR, Petrović SD, Avramov Ivić M. Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode. in Journal of Electroanalytical Chemistry. 2016;782:103-107.
doi:10.1016/j.jelechem.2016.10.022 .

Lović, Jelena, Trišović, Nemanja, Antanasijevic, Jelena, Nikolić, Nebojša D., Stevanović, Sanja, Mijin, Dušan, Vukovic, Dragan, Mladenović, Aleksandar R., Petrović, Slobodan D., Avramov Ivić, Milka, "Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode" in Journal of Electroanalytical Chemistry, 782 (2016):103-107,
https://doi.org/10.1016/j.jelechem.2016.10.022 . .

TY  - JOUR
AU  - Arsovski, Violeta M
AU  - Božić, Bojan
AU  - Mirkovic, Jelena M
AU  - Vitnik, Vesna
AU  - Vitnik, Željko
AU  - Petrović, Slobodan D.
AU  - Ušćumlić, Gordana
AU  - Mijin, Dušan
PY  - 2015
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1719
AB  - To complement a previous UV study, we present a quantitative evaluation of substituent effects on spectroscopic data (H-1 and C-13 NMR chemical shifts as well as FT-IR absorption frequency) applied to N, N'-bisarylmalonamides, using simple and extended Hammett equations as well as the Swain-Lupton equation. Furthermore, the DFT CAM-B3LYP/6-311+G(d,p) method was applied to study the impact of different solvents on the geometry of the molecules and their spectral data. Additionally, experimental data are correlated with theoretical results; excellent linear dependence was obtained. The overall results presented in this paper show that N, N'-bisarylmalonamides are prominent candidates for model molecules.
PB  - Springer, New York
T2  - Journal of Molecular Modeling
T1  - Computational and spectroscopic data correlation study of N,N '-bisarylmalonamides (Part II)
VL  - 21
IS  - 9
DO  - 10.1007/s00894-015-2777-z
ER  - 

@article{
author = "Arsovski, Violeta M and Božić, Bojan and Mirkovic, Jelena M and Vitnik, Vesna and Vitnik, Željko and Petrović, Slobodan D. and Ušćumlić, Gordana and Mijin, Dušan",
year = "2015",
abstract = "To complement a previous UV study, we present a quantitative evaluation of substituent effects on spectroscopic data (H-1 and C-13 NMR chemical shifts as well as FT-IR absorption frequency) applied to N, N'-bisarylmalonamides, using simple and extended Hammett equations as well as the Swain-Lupton equation. Furthermore, the DFT CAM-B3LYP/6-311+G(d,p) method was applied to study the impact of different solvents on the geometry of the molecules and their spectral data. Additionally, experimental data are correlated with theoretical results; excellent linear dependence was obtained. The overall results presented in this paper show that N, N'-bisarylmalonamides are prominent candidates for model molecules.",
publisher = "Springer, New York",
journal = "Journal of Molecular Modeling",
title = "Computational and spectroscopic data correlation study of N,N '-bisarylmalonamides (Part II)",
volume = "21",
number = "9",
doi = "10.1007/s00894-015-2777-z"
}

Arsovski, V. M., Božić, B., Mirkovic, J. M., Vitnik, V., Vitnik, Ž., Petrović, S. D., Ušćumlić, G.,& Mijin, D.. (2015). Computational and spectroscopic data correlation study of N,N '-bisarylmalonamides (Part II). in Journal of Molecular Modeling
Springer, New York., 21(9).
https://doi.org/10.1007/s00894-015-2777-z

Arsovski VM, Božić B, Mirkovic JM, Vitnik V, Vitnik Ž, Petrović SD, Ušćumlić G, Mijin D. Computational and spectroscopic data correlation study of N,N '-bisarylmalonamides (Part II). in Journal of Molecular Modeling. 2015;21(9).
doi:10.1007/s00894-015-2777-z .

Arsovski, Violeta M, Božić, Bojan, Mirkovic, Jelena M, Vitnik, Vesna, Vitnik, Željko, Petrović, Slobodan D., Ušćumlić, Gordana, Mijin, Dušan, "Computational and spectroscopic data correlation study of N,N '-bisarylmalonamides (Part II)" in Journal of Molecular Modeling, 21, no. 9 (2015),
https://doi.org/10.1007/s00894-015-2777-z . .

TY  - JOUR
AU  - Trišović, Nemanja
AU  - Božić, Bojan
AU  - Lović, Jelena
AU  - Vitnik, Vesna
AU  - Vitnik, Željko
AU  - Petrović, Slobodan D.
AU  - Avramov Ivić, Milka
PY  - 2015
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1756
AB  - Phenytoin (5,5-diphenylhydantoin), one of the most frequently used anticonvulsant and antiarrhythmic drugs, was examined and determined at bare gold electrode in 0.05 M NaHCO3 using its anodic activity by cyclic voltammetry (CV) and square wave voltammetry (SWV). Gold electrode is highly sensitive to the phenytoin concentration (the investigated level of concentrations is usually found in human serum of patients treated with phenytoin), providing linear relationships for a set of lower concentrations (0.5, 0.6, 0.8, 1.0 mu mol dm(-3)) and for a set of higher concentrations (10, 20, 30, 40, 50 mu mol dm(-3)). The effects of the substituent on the phenyl rings on the electrochemical behavior of two derivatives, 5,5-di(4-chlorophenyl) hydantoin and 5,5-di(4-methylphenyl) hydantoin, were examined by CV. A computational study in correlation with the experimental voltammetric results enabled to propose the oxidation mechanisms: the investigated compounds undergo oxidation involving transfer of 1e(-) and 1 proton by irreversible, diffusion controlled process.
PB  - Oxford : Pergamon-Elsevier Science Ltd
T2  - Electrochimica Acta
T1  - Electrochemical characterization of phenytoin and its derivatives on bare gold electrode
VL  - 161
SP  - 378
EP  - 387
DO  - 10.1016/j.electacta.2015.02.114
ER  - 

@article{
author = "Trišović, Nemanja and Božić, Bojan and Lović, Jelena and Vitnik, Vesna and Vitnik, Željko and Petrović, Slobodan D. and Avramov Ivić, Milka",
year = "2015",
abstract = "Phenytoin (5,5-diphenylhydantoin), one of the most frequently used anticonvulsant and antiarrhythmic drugs, was examined and determined at bare gold electrode in 0.05 M NaHCO3 using its anodic activity by cyclic voltammetry (CV) and square wave voltammetry (SWV). Gold electrode is highly sensitive to the phenytoin concentration (the investigated level of concentrations is usually found in human serum of patients treated with phenytoin), providing linear relationships for a set of lower concentrations (0.5, 0.6, 0.8, 1.0 mu mol dm(-3)) and for a set of higher concentrations (10, 20, 30, 40, 50 mu mol dm(-3)). The effects of the substituent on the phenyl rings on the electrochemical behavior of two derivatives, 5,5-di(4-chlorophenyl) hydantoin and 5,5-di(4-methylphenyl) hydantoin, were examined by CV. A computational study in correlation with the experimental voltammetric results enabled to propose the oxidation mechanisms: the investigated compounds undergo oxidation involving transfer of 1e(-) and 1 proton by irreversible, diffusion controlled process.",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "Electrochimica Acta",
title = "Electrochemical characterization of phenytoin and its derivatives on bare gold electrode",
volume = "161",
pages = "378-387",
doi = "10.1016/j.electacta.2015.02.114"
}

Trišović, N., Božić, B., Lović, J., Vitnik, V., Vitnik, Ž., Petrović, S. D.,& Avramov Ivić, M.. (2015). Electrochemical characterization of phenytoin and its derivatives on bare gold electrode. in Electrochimica Acta
Oxford : Pergamon-Elsevier Science Ltd., 161, 378-387.
https://doi.org/10.1016/j.electacta.2015.02.114

Trišović N, Božić B, Lović J, Vitnik V, Vitnik Ž, Petrović SD, Avramov Ivić M. Electrochemical characterization of phenytoin and its derivatives on bare gold electrode. in Electrochimica Acta. 2015;161:378-387.
doi:10.1016/j.electacta.2015.02.114 .

Trišović, Nemanja, Božić, Bojan, Lović, Jelena, Vitnik, Vesna, Vitnik, Željko, Petrović, Slobodan D., Avramov Ivić, Milka, "Electrochemical characterization of phenytoin and its derivatives on bare gold electrode" in Electrochimica Acta, 161 (2015):378-387,
https://doi.org/10.1016/j.electacta.2015.02.114 . .

TY  - JOUR
AU  - Tolic, Ljiljana
AU  - Lović, Jelena
AU  - Petrović, Slobodan D.
AU  - Mijin, Dušan
AU  - Grujic, Svetlana
AU  - Lausevic, Mila
AU  - Avramov Ivić, Milka
PY  - 2015
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1725
AB  - Anisomycin is an immunosuppressant in low doses ( LT 0.1 mu M) with possible application in treatment of some autoimmune diseases and in inhibiting transplantation rejection. Anisomycin suppresses malignant tumor cell growth and affects memory. For the first time it was the subject of the electrochemical investigations by cyclic voltammetry and square wave voltammetry on gold electrode in 0.05 M NaHCO3 using its electrochemical activity. The cyclic voltammetry experiments at different sweep rates show that electrochemical process is irreversible and diffusion controlled. Based on square wave voltammetry measurements, the calculated values of LOD and LOQ were 1 and 4 nM (in the absence of biological fluid), as well as 2 and 6 nM (in the presence of spiked urine) indicating the high sensitivity of the proposed electroanalytical method. High performance liquid chromatography-tandem mass spectrometry was a reference method for quantification of anisomycin and served for structural identification of its hydrolysis product (deacetylanisomycin).
PB  - Elsevier Science Inc, New York
T2  - Electrochemistry Communications
T1  - Investigation of electrochemical behavior of anisomycin on gold electrode followed by HPLC-MS/MS analysis
VL  - 58
SP  - 20
EP  - 24
DO  - 10.1016/j.elecom.2015.05.017
ER  - 

@article{
author = "Tolic, Ljiljana and Lović, Jelena and Petrović, Slobodan D. and Mijin, Dušan and Grujic, Svetlana and Lausevic, Mila and Avramov Ivić, Milka",
year = "2015",
abstract = "Anisomycin is an immunosuppressant in low doses ( LT 0.1 mu M) with possible application in treatment of some autoimmune diseases and in inhibiting transplantation rejection. Anisomycin suppresses malignant tumor cell growth and affects memory. For the first time it was the subject of the electrochemical investigations by cyclic voltammetry and square wave voltammetry on gold electrode in 0.05 M NaHCO3 using its electrochemical activity. The cyclic voltammetry experiments at different sweep rates show that electrochemical process is irreversible and diffusion controlled. Based on square wave voltammetry measurements, the calculated values of LOD and LOQ were 1 and 4 nM (in the absence of biological fluid), as well as 2 and 6 nM (in the presence of spiked urine) indicating the high sensitivity of the proposed electroanalytical method. High performance liquid chromatography-tandem mass spectrometry was a reference method for quantification of anisomycin and served for structural identification of its hydrolysis product (deacetylanisomycin).",
publisher = "Elsevier Science Inc, New York",
journal = "Electrochemistry Communications",
title = "Investigation of electrochemical behavior of anisomycin on gold electrode followed by HPLC-MS/MS analysis",
volume = "58",
pages = "20-24",
doi = "10.1016/j.elecom.2015.05.017"
}

Tolic, L., Lović, J., Petrović, S. D., Mijin, D., Grujic, S., Lausevic, M.,& Avramov Ivić, M.. (2015). Investigation of electrochemical behavior of anisomycin on gold electrode followed by HPLC-MS/MS analysis. in Electrochemistry Communications
Elsevier Science Inc, New York., 58, 20-24.
https://doi.org/10.1016/j.elecom.2015.05.017

Tolic L, Lović J, Petrović SD, Mijin D, Grujic S, Lausevic M, Avramov Ivić M. Investigation of electrochemical behavior of anisomycin on gold electrode followed by HPLC-MS/MS analysis. in Electrochemistry Communications. 2015;58:20-24.
doi:10.1016/j.elecom.2015.05.017 .

Tolic, Ljiljana, Lović, Jelena, Petrović, Slobodan D., Mijin, Dušan, Grujic, Svetlana, Lausevic, Mila, Avramov Ivić, Milka, "Investigation of electrochemical behavior of anisomycin on gold electrode followed by HPLC-MS/MS analysis" in Electrochemistry Communications, 58 (2015):20-24,
https://doi.org/10.1016/j.elecom.2015.05.017 . .

TY  - JOUR
AU  - Mladenović, Aleksandar R.
AU  - Jadranin, Milka
AU  - Pavlović, Aleksandar D.
AU  - Petrović, Slobodan D.
AU  - Drmanić, Saša Ž.
AU  - Avramov Ivić, Milka
AU  - Mijin, Dušan
PY  - 2015
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1731
AB  - This study describes the investigation of degradation products of donepezil (DP) using a stability-indicating RP-HPLC method for determination of donepezil, which is a centrally acting reversible acetyl cholinesterase inhibitor. In order to investigate the stability of the drug and formed degradation products, a forced degradation study of the drug sample and finished product under different forced degradation conditions was conducted. Donepezil hydrochloride and donepezil tablets were subjected to stress degradation conditions recommended by the International Conference on Harmonization (ICH). Donepezil hydrochloride solutions were subjected to acid and alkali hydrolysis, chemical oxidation and thermal degradation. Significant degradation was observed under alkali hydrolysis and oxidative degradation conditions. Additional degradation products were observed under the conditions of oxidative degradation. The degradation products observed during forced degradation studies were monitored using the developed high performance liquid chromatography (HPLC) method. The parent method was modified in order to obtain LC-MS compatible method, which was used to identify the degradation products from forced degradation samples using high resolution mass spectrometry. The mass spectrum provided the precise mass from which the molecular formula of the drug substance and formed degradation products was derived, and proved the specificity of the method unambiguously.
AB  - Proučavanje degradacionih proizvoda donepezila je izvršeno korišćenjem RP-HPLC metode za određivanje stabilnosti donepezila, leka koji pripada grupi reverzibilnih inhibitora acetilholinesteraze. U cilju ispitivanja stabilnosti leka i njegovih degradacionih proizvoda sprovedena je studija forsirane degradacije čiste supstance kao i farmaceutskog proizvoda pod različitim uslovima. Donepezil-hidrohlorid i donepezil tablete su podvrgnuti različitim uslovima degradacije prema preporukama Internacionalne konferencije za harmonizaciju. Rastvori donepezil-hidrohlorida su podvrgnuti kiseloj i baznoj hidrolizi, hemijskoj oksidaciji i termalnoj degradaciji. Pri baznoj hidrolizi i hemijskoj oksidaciji uočena je značajna degradacija polaznog molekula. Oksidativnom degradacijom nastaju i proizvodi koji nisu uočeni kod ostalih postupaka forsirane degradacije. Nastali proizvodi analizirani su novorazvijenom HPLC metodom. Osnovna metoda je modifikovana u cilju dobijanja LC-MS kompatibilne metode kako bi se identifikovali nastali degradacioni proizvodi. Na osnovu resultata dobijenih masenom spektrometrijom dobijene su tačne mase proizvoda degradacije, čime je omogućeno određivanje njihovih molekulskih formula.
PB  - Association of the Chemical Engineers of Serbia
T2  - Chemical Industry and Chemical Engineering Quarterly / CICEQ
T1  - Liquid chromatography and liquid chromatography-mass spectrometry analysis of donepezil degradation products
T1  - Analiza degradacionih proizvoda donepezila primenom tečne hromatografije i tečne hromatografije-masene spektrometrije
VL  - 21
IS  - 3
SP  - 447
EP  - 455
DO  - 10.2298/CICEQ141023047M
ER  - 

@article{
author = "Mladenović, Aleksandar R. and Jadranin, Milka and Pavlović, Aleksandar D. and Petrović, Slobodan D. and Drmanić, Saša Ž. and Avramov Ivić, Milka and Mijin, Dušan",
year = "2015",
abstract = "This study describes the investigation of degradation products of donepezil (DP) using a stability-indicating RP-HPLC method for determination of donepezil, which is a centrally acting reversible acetyl cholinesterase inhibitor. In order to investigate the stability of the drug and formed degradation products, a forced degradation study of the drug sample and finished product under different forced degradation conditions was conducted. Donepezil hydrochloride and donepezil tablets were subjected to stress degradation conditions recommended by the International Conference on Harmonization (ICH). Donepezil hydrochloride solutions were subjected to acid and alkali hydrolysis, chemical oxidation and thermal degradation. Significant degradation was observed under alkali hydrolysis and oxidative degradation conditions. Additional degradation products were observed under the conditions of oxidative degradation. The degradation products observed during forced degradation studies were monitored using the developed high performance liquid chromatography (HPLC) method. The parent method was modified in order to obtain LC-MS compatible method, which was used to identify the degradation products from forced degradation samples using high resolution mass spectrometry. The mass spectrum provided the precise mass from which the molecular formula of the drug substance and formed degradation products was derived, and proved the specificity of the method unambiguously., Proučavanje degradacionih proizvoda donepezila je izvršeno korišćenjem RP-HPLC metode za određivanje stabilnosti donepezila, leka koji pripada grupi reverzibilnih inhibitora acetilholinesteraze. U cilju ispitivanja stabilnosti leka i njegovih degradacionih proizvoda sprovedena je studija forsirane degradacije čiste supstance kao i farmaceutskog proizvoda pod različitim uslovima. Donepezil-hidrohlorid i donepezil tablete su podvrgnuti različitim uslovima degradacije prema preporukama Internacionalne konferencije za harmonizaciju. Rastvori donepezil-hidrohlorida su podvrgnuti kiseloj i baznoj hidrolizi, hemijskoj oksidaciji i termalnoj degradaciji. Pri baznoj hidrolizi i hemijskoj oksidaciji uočena je značajna degradacija polaznog molekula. Oksidativnom degradacijom nastaju i proizvodi koji nisu uočeni kod ostalih postupaka forsirane degradacije. Nastali proizvodi analizirani su novorazvijenom HPLC metodom. Osnovna metoda je modifikovana u cilju dobijanja LC-MS kompatibilne metode kako bi se identifikovali nastali degradacioni proizvodi. Na osnovu resultata dobijenih masenom spektrometrijom dobijene su tačne mase proizvoda degradacije, čime je omogućeno određivanje njihovih molekulskih formula.",
publisher = "Association of the Chemical Engineers of Serbia",
journal = "Chemical Industry and Chemical Engineering Quarterly / CICEQ",
title = "Liquid chromatography and liquid chromatography-mass spectrometry analysis of donepezil degradation products, Analiza degradacionih proizvoda donepezila primenom tečne hromatografije i tečne hromatografije-masene spektrometrije",
volume = "21",
number = "3",
pages = "447-455",
doi = "10.2298/CICEQ141023047M"
}

Mladenović, A. R., Jadranin, M., Pavlović, A. D., Petrović, S. D., Drmanić, S. Ž., Avramov Ivić, M.,& Mijin, D.. (2015). Liquid chromatography and liquid chromatography-mass spectrometry analysis of donepezil degradation products. in Chemical Industry and Chemical Engineering Quarterly / CICEQ
Association of the Chemical Engineers of Serbia., 21(3), 447-455.
https://doi.org/10.2298/CICEQ141023047M

Mladenović AR, Jadranin M, Pavlović AD, Petrović SD, Drmanić SŽ, Avramov Ivić M, Mijin D. Liquid chromatography and liquid chromatography-mass spectrometry analysis of donepezil degradation products. in Chemical Industry and Chemical Engineering Quarterly / CICEQ. 2015;21(3):447-455.
doi:10.2298/CICEQ141023047M .

Mladenović, Aleksandar R., Jadranin, Milka, Pavlović, Aleksandar D., Petrović, Slobodan D., Drmanić, Saša Ž., Avramov Ivić, Milka, Mijin, Dušan, "Liquid chromatography and liquid chromatography-mass spectrometry analysis of donepezil degradation products" in Chemical Industry and Chemical Engineering Quarterly / CICEQ, 21, no. 3 (2015):447-455,
https://doi.org/10.2298/CICEQ141023047M . .

TY  - JOUR
AU  - Arsovski, Violeta M
AU  - Božić, Bojan
AU  - Mirkovic, Jelena M
AU  - Vitnik, Vesna
AU  - Vitnik, Željko
AU  - Fabian, Walter M F
AU  - Petrović, Slobodan D.
AU  - Mijin, Dušan
PY  - 2014
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1545
AB  - The UV absorption spectra of ten N,N'-bisarylmalonamides have been recorded in the range 200-400 nm in a set of selected solvents. The solute-solvent interactions have been analyzed on the basis of the linear solvation energy relationship (LSER) concept proposed by Kamlet and Taft. The effects of substituents on the absorption spectra have been interpreted by correlating absorption frequencies with Hammett substituent constants. Furthermore, the experimental findings have been interpreted using the DFT CAM-B3LYP/6-311+G(d,p) method. Electronic energies have been calculated using the same method in combination with the implicit solvation model (conductor-like polarizable continuum model, CPCM) as well as with the explicit addition of two molecules of solvent.
PB  - Springer, New York
T2  - Journal of Molecular Modeling
T1  - Spectroscopic and quantum mechanical investigation of N,N '-bisarylmalonamides: solvent and structural effects
VL  - 20
IS  - 8
DO  - 10.1007/s00894-014-2384-4
ER  - 

@article{
author = "Arsovski, Violeta M and Božić, Bojan and Mirkovic, Jelena M and Vitnik, Vesna and Vitnik, Željko and Fabian, Walter M F and Petrović, Slobodan D. and Mijin, Dušan",
year = "2014",
abstract = "The UV absorption spectra of ten N,N'-bisarylmalonamides have been recorded in the range 200-400 nm in a set of selected solvents. The solute-solvent interactions have been analyzed on the basis of the linear solvation energy relationship (LSER) concept proposed by Kamlet and Taft. The effects of substituents on the absorption spectra have been interpreted by correlating absorption frequencies with Hammett substituent constants. Furthermore, the experimental findings have been interpreted using the DFT CAM-B3LYP/6-311+G(d,p) method. Electronic energies have been calculated using the same method in combination with the implicit solvation model (conductor-like polarizable continuum model, CPCM) as well as with the explicit addition of two molecules of solvent.",
publisher = "Springer, New York",
journal = "Journal of Molecular Modeling",
title = "Spectroscopic and quantum mechanical investigation of N,N '-bisarylmalonamides: solvent and structural effects",
volume = "20",
number = "8",
doi = "10.1007/s00894-014-2384-4"
}

Arsovski, V. M., Božić, B., Mirkovic, J. M., Vitnik, V., Vitnik, Ž., Fabian, W. M. F., Petrović, S. D.,& Mijin, D.. (2014). Spectroscopic and quantum mechanical investigation of N,N '-bisarylmalonamides: solvent and structural effects. in Journal of Molecular Modeling
Springer, New York., 20(8).
https://doi.org/10.1007/s00894-014-2384-4

Arsovski VM, Božić B, Mirkovic JM, Vitnik V, Vitnik Ž, Fabian WMF, Petrović SD, Mijin D. Spectroscopic and quantum mechanical investigation of N,N '-bisarylmalonamides: solvent and structural effects. in Journal of Molecular Modeling. 2014;20(8).
doi:10.1007/s00894-014-2384-4 .

Arsovski, Violeta M, Božić, Bojan, Mirkovic, Jelena M, Vitnik, Vesna, Vitnik, Željko, Fabian, Walter M F, Petrović, Slobodan D., Mijin, Dušan, "Spectroscopic and quantum mechanical investigation of N,N '-bisarylmalonamides: solvent and structural effects" in Journal of Molecular Modeling, 20, no. 8 (2014),
https://doi.org/10.1007/s00894-014-2384-4 . .

TY  - JOUR
AU  - Trišović, Nemanja
AU  - Božić, Bojan
AU  - Petrović, Slobodan D.
AU  - Tadić, Svetlana J.
AU  - Avramov Ivić, Milka
PY  - 2014
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1466
AB  - The anodic behaviour of carbamazepine (CBZ), an anticonvulsant drug, has been studied on gold electrode in 0.1 mol dm-3 phosphate buffer of pH 7.0 by using cyclic voltammetry. It has been found that the value of the oxidative current of pure CBZ at 0.90 V vs. SCE is a linear function of the concentration in a range from 1.0X10-7 to 1.0X10-4 mol dm-3. The detection of CBZ in the concentration of 1.0X10-8 mol dm-3 is among the lowest that have been reported for this drug using voltammetric techniques. CBZ as a content of tablet Galepsine® has been quantitatively determined. It has also been demonstrated that the modification of gold electrode with bovine serum albumin (BSA) results in a decrease of the oxidative peak current due to the binding of the drug to BSA.
AB  - Anodno ponašanje jednog od najsigurnijih i najefikasnijih antikonvulzivnih lekova karbamazepina (CBZ) proučavano je po prvi put na elektrodi od zlata u 0.1 mol dm-3 fosfatnom puferu pH 7.0 pomoću ciklične voltametrije. Karbamazepin kao standard i kao sastojak komercijalnog oblika ( tablete) Galepsin® podleže anodnoj oksidaciji. Utvrđeno je da je vrednost struja oksidacije čistog CBZ-a na 0.90 V linearna funkcija koncentracija u opsegu od 1.0x10-7 do 1.0x10-4 mol dm-3. CBZ je detektovan i u koncentaraciji od 1.0x10-8 mol dm-3 koja je među najnižim koje su objavljene do sada za ovaj lek korišćenjem voltametrijskih tehnika. CBZ kao sadržaj tablete Galepsin® je kvantitativno određen, pri čemu je na 0.90 V takođe dobivena linearna zavisnost vrednosti struja oksidacije od ispitivanih koncentracija leka (1.0x10-6-1.0x10-4 mol dm-3). Pokazano je da prisutni ekscipijenti u tableti ne utiču na proces elektrooksidacije CBZ u fosfatnom puferu. Takođe je pokazano da modifikovanje elektrode od zlata albuminom goveđeg seruma (BSA) ima za posledicu smanjenje struja oksidativnog pika CBZ-a usled vezivanja leka za BSA. Kvantitativno određivanje CBZ i kao sadrzaja tablete Galepsin® na elektrodi od zlata cikličnom voltametrijom u fosfatnom puferu pH 7.0 je brza, jednostavna i efikasna metoda koja je korisna dopuna standardnoj metodi, tečnoj hromatografiji visokih performansi (HPLC).
PB  - Association of Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - Electrochemical characterization and determination of carbamazepine as pharmaceutical standard and tablet content on gold electrode
T1  - Elektrohemijsko karakterisanje i određivanje karbamazepina kao farmaceutskog standarda i sadržaja tablete na elektrodi od zlata
VL  - 68
IS  - 2
SP  - 207
EP  - 212
DO  - 10.2298/HEMIND130125045T
ER  - 

@article{
author = "Trišović, Nemanja and Božić, Bojan and Petrović, Slobodan D. and Tadić, Svetlana J. and Avramov Ivić, Milka",
year = "2014",
abstract = "The anodic behaviour of carbamazepine (CBZ), an anticonvulsant drug, has been studied on gold electrode in 0.1 mol dm-3 phosphate buffer of pH 7.0 by using cyclic voltammetry. It has been found that the value of the oxidative current of pure CBZ at 0.90 V vs. SCE is a linear function of the concentration in a range from 1.0X10-7 to 1.0X10-4 mol dm-3. The detection of CBZ in the concentration of 1.0X10-8 mol dm-3 is among the lowest that have been reported for this drug using voltammetric techniques. CBZ as a content of tablet Galepsine® has been quantitatively determined. It has also been demonstrated that the modification of gold electrode with bovine serum albumin (BSA) results in a decrease of the oxidative peak current due to the binding of the drug to BSA., Anodno ponašanje jednog od najsigurnijih i najefikasnijih antikonvulzivnih lekova karbamazepina (CBZ) proučavano je po prvi put na elektrodi od zlata u 0.1 mol dm-3 fosfatnom puferu pH 7.0 pomoću ciklične voltametrije. Karbamazepin kao standard i kao sastojak komercijalnog oblika ( tablete) Galepsin® podleže anodnoj oksidaciji. Utvrđeno je da je vrednost struja oksidacije čistog CBZ-a na 0.90 V linearna funkcija koncentracija u opsegu od 1.0x10-7 do 1.0x10-4 mol dm-3. CBZ je detektovan i u koncentaraciji od 1.0x10-8 mol dm-3 koja je među najnižim koje su objavljene do sada za ovaj lek korišćenjem voltametrijskih tehnika. CBZ kao sadržaj tablete Galepsin® je kvantitativno određen, pri čemu je na 0.90 V takođe dobivena linearna zavisnost vrednosti struja oksidacije od ispitivanih koncentracija leka (1.0x10-6-1.0x10-4 mol dm-3). Pokazano je da prisutni ekscipijenti u tableti ne utiču na proces elektrooksidacije CBZ u fosfatnom puferu. Takođe je pokazano da modifikovanje elektrode od zlata albuminom goveđeg seruma (BSA) ima za posledicu smanjenje struja oksidativnog pika CBZ-a usled vezivanja leka za BSA. Kvantitativno određivanje CBZ i kao sadrzaja tablete Galepsin® na elektrodi od zlata cikličnom voltametrijom u fosfatnom puferu pH 7.0 je brza, jednostavna i efikasna metoda koja je korisna dopuna standardnoj metodi, tečnoj hromatografiji visokih performansi (HPLC).",
publisher = "Association of Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "Electrochemical characterization and determination of carbamazepine as pharmaceutical standard and tablet content on gold electrode, Elektrohemijsko karakterisanje i određivanje karbamazepina kao farmaceutskog standarda i sadržaja tablete na elektrodi od zlata",
volume = "68",
number = "2",
pages = "207-212",
doi = "10.2298/HEMIND130125045T"
}

Trišović, N., Božić, B., Petrović, S. D., Tadić, S. J.,& Avramov Ivić, M.. (2014). Electrochemical characterization and determination of carbamazepine as pharmaceutical standard and tablet content on gold electrode. in Hemijska industrija
Association of Chemical Engineers of Serbia., 68(2), 207-212.
https://doi.org/10.2298/HEMIND130125045T

Trišović N, Božić B, Petrović SD, Tadić SJ, Avramov Ivić M. Electrochemical characterization and determination of carbamazepine as pharmaceutical standard and tablet content on gold electrode. in Hemijska industrija. 2014;68(2):207-212.
doi:10.2298/HEMIND130125045T .

Trišović, Nemanja, Božić, Bojan, Petrović, Slobodan D., Tadić, Svetlana J., Avramov Ivić, Milka, "Electrochemical characterization and determination of carbamazepine as pharmaceutical standard and tablet content on gold electrode" in Hemijska industrija, 68, no. 2 (2014):207-212,
https://doi.org/10.2298/HEMIND130125045T . .

TY  - JOUR
AU  - Jevtic, Dubravka R.
AU  - Avramov Ivić, Milka
AU  - Reljin, Irini S.
AU  - Reljin, Branimir D.
AU  - Plavec, Goran I.
AU  - Petrović, Slobodan D.
AU  - Mijin, Dušan
PY  - 2014
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1516
AB  - The automated, computer-aided method for differentiation and classification of malignant (M) from benign (B) cases, by analyzing the UV/VIS spectra of pleural effusions is described. It was shown that by two independent objective features, the maximum of Katz fractal dimension (KFDmax) and the area under normalized UV/VIS absorbance curve (Area), highly reliable M-B classification is possible. In the Area-KFDmax space M and B samples are linearly separable permitting thus the use of linear support vector machine as a classification tool. By analyzing 104 samples of UV/VIS spectra of pleural effusions (88 M and 16 B) collected from patients at the Clinic for Lung Diseases and Tuberculosis, Military Medical Academy in Belgrade, the accuracy of 95.45% for M cases and 100% for B cases are obtained by using the proposed method. It was shown that by applying some modifications, which are suggested in the paper, the accuracy of 100% for M cases can be reached.
PB  - Elsevier
T2  - Physica A: Statistical Mechanics and its Applications
T1  - Diagnostic spectroscopic and computer-aided evaluation of malignancy from UV/VIS spectra of clear pleural effusions
VL  - 403
SP  - 206
EP  - 216
DO  - 10.1016/j.physa.2014.02.026
ER  - 

@article{
author = "Jevtic, Dubravka R. and Avramov Ivić, Milka and Reljin, Irini S. and Reljin, Branimir D. and Plavec, Goran I. and Petrović, Slobodan D. and Mijin, Dušan",
year = "2014",
abstract = "The automated, computer-aided method for differentiation and classification of malignant (M) from benign (B) cases, by analyzing the UV/VIS spectra of pleural effusions is described. It was shown that by two independent objective features, the maximum of Katz fractal dimension (KFDmax) and the area under normalized UV/VIS absorbance curve (Area), highly reliable M-B classification is possible. In the Area-KFDmax space M and B samples are linearly separable permitting thus the use of linear support vector machine as a classification tool. By analyzing 104 samples of UV/VIS spectra of pleural effusions (88 M and 16 B) collected from patients at the Clinic for Lung Diseases and Tuberculosis, Military Medical Academy in Belgrade, the accuracy of 95.45% for M cases and 100% for B cases are obtained by using the proposed method. It was shown that by applying some modifications, which are suggested in the paper, the accuracy of 100% for M cases can be reached.",
publisher = "Elsevier",
journal = "Physica A: Statistical Mechanics and its Applications",
title = "Diagnostic spectroscopic and computer-aided evaluation of malignancy from UV/VIS spectra of clear pleural effusions",
volume = "403",
pages = "206-216",
doi = "10.1016/j.physa.2014.02.026"
}

Jevtic, D. R., Avramov Ivić, M., Reljin, I. S., Reljin, B. D., Plavec, G. I., Petrović, S. D.,& Mijin, D.. (2014). Diagnostic spectroscopic and computer-aided evaluation of malignancy from UV/VIS spectra of clear pleural effusions. in Physica A: Statistical Mechanics and its Applications
Elsevier., 403, 206-216.
https://doi.org/10.1016/j.physa.2014.02.026

Jevtic DR, Avramov Ivić M, Reljin IS, Reljin BD, Plavec GI, Petrović SD, Mijin D. Diagnostic spectroscopic and computer-aided evaluation of malignancy from UV/VIS spectra of clear pleural effusions. in Physica A: Statistical Mechanics and its Applications. 2014;403:206-216.
doi:10.1016/j.physa.2014.02.026 .

Jevtic, Dubravka R., Avramov Ivić, Milka, Reljin, Irini S., Reljin, Branimir D., Plavec, Goran I., Petrović, Slobodan D., Mijin, Dušan, "Diagnostic spectroscopic and computer-aided evaluation of malignancy from UV/VIS spectra of clear pleural effusions" in Physica A: Statistical Mechanics and its Applications, 403 (2014):206-216,
https://doi.org/10.1016/j.physa.2014.02.026 . .

TY  - JOUR
AU  - Mladenović, Aleksandar R.
AU  - Mijin, Dušan
AU  - Drmanić, Saša Ž.
AU  - Vajs, Vlatka
AU  - Jovanović, Vladislava M.
AU  - Petrović, Slobodan D.
AU  - Avramov Ivić, Milka
PY  - 2014
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1577
AB  - The oxidative ability of donepezil, a frequently prescribed drug for the treatment of Alzheimer's disease is reported for the first time at a gold electrode. It was oxidized by cyclic voltammetry and determined by square wave voltammetry in phosphate buffer electrolyte. Electrochemical degradation of donepezil was carried out by long term potential cycling. The identification and characterization of the major product, isolated by preparative high performance liquid chromatography, was performed by high resolution mass spectrometry and 1D and 2D nuclear magnetic resonance spectroscopy. Donepezil hydroxy derivative was identified as the major electrochemical oxidation product from donepezil.
PB  - Wiley-Blackwell, Malden
T2  - Electroanalysis
T1  - Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode
VL  - 26
IS  - 5
SP  - 893
EP  - 897
DO  - 10.1002/elan.201400034
ER  - 

@article{
author = "Mladenović, Aleksandar R. and Mijin, Dušan and Drmanić, Saša Ž. and Vajs, Vlatka and Jovanović, Vladislava M. and Petrović, Slobodan D. and Avramov Ivić, Milka",
year = "2014",
abstract = "The oxidative ability of donepezil, a frequently prescribed drug for the treatment of Alzheimer's disease is reported for the first time at a gold electrode. It was oxidized by cyclic voltammetry and determined by square wave voltammetry in phosphate buffer electrolyte. Electrochemical degradation of donepezil was carried out by long term potential cycling. The identification and characterization of the major product, isolated by preparative high performance liquid chromatography, was performed by high resolution mass spectrometry and 1D and 2D nuclear magnetic resonance spectroscopy. Donepezil hydroxy derivative was identified as the major electrochemical oxidation product from donepezil.",
publisher = "Wiley-Blackwell, Malden",
journal = "Electroanalysis",
title = "Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode",
volume = "26",
number = "5",
pages = "893-897",
doi = "10.1002/elan.201400034"
}

Mladenović, A. R., Mijin, D., Drmanić, S. Ž., Vajs, V., Jovanović, V. M., Petrović, S. D.,& Avramov Ivić, M.. (2014). Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode. in Electroanalysis
Wiley-Blackwell, Malden., 26(5), 893-897.
https://doi.org/10.1002/elan.201400034

Mladenović AR, Mijin D, Drmanić SŽ, Vajs V, Jovanović VM, Petrović SD, Avramov Ivić M. Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode. in Electroanalysis. 2014;26(5):893-897.
doi:10.1002/elan.201400034 .

Mladenović, Aleksandar R., Mijin, Dušan, Drmanić, Saša Ž., Vajs, Vlatka, Jovanović, Vladislava M., Petrović, Slobodan D., Avramov Ivić, Milka, "Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode" in Electroanalysis, 26, no. 5 (2014):893-897,
https://doi.org/10.1002/elan.201400034 . .