Diagnostic spectroscopic and computer-aided evaluation of malignancy from UV/VIS spectra of clear pleural effusions
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AuthorsJevtic, Dubravka R.
Avramov Ivić, Milka
Reljin, Irini S.
Reljin, Branimir D.
Plavec, Goran I.
Petrović, Slobodan D.
Article (Published version)
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The automated, computer-aided method for differentiation and classification of malignant (M) from benign (B) cases, by analyzing the UV/VIS spectra of pleural effusions is described. It was shown that by two independent objective features, the maximum of Katz fractal dimension (KFDmax) and the area under normalized UV/VIS absorbance curve (Area), highly reliable M-B classification is possible. In the Area-KFDmax space M and B samples are linearly separable permitting thus the use of linear support vector machine as a classification tool. By analyzing 104 samples of UV/VIS spectra of pleural effusions (88 M and 16 B) collected from patients at the Clinic for Lung Diseases and Tuberculosis, Military Medical Academy in Belgrade, the accuracy of 95.45% for M cases and 100% for B cases are obtained by using the proposed method. It was shown that by applying some modifications, which are suggested in the paper, the accuracy of 100% for M cases can be reached.
Keywords:Pleural effusions / Malignancy / Katz fractal dimension / UV/VIS diagnostic method / Clinical praxis
Source:Physica A: Statistical Mechanics and its Applications, 2014, 403, 206-216
- Elsevier Science Bv, Amsterdam