Investigation of electrochemical behavior of anisomycin on gold electrode followed by HPLC-MS/MS analysis
Само за регистроване кориснике
2015
Аутори
Tolic, LjiljanaLović, Jelena
Petrović, Slobodan D.
Mijin, Dušan
Grujic, Svetlana
Lausevic, Mila
Avramov Ivić, Milka
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Anisomycin is an immunosuppressant in low doses ( LT 0.1 mu M) with possible application in treatment of some autoimmune diseases and in inhibiting transplantation rejection. Anisomycin suppresses malignant tumor cell growth and affects memory. For the first time it was the subject of the electrochemical investigations by cyclic voltammetry and square wave voltammetry on gold electrode in 0.05 M NaHCO3 using its electrochemical activity. The cyclic voltammetry experiments at different sweep rates show that electrochemical process is irreversible and diffusion controlled. Based on square wave voltammetry measurements, the calculated values of LOD and LOQ were 1 and 4 nM (in the absence of biological fluid), as well as 2 and 6 nM (in the presence of spiked urine) indicating the high sensitivity of the proposed electroanalytical method. High performance liquid chromatography-tandem mass spectrometry was a reference method for quantification of anisomycin and served for structural identifi...cation of its hydrolysis product (deacetylanisomycin).
Кључне речи:
Anisomycin / Electroactivity / SWV / HPLC-MS/MSИзвор:
Electrochemistry Communications, 2015, 58, 20-24Издавач:
- Elsevier Science Inc, New York
Финансирање / пројекти:
- Проучавање синтезе, структуре и активности органских једињења природног и синтетског порекла (RS-MESTD-Basic Research (BR or ON)-172013)
- Нов приступ дизајнирању материјала за конверзију и складиштење енергије (RS-MESTD-Basic Research (BR or ON)-172060)
- Развој и примена метода и материјала за мониторинг нових загађујућих и токсичних органских материја и тешких метала (RS-MESTD-Basic Research (BR or ON)-172007)
DOI: 10.1016/j.elecom.2015.05.017
ISSN: 1388-2481
WoS: 000360514600005
Scopus: 2-s2.0-84934888024
Институција/група
IHTMTY - JOUR AU - Tolic, Ljiljana AU - Lović, Jelena AU - Petrović, Slobodan D. AU - Mijin, Dušan AU - Grujic, Svetlana AU - Lausevic, Mila AU - Avramov Ivić, Milka PY - 2015 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1725 AB - Anisomycin is an immunosuppressant in low doses ( LT 0.1 mu M) with possible application in treatment of some autoimmune diseases and in inhibiting transplantation rejection. Anisomycin suppresses malignant tumor cell growth and affects memory. For the first time it was the subject of the electrochemical investigations by cyclic voltammetry and square wave voltammetry on gold electrode in 0.05 M NaHCO3 using its electrochemical activity. The cyclic voltammetry experiments at different sweep rates show that electrochemical process is irreversible and diffusion controlled. Based on square wave voltammetry measurements, the calculated values of LOD and LOQ were 1 and 4 nM (in the absence of biological fluid), as well as 2 and 6 nM (in the presence of spiked urine) indicating the high sensitivity of the proposed electroanalytical method. High performance liquid chromatography-tandem mass spectrometry was a reference method for quantification of anisomycin and served for structural identification of its hydrolysis product (deacetylanisomycin). PB - Elsevier Science Inc, New York T2 - Electrochemistry Communications T1 - Investigation of electrochemical behavior of anisomycin on gold electrode followed by HPLC-MS/MS analysis VL - 58 SP - 20 EP - 24 DO - 10.1016/j.elecom.2015.05.017 ER -
@article{ author = "Tolic, Ljiljana and Lović, Jelena and Petrović, Slobodan D. and Mijin, Dušan and Grujic, Svetlana and Lausevic, Mila and Avramov Ivić, Milka", year = "2015", abstract = "Anisomycin is an immunosuppressant in low doses ( LT 0.1 mu M) with possible application in treatment of some autoimmune diseases and in inhibiting transplantation rejection. Anisomycin suppresses malignant tumor cell growth and affects memory. For the first time it was the subject of the electrochemical investigations by cyclic voltammetry and square wave voltammetry on gold electrode in 0.05 M NaHCO3 using its electrochemical activity. The cyclic voltammetry experiments at different sweep rates show that electrochemical process is irreversible and diffusion controlled. Based on square wave voltammetry measurements, the calculated values of LOD and LOQ were 1 and 4 nM (in the absence of biological fluid), as well as 2 and 6 nM (in the presence of spiked urine) indicating the high sensitivity of the proposed electroanalytical method. High performance liquid chromatography-tandem mass spectrometry was a reference method for quantification of anisomycin and served for structural identification of its hydrolysis product (deacetylanisomycin).", publisher = "Elsevier Science Inc, New York", journal = "Electrochemistry Communications", title = "Investigation of electrochemical behavior of anisomycin on gold electrode followed by HPLC-MS/MS analysis", volume = "58", pages = "20-24", doi = "10.1016/j.elecom.2015.05.017" }
Tolic, L., Lović, J., Petrović, S. D., Mijin, D., Grujic, S., Lausevic, M.,& Avramov Ivić, M.. (2015). Investigation of electrochemical behavior of anisomycin on gold electrode followed by HPLC-MS/MS analysis. in Electrochemistry Communications Elsevier Science Inc, New York., 58, 20-24. https://doi.org/10.1016/j.elecom.2015.05.017
Tolic L, Lović J, Petrović SD, Mijin D, Grujic S, Lausevic M, Avramov Ivić M. Investigation of electrochemical behavior of anisomycin on gold electrode followed by HPLC-MS/MS analysis. in Electrochemistry Communications. 2015;58:20-24. doi:10.1016/j.elecom.2015.05.017 .
Tolic, Ljiljana, Lović, Jelena, Petrović, Slobodan D., Mijin, Dušan, Grujic, Svetlana, Lausevic, Mila, Avramov Ivić, Milka, "Investigation of electrochemical behavior of anisomycin on gold electrode followed by HPLC-MS/MS analysis" in Electrochemistry Communications, 58 (2015):20-24, https://doi.org/10.1016/j.elecom.2015.05.017 . .