TY  - JOUR
AU  - Vučković, Ivan
AU  - Stiković, Sonja
AU  - Stešević, Danijela
AU  - Jadranin, Milka
AU  - Trifunović, Snežana
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4919
AB  - The plant species Pimpinella serbica (Vis.) Drude, endemic to West Balkans, belongs to the genus Pimpinella L. (Apiaceae) according to newer botanical classification. Initially, the plant was described as Pancicia serbica Vis. and long considered as a monotypic genus. Previous phytochemical inves­tigations of this plant were limited to the essential oil analysis by the GC–MS method. This is first study that includes LC-DAD–MS screening of the extracts of the roots and aerial parts, followed by isolation of secondary metabolites using chromatographic techniques. Five compounds belonging to phenylpropanoids and polyacetylenes, well known for their bioactivities, were isolated and struc­turally determined by combined spectroscopic methods (UV, NMR, MS). Dil­lapiole (1), nothoapiole (2) and oplopantriol A 18-acetate (4) were found in both extracts, while falcarindiol (3) was isolated from the roots and dendrotrifidol (5) from the aerial parts only. The phytochemical profile of P. serbica L. supports its position in the Pimpinella L. genus.
AB  - Ендемска врста Западног Балкана Pimpinella serbica (Vis.) Drude према последњој ботаничкој класификацији припада роду Pimpinella L. (Apiaceae), мада је најпре била описана као Pancicia serbica Vis. и дуго је сматрана једином припадајућом врстом овог рода. Претходна фитохемијска испитивања ове врсте обухватају само анализу етарског уља GC–MS техником, тако да је ово прво детаљно испитивање биљке које укључује LCDAD– MS анализу праћену изоловањем секундарних метаболита биљке применом хро- матографских техника. Пет једињења која припадају групи фенилпропаноида и поли- ацетилена, добро познатих по својим биолошким активностима, изоловано је из екстра- ката надземног дела и корена биљке. Њихова структура је одређена применом спек- троскопских метода (UV, NMR, MS). Дилапиол (1), нотоапиол (2) и оплопантриол А 18-ацетат (4) нађени су у оба екстракта, док је фалкариндиол (3) изолован само из екс- тракта корена, а дендротрифидол (5) само из екстракта надземног дела биљке. Фито- хемијски профил биљке P. serbica подржава њену припадност роду Pimpinella L.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Phytochemical investigation of Pimpinella serbica
T1  - Фитохемијско испитивање врсте Pimpinella serbica
IS  - 12
SP  - 1241
EP  - 1247
DO  - 10.2298/JSC210816081V
ER  - 

@article{
author = "Vučković, Ivan and Stiković, Sonja and Stešević, Danijela and Jadranin, Milka and Trifunović, Snežana",
year = "2021",
abstract = "The plant species Pimpinella serbica (Vis.) Drude, endemic to West Balkans, belongs to the genus Pimpinella L. (Apiaceae) according to newer botanical classification. Initially, the plant was described as Pancicia serbica Vis. and long considered as a monotypic genus. Previous phytochemical inves­tigations of this plant were limited to the essential oil analysis by the GC–MS method. This is first study that includes LC-DAD–MS screening of the extracts of the roots and aerial parts, followed by isolation of secondary metabolites using chromatographic techniques. Five compounds belonging to phenylpropanoids and polyacetylenes, well known for their bioactivities, were isolated and struc­turally determined by combined spectroscopic methods (UV, NMR, MS). Dil­lapiole (1), nothoapiole (2) and oplopantriol A 18-acetate (4) were found in both extracts, while falcarindiol (3) was isolated from the roots and dendrotrifidol (5) from the aerial parts only. The phytochemical profile of P. serbica L. supports its position in the Pimpinella L. genus., Ендемска врста Западног Балкана Pimpinella serbica (Vis.) Drude према последњој ботаничкој класификацији припада роду Pimpinella L. (Apiaceae), мада је најпре била описана као Pancicia serbica Vis. и дуго је сматрана једином припадајућом врстом овог рода. Претходна фитохемијска испитивања ове врсте обухватају само анализу етарског уља GC–MS техником, тако да је ово прво детаљно испитивање биљке које укључује LCDAD– MS анализу праћену изоловањем секундарних метаболита биљке применом хро- матографских техника. Пет једињења која припадају групи фенилпропаноида и поли- ацетилена, добро познатих по својим биолошким активностима, изоловано је из екстра- ката надземног дела и корена биљке. Њихова структура је одређена применом спек- троскопских метода (UV, NMR, MS). Дилапиол (1), нотоапиол (2) и оплопантриол А 18-ацетат (4) нађени су у оба екстракта, док је фалкариндиол (3) изолован само из екс- тракта корена, а дендротрифидол (5) само из екстракта надземног дела биљке. Фито- хемијски профил биљке P. serbica подржава њену припадност роду Pimpinella L.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Phytochemical investigation of Pimpinella serbica, Фитохемијско испитивање врсте Pimpinella serbica",
number = "12",
pages = "1241-1247",
doi = "10.2298/JSC210816081V"
}

Vučković, I., Stiković, S., Stešević, D., Jadranin, M.,& Trifunović, S.. (2021). Phytochemical investigation of Pimpinella serbica. in Journal of the Serbian Chemical Society
Serbian Chemical Society.(12), 1241-1247.
https://doi.org/10.2298/JSC210816081V

Vučković I, Stiković S, Stešević D, Jadranin M, Trifunović S. Phytochemical investigation of Pimpinella serbica. in Journal of the Serbian Chemical Society. 2021;(12):1241-1247.
doi:10.2298/JSC210816081V .

Vučković, Ivan, Stiković, Sonja, Stešević, Danijela, Jadranin, Milka, Trifunović, Snežana, "Phytochemical investigation of Pimpinella serbica" in Journal of the Serbian Chemical Society, no. 12 (2021):1241-1247,
https://doi.org/10.2298/JSC210816081V . .

TY  - DATA
AU  - Novaković, Miroslav
AU  - Đorđević, Iris
AU  - Todorović, Nina
AU  - Trifunovic, Snežana
AU  - Anđelković, Boban D.
AU  - Mandić, Boris
AU  - Jadranin, Milka
AU  - Vučković, Ivan
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan
AU  - Tešević, Vele
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4447
AB  - Table S1. HPLC program for the quantification of the main compounds from the C. coggygria CH2Cl2/MeOH extract Figure S1. UV spectra of 14 in MeOH, with addition of AlCl3, and HCl Figure S2. UV spectra of compound 14 in MeOH, with NaOAc, NaOAc+H3BO3 and with NaOMe Figure S3. 1H NMR spectrum of compound 14 Figure S4. 13C NMR spectrum of compound 14 Figure S5. Aromatic part of the COSY spectrum of 14 Figure S6. Aromatic part of the NOESY spectrum of 14 Figure S7. Aromatic part of the HSQC spectrum of 14 Figure S8. Aromatic part of the HMBC spectrum of 14 Figure S9. Key HMBC correlations of 14 Table S2. 1H, 13C NMR and HMBC data of 14 (CD3OD, δ ppm, J in Hz) Figure S10. Aromatic part of the 1H NMR spectrum of 15 Figure S11. Aliphatic part of the 1H NMR spectrum of 15 Figure S12. 13C NMR spectrum of 15 Figure S13. HSQC spectrum of 15 Figure S14. The first part of the HMBC spectrum of 15 Figure S15. The second part of the HMBC spectrum of 15 Figure S16. HMBC (4 Hz) correlation H-7''/C-4' (15) Figure S17. The first part of the NOESY spectrum of 15 Figure S18. The second part of the NOESY spectrum of 15 Table S3. 1H and 13C NMR data of 15 (CD3OD, δ ppm, J in Hz) Figure S19. 3-Aryl-propanol moiety in 15 Figure S20. Key HMBC correlations in 15 Figure S21. UV spectrum of 15 Figure S22. UV spectrum of 10
PB  - Taylor and Francis Ltd.
T2  - Natural Product Research
T1  - Supplementary material for: "New aurone epoxide and auronolignan from the heartwood of Cotinus coggygria Scop."
DO  - 10.6084/m9.figshare.7418396.v1
ER  - 

@misc{
author = "Novaković, Miroslav and Đorđević, Iris and Todorović, Nina and Trifunovic, Snežana and Anđelković, Boban D. and Mandić, Boris and Jadranin, Milka and Vučković, Ivan and Vajs, Vlatka and Milosavljević, Slobodan and Tešević, Vele",
year = "2018",
abstract = "Table S1. HPLC program for the quantification of the main compounds from the C. coggygria CH2Cl2/MeOH extract Figure S1. UV spectra of 14 in MeOH, with addition of AlCl3, and HCl Figure S2. UV spectra of compound 14 in MeOH, with NaOAc, NaOAc+H3BO3 and with NaOMe Figure S3. 1H NMR spectrum of compound 14 Figure S4. 13C NMR spectrum of compound 14 Figure S5. Aromatic part of the COSY spectrum of 14 Figure S6. Aromatic part of the NOESY spectrum of 14 Figure S7. Aromatic part of the HSQC spectrum of 14 Figure S8. Aromatic part of the HMBC spectrum of 14 Figure S9. Key HMBC correlations of 14 Table S2. 1H, 13C NMR and HMBC data of 14 (CD3OD, δ ppm, J in Hz) Figure S10. Aromatic part of the 1H NMR spectrum of 15 Figure S11. Aliphatic part of the 1H NMR spectrum of 15 Figure S12. 13C NMR spectrum of 15 Figure S13. HSQC spectrum of 15 Figure S14. The first part of the HMBC spectrum of 15 Figure S15. The second part of the HMBC spectrum of 15 Figure S16. HMBC (4 Hz) correlation H-7''/C-4' (15) Figure S17. The first part of the NOESY spectrum of 15 Figure S18. The second part of the NOESY spectrum of 15 Table S3. 1H and 13C NMR data of 15 (CD3OD, δ ppm, J in Hz) Figure S19. 3-Aryl-propanol moiety in 15 Figure S20. Key HMBC correlations in 15 Figure S21. UV spectrum of 15 Figure S22. UV spectrum of 10",
publisher = "Taylor and Francis Ltd.",
journal = "Natural Product Research",
title = "Supplementary material for: "New aurone epoxide and auronolignan from the heartwood of Cotinus coggygria Scop."",
doi = "10.6084/m9.figshare.7418396.v1"
}

Novaković, M., Đorđević, I., Todorović, N., Trifunovic, S., Anđelković, B. D., Mandić, B., Jadranin, M., Vučković, I., Vajs, V., Milosavljević, S.,& Tešević, V.. (2018). Supplementary material for: "New aurone epoxide and auronolignan from the heartwood of Cotinus coggygria Scop.". in Natural Product Research
Taylor and Francis Ltd...
https://doi.org/10.6084/m9.figshare.7418396.v1

Novaković M, Đorđević I, Todorović N, Trifunovic S, Anđelković BD, Mandić B, Jadranin M, Vučković I, Vajs V, Milosavljević S, Tešević V. Supplementary material for: "New aurone epoxide and auronolignan from the heartwood of Cotinus coggygria Scop.". in Natural Product Research. 2018;.
doi:10.6084/m9.figshare.7418396.v1 .

Novaković, Miroslav, Đorđević, Iris, Todorović, Nina, Trifunovic, Snežana, Anđelković, Boban D., Mandić, Boris, Jadranin, Milka, Vučković, Ivan, Vajs, Vlatka, Milosavljević, Slobodan, Tešević, Vele, "Supplementary material for: "New aurone epoxide and auronolignan from the heartwood of Cotinus coggygria Scop."" in Natural Product Research (2018),
https://doi.org/10.6084/m9.figshare.7418396.v1 . .

TY  - JOUR
AU  - Novaković, Miroslav
AU  - Đorđević, Iris
AU  - Todorović, Nina
AU  - Trifunovic, S.
AU  - Anđelković, Boban D.
AU  - Mandić, Boris
AU  - Jadranin, Milka
AU  - Vučković, Ivan
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan
AU  - Tešević, Vele
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2389
AB  - New aurone epoxide, 2,10-oxy-10-methoxysulfuretin (14), and new auronolignan (15), named cotinignan A, were isolated by silica gel column and semipreparative HPLC chromatography from the methylene chloride/methanol extract of Cotinus coggygria Scop. heartwood. In addition, thirteen known secondary metabolites namely sulfuretin, 2,3-trans-fustin, fisetin, butin, butein, taxifolin, eriodictyol, 3',5,5',7–tetrahydroxyflavanone, 3',4',7-trihydroxyflavone, 3-O-methyl-2,3-trans-fustin, 3-O-galloyl-2,3-trans-fustin, β-resorcylic acid and 3-O-β-sitosterol glucoside were isolated as well. Their structures were elucidated by 1D and 2D NMR, HR-ESI-MS, IR and UV. Ten out of eleven isolated flavonoids possess 7, 3' and 4' hydroxy groups. These structural features could be considered as chemotaxonomic characteristic of flavonoids from C. coggygria. Cotinignan A (15) represents new subclass of secondary metabolites - auronolignans. (Figure presented.).
PB  - Taylor and Francis Ltd.
T2  - Natural Product Research
T1  - New aurone epoxide and auronolignan from the heartwood of Cotinus coggygria Scop
VL  - 33
IS  - 19
SP  - 2837
EP  - 2844
DO  - 10.1080/14786419.2018.1508141
ER  - 

@article{
author = "Novaković, Miroslav and Đorđević, Iris and Todorović, Nina and Trifunovic, S. and Anđelković, Boban D. and Mandić, Boris and Jadranin, Milka and Vučković, Ivan and Vajs, Vlatka and Milosavljević, Slobodan and Tešević, Vele",
year = "2018",
abstract = "New aurone epoxide, 2,10-oxy-10-methoxysulfuretin (14), and new auronolignan (15), named cotinignan A, were isolated by silica gel column and semipreparative HPLC chromatography from the methylene chloride/methanol extract of Cotinus coggygria Scop. heartwood. In addition, thirteen known secondary metabolites namely sulfuretin, 2,3-trans-fustin, fisetin, butin, butein, taxifolin, eriodictyol, 3',5,5',7–tetrahydroxyflavanone, 3',4',7-trihydroxyflavone, 3-O-methyl-2,3-trans-fustin, 3-O-galloyl-2,3-trans-fustin, β-resorcylic acid and 3-O-β-sitosterol glucoside were isolated as well. Their structures were elucidated by 1D and 2D NMR, HR-ESI-MS, IR and UV. Ten out of eleven isolated flavonoids possess 7, 3' and 4' hydroxy groups. These structural features could be considered as chemotaxonomic characteristic of flavonoids from C. coggygria. Cotinignan A (15) represents new subclass of secondary metabolites - auronolignans. (Figure presented.).",
publisher = "Taylor and Francis Ltd.",
journal = "Natural Product Research",
title = "New aurone epoxide and auronolignan from the heartwood of Cotinus coggygria Scop",
volume = "33",
number = "19",
pages = "2837-2844",
doi = "10.1080/14786419.2018.1508141"
}

Novaković, M., Đorđević, I., Todorović, N., Trifunovic, S., Anđelković, B. D., Mandić, B., Jadranin, M., Vučković, I., Vajs, V., Milosavljević, S.,& Tešević, V.. (2018). New aurone epoxide and auronolignan from the heartwood of Cotinus coggygria Scop. in Natural Product Research
Taylor and Francis Ltd.., 33(19), 2837-2844.
https://doi.org/10.1080/14786419.2018.1508141

Novaković M, Đorđević I, Todorović N, Trifunovic S, Anđelković BD, Mandić B, Jadranin M, Vučković I, Vajs V, Milosavljević S, Tešević V. New aurone epoxide and auronolignan from the heartwood of Cotinus coggygria Scop. in Natural Product Research. 2018;33(19):2837-2844.
doi:10.1080/14786419.2018.1508141 .

Novaković, Miroslav, Đorđević, Iris, Todorović, Nina, Trifunovic, S., Anđelković, Boban D., Mandić, Boris, Jadranin, Milka, Vučković, Ivan, Vajs, Vlatka, Milosavljević, Slobodan, Tešević, Vele, "New aurone epoxide and auronolignan from the heartwood of Cotinus coggygria Scop" in Natural Product Research, 33, no. 19 (2018):2837-2844,
https://doi.org/10.1080/14786419.2018.1508141 . .

TY  - JOUR
AU  - Marin, Marija
AU  - Novaković, Miroslav
AU  - Vučković, Ivan
AU  - Tešević, Vele
AU  - Kolarevic, Stoimir
AU  - Vukovic-Gacic, Branka
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2314
AB  - The composition of the essential oil (EO) obtained by hydrodistillation from the leaves of Thymus capitatus Hoff. et Link. growing wild in Sythonia (Greece) was analysed by GC-FID, GC-MS and quantitative H-1 NMR spectroscopy. Thirty nine compounds were identified, representing approximately 99.0 % of the oil. Major component determined by GC-FID was carvacrol (81.8 %), followed by linalool (3.5 %) and (E)-caryophyllenc (3.5 %). Abundance of carvacrol determined by quantitative H-1 NMR spectroscopy was 74.9 % and was in reasonable agreement with GC-FID result. The oil was tested for the antioxidant activity in DPPH assay and showed a dose dependent free radical scavenging activity with EC50 value of 1.03 mu g/ml. Antimicrobial effect of the EO was tested against Gram negative, Gram positive bacteria, and fungi. The tested EO showed significant activity against fungi, especially S. cerevisiae. The most sensitive bacteria were E. coil ATCC 25922, E. fecalis and S. epidermidis. Human pathogen Burkholderia cepacia, ATCC 25416 was used in the investigation of T capitatus for the fast time.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Essential Oil Bearing Plants
T1  - Wild Thymus capitatus Hoff. Et Link. Chemical Composition, Antioxidant and Antimicrobial Activities of the Essential Oil
VL  - 21
IS  - 2
SP  - 388
EP  - 399
DO  - 10.1080/0972060X.2018.1449668
ER  - 

@article{
author = "Marin, Marija and Novaković, Miroslav and Vučković, Ivan and Tešević, Vele and Kolarevic, Stoimir and Vukovic-Gacic, Branka",
year = "2018",
abstract = "The composition of the essential oil (EO) obtained by hydrodistillation from the leaves of Thymus capitatus Hoff. et Link. growing wild in Sythonia (Greece) was analysed by GC-FID, GC-MS and quantitative H-1 NMR spectroscopy. Thirty nine compounds were identified, representing approximately 99.0 % of the oil. Major component determined by GC-FID was carvacrol (81.8 %), followed by linalool (3.5 %) and (E)-caryophyllenc (3.5 %). Abundance of carvacrol determined by quantitative H-1 NMR spectroscopy was 74.9 % and was in reasonable agreement with GC-FID result. The oil was tested for the antioxidant activity in DPPH assay and showed a dose dependent free radical scavenging activity with EC50 value of 1.03 mu g/ml. Antimicrobial effect of the EO was tested against Gram negative, Gram positive bacteria, and fungi. The tested EO showed significant activity against fungi, especially S. cerevisiae. The most sensitive bacteria were E. coil ATCC 25922, E. fecalis and S. epidermidis. Human pathogen Burkholderia cepacia, ATCC 25416 was used in the investigation of T capitatus for the fast time.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Essential Oil Bearing Plants",
title = "Wild Thymus capitatus Hoff. Et Link. Chemical Composition, Antioxidant and Antimicrobial Activities of the Essential Oil",
volume = "21",
number = "2",
pages = "388-399",
doi = "10.1080/0972060X.2018.1449668"
}

Marin, M., Novaković, M., Vučković, I., Tešević, V., Kolarevic, S.,& Vukovic-Gacic, B.. (2018). Wild Thymus capitatus Hoff. Et Link. Chemical Composition, Antioxidant and Antimicrobial Activities of the Essential Oil. in Journal of Essential Oil Bearing Plants
Taylor & Francis Ltd, Abingdon., 21(2), 388-399.
https://doi.org/10.1080/0972060X.2018.1449668

Marin M, Novaković M, Vučković I, Tešević V, Kolarevic S, Vukovic-Gacic B. Wild Thymus capitatus Hoff. Et Link. Chemical Composition, Antioxidant and Antimicrobial Activities of the Essential Oil. in Journal of Essential Oil Bearing Plants. 2018;21(2):388-399.
doi:10.1080/0972060X.2018.1449668 .

Marin, Marija, Novaković, Miroslav, Vučković, Ivan, Tešević, Vele, Kolarevic, Stoimir, Vukovic-Gacic, Branka, "Wild Thymus capitatus Hoff. Et Link. Chemical Composition, Antioxidant and Antimicrobial Activities of the Essential Oil" in Journal of Essential Oil Bearing Plants, 21, no. 2 (2018):388-399,
https://doi.org/10.1080/0972060X.2018.1449668 . .

TY  - JOUR
AU  - Anđelković, Boban D.
AU  - Vujisić, Ljubodrag V.
AU  - Vučković, Ivan
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Gođevac, Dejan
PY  - 2017
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2266
AB  - Herein, we propose rapid and simple spectroscopic methods to determine the chemical composition of propolis derived from various Populus species using a metabolomics approach. In order to correlate variability in Populus type propolis composition with the altitude of its collection, NMR, IR, and DV spec-troscopy followed by OPLS was conducted. The botanical origin of propolis was established by comparing propolis spectral data to those of buds of various Populus species. An O2PLS method was utilized to integrate two blocks of data. According to OPLS and O2PLS, the major compounds in propolis samples, collected from temperate continental climate above 500 m, were phenolic glycerides originating from P. tremula buds. Flavonoids were predominant in propolis samples collected below 400 m, originating from P. nigra and P.x euramericana buds. Samples collected at 400-500 m were of mixed origin, with variable amounts of all detected metabolites.
PB  - Elsevier
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Metabolomics study of Populus type propolis
VL  - 135
SP  - 217
EP  - 226
DO  - 10.1016/j.jpba.2016.12.003
ER  - 

@article{
author = "Anđelković, Boban D. and Vujisić, Ljubodrag V. and Vučković, Ivan and Tešević, Vele and Vajs, Vlatka and Gođevac, Dejan",
year = "2017",
abstract = "Herein, we propose rapid and simple spectroscopic methods to determine the chemical composition of propolis derived from various Populus species using a metabolomics approach. In order to correlate variability in Populus type propolis composition with the altitude of its collection, NMR, IR, and DV spec-troscopy followed by OPLS was conducted. The botanical origin of propolis was established by comparing propolis spectral data to those of buds of various Populus species. An O2PLS method was utilized to integrate two blocks of data. According to OPLS and O2PLS, the major compounds in propolis samples, collected from temperate continental climate above 500 m, were phenolic glycerides originating from P. tremula buds. Flavonoids were predominant in propolis samples collected below 400 m, originating from P. nigra and P.x euramericana buds. Samples collected at 400-500 m were of mixed origin, with variable amounts of all detected metabolites.",
publisher = "Elsevier",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Metabolomics study of Populus type propolis",
volume = "135",
pages = "217-226",
doi = "10.1016/j.jpba.2016.12.003"
}

Anđelković, B. D., Vujisić, L. V., Vučković, I., Tešević, V., Vajs, V.,& Gođevac, D.. (2017). Metabolomics study of Populus type propolis. in Journal of Pharmaceutical and Biomedical Analysis
Elsevier., 135, 217-226.
https://doi.org/10.1016/j.jpba.2016.12.003

Anđelković BD, Vujisić LV, Vučković I, Tešević V, Vajs V, Gođevac D. Metabolomics study of Populus type propolis. in Journal of Pharmaceutical and Biomedical Analysis. 2017;135:217-226.
doi:10.1016/j.jpba.2016.12.003 .

Anđelković, Boban D., Vujisić, Ljubodrag V., Vučković, Ivan, Tešević, Vele, Vajs, Vlatka, Gođevac, Dejan, "Metabolomics study of Populus type propolis" in Journal of Pharmaceutical and Biomedical Analysis, 135 (2017):217-226,
https://doi.org/10.1016/j.jpba.2016.12.003 . .

TY  - JOUR
AU  - Anđelković, Boban D.
AU  - Vujisić, Ljubodrag V.
AU  - Vučković, Ivan
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Gođevac, Dejan
PY  - 2017
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3046
AB  - Herein, we propose rapid and simple spectroscopic methods to determine the chemical composition of propolis derived from various Populus species using a metabolomics approach. In order to correlate variability in Populus type propolis composition with the altitude of its collection, NMR, IR, and DV spec-troscopy followed by OPLS was conducted. The botanical origin of propolis was established by comparing propolis spectral data to those of buds of various Populus species. An O2PLS method was utilized to integrate two blocks of data. According to OPLS and O2PLS, the major compounds in propolis samples, collected from temperate continental climate above 500 m, were phenolic glycerides originating from P. tremula buds. Flavonoids were predominant in propolis samples collected below 400 m, originating from P. nigra and P.x euramericana buds. Samples collected at 400-500 m were of mixed origin, with variable amounts of all detected metabolites.
PB  - Elsevier
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Metabolomics study of Populus type propolis
VL  - 135
SP  - 217
EP  - 226
DO  - 10.1016/j.jpba.2016.12.003
ER  - 

@article{
author = "Anđelković, Boban D. and Vujisić, Ljubodrag V. and Vučković, Ivan and Tešević, Vele and Vajs, Vlatka and Gođevac, Dejan",
year = "2017",
abstract = "Herein, we propose rapid and simple spectroscopic methods to determine the chemical composition of propolis derived from various Populus species using a metabolomics approach. In order to correlate variability in Populus type propolis composition with the altitude of its collection, NMR, IR, and DV spec-troscopy followed by OPLS was conducted. The botanical origin of propolis was established by comparing propolis spectral data to those of buds of various Populus species. An O2PLS method was utilized to integrate two blocks of data. According to OPLS and O2PLS, the major compounds in propolis samples, collected from temperate continental climate above 500 m, were phenolic glycerides originating from P. tremula buds. Flavonoids were predominant in propolis samples collected below 400 m, originating from P. nigra and P.x euramericana buds. Samples collected at 400-500 m were of mixed origin, with variable amounts of all detected metabolites.",
publisher = "Elsevier",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Metabolomics study of Populus type propolis",
volume = "135",
pages = "217-226",
doi = "10.1016/j.jpba.2016.12.003"
}

Anđelković, B. D., Vujisić, L. V., Vučković, I., Tešević, V., Vajs, V.,& Gođevac, D.. (2017). Metabolomics study of Populus type propolis. in Journal of Pharmaceutical and Biomedical Analysis
Elsevier., 135, 217-226.
https://doi.org/10.1016/j.jpba.2016.12.003

Anđelković BD, Vujisić LV, Vučković I, Tešević V, Vajs V, Gođevac D. Metabolomics study of Populus type propolis. in Journal of Pharmaceutical and Biomedical Analysis. 2017;135:217-226.
doi:10.1016/j.jpba.2016.12.003 .

Anđelković, Boban D., Vujisić, Ljubodrag V., Vučković, Ivan, Tešević, Vele, Vajs, Vlatka, Gođevac, Dejan, "Metabolomics study of Populus type propolis" in Journal of Pharmaceutical and Biomedical Analysis, 135 (2017):217-226,
https://doi.org/10.1016/j.jpba.2016.12.003 . .

TY  - DATA
AU  - Vlajic, Marina D
AU  - Trifunović, Snežana
AU  - Simić, Milena R.
AU  - Vujisić, Ljubodrag V.
AU  - Vučković, Ivan
AU  - Novaković, Miroslav
AU  - Nikolic-Mandic, Snezana D
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan
AU  - Mandić, Boris
PY  - 2015
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4466
AB  - Experimental details relating to the article: Mandić, B., Vlajic, M. D., Trifunović, S., Simić, M. R., Vujisić, L. V., Vučković, I., Novaković, M., Nikolic-Mandic, S. D., Tešević, V., Vajs, V.,& Milosavljević, S. (2015). Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge. Natural Product Research, 29(9), 887-890. https://doi.org/10.1080/14786419.2014.991929. Figure S1. Structures of monitored PAs from R. umbellata (1 - 6). Figure S2. Yields of PAs in relation to days of maceration in the methanol. Figure S3. Yields of PAs extracted with methanol, ethanol and sulphuric acid during four days at dark place and room temperature. Figure S4. Yields of PAs (1-6) in relation to molarity of sulphuric acid used for their extraction. Figure S5. Yields of PAs (1-6) in relation to days of maceration with 1 M sulphuric acid, at room temperature. Figure S6. Yields of PAs (1-6) in relation to days of ultrasonic assisted extraction with 1 M sulphuric acid. Figure S7. Yields of PAs (1-6) in relation to days of extraction with 1 M sulphuric acid by overhead rotary mixer.  Figure S8. Comparison of yields of PAs (1-6) accomplished after four days of maceration, three days of extraction by ultrasonic bath and overhead rotary mixer assisted extractions of plant material with 1M sulphuric acid. Figure S9. Yields of PAs (1-6) isolated from 1.00 g of the plant material (with 1M sulphuric acid during the extraction by overhead rotary mixer for three days) in relation to the volume (ml) of sulphuric acid. Figure S10. Yields of isolated PAs (1-6) in relation to pH values of aqueous solutions for alkaline extraction of PAs with CH2Cl2. Figure S11. Yields of isolated PAs in relation to the number of continuous alkaline re-extractions with CH2Cl2 at pH 9.
PB  - Taylor & Francis
T2  - Natural Product Research
T1  - Supplementary material for: "Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge"
DO  - 10.6084/m9.figshare.1276004.v2
ER  - 

@misc{
author = "Vlajic, Marina D and Trifunović, Snežana and Simić, Milena R. and Vujisić, Ljubodrag V. and Vučković, Ivan and Novaković, Miroslav and Nikolic-Mandic, Snezana D and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan and Mandić, Boris",
year = "2015",
abstract = "Experimental details relating to the article: Mandić, B., Vlajic, M. D., Trifunović, S., Simić, M. R., Vujisić, L. V., Vučković, I., Novaković, M., Nikolic-Mandic, S. D., Tešević, V., Vajs, V.,& Milosavljević, S. (2015). Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge. Natural Product Research, 29(9), 887-890. https://doi.org/10.1080/14786419.2014.991929. Figure S1. Structures of monitored PAs from R. umbellata (1 - 6). Figure S2. Yields of PAs in relation to days of maceration in the methanol. Figure S3. Yields of PAs extracted with methanol, ethanol and sulphuric acid during four days at dark place and room temperature. Figure S4. Yields of PAs (1-6) in relation to molarity of sulphuric acid used for their extraction. Figure S5. Yields of PAs (1-6) in relation to days of maceration with 1 M sulphuric acid, at room temperature. Figure S6. Yields of PAs (1-6) in relation to days of ultrasonic assisted extraction with 1 M sulphuric acid. Figure S7. Yields of PAs (1-6) in relation to days of extraction with 1 M sulphuric acid by overhead rotary mixer.  Figure S8. Comparison of yields of PAs (1-6) accomplished after four days of maceration, three days of extraction by ultrasonic bath and overhead rotary mixer assisted extractions of plant material with 1M sulphuric acid. Figure S9. Yields of PAs (1-6) isolated from 1.00 g of the plant material (with 1M sulphuric acid during the extraction by overhead rotary mixer for three days) in relation to the volume (ml) of sulphuric acid. Figure S10. Yields of isolated PAs (1-6) in relation to pH values of aqueous solutions for alkaline extraction of PAs with CH2Cl2. Figure S11. Yields of isolated PAs in relation to the number of continuous alkaline re-extractions with CH2Cl2 at pH 9.",
publisher = "Taylor & Francis",
journal = "Natural Product Research",
title = "Supplementary material for: "Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge"",
doi = "10.6084/m9.figshare.1276004.v2"
}

Vlajic, M. D., Trifunović, S., Simić, M. R., Vujisić, L. V., Vučković, I., Novaković, M., Nikolic-Mandic, S. D., Tešević, V., Vajs, V., Milosavljević, S.,& Mandić, B.. (2015). Supplementary material for: "Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge". in Natural Product Research
Taylor & Francis..
https://doi.org/10.6084/m9.figshare.1276004.v2

Vlajic MD, Trifunović S, Simić MR, Vujisić LV, Vučković I, Novaković M, Nikolic-Mandic SD, Tešević V, Vajs V, Milosavljević S, Mandić B. Supplementary material for: "Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge". in Natural Product Research. 2015;.
doi:10.6084/m9.figshare.1276004.v2 .

Vlajic, Marina D, Trifunović, Snežana, Simić, Milena R., Vujisić, Ljubodrag V., Vučković, Ivan, Novaković, Miroslav, Nikolic-Mandic, Snezana D, Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan, Mandić, Boris, "Supplementary material for: "Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge"" in Natural Product Research (2015),
https://doi.org/10.6084/m9.figshare.1276004.v2 . .

TY  - JOUR
AU  - Mandić, Boris
AU  - Vlajic, Marina D
AU  - Trifunović, Snežana
AU  - Simić, Milena R.
AU  - Vujisić, Ljubodrag V.
AU  - Vučković, Ivan
AU  - Novaković, Miroslav
AU  - Nikolic-Mandic, Snezana D
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan
PY  - 2015
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1780
AB  - Procedure for isolation of pyrrolizidine alkaloids (PAs) from Rindera umbellata Bunge plant species was optimised. Different extraction media (methanol, ethanol and sulphuric acid), concentration and volume of sulphuric acid, pH of PA solution for alkaline extraction, extraction time and techniques (maceration, ultrasonic and overhead rotary mixer assisted extraction) were investigated. The yields of six PAs (7-angeloyl heliotridane, 7-angeloyl heliotridine, lindelofine, 7-angeloyl rinderine, punctanecine and heliosupine) were monitored by GC-MS/FID. The best results for the isolation all of six PAs were obtained when the extraction was performed with 1M sulphuric acid (30mL per 1.00g of dried sample) by overhead rotary mixer during three days. Optimal pH value for alkaline extraction of PAs with CH2Cl2 was 9, and the extraction should be performed with four portions of 30mL of CH2Cl2. This procedure could be also useful for a plant sample preparation for GC and LC analyses of PAs.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge
VL  - 29
IS  - 9
SP  - 887
EP  - 890
DO  - 10.1080/14786419.2014.991929
ER  - 

@article{
author = "Mandić, Boris and Vlajic, Marina D and Trifunović, Snežana and Simić, Milena R. and Vujisić, Ljubodrag V. and Vučković, Ivan and Novaković, Miroslav and Nikolic-Mandic, Snezana D and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan",
year = "2015",
abstract = "Procedure for isolation of pyrrolizidine alkaloids (PAs) from Rindera umbellata Bunge plant species was optimised. Different extraction media (methanol, ethanol and sulphuric acid), concentration and volume of sulphuric acid, pH of PA solution for alkaline extraction, extraction time and techniques (maceration, ultrasonic and overhead rotary mixer assisted extraction) were investigated. The yields of six PAs (7-angeloyl heliotridane, 7-angeloyl heliotridine, lindelofine, 7-angeloyl rinderine, punctanecine and heliosupine) were monitored by GC-MS/FID. The best results for the isolation all of six PAs were obtained when the extraction was performed with 1M sulphuric acid (30mL per 1.00g of dried sample) by overhead rotary mixer during three days. Optimal pH value for alkaline extraction of PAs with CH2Cl2 was 9, and the extraction should be performed with four portions of 30mL of CH2Cl2. This procedure could be also useful for a plant sample preparation for GC and LC analyses of PAs.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge",
volume = "29",
number = "9",
pages = "887-890",
doi = "10.1080/14786419.2014.991929"
}

Mandić, B., Vlajic, M. D., Trifunović, S., Simić, M. R., Vujisić, L. V., Vučković, I., Novaković, M., Nikolic-Mandic, S. D., Tešević, V., Vajs, V.,& Milosavljević, S.. (2015). Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 29(9), 887-890.
https://doi.org/10.1080/14786419.2014.991929

Mandić B, Vlajic MD, Trifunović S, Simić MR, Vujisić LV, Vučković I, Novaković M, Nikolic-Mandic SD, Tešević V, Vajs V, Milosavljević S. Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge. in Natural Product Research. 2015;29(9):887-890.
doi:10.1080/14786419.2014.991929 .

Mandić, Boris, Vlajic, Marina D, Trifunović, Snežana, Simić, Milena R., Vujisić, Ljubodrag V., Vučković, Ivan, Novaković, Miroslav, Nikolic-Mandic, Snezana D, Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan, "Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge" in Natural Product Research, 29, no. 9 (2015):887-890,
https://doi.org/10.1080/14786419.2014.991929 . .

TY  - JOUR
AU  - Vujisić, Ljubodrag V.
AU  - Antic, Dragan Z.
AU  - Vučković, Ivan
AU  - Sekulic, Tatjana Lj.
AU  - Tomić, Vladimir T.
AU  - Mandić, Boris
AU  - Tešević, Vele
AU  - Curcic, Bozidar P. M.
AU  - Vajs, Vlatka
AU  - Makarov, Slobodan E.
PY  - 2014
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2733
AB  - The defensive secretions of two blaniulid millipedes, Nopoiulus kochii and Cibiniulus phlepsii, were characterized by GC-FID and GC/MS analyses, which showed the presence of a complex mixture of benzoquinones, hydroquinones, and oleates. Altogether, 13 compounds were identified. The major compound in the secretions of both analyzed species was 2-methyl-1,4-benzoquinone (toluquinone). The second major constituent in the N. kochii secretion was 2-methyl-3,4-(methylenedioxy)phenol, while in that of C. phlepsii, it was 2-methoxy-3-methyl-1,4-benzoquinone. The defensive secretion of N. kochii also showed a high content of hydroquinones (13.5%) in comparison to that of C. phlepsii (0.8%). Hexyl oleate and octyl oleate were detected for the first time in defensive millipede fluids. The chemical composition of the defensive secretions supports the chemotaxonomic position of the family Blaniulidae in the 'quinone' millipede clade.
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - Chemistry and Biodiversity
T1  - Chemical Defense in Millipedes (Myriapoda, Diplopoda): Do Representatives of the Family Blaniulidae Belong to the 'Quinone' Clade?
VL  - 11
IS  - 3
SP  - 483
EP  - 490
DO  - 10.1002/cbdv.201300355
ER  - 

@article{
author = "Vujisić, Ljubodrag V. and Antic, Dragan Z. and Vučković, Ivan and Sekulic, Tatjana Lj. and Tomić, Vladimir T. and Mandić, Boris and Tešević, Vele and Curcic, Bozidar P. M. and Vajs, Vlatka and Makarov, Slobodan E.",
year = "2014",
abstract = "The defensive secretions of two blaniulid millipedes, Nopoiulus kochii and Cibiniulus phlepsii, were characterized by GC-FID and GC/MS analyses, which showed the presence of a complex mixture of benzoquinones, hydroquinones, and oleates. Altogether, 13 compounds were identified. The major compound in the secretions of both analyzed species was 2-methyl-1,4-benzoquinone (toluquinone). The second major constituent in the N. kochii secretion was 2-methyl-3,4-(methylenedioxy)phenol, while in that of C. phlepsii, it was 2-methoxy-3-methyl-1,4-benzoquinone. The defensive secretion of N. kochii also showed a high content of hydroquinones (13.5%) in comparison to that of C. phlepsii (0.8%). Hexyl oleate and octyl oleate were detected for the first time in defensive millipede fluids. The chemical composition of the defensive secretions supports the chemotaxonomic position of the family Blaniulidae in the 'quinone' millipede clade.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Chemistry and Biodiversity",
title = "Chemical Defense in Millipedes (Myriapoda, Diplopoda): Do Representatives of the Family Blaniulidae Belong to the 'Quinone' Clade?",
volume = "11",
number = "3",
pages = "483-490",
doi = "10.1002/cbdv.201300355"
}

Vujisić, L. V., Antic, D. Z., Vučković, I., Sekulic, T. Lj., Tomić, V. T., Mandić, B., Tešević, V., Curcic, B. P. M., Vajs, V.,& Makarov, S. E.. (2014). Chemical Defense in Millipedes (Myriapoda, Diplopoda): Do Representatives of the Family Blaniulidae Belong to the 'Quinone' Clade?. in Chemistry and Biodiversity
Wiley-V C H Verlag Gmbh, Weinheim., 11(3), 483-490.
https://doi.org/10.1002/cbdv.201300355

Vujisić LV, Antic DZ, Vučković I, Sekulic TL, Tomić VT, Mandić B, Tešević V, Curcic BPM, Vajs V, Makarov SE. Chemical Defense in Millipedes (Myriapoda, Diplopoda): Do Representatives of the Family Blaniulidae Belong to the 'Quinone' Clade?. in Chemistry and Biodiversity. 2014;11(3):483-490.
doi:10.1002/cbdv.201300355 .

Vujisić, Ljubodrag V., Antic, Dragan Z., Vučković, Ivan, Sekulic, Tatjana Lj., Tomić, Vladimir T., Mandić, Boris, Tešević, Vele, Curcic, Bozidar P. M., Vajs, Vlatka, Makarov, Slobodan E., "Chemical Defense in Millipedes (Myriapoda, Diplopoda): Do Representatives of the Family Blaniulidae Belong to the 'Quinone' Clade?" in Chemistry and Biodiversity, 11, no. 3 (2014):483-490,
https://doi.org/10.1002/cbdv.201300355 . .

TY  - JOUR
AU  - Novaković, Miroslav
AU  - Pešić, Milica
AU  - Trifunović, Snežana
AU  - Vučković, Ivan
AU  - Todorović, Nina
AU  - Podolski-Renic, Ana
AU  - Dinić, Jelena
AU  - Stojkovic, Sonja
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan
PY  - 2014
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1549
AB  - An extended study of minor diarylheptanoids from the bark of black alder has resulted in the isolation of twenty diarylheptanoids, ten of which have not previously been reported (14-18, 20-24). The structures and configurations of all compounds were elucidated by NMR, HRESIMS, UV, IR, and CD. The anti-cancer potency of twenty diarylheptanoids and four previously isolated compounds (7, 10, 12, 13) was investigated in human non-small cell lung carcinoma cell lines (sensitive and multi-drug resistant variants) as well as in normal human keratinocytes. Diarylheptanoids with a p-coumaroyl group, 14 and 18, platyphylloside (1), platyphyllonol-5-O-beta-D-xylopyranoside (2), alnuside B (4) and hirsutenone (9) exhibited strong anti-cancer activity, considerably higher than diarylheptanoid curcumin, which served as a positive control. Compounds 4, 9, 14, and 18 displayed significant selectivity towards the cancer cells. Structure/activity analysis of twenty-four closely related diarylheptanoids revealed a high dependence of cytotoxic action on the presence of a carbonyl group at C-3. Substitution of a heptane chain on C-5 and a number of hydroxyl groups in the aromatic rings also emerged as a significant structural feature that influenced their cytotoxic potential.
PB  - Oxford : Pergamon-Elsevier Science Ltd
T2  - Phytochemistry
T1  - Diarylheptanoids from the bark of black alder inhibit the growth of sensitive and multi-drug resistant non-small cell lung carcinoma cells
VL  - 97
SP  - 46
EP  - 54
DO  - 10.1016/j.phytochem.2013.11.001
ER  - 

@article{
author = "Novaković, Miroslav and Pešić, Milica and Trifunović, Snežana and Vučković, Ivan and Todorović, Nina and Podolski-Renic, Ana and Dinić, Jelena and Stojkovic, Sonja and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan",
year = "2014",
abstract = "An extended study of minor diarylheptanoids from the bark of black alder has resulted in the isolation of twenty diarylheptanoids, ten of which have not previously been reported (14-18, 20-24). The structures and configurations of all compounds were elucidated by NMR, HRESIMS, UV, IR, and CD. The anti-cancer potency of twenty diarylheptanoids and four previously isolated compounds (7, 10, 12, 13) was investigated in human non-small cell lung carcinoma cell lines (sensitive and multi-drug resistant variants) as well as in normal human keratinocytes. Diarylheptanoids with a p-coumaroyl group, 14 and 18, platyphylloside (1), platyphyllonol-5-O-beta-D-xylopyranoside (2), alnuside B (4) and hirsutenone (9) exhibited strong anti-cancer activity, considerably higher than diarylheptanoid curcumin, which served as a positive control. Compounds 4, 9, 14, and 18 displayed significant selectivity towards the cancer cells. Structure/activity analysis of twenty-four closely related diarylheptanoids revealed a high dependence of cytotoxic action on the presence of a carbonyl group at C-3. Substitution of a heptane chain on C-5 and a number of hydroxyl groups in the aromatic rings also emerged as a significant structural feature that influenced their cytotoxic potential.",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "Phytochemistry",
title = "Diarylheptanoids from the bark of black alder inhibit the growth of sensitive and multi-drug resistant non-small cell lung carcinoma cells",
volume = "97",
pages = "46-54",
doi = "10.1016/j.phytochem.2013.11.001"
}

Novaković, M., Pešić, M., Trifunović, S., Vučković, I., Todorović, N., Podolski-Renic, A., Dinić, J., Stojkovic, S., Tešević, V., Vajs, V.,& Milosavljević, S.. (2014). Diarylheptanoids from the bark of black alder inhibit the growth of sensitive and multi-drug resistant non-small cell lung carcinoma cells. in Phytochemistry
Oxford : Pergamon-Elsevier Science Ltd., 97, 46-54.
https://doi.org/10.1016/j.phytochem.2013.11.001

Novaković M, Pešić M, Trifunović S, Vučković I, Todorović N, Podolski-Renic A, Dinić J, Stojkovic S, Tešević V, Vajs V, Milosavljević S. Diarylheptanoids from the bark of black alder inhibit the growth of sensitive and multi-drug resistant non-small cell lung carcinoma cells. in Phytochemistry. 2014;97:46-54.
doi:10.1016/j.phytochem.2013.11.001 .

Novaković, Miroslav, Pešić, Milica, Trifunović, Snežana, Vučković, Ivan, Todorović, Nina, Podolski-Renic, Ana, Dinić, Jelena, Stojkovic, Sonja, Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan, "Diarylheptanoids from the bark of black alder inhibit the growth of sensitive and multi-drug resistant non-small cell lung carcinoma cells" in Phytochemistry, 97 (2014):46-54,
https://doi.org/10.1016/j.phytochem.2013.11.001 . .

TY  - JOUR
AU  - Cvetković, Mirjana
AU  - Đorđević, Iris
AU  - Jadranin, Milka
AU  - Vajs, Vlatka
AU  - Vučković, Ivan
AU  - Menković, Nebojša
AU  - Milosavljević, Slobodan
AU  - Tešević, Vele
PY  - 2014
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1430
AB  - Analysis of composition of sesquiterpene lactone fraction of leaf cuticular neutral lipids of Amphoricarpos complex from two different localities in north Montenegro, i.e., canyon of river Tara (A. autariatus ssp. autariatus) and mountain Zeletin (A. autariatus ssp. bertisceus) afforded sesquiterpene lactones with guaianolide skeletons (17 compounds), so called amphoricarpolides, typical for this genus. Nine of them, 9-17, were new compounds, and their structures were elucidated by detailed analyses of IR, NMR, and MS data.
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - Chemistry & Biodiversity
T1  - Further Amphoricarpolides from the Surface Extracts of Amphoricarpos Complex from Montenegro
VL  - 11
IS  - 9
SP  - 1428
EP  - 1437
DO  - 10.1002/cbdv.201400101
ER  - 

@article{
author = "Cvetković, Mirjana and Đorđević, Iris and Jadranin, Milka and Vajs, Vlatka and Vučković, Ivan and Menković, Nebojša and Milosavljević, Slobodan and Tešević, Vele",
year = "2014",
abstract = "Analysis of composition of sesquiterpene lactone fraction of leaf cuticular neutral lipids of Amphoricarpos complex from two different localities in north Montenegro, i.e., canyon of river Tara (A. autariatus ssp. autariatus) and mountain Zeletin (A. autariatus ssp. bertisceus) afforded sesquiterpene lactones with guaianolide skeletons (17 compounds), so called amphoricarpolides, typical for this genus. Nine of them, 9-17, were new compounds, and their structures were elucidated by detailed analyses of IR, NMR, and MS data.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Chemistry & Biodiversity",
title = "Further Amphoricarpolides from the Surface Extracts of Amphoricarpos Complex from Montenegro",
volume = "11",
number = "9",
pages = "1428-1437",
doi = "10.1002/cbdv.201400101"
}

Cvetković, M., Đorđević, I., Jadranin, M., Vajs, V., Vučković, I., Menković, N., Milosavljević, S.,& Tešević, V.. (2014). Further Amphoricarpolides from the Surface Extracts of Amphoricarpos Complex from Montenegro. in Chemistry & Biodiversity
Wiley-V C H Verlag Gmbh, Weinheim., 11(9), 1428-1437.
https://doi.org/10.1002/cbdv.201400101

Cvetković M, Đorđević I, Jadranin M, Vajs V, Vučković I, Menković N, Milosavljević S, Tešević V. Further Amphoricarpolides from the Surface Extracts of Amphoricarpos Complex from Montenegro. in Chemistry & Biodiversity. 2014;11(9):1428-1437.
doi:10.1002/cbdv.201400101 .

Cvetković, Mirjana, Đorđević, Iris, Jadranin, Milka, Vajs, Vlatka, Vučković, Ivan, Menković, Nebojša, Milosavljević, Slobodan, Tešević, Vele, "Further Amphoricarpolides from the Surface Extracts of Amphoricarpos Complex from Montenegro" in Chemistry & Biodiversity, 11, no. 9 (2014):1428-1437,
https://doi.org/10.1002/cbdv.201400101 . .

TY  - JOUR
AU  - Aljančić, Ivana
AU  - Vučković, Ivan
AU  - Jadranin, Milka
AU  - Pešić, Milica
AU  - Đorđević, Iris
AU  - Podolski-Renic, Ana
AU  - Stojkovic, Sonja
AU  - Menković, Nebojša
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan
PY  - 2014
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1542
AB  - Dimers tomoroside A (1) and tomoroside B (2) of the co-occuring known chalcone monomer (3), along with the seven known flavonoid glucosides (4-10), were isolated from the aerial parts of Helichrysum zivojinii Cernjavski & Soska. The structures of the isolated compounds were elucidated by spectroscopic techniques. Compound 1 inhibited topo Ha and hif-1 alpha expression and stimulated doxorubicin anticancer effect, while 2 increased the expression of hif-1 alpha a, probably acting as antioxidant and redox status modulator. Notably, 2 synergized with Tipifarnib showing potential to improve the action of this new chemotherapeutic involved in the modulation of mitogene activated protein (MAP) kinase signaling pathway.
PB  - Oxford : Pergamon-Elsevier Science Ltd
T2  - Phytochemistry
T1  - Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines
VL  - 98
SP  - 190
EP  - 196
DO  - 10.1016/j.phytochem.2013.11.025
ER  - 

@article{
author = "Aljančić, Ivana and Vučković, Ivan and Jadranin, Milka and Pešić, Milica and Đorđević, Iris and Podolski-Renic, Ana and Stojkovic, Sonja and Menković, Nebojša and Vajs, Vlatka and Milosavljević, Slobodan",
year = "2014",
abstract = "Dimers tomoroside A (1) and tomoroside B (2) of the co-occuring known chalcone monomer (3), along with the seven known flavonoid glucosides (4-10), were isolated from the aerial parts of Helichrysum zivojinii Cernjavski & Soska. The structures of the isolated compounds were elucidated by spectroscopic techniques. Compound 1 inhibited topo Ha and hif-1 alpha expression and stimulated doxorubicin anticancer effect, while 2 increased the expression of hif-1 alpha a, probably acting as antioxidant and redox status modulator. Notably, 2 synergized with Tipifarnib showing potential to improve the action of this new chemotherapeutic involved in the modulation of mitogene activated protein (MAP) kinase signaling pathway.",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "Phytochemistry",
title = "Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines",
volume = "98",
pages = "190-196",
doi = "10.1016/j.phytochem.2013.11.025"
}

Aljančić, I., Vučković, I., Jadranin, M., Pešić, M., Đorđević, I., Podolski-Renic, A., Stojkovic, S., Menković, N., Vajs, V.,& Milosavljević, S.. (2014). Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines. in Phytochemistry
Oxford : Pergamon-Elsevier Science Ltd., 98, 190-196.
https://doi.org/10.1016/j.phytochem.2013.11.025

Aljančić I, Vučković I, Jadranin M, Pešić M, Đorđević I, Podolski-Renic A, Stojkovic S, Menković N, Vajs V, Milosavljević S. Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines. in Phytochemistry. 2014;98:190-196.
doi:10.1016/j.phytochem.2013.11.025 .

Aljančić, Ivana, Vučković, Ivan, Jadranin, Milka, Pešić, Milica, Đorđević, Iris, Podolski-Renic, Ana, Stojkovic, Sonja, Menković, Nebojša, Vajs, Vlatka, Milosavljević, Slobodan, "Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines" in Phytochemistry, 98 (2014):190-196,
https://doi.org/10.1016/j.phytochem.2013.11.025 . .

TY  - JOUR
AU  - Trifunović, Snežana
AU  - Isaković, Anđelka M.
AU  - Isaković, Aleksandra
AU  - Vučković, Ivan
AU  - Mandić, Boris
AU  - Novaković, Miroslav
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan
AU  - Trajković, Vladimir
PY  - 2014
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3120
AB  - Further phytochemical investigation into the aerial parts of Achillea clavennae has resulted in the 3 isolation of three new sesquiterpene lactones: two highly oxygenated germacranolides (1, 2) and 4 the iso-seco-guaianolide, 9(R)-acetoxy-3-O-methyl-iso-seco-tanapartholide (3). Eight known 5 compounds were also found in this plant species, of which 9 α -acetoxycanin (5), sintenin (6) and 6 oleanolic acid (7) were detected for the first time. The structures of the isolated compounds were 7 elucidated by combined spectroscopic methods (1D and 2D NMR, HRESIMS, CIMS, FTIR). 8 While the predominant metabolite germacranolide sintenin (6) was not cytotoxic, the new iso-9 seco-guaianolide (3) displayed cytotoxicity comparable to that of cisplatin and the lactone 10 apressin (4), inducing partly apoptotic death in human U251 and rat C6 glioma cell lines.
PB  - Georg Thieme Verlag
T2  - Planta medica
T1  - Isolation, characterization and in vitro cytotoxicity of new sesquiterpenoids from Achillea clavennae
VL  - 80
IS  - 4
SP  - 275
EP  - 305
DO  - 10.1055/s-0033-1360312
ER  - 

@article{
author = "Trifunović, Snežana and Isaković, Anđelka M. and Isaković, Aleksandra and Vučković, Ivan and Mandić, Boris and Novaković, Miroslav and Vajs, Vlatka and Milosavljević, Slobodan and Trajković, Vladimir",
year = "2014",
abstract = "Further phytochemical investigation into the aerial parts of Achillea clavennae has resulted in the 3 isolation of three new sesquiterpene lactones: two highly oxygenated germacranolides (1, 2) and 4 the iso-seco-guaianolide, 9(R)-acetoxy-3-O-methyl-iso-seco-tanapartholide (3). Eight known 5 compounds were also found in this plant species, of which 9 α -acetoxycanin (5), sintenin (6) and 6 oleanolic acid (7) were detected for the first time. The structures of the isolated compounds were 7 elucidated by combined spectroscopic methods (1D and 2D NMR, HRESIMS, CIMS, FTIR). 8 While the predominant metabolite germacranolide sintenin (6) was not cytotoxic, the new iso-9 seco-guaianolide (3) displayed cytotoxicity comparable to that of cisplatin and the lactone 10 apressin (4), inducing partly apoptotic death in human U251 and rat C6 glioma cell lines.",
publisher = "Georg Thieme Verlag",
journal = "Planta medica",
title = "Isolation, characterization and in vitro cytotoxicity of new sesquiterpenoids from Achillea clavennae",
volume = "80",
number = "4",
pages = "275-305",
doi = "10.1055/s-0033-1360312"
}

Trifunović, S., Isaković, A. M., Isaković, A., Vučković, I., Mandić, B., Novaković, M., Vajs, V., Milosavljević, S.,& Trajković, V.. (2014). Isolation, characterization and in vitro cytotoxicity of new sesquiterpenoids from Achillea clavennae. in Planta medica
Georg Thieme Verlag., 80(4), 275-305.
https://doi.org/10.1055/s-0033-1360312

Trifunović S, Isaković AM, Isaković A, Vučković I, Mandić B, Novaković M, Vajs V, Milosavljević S, Trajković V. Isolation, characterization and in vitro cytotoxicity of new sesquiterpenoids from Achillea clavennae. in Planta medica. 2014;80(4):275-305.
doi:10.1055/s-0033-1360312 .

Trifunović, Snežana, Isaković, Anđelka M., Isaković, Aleksandra, Vučković, Ivan, Mandić, Boris, Novaković, Miroslav, Vajs, Vlatka, Milosavljević, Slobodan, Trajković, Vladimir, "Isolation, characterization and in vitro cytotoxicity of new sesquiterpenoids from Achillea clavennae" in Planta medica, 80, no. 4 (2014):275-305,
https://doi.org/10.1055/s-0033-1360312 . .

TY  - JOUR
AU  - Novaković, Miroslav
AU  - Stanković, Miroslava
AU  - Vučković, Ivan
AU  - Todorović, Nina
AU  - Trifunović, Snežana
AU  - Apostolovic, Danijela
AU  - Mandić, Boris
AU  - Veljić, Milan
AU  - Marin, Petar D.
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan
PY  - 2014
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1596
AB  - Nine diarylheptanoids, 1-9, catechin (11), and a phenolic glucoside, 10, were isolated from the bark of green alder (Alnus viridis). Four of the isolated compounds, i.e., 2, 5, 8, 10, are new. The structures of 1-11 were determined on the basis of spectroscopic data. All isolated compounds were evaluated for their in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using cytokinesis-block micronucleus (CBMN) assay. Almost all of them exerted a pronounced effect of decreasing DNA damage of human lymphocytes, acting stronger than the known synthetic protector amifostine.
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - Chemistry & Biodiversity
T1  - Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection
VL  - 11
IS  - 6
SP  - 872
EP  - 885
DO  - 10.1002/cbdv.201300277
ER  - 

@article{
author = "Novaković, Miroslav and Stanković, Miroslava and Vučković, Ivan and Todorović, Nina and Trifunović, Snežana and Apostolovic, Danijela and Mandić, Boris and Veljić, Milan and Marin, Petar D. and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan",
year = "2014",
abstract = "Nine diarylheptanoids, 1-9, catechin (11), and a phenolic glucoside, 10, were isolated from the bark of green alder (Alnus viridis). Four of the isolated compounds, i.e., 2, 5, 8, 10, are new. The structures of 1-11 were determined on the basis of spectroscopic data. All isolated compounds were evaluated for their in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using cytokinesis-block micronucleus (CBMN) assay. Almost all of them exerted a pronounced effect of decreasing DNA damage of human lymphocytes, acting stronger than the known synthetic protector amifostine.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Chemistry & Biodiversity",
title = "Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection",
volume = "11",
number = "6",
pages = "872-885",
doi = "10.1002/cbdv.201300277"
}

Novaković, M., Stanković, M., Vučković, I., Todorović, N., Trifunović, S., Apostolovic, D., Mandić, B., Veljić, M., Marin, P. D., Tešević, V., Vajs, V.,& Milosavljević, S.. (2014). Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection. in Chemistry & Biodiversity
Wiley-V C H Verlag Gmbh, Weinheim., 11(6), 872-885.
https://doi.org/10.1002/cbdv.201300277

Novaković M, Stanković M, Vučković I, Todorović N, Trifunović S, Apostolovic D, Mandić B, Veljić M, Marin PD, Tešević V, Vajs V, Milosavljević S. Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection. in Chemistry & Biodiversity. 2014;11(6):872-885.
doi:10.1002/cbdv.201300277 .

Novaković, Miroslav, Stanković, Miroslava, Vučković, Ivan, Todorović, Nina, Trifunović, Snežana, Apostolovic, Danijela, Mandić, Boris, Veljić, Milan, Marin, Petar D., Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan, "Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection" in Chemistry & Biodiversity, 11, no. 6 (2014):872-885,
https://doi.org/10.1002/cbdv.201300277 . .

TY  - JOUR
AU  - Trifunović, Snežana
AU  - Isaković, Anđelka M.
AU  - Isaković, Aleksandra
AU  - Vučković, Ivan
AU  - Mandić, Boris
AU  - Novaković, Miroslav
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan
AU  - Trajković, Vladimir
PY  - 2014
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1534
AB  - Further phytochemical investigation of the aerial parts of Achillea clavennae has resulted in the isolation of three new sesquiterpene lactones: two highly oxygenated germacranolides (1, 2) and the iso-seco-guaianolide 9(R)-acetoxy-3-O-methyl-iso-seco-tanapartholide (3). Eight known compounds were also found, of which 9-acetoxycanin (5), sintenin (6), and oleanolic acid (7) were detected for the first time. The structures of the isolated compounds were elucidated by combined spectroscopic methods (1D and 2DNMR, HRESIMS, CIMS, and FTIR). While the predominant metabolite germacranolide sintenin (6) was not cytotoxic, the new iso-seco-guaianolide (3) displayed cytotoxicity comparable to that of cisplatin and the lactone apressin (4), inducing partly apoptotic death in human U251 and rat C6 glioma cell lines.
PB  - Georg Thieme Verlag Kg, Stuttgart
T2  - Planta Medica
T1  - Isolation, Characterization, and In Vitro Cytotoxicity of New Sesquiterpenoids from Achillea clavennae
VL  - 80
IS  - 4
SP  - 297
EP  - 305
DO  - 10.1055/s-0033-1360312
ER  - 

@article{
author = "Trifunović, Snežana and Isaković, Anđelka M. and Isaković, Aleksandra and Vučković, Ivan and Mandić, Boris and Novaković, Miroslav and Vajs, Vlatka and Milosavljević, Slobodan and Trajković, Vladimir",
year = "2014",
abstract = "Further phytochemical investigation of the aerial parts of Achillea clavennae has resulted in the isolation of three new sesquiterpene lactones: two highly oxygenated germacranolides (1, 2) and the iso-seco-guaianolide 9(R)-acetoxy-3-O-methyl-iso-seco-tanapartholide (3). Eight known compounds were also found, of which 9-acetoxycanin (5), sintenin (6), and oleanolic acid (7) were detected for the first time. The structures of the isolated compounds were elucidated by combined spectroscopic methods (1D and 2DNMR, HRESIMS, CIMS, and FTIR). While the predominant metabolite germacranolide sintenin (6) was not cytotoxic, the new iso-seco-guaianolide (3) displayed cytotoxicity comparable to that of cisplatin and the lactone apressin (4), inducing partly apoptotic death in human U251 and rat C6 glioma cell lines.",
publisher = "Georg Thieme Verlag Kg, Stuttgart",
journal = "Planta Medica",
title = "Isolation, Characterization, and In Vitro Cytotoxicity of New Sesquiterpenoids from Achillea clavennae",
volume = "80",
number = "4",
pages = "297-305",
doi = "10.1055/s-0033-1360312"
}

Trifunović, S., Isaković, A. M., Isaković, A., Vučković, I., Mandić, B., Novaković, M., Vajs, V., Milosavljević, S.,& Trajković, V.. (2014). Isolation, Characterization, and In Vitro Cytotoxicity of New Sesquiterpenoids from Achillea clavennae. in Planta Medica
Georg Thieme Verlag Kg, Stuttgart., 80(4), 297-305.
https://doi.org/10.1055/s-0033-1360312

Trifunović S, Isaković AM, Isaković A, Vučković I, Mandić B, Novaković M, Vajs V, Milosavljević S, Trajković V. Isolation, Characterization, and In Vitro Cytotoxicity of New Sesquiterpenoids from Achillea clavennae. in Planta Medica. 2014;80(4):297-305.
doi:10.1055/s-0033-1360312 .

Trifunović, Snežana, Isaković, Anđelka M., Isaković, Aleksandra, Vučković, Ivan, Mandić, Boris, Novaković, Miroslav, Vajs, Vlatka, Milosavljević, Slobodan, Trajković, Vladimir, "Isolation, Characterization, and In Vitro Cytotoxicity of New Sesquiterpenoids from Achillea clavennae" in Planta Medica, 80, no. 4 (2014):297-305,
https://doi.org/10.1055/s-0033-1360312 . .

TY  - JOUR
AU  - Mandić, Boris
AU  - Simić, Milena R.
AU  - Vučković, Ivan
AU  - Vujisić, Ljubodrag V.
AU  - Novaković, Miroslav
AU  - Trifunović, Snežana
AU  - Nikolic-Mandic, Snezana D.
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan
PY  - 2013
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1241
AB  - The examination of the aerial parts, roots, and seeds of the endemic plant Rindera umbellata is reported in this paper for the first time. Phytochemical investigation of R. umbellata led to the isolation and characterization of ten pyrrolizidine alkaloids and eleven fatty acids in the form of triglycerides. Pyrrolizidine alkaloids 1-9 were found in the aerial parts, 7 and 8 in the roots, and 6-10, together with eleven fatty acids, in the seeds of this plant species. The structures of compounds 1-10 were established based on spectroscopic studies (H-1- and C-13-NMR, 2D NMR, IR and CI-MS). After trans-esterification, methyl esters of the fatty acids were analyzed using GC-MS. The effect of lindelofine-N-oxide (7) on tubulin polymerization was determined.
PB  - MDPI
T2  - Molecules
T1  - Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization
VL  - 18
IS  - 9
SP  - 10694
EP  - 10706
DO  - 10.3390/molecules180910694
ER  - 

@article{
author = "Mandić, Boris and Simić, Milena R. and Vučković, Ivan and Vujisić, Ljubodrag V. and Novaković, Miroslav and Trifunović, Snežana and Nikolic-Mandic, Snezana D. and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan",
year = "2013",
abstract = "The examination of the aerial parts, roots, and seeds of the endemic plant Rindera umbellata is reported in this paper for the first time. Phytochemical investigation of R. umbellata led to the isolation and characterization of ten pyrrolizidine alkaloids and eleven fatty acids in the form of triglycerides. Pyrrolizidine alkaloids 1-9 were found in the aerial parts, 7 and 8 in the roots, and 6-10, together with eleven fatty acids, in the seeds of this plant species. The structures of compounds 1-10 were established based on spectroscopic studies (H-1- and C-13-NMR, 2D NMR, IR and CI-MS). After trans-esterification, methyl esters of the fatty acids were analyzed using GC-MS. The effect of lindelofine-N-oxide (7) on tubulin polymerization was determined.",
publisher = "MDPI",
journal = "Molecules",
title = "Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization",
volume = "18",
number = "9",
pages = "10694-10706",
doi = "10.3390/molecules180910694"
}

Mandić, B., Simić, M. R., Vučković, I., Vujisić, L. V., Novaković, M., Trifunović, S., Nikolic-Mandic, S. D., Tešević, V., Vajs, V.,& Milosavljević, S.. (2013). Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization. in Molecules
MDPI., 18(9), 10694-10706.
https://doi.org/10.3390/molecules180910694

Mandić B, Simić MR, Vučković I, Vujisić LV, Novaković M, Trifunović S, Nikolic-Mandic SD, Tešević V, Vajs V, Milosavljević S. Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization. in Molecules. 2013;18(9):10694-10706.
doi:10.3390/molecules180910694 .

Mandić, Boris, Simić, Milena R., Vučković, Ivan, Vujisić, Ljubodrag V., Novaković, Miroslav, Trifunović, Snežana, Nikolic-Mandic, Snezana D., Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan, "Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization" in Molecules, 18, no. 9 (2013):10694-10706,
https://doi.org/10.3390/molecules180910694 . .

TY  - JOUR
AU  - Novaković, Miroslav
AU  - Stanković, Miroslava
AU  - Vučković, Ivan
AU  - Todorović, Nina
AU  - Trifunović, Snežana
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan
PY  - 2013
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1358
PB  - Georg Thieme Verlag Kg, Stuttgart
T2  - Planta Medica
T1  - Diarylheptanoids from Alnus glutinosa Bark and Their Chemoprotective Effect on Human Lymphocytes DNA
VL  - 79
IS  - 6
SP  - 499
EP  - 505
DO  - 10.1055/s-0032-1328301
ER  - 

@article{
author = "Novaković, Miroslav and Stanković, Miroslava and Vučković, Ivan and Todorović, Nina and Trifunović, Snežana and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan",
year = "2013",
publisher = "Georg Thieme Verlag Kg, Stuttgart",
journal = "Planta Medica",
title = "Diarylheptanoids from Alnus glutinosa Bark and Their Chemoprotective Effect on Human Lymphocytes DNA",
volume = "79",
number = "6",
pages = "499-505",
doi = "10.1055/s-0032-1328301"
}

Novaković, M., Stanković, M., Vučković, I., Todorović, N., Trifunović, S., Tešević, V., Vajs, V.,& Milosavljević, S.. (2013). Diarylheptanoids from Alnus glutinosa Bark and Their Chemoprotective Effect on Human Lymphocytes DNA. in Planta Medica
Georg Thieme Verlag Kg, Stuttgart., 79(6), 499-505.
https://doi.org/10.1055/s-0032-1328301

Novaković M, Stanković M, Vučković I, Todorović N, Trifunović S, Tešević V, Vajs V, Milosavljević S. Diarylheptanoids from Alnus glutinosa Bark and Their Chemoprotective Effect on Human Lymphocytes DNA. in Planta Medica. 2013;79(6):499-505.
doi:10.1055/s-0032-1328301 .

Novaković, Miroslav, Stanković, Miroslava, Vučković, Ivan, Todorović, Nina, Trifunović, Snežana, Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan, "Diarylheptanoids from Alnus glutinosa Bark and Their Chemoprotective Effect on Human Lymphocytes DNA" in Planta Medica, 79, no. 6 (2013):499-505,
https://doi.org/10.1055/s-0032-1328301 . .

TY  - JOUR
AU  - Vujisić, Ljubodrag V.
AU  - Vučković, Ivan
AU  - Makarov, Slobodan E.
AU  - Ilic, Bojan S.
AU  - Antic, Dragan Z.
AU  - Jadranin, Milka
AU  - Todorović, Nina
AU  - Mrkić, Ivan
AU  - Vajs, Vlatka
AU  - Lučić, Luka
AU  - Curcic, Bozidar P. M.
AU  - Mitic, Bojan M.
PY  - 2013
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1177
AB  - The geophilomorph centipede, Himantarium gabrielis, when disturbed, discharges a viscous and proteinaceous secretion from the sternal glands. This exudate was found by gas chromatography-mass spectrometry, liquid chromatography-high resolution mass spectrometry, liquid chromatography-mass spectrometry-mass spectrometry and NMR analyses to be composed of hydrogen cyanide, benzaldehyde, benzoyl nitrile, benzyl nitrile, mandelonitrile, mandelonitrile benzoate, 3,7,6O-trimethylguanine (himantarine), farnesyl 2,3-dihydrofarnesoate and farnesyl farnesoate. This is the first report on the presence of benzyl nitrile and mandelonitrile benzoate in secreted substances from centipedes. Farnesyl 2,3-dihydrofarnesoate is a new compound, while himantarine and farnesyl farnesoate were not known as natural products. A post-secretion release of hydrogen cyanide by reaction of mandelonitrile and benzoyl nitrile was observed by NMR, and hydrogen cyanide signals were completely assigned. In addition, a protein component of the secretion was analysed by electrophoresis which revealed the presence of a major 55 kDa protein. Analyses of the defensive exudates of other geophilomorph families should produce further chemical surprises.
PB  - Springer, New York
T2  - Naturwissenschaften
T1  - Chemistry of the sternal gland secretion of the Mediterranean centipede Himantarium gabrielis (Linnaeus, 1767) (Chilopoda: Geophilomorpha: Himantariidae)
VL  - 100
IS  - 9
SP  - 861
EP  - 870
DO  - 10.1007/s00114-013-1086-6
ER  - 

@article{
author = "Vujisić, Ljubodrag V. and Vučković, Ivan and Makarov, Slobodan E. and Ilic, Bojan S. and Antic, Dragan Z. and Jadranin, Milka and Todorović, Nina and Mrkić, Ivan and Vajs, Vlatka and Lučić, Luka and Curcic, Bozidar P. M. and Mitic, Bojan M.",
year = "2013",
abstract = "The geophilomorph centipede, Himantarium gabrielis, when disturbed, discharges a viscous and proteinaceous secretion from the sternal glands. This exudate was found by gas chromatography-mass spectrometry, liquid chromatography-high resolution mass spectrometry, liquid chromatography-mass spectrometry-mass spectrometry and NMR analyses to be composed of hydrogen cyanide, benzaldehyde, benzoyl nitrile, benzyl nitrile, mandelonitrile, mandelonitrile benzoate, 3,7,6O-trimethylguanine (himantarine), farnesyl 2,3-dihydrofarnesoate and farnesyl farnesoate. This is the first report on the presence of benzyl nitrile and mandelonitrile benzoate in secreted substances from centipedes. Farnesyl 2,3-dihydrofarnesoate is a new compound, while himantarine and farnesyl farnesoate were not known as natural products. A post-secretion release of hydrogen cyanide by reaction of mandelonitrile and benzoyl nitrile was observed by NMR, and hydrogen cyanide signals were completely assigned. In addition, a protein component of the secretion was analysed by electrophoresis which revealed the presence of a major 55 kDa protein. Analyses of the defensive exudates of other geophilomorph families should produce further chemical surprises.",
publisher = "Springer, New York",
journal = "Naturwissenschaften",
title = "Chemistry of the sternal gland secretion of the Mediterranean centipede Himantarium gabrielis (Linnaeus, 1767) (Chilopoda: Geophilomorpha: Himantariidae)",
volume = "100",
number = "9",
pages = "861-870",
doi = "10.1007/s00114-013-1086-6"
}

Vujisić, L. V., Vučković, I., Makarov, S. E., Ilic, B. S., Antic, D. Z., Jadranin, M., Todorović, N., Mrkić, I., Vajs, V., Lučić, L., Curcic, B. P. M.,& Mitic, B. M.. (2013). Chemistry of the sternal gland secretion of the Mediterranean centipede Himantarium gabrielis (Linnaeus, 1767) (Chilopoda: Geophilomorpha: Himantariidae). in Naturwissenschaften
Springer, New York., 100(9), 861-870.
https://doi.org/10.1007/s00114-013-1086-6

Vujisić LV, Vučković I, Makarov SE, Ilic BS, Antic DZ, Jadranin M, Todorović N, Mrkić I, Vajs V, Lučić L, Curcic BPM, Mitic BM. Chemistry of the sternal gland secretion of the Mediterranean centipede Himantarium gabrielis (Linnaeus, 1767) (Chilopoda: Geophilomorpha: Himantariidae). in Naturwissenschaften. 2013;100(9):861-870.
doi:10.1007/s00114-013-1086-6 .

Vujisić, Ljubodrag V., Vučković, Ivan, Makarov, Slobodan E., Ilic, Bojan S., Antic, Dragan Z., Jadranin, Milka, Todorović, Nina, Mrkić, Ivan, Vajs, Vlatka, Lučić, Luka, Curcic, Bozidar P. M., Mitic, Bojan M., "Chemistry of the sternal gland secretion of the Mediterranean centipede Himantarium gabrielis (Linnaeus, 1767) (Chilopoda: Geophilomorpha: Himantariidae)" in Naturwissenschaften, 100, no. 9 (2013):861-870,
https://doi.org/10.1007/s00114-013-1086-6 . .

TY  - JOUR
AU  - Makarov, Slobodan E.
AU  - Vujisić, Ljubodrag V.
AU  - Curcic, Bozidar P. M.
AU  - Ilic, Bojan S.
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Vučković, Ivan
AU  - Mitic, Bojan M.
AU  - Lučić, Luka
AU  - Đorđević, Iris
PY  - 2012
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2736
AB  - Makarov S. E., Vujisic L.V., Curcic B.P.M., Ilic B.S., Tesevic V.V., Vajs V.E., Vuckovic I.M., Mitic B. M., Lucic L.R. and Dordevic I.Z. 2012. Chemical defense in the cave-dwelling millipede Brachydesmus troglobius Daday, 1889 (Diplopoda, Polydesmidae). International Journal of Speleology, 41(1), 95-100. Tampa, FL (USA). ISSN 0392-6672. http://dx.doi.org/10.5038/1827-806X.41.1.10 The troglomorphic millipede Brachydesmus troglobius Daday, 1889 (Polydesmida: Polydesmidae) secretes allomones from glands on both lateral surfaces of its body segments. The secretion was identified by gas chromatography-mass spectrometry (GC-MS) analysis with electron and chemical ionization, and was shown to be composed of a mixture of benzaldehyde, benzyl alcohol, benzoylnitrile, benzoic acid and mandelonitrile benzoate. Hydrogen cyanide was qualitatively identified by the picric acid test. This is the first identification of these compounds in a cave-dwelling polydesmid.
PB  - Societa Speleologica Italiana, Bologna
T2  - International Journal of Speleology
T1  - Chemical defense in the cave-dwelling millipede Brachydesmus troglobius Daday, 1889 (Diplopoda, Polydesmidae)
VL  - 41
IS  - 1
SP  - 95
EP  - 100
DO  - 10.5038/1827-806X.41.1.10
ER  - 

@article{
author = "Makarov, Slobodan E. and Vujisić, Ljubodrag V. and Curcic, Bozidar P. M. and Ilic, Bojan S. and Tešević, Vele and Vajs, Vlatka and Vučković, Ivan and Mitic, Bojan M. and Lučić, Luka and Đorđević, Iris",
year = "2012",
abstract = "Makarov S. E., Vujisic L.V., Curcic B.P.M., Ilic B.S., Tesevic V.V., Vajs V.E., Vuckovic I.M., Mitic B. M., Lucic L.R. and Dordevic I.Z. 2012. Chemical defense in the cave-dwelling millipede Brachydesmus troglobius Daday, 1889 (Diplopoda, Polydesmidae). International Journal of Speleology, 41(1), 95-100. Tampa, FL (USA). ISSN 0392-6672. http://dx.doi.org/10.5038/1827-806X.41.1.10 The troglomorphic millipede Brachydesmus troglobius Daday, 1889 (Polydesmida: Polydesmidae) secretes allomones from glands on both lateral surfaces of its body segments. The secretion was identified by gas chromatography-mass spectrometry (GC-MS) analysis with electron and chemical ionization, and was shown to be composed of a mixture of benzaldehyde, benzyl alcohol, benzoylnitrile, benzoic acid and mandelonitrile benzoate. Hydrogen cyanide was qualitatively identified by the picric acid test. This is the first identification of these compounds in a cave-dwelling polydesmid.",
publisher = "Societa Speleologica Italiana, Bologna",
journal = "International Journal of Speleology",
title = "Chemical defense in the cave-dwelling millipede Brachydesmus troglobius Daday, 1889 (Diplopoda, Polydesmidae)",
volume = "41",
number = "1",
pages = "95-100",
doi = "10.5038/1827-806X.41.1.10"
}

Makarov, S. E., Vujisić, L. V., Curcic, B. P. M., Ilic, B. S., Tešević, V., Vajs, V., Vučković, I., Mitic, B. M., Lučić, L.,& Đorđević, I.. (2012). Chemical defense in the cave-dwelling millipede Brachydesmus troglobius Daday, 1889 (Diplopoda, Polydesmidae). in International Journal of Speleology
Societa Speleologica Italiana, Bologna., 41(1), 95-100.
https://doi.org/10.5038/1827-806X.41.1.10

Makarov SE, Vujisić LV, Curcic BPM, Ilic BS, Tešević V, Vajs V, Vučković I, Mitic BM, Lučić L, Đorđević I. Chemical defense in the cave-dwelling millipede Brachydesmus troglobius Daday, 1889 (Diplopoda, Polydesmidae). in International Journal of Speleology. 2012;41(1):95-100.
doi:10.5038/1827-806X.41.1.10 .

Makarov, Slobodan E., Vujisić, Ljubodrag V., Curcic, Bozidar P. M., Ilic, Bojan S., Tešević, Vele, Vajs, Vlatka, Vučković, Ivan, Mitic, Bojan M., Lučić, Luka, Đorđević, Iris, "Chemical defense in the cave-dwelling millipede Brachydesmus troglobius Daday, 1889 (Diplopoda, Polydesmidae)" in International Journal of Speleology, 41, no. 1 (2012):95-100,
https://doi.org/10.5038/1827-806X.41.1.10 . .

TY  - JOUR
AU  - Rabtti, El Hadi M. A.
AU  - Natić, Maja
AU  - Milojković-Opsenica, Dušanka
AU  - Trifković, Jelena
AU  - Tosti, Tomislav
AU  - Vučković, Ivan
AU  - Vajs, Vlatka
AU  - Tešić, Živoslav
PY  - 2012
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1554
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2721
AB  - Four lipophilicity descriptors (R-M(0), b, C-0 and PCl) for twelve coumarin derivatives were determined by reversed-phase thin-layer chromatography in order to analyze the descriptor which best describes the lipophilicity of the investigated coumarins. Moreover, possible chemical toxicity of coumarins, expressed as the probability of a compound to cause organ-specific health effects, was calculated using ACD/Tox Suite program. The quantitative relationships between toxicity and molecular descriptors, including experimentally determined lipophilicity descriptors obtained in current study were investigated using partial least square regression. The best models were obtained for kidney and liver health effects. Quantitative structure-toxicity relationship models revealed the importance of electric polarization descriptors, size descriptors and lipophilicity descriptors. The obtained models were used for the selection of the structural features of the compounds that are significantly affecting their absorption, distribution, metabolism, excretion and toxicity.
AB  - Primenom reverzno-fazne tankoslojne hromatografije na dvanaest derivata kumarina određena su četiri parametara lipofilnosti (RM0, b, C0 i PC1). Korelacijom dobijenih rezultata sa izračunatim log P vrednostima utvrđen je deskriptor koji na najbolji način opisuje lipofilnost ispitivanih kumarina. Pored toga izračunata je moguća hemijska toksičnost kumarina, izražena kao verovatnoća uticaja pomenutih jedinjenja na specifične organe (krv, kardiovaskularni sistem, gastrointestinalni sistem, bubrege, jetru i pluća) a koja je izračunata primenom ACD/Tox Suite programa. Dobijene vrednosti toksičnosti korelisane su sa molekulskim deskriptorima i eksperimentalno određenim parametrima lipofilnosti, primenom metode parcijalne regresije najmanjih kvadrata (partial least square regression). Uzimajući u obzir parametre koji opisuju kvalitet modela zavisnosti strukture i toksičnosti, utvrđeno je da su najbolji modeli dobijeni za uticaj kumarina na bubrege i jetru. Svi dobijeni modeli ukazuju na značaj električno polarizacionih deskriptora, kao i deskriptora koji opisuju veličinu i lipofilnost jedinjenja, a upotrebljeni su za utvrđivanje strukturnih karakteristika koje značajno utiču na njihovu apsorpciju, distribuciju, metabolizam, izlučivanje i toksičnost.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Quantitative structure-toxicity relationship study of some natural and synthetic coumarins using retention parameters
T1  - Analiza zavisnosti strukture i toksičnosti nekih prirodnih i sintetičkih kumarina korišćenjem retencionih parametara
VL  - 77
IS  - 10
SP  - 1443
EP  - 1456
DO  - 10.2298/JSC120716091R
ER  - 

@article{
author = "Rabtti, El Hadi M. A. and Natić, Maja and Milojković-Opsenica, Dušanka and Trifković, Jelena and Tosti, Tomislav and Vučković, Ivan and Vajs, Vlatka and Tešić, Živoslav",
year = "2012",
abstract = "Four lipophilicity descriptors (R-M(0), b, C-0 and PCl) for twelve coumarin derivatives were determined by reversed-phase thin-layer chromatography in order to analyze the descriptor which best describes the lipophilicity of the investigated coumarins. Moreover, possible chemical toxicity of coumarins, expressed as the probability of a compound to cause organ-specific health effects, was calculated using ACD/Tox Suite program. The quantitative relationships between toxicity and molecular descriptors, including experimentally determined lipophilicity descriptors obtained in current study were investigated using partial least square regression. The best models were obtained for kidney and liver health effects. Quantitative structure-toxicity relationship models revealed the importance of electric polarization descriptors, size descriptors and lipophilicity descriptors. The obtained models were used for the selection of the structural features of the compounds that are significantly affecting their absorption, distribution, metabolism, excretion and toxicity., Primenom reverzno-fazne tankoslojne hromatografije na dvanaest derivata kumarina određena su četiri parametara lipofilnosti (RM0, b, C0 i PC1). Korelacijom dobijenih rezultata sa izračunatim log P vrednostima utvrđen je deskriptor koji na najbolji način opisuje lipofilnost ispitivanih kumarina. Pored toga izračunata je moguća hemijska toksičnost kumarina, izražena kao verovatnoća uticaja pomenutih jedinjenja na specifične organe (krv, kardiovaskularni sistem, gastrointestinalni sistem, bubrege, jetru i pluća) a koja je izračunata primenom ACD/Tox Suite programa. Dobijene vrednosti toksičnosti korelisane su sa molekulskim deskriptorima i eksperimentalno određenim parametrima lipofilnosti, primenom metode parcijalne regresije najmanjih kvadrata (partial least square regression). Uzimajući u obzir parametre koji opisuju kvalitet modela zavisnosti strukture i toksičnosti, utvrđeno je da su najbolji modeli dobijeni za uticaj kumarina na bubrege i jetru. Svi dobijeni modeli ukazuju na značaj električno polarizacionih deskriptora, kao i deskriptora koji opisuju veličinu i lipofilnost jedinjenja, a upotrebljeni su za utvrđivanje strukturnih karakteristika koje značajno utiču na njihovu apsorpciju, distribuciju, metabolizam, izlučivanje i toksičnost.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Quantitative structure-toxicity relationship study of some natural and synthetic coumarins using retention parameters, Analiza zavisnosti strukture i toksičnosti nekih prirodnih i sintetičkih kumarina korišćenjem retencionih parametara",
volume = "77",
number = "10",
pages = "1443-1456",
doi = "10.2298/JSC120716091R"
}

Rabtti, E. H. M. A., Natić, M., Milojković-Opsenica, D., Trifković, J., Tosti, T., Vučković, I., Vajs, V.,& Tešić, Ž.. (2012). Quantitative structure-toxicity relationship study of some natural and synthetic coumarins using retention parameters. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 77(10), 1443-1456.
https://doi.org/10.2298/JSC120716091R

Rabtti EHMA, Natić M, Milojković-Opsenica D, Trifković J, Tosti T, Vučković I, Vajs V, Tešić Ž. Quantitative structure-toxicity relationship study of some natural and synthetic coumarins using retention parameters. in Journal of the Serbian Chemical Society. 2012;77(10):1443-1456.
doi:10.2298/JSC120716091R .

Rabtti, El Hadi M. A., Natić, Maja, Milojković-Opsenica, Dušanka, Trifković, Jelena, Tosti, Tomislav, Vučković, Ivan, Vajs, Vlatka, Tešić, Živoslav, "Quantitative structure-toxicity relationship study of some natural and synthetic coumarins using retention parameters" in Journal of the Serbian Chemical Society, 77, no. 10 (2012):1443-1456,
https://doi.org/10.2298/JSC120716091R . .

TY  - JOUR
AU  - Rabtti, El Hadi M. A.
AU  - Natić, Maja
AU  - Milojković-Opsenica, Dušanka
AU  - Trifković, Jelena
AU  - Vučković, Ivan
AU  - Vajs, Vlatka
AU  - Tešić, Živoslav
PY  - 2012
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2726
AB  - The lipophilic character of twelve coumarins was investigated by reversed-phase thin-layer chromatography (RP TLC) on RP-18 silica. The three different binary solvent systems composed of water and organic modifier (methanol, tetrahydrofuran or acetonitrile) were used in order to determine retention parameter (R-M(0)) and octanol-water partition coefficient (log P-OW) as a measure of the lipophilicity of the tested compounds. Lipophilicity parameter (log P-OW) was experimentally determined using eight standard solutes with known log P-OW values which were analyzed under the same chromatographic conditions as the target substances. Lipophilicity parameters together with 2D molecular descriptors were subjected to the multivariate statistical analysis (principal component analysis (PCA) and partial least square (PLS) regression) in order to reveal the most influential factors governing the retention, i.e., lipophilicity of the investigated compounds. The quantitative structure-retention relationship models reveal the importance of descriptors which describe the size and the shape of the molecule as well as their polar properties.
PB  - Soc Brasileira Quimica, Sao Paulo
T2  - Journal of the Brazilian Chemical Society
T1  - RP TLC-Based Lipophilicity Assessment of Some Natural and Synthetic Coumarins
VL  - 23
IS  - 3
SP  - 522
UR  - https://hdl.handle.net/21.15107/rcub_cherry_1274
ER  - 

@article{
author = "Rabtti, El Hadi M. A. and Natić, Maja and Milojković-Opsenica, Dušanka and Trifković, Jelena and Vučković, Ivan and Vajs, Vlatka and Tešić, Živoslav",
year = "2012",
abstract = "The lipophilic character of twelve coumarins was investigated by reversed-phase thin-layer chromatography (RP TLC) on RP-18 silica. The three different binary solvent systems composed of water and organic modifier (methanol, tetrahydrofuran or acetonitrile) were used in order to determine retention parameter (R-M(0)) and octanol-water partition coefficient (log P-OW) as a measure of the lipophilicity of the tested compounds. Lipophilicity parameter (log P-OW) was experimentally determined using eight standard solutes with known log P-OW values which were analyzed under the same chromatographic conditions as the target substances. Lipophilicity parameters together with 2D molecular descriptors were subjected to the multivariate statistical analysis (principal component analysis (PCA) and partial least square (PLS) regression) in order to reveal the most influential factors governing the retention, i.e., lipophilicity of the investigated compounds. The quantitative structure-retention relationship models reveal the importance of descriptors which describe the size and the shape of the molecule as well as their polar properties.",
publisher = "Soc Brasileira Quimica, Sao Paulo",
journal = "Journal of the Brazilian Chemical Society",
title = "RP TLC-Based Lipophilicity Assessment of Some Natural and Synthetic Coumarins",
volume = "23",
number = "3",
pages = "522",
url = "https://hdl.handle.net/21.15107/rcub_cherry_1274"
}

Rabtti, E. H. M. A., Natić, M., Milojković-Opsenica, D., Trifković, J., Vučković, I., Vajs, V.,& Tešić, Ž.. (2012). RP TLC-Based Lipophilicity Assessment of Some Natural and Synthetic Coumarins. in Journal of the Brazilian Chemical Society
Soc Brasileira Quimica, Sao Paulo., 23(3), 522.
https://hdl.handle.net/21.15107/rcub_cherry_1274

Rabtti EHMA, Natić M, Milojković-Opsenica D, Trifković J, Vučković I, Vajs V, Tešić Ž. RP TLC-Based Lipophilicity Assessment of Some Natural and Synthetic Coumarins. in Journal of the Brazilian Chemical Society. 2012;23(3):522.
https://hdl.handle.net/21.15107/rcub_cherry_1274 .

Rabtti, El Hadi M. A., Natić, Maja, Milojković-Opsenica, Dušanka, Trifković, Jelena, Vučković, Ivan, Vajs, Vlatka, Tešić, Živoslav, "RP TLC-Based Lipophilicity Assessment of Some Natural and Synthetic Coumarins" in Journal of the Brazilian Chemical Society, 23, no. 3 (2012):522,
https://hdl.handle.net/21.15107/rcub_cherry_1274 .

TY  - JOUR
AU  - Stankovic, Nada
AU  - Radulovic, Vanja
AU  - Petković, Miloš
AU  - Vučković, Ivan
AU  - Jadranin, Milka
AU  - Vasiljevic, Branka
AU  - Nikodinović-Runić, Jasmina
PY  - 2012
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1125
AB  - A Gram-positive, red-pigment-producing bacterial strain, designated JS520 was isolated from the pristine sediment from the cave on mountain Miroc in Serbia. Strain was confirmed to belong to Streptomyces genus based on phenotypic and genetic analysis. Streptomyces sp. JS520 has the ability to produce exceptionally high amounts of deep red pigment into both solid and liquid media. Liquid chromatography and mass spectroscopy of the purified pigments revealed the major component to be undecylprodigiosin (93 %) with minor component being oxidatively cyclized derivative. The pigment production was affected by medium composition, temperature, pH, and the aeration rate. By medium optimization, yields of undecylprodigiosin of 138 mg l(-1) were achieved, what is the highest level of undecylprodigiosin production reported for the members of Gram-positive Streptomyces genus. Purified pigment had antimicrobial properties against bacterial Bacillus and Micrococcus species (50 mu g ml(-1)) and against Candida albicans species (100-200 mu g ml(-1) range). The ability to affect auto-oxidation of the linoleic acid was demonstrated for the purified undecylprodigiosin, suggesting antioxidative properties of this pigment. Multiple ecophysiological roles of the pigment were revealed by comparing cultures grown under pigment-producing and pigment-nonproducing conditions. Cells grown under undecylprodigiosin-producing conditions could tolerate presence of hydrogen peroxide exhibiting three times smaller zones of inhibition at 100 mM H2O2. Undecylprodigiosin-producing cells were also less susceptible to tetracycline, kanamycin, chloramphenicol, and 8-hydroxyquinoline. While the growth of the cells not producing pigment was completely inhibited by 15 min of exposure to ultraviolet light (254 nm), cells producing undecylprodigiosin and cells supplied with purified pigment in vitro showed survival rates at 22 and 8 %, respectively.
PB  - Springer, New York
T2  - Applied Microbiology and Biotechnology
T1  - Streptomyces sp JS520 produces exceptionally high quantities of undecylprodigiosin with antibacterial, antioxidative, and UV-protective properties
VL  - 96
IS  - 5
SP  - 1217
EP  - 1231
DO  - 10.1007/s00253-012-4237-3
ER  - 

@article{
author = "Stankovic, Nada and Radulovic, Vanja and Petković, Miloš and Vučković, Ivan and Jadranin, Milka and Vasiljevic, Branka and Nikodinović-Runić, Jasmina",
year = "2012",
abstract = "A Gram-positive, red-pigment-producing bacterial strain, designated JS520 was isolated from the pristine sediment from the cave on mountain Miroc in Serbia. Strain was confirmed to belong to Streptomyces genus based on phenotypic and genetic analysis. Streptomyces sp. JS520 has the ability to produce exceptionally high amounts of deep red pigment into both solid and liquid media. Liquid chromatography and mass spectroscopy of the purified pigments revealed the major component to be undecylprodigiosin (93 %) with minor component being oxidatively cyclized derivative. The pigment production was affected by medium composition, temperature, pH, and the aeration rate. By medium optimization, yields of undecylprodigiosin of 138 mg l(-1) were achieved, what is the highest level of undecylprodigiosin production reported for the members of Gram-positive Streptomyces genus. Purified pigment had antimicrobial properties against bacterial Bacillus and Micrococcus species (50 mu g ml(-1)) and against Candida albicans species (100-200 mu g ml(-1) range). The ability to affect auto-oxidation of the linoleic acid was demonstrated for the purified undecylprodigiosin, suggesting antioxidative properties of this pigment. Multiple ecophysiological roles of the pigment were revealed by comparing cultures grown under pigment-producing and pigment-nonproducing conditions. Cells grown under undecylprodigiosin-producing conditions could tolerate presence of hydrogen peroxide exhibiting three times smaller zones of inhibition at 100 mM H2O2. Undecylprodigiosin-producing cells were also less susceptible to tetracycline, kanamycin, chloramphenicol, and 8-hydroxyquinoline. While the growth of the cells not producing pigment was completely inhibited by 15 min of exposure to ultraviolet light (254 nm), cells producing undecylprodigiosin and cells supplied with purified pigment in vitro showed survival rates at 22 and 8 %, respectively.",
publisher = "Springer, New York",
journal = "Applied Microbiology and Biotechnology",
title = "Streptomyces sp JS520 produces exceptionally high quantities of undecylprodigiosin with antibacterial, antioxidative, and UV-protective properties",
volume = "96",
number = "5",
pages = "1217-1231",
doi = "10.1007/s00253-012-4237-3"
}

Stankovic, N., Radulovic, V., Petković, M., Vučković, I., Jadranin, M., Vasiljevic, B.,& Nikodinović-Runić, J.. (2012). Streptomyces sp JS520 produces exceptionally high quantities of undecylprodigiosin with antibacterial, antioxidative, and UV-protective properties. in Applied Microbiology and Biotechnology
Springer, New York., 96(5), 1217-1231.
https://doi.org/10.1007/s00253-012-4237-3

Stankovic N, Radulovic V, Petković M, Vučković I, Jadranin M, Vasiljevic B, Nikodinović-Runić J. Streptomyces sp JS520 produces exceptionally high quantities of undecylprodigiosin with antibacterial, antioxidative, and UV-protective properties. in Applied Microbiology and Biotechnology. 2012;96(5):1217-1231.
doi:10.1007/s00253-012-4237-3 .

Stankovic, Nada, Radulovic, Vanja, Petković, Miloš, Vučković, Ivan, Jadranin, Milka, Vasiljevic, Branka, Nikodinović-Runić, Jasmina, "Streptomyces sp JS520 produces exceptionally high quantities of undecylprodigiosin with antibacterial, antioxidative, and UV-protective properties" in Applied Microbiology and Biotechnology, 96, no. 5 (2012):1217-1231,
https://doi.org/10.1007/s00253-012-4237-3 . .

TY  - JOUR
AU  - Marin, Marija
AU  - Novaković, Miroslav
AU  - Tešević, Vele
AU  - Vučković, Ivan
AU  - Milojevic, Natasa
AU  - Vukovic-Gacic, Branka
AU  - Marin, Petar D.
PY  - 2012
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/965
AB  - The composition of the essential oil of Satureja montana was examined by gas chromatographymass spectrometry and 1H nuclear magnetic resonance spectroscopy. Forty-three compounds were identified, representing approximately 99% of the oil. Major components were ?-terpinene (8.7%), p-cymene (16.9%) and carvacrol (44.5%). The oil was tested for its antioxidant activity by using the 1,1-diphenyl-2-picryl hydrazyl assay and showed dose-dependent free-radical-scavenging activity with an EC50 value of 4.21 mg/ml. The antimicrobial effect of the essential oil was tested against six strains of Gram-negative bacteria, seven strains of Gram-positive bacteria and two fungi. The human pathogens Burkholderia cepacia ATCC 25416 (Gram negative) and Listeria innocua (Gram positive) were used in the investigation of S. montana for the first time. The minimum inhibitory concentration of the essential oil ranged from 0.625 to 5.0 mu l/well for Gram-negative bacteria, and from 0.312 to 1.125 mu l/well for Gram-positive bacteria. For the two fungi tested, Candida and Saccharomyces, the value was 0.234 mu l/tube. The essential oil tested showed significant activity against fungi and Gram-positive bacteria, especially Bacillus subtilis, Staphylococcus epidermidis and Listeria innocua, and among Gram-negative bacteria extreme sensitivity was detected in Escherichia coli SY252, SY252 lpcA and ATTCC 25922 strains. Copyright
PB  - Wiley-Blackwell, Malden
T2  - Flavour and Fragrance Journal
T1  - Antioxidative, antibacterial and antifungal activity of the essential oil of wild-growing Satureja montana L. from Dalmatia, Croatia
VL  - 27
IS  - 3
SP  - 216
EP  - 223
DO  - 10.1002/ffj.3082
ER  - 

@article{
author = "Marin, Marija and Novaković, Miroslav and Tešević, Vele and Vučković, Ivan and Milojevic, Natasa and Vukovic-Gacic, Branka and Marin, Petar D.",
year = "2012",
abstract = "The composition of the essential oil of Satureja montana was examined by gas chromatographymass spectrometry and 1H nuclear magnetic resonance spectroscopy. Forty-three compounds were identified, representing approximately 99% of the oil. Major components were ?-terpinene (8.7%), p-cymene (16.9%) and carvacrol (44.5%). The oil was tested for its antioxidant activity by using the 1,1-diphenyl-2-picryl hydrazyl assay and showed dose-dependent free-radical-scavenging activity with an EC50 value of 4.21 mg/ml. The antimicrobial effect of the essential oil was tested against six strains of Gram-negative bacteria, seven strains of Gram-positive bacteria and two fungi. The human pathogens Burkholderia cepacia ATCC 25416 (Gram negative) and Listeria innocua (Gram positive) were used in the investigation of S. montana for the first time. The minimum inhibitory concentration of the essential oil ranged from 0.625 to 5.0 mu l/well for Gram-negative bacteria, and from 0.312 to 1.125 mu l/well for Gram-positive bacteria. For the two fungi tested, Candida and Saccharomyces, the value was 0.234 mu l/tube. The essential oil tested showed significant activity against fungi and Gram-positive bacteria, especially Bacillus subtilis, Staphylococcus epidermidis and Listeria innocua, and among Gram-negative bacteria extreme sensitivity was detected in Escherichia coli SY252, SY252 lpcA and ATTCC 25922 strains. Copyright",
publisher = "Wiley-Blackwell, Malden",
journal = "Flavour and Fragrance Journal",
title = "Antioxidative, antibacterial and antifungal activity of the essential oil of wild-growing Satureja montana L. from Dalmatia, Croatia",
volume = "27",
number = "3",
pages = "216-223",
doi = "10.1002/ffj.3082"
}

Marin, M., Novaković, M., Tešević, V., Vučković, I., Milojevic, N., Vukovic-Gacic, B.,& Marin, P. D.. (2012). Antioxidative, antibacterial and antifungal activity of the essential oil of wild-growing Satureja montana L. from Dalmatia, Croatia. in Flavour and Fragrance Journal
Wiley-Blackwell, Malden., 27(3), 216-223.
https://doi.org/10.1002/ffj.3082

Marin M, Novaković M, Tešević V, Vučković I, Milojevic N, Vukovic-Gacic B, Marin PD. Antioxidative, antibacterial and antifungal activity of the essential oil of wild-growing Satureja montana L. from Dalmatia, Croatia. in Flavour and Fragrance Journal. 2012;27(3):216-223.
doi:10.1002/ffj.3082 .

Marin, Marija, Novaković, Miroslav, Tešević, Vele, Vučković, Ivan, Milojevic, Natasa, Vukovic-Gacic, Branka, Marin, Petar D., "Antioxidative, antibacterial and antifungal activity of the essential oil of wild-growing Satureja montana L. from Dalmatia, Croatia" in Flavour and Fragrance Journal, 27, no. 3 (2012):216-223,
https://doi.org/10.1002/ffj.3082 . .

TY  - JOUR
AU  - Gođevac, Dejan
AU  - Vujisić, Ljubodrag V.
AU  - Vučković, Ivan
AU  - Vajs, Vlatka
AU  - Soković, Marina
AU  - Marin, Petar D.
AU  - Tešević, Vele
PY  - 2012
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/980
AB  - An investigation of the chemical composition and antimicrobial activity of the essential oil of Galatella linosyris is presented. The chemical analysis (GC/MS, NMR) showed that sabinene (40 %), β-pinene (35.5 %), α-pinene (4.5 %), limonene (4 %), γ-muurolene (4 %), and (E)-caryophyllene (3.3 %) were dominant components in this oil. Microdilution assays were used to evaluate the minimum inhibitory concentration (MIC) and the minimum bactericidal/ fungicidal concentrations (MBC/MFC). G. linosyris essential oil exhibited better antibacterial activity against some of the tested bacteria than antifungal activity.
AB  - U ovom radu je prikazano ispitivanje hemijskog sastava i antimikrobne aktivnosti etarskog ulja biljne vrste Galatella linosyris. Hemijskom analizom (GC-MS i NMR) je utvrđeno da su glavni sastojci ovog etarskog ulja sabinen (40 %), β-pinen (35,5 %) , α-pinen (4,5 %), limonen (4 %), γ-muurolen (4 %) i (E)-kariofilen (3,3 %). Za procenu minimalne inhibitorne koncentracije (MIC) i minimalne baktericidne/fungicidne koncentracije (MBC/ /MFC) korišćeni su testovi mikrorazblaženja. Etarsko ulje G. linosyris je pokazalo bolju antibakterijsku nego antifungalnu aktivnost.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Composition and antimicrobial activity of the essential oil from Galatella linosyris (L.) Rchb. f. (Asteraceae)
T1  - Sastav i antimikrobna aktivnost etarskog ulja iz Galatella linosyris (L.) Rchb. f. (Asteraceae)
VL  - 77
IS  - 5
SP  - 619
EP  - 626
DO  - 10.2298/JSC110915213G
ER  - 

@article{
author = "Gođevac, Dejan and Vujisić, Ljubodrag V. and Vučković, Ivan and Vajs, Vlatka and Soković, Marina and Marin, Petar D. and Tešević, Vele",
year = "2012",
abstract = "An investigation of the chemical composition and antimicrobial activity of the essential oil of Galatella linosyris is presented. The chemical analysis (GC/MS, NMR) showed that sabinene (40 %), β-pinene (35.5 %), α-pinene (4.5 %), limonene (4 %), γ-muurolene (4 %), and (E)-caryophyllene (3.3 %) were dominant components in this oil. Microdilution assays were used to evaluate the minimum inhibitory concentration (MIC) and the minimum bactericidal/ fungicidal concentrations (MBC/MFC). G. linosyris essential oil exhibited better antibacterial activity against some of the tested bacteria than antifungal activity., U ovom radu je prikazano ispitivanje hemijskog sastava i antimikrobne aktivnosti etarskog ulja biljne vrste Galatella linosyris. Hemijskom analizom (GC-MS i NMR) je utvrđeno da su glavni sastojci ovog etarskog ulja sabinen (40 %), β-pinen (35,5 %) , α-pinen (4,5 %), limonen (4 %), γ-muurolen (4 %) i (E)-kariofilen (3,3 %). Za procenu minimalne inhibitorne koncentracije (MIC) i minimalne baktericidne/fungicidne koncentracije (MBC/ /MFC) korišćeni su testovi mikrorazblaženja. Etarsko ulje G. linosyris je pokazalo bolju antibakterijsku nego antifungalnu aktivnost.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Composition and antimicrobial activity of the essential oil from Galatella linosyris (L.) Rchb. f. (Asteraceae), Sastav i antimikrobna aktivnost etarskog ulja iz Galatella linosyris (L.) Rchb. f. (Asteraceae)",
volume = "77",
number = "5",
pages = "619-626",
doi = "10.2298/JSC110915213G"
}

Gođevac, D., Vujisić, L. V., Vučković, I., Vajs, V., Soković, M., Marin, P. D.,& Tešević, V.. (2012). Composition and antimicrobial activity of the essential oil from Galatella linosyris (L.) Rchb. f. (Asteraceae). in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 77(5), 619-626.
https://doi.org/10.2298/JSC110915213G

Gođevac D, Vujisić LV, Vučković I, Vajs V, Soković M, Marin PD, Tešević V. Composition and antimicrobial activity of the essential oil from Galatella linosyris (L.) Rchb. f. (Asteraceae). in Journal of the Serbian Chemical Society. 2012;77(5):619-626.
doi:10.2298/JSC110915213G .

Gođevac, Dejan, Vujisić, Ljubodrag V., Vučković, Ivan, Vajs, Vlatka, Soković, Marina, Marin, Petar D., Tešević, Vele, "Composition and antimicrobial activity of the essential oil from Galatella linosyris (L.) Rchb. f. (Asteraceae)" in Journal of the Serbian Chemical Society, 77, no. 5 (2012):619-626,
https://doi.org/10.2298/JSC110915213G . .

TY  - JOUR
AU  - Janaćković, Peđa T.
AU  - Soković, Marina
AU  - Vujisić, Ljubodrag V.
AU  - Vajs, Vlatka
AU  - Vučković, Ivan
AU  - Krivosej, Zoran
AU  - Marin, Petar D.
PY  - 2011
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2739
AB  - The essential oil from aerial parts of Seseli globiferum Vis. obtained by hydrodistillation with Clevenger-type apparatus was analyzed by GC-MS. Twenty-eight compounds were identified, representing 99.4% of the total oil. The main components of the oil were sabinene (38.0%), alpha-pinene (21.2%) and beta-phellandrene (13.5%). The microbial growth inhibitory properties of the isolated essential oil were determined using the broth microdilution method against seven bacterial species: Salmonella typhimurium (ATCC 13311), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Enterobacter cloacae (clinical isolates), Bacillus cereus (clinical isolates), Staphylococcus aureus (ATCC 25923), Staphylococcus epidermidis (ATCC 12228), Micrococcus flaw's (ATCC 10240) and three fungal species: Aspergillus niger (ATCC 6275), Aspergillus versicolor (ATCC 11730), Trichoderma viride (IAM 5061) and Penicillium funiculosum (ATCC 36839). The essential oil showed activity against bacteria P. aeruginosa, followed by M flavus, L. monocytigenes and E. coli, and all investigated fungal species.
PB  - Natural Products Inc, Westerville
T2  - Natural Product Communications
T1  - Composition and Antimicrobial Activity of Seseli globiferum Essential Oil
VL  - 6
IS  - 8
SP  - 1163
EP  - 1166
DO  - 10.1177/1934578X1100600831
ER  - 

@article{
author = "Janaćković, Peđa T. and Soković, Marina and Vujisić, Ljubodrag V. and Vajs, Vlatka and Vučković, Ivan and Krivosej, Zoran and Marin, Petar D.",
year = "2011",
abstract = "The essential oil from aerial parts of Seseli globiferum Vis. obtained by hydrodistillation with Clevenger-type apparatus was analyzed by GC-MS. Twenty-eight compounds were identified, representing 99.4% of the total oil. The main components of the oil were sabinene (38.0%), alpha-pinene (21.2%) and beta-phellandrene (13.5%). The microbial growth inhibitory properties of the isolated essential oil were determined using the broth microdilution method against seven bacterial species: Salmonella typhimurium (ATCC 13311), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Enterobacter cloacae (clinical isolates), Bacillus cereus (clinical isolates), Staphylococcus aureus (ATCC 25923), Staphylococcus epidermidis (ATCC 12228), Micrococcus flaw's (ATCC 10240) and three fungal species: Aspergillus niger (ATCC 6275), Aspergillus versicolor (ATCC 11730), Trichoderma viride (IAM 5061) and Penicillium funiculosum (ATCC 36839). The essential oil showed activity against bacteria P. aeruginosa, followed by M flavus, L. monocytigenes and E. coli, and all investigated fungal species.",
publisher = "Natural Products Inc, Westerville",
journal = "Natural Product Communications",
title = "Composition and Antimicrobial Activity of Seseli globiferum Essential Oil",
volume = "6",
number = "8",
pages = "1163-1166",
doi = "10.1177/1934578X1100600831"
}

Janaćković, P. T., Soković, M., Vujisić, L. V., Vajs, V., Vučković, I., Krivosej, Z.,& Marin, P. D.. (2011). Composition and Antimicrobial Activity of Seseli globiferum Essential Oil. in Natural Product Communications
Natural Products Inc, Westerville., 6(8), 1163-1166.
https://doi.org/10.1177/1934578X1100600831

Janaćković PT, Soković M, Vujisić LV, Vajs V, Vučković I, Krivosej Z, Marin PD. Composition and Antimicrobial Activity of Seseli globiferum Essential Oil. in Natural Product Communications. 2011;6(8):1163-1166.
doi:10.1177/1934578X1100600831 .

Janaćković, Peđa T., Soković, Marina, Vujisić, Ljubodrag V., Vajs, Vlatka, Vučković, Ivan, Krivosej, Zoran, Marin, Petar D., "Composition and Antimicrobial Activity of Seseli globiferum Essential Oil" in Natural Product Communications, 6, no. 8 (2011):1163-1166,
https://doi.org/10.1177/1934578X1100600831 . .