Isolation, Characterization, and In Vitro Cytotoxicity of New Sesquiterpenoids from Achillea clavennae
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Isakovic, Andelka M.
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Further phytochemical investigation of the aerial parts of Achillea clavennae has resulted in the isolation of three new sesquiterpene lactones: two highly oxygenated germacranolides (1, 2) and the iso-seco-guaianolide 9(R)-acetoxy-3-O-methyl-iso-seco-tanapartholide (3). Eight known compounds were also found, of which 9-acetoxycanin (5), sintenin (6), and oleanolic acid (7) were detected for the first time. The structures of the isolated compounds were elucidated by combined spectroscopic methods (1D and 2DNMR, HRESIMS, CIMS, and FTIR). While the predominant metabolite germacranolide sintenin (6) was not cytotoxic, the new iso-seco-guaianolide (3) displayed cytotoxicity comparable to that of cisplatin and the lactone apressin (4), inducing partly apoptotic death in human U251 and rat C6 glioma cell lines.
Keywords:Achillea clavennae L. / Asteraceae / sesquiterpene lactones / iso-seco-guaianolide / NMR / cytotoxicity / apoptosis
Source:Planta Medica, 2014, 80, 4, 297-305
- Georg Thieme Verlag Kg, Stuttgart
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- The peer-reviewed version: http://cer.ihtm.bg.ac.rs/handle/123456789/3120