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The stability of the extended model of hypothalamic-pituitary-adrenal axis examined by stoichiometric network analysis
dc.creator | Markovic, V. M. | |
dc.creator | Čupić, Željko | |
dc.creator | Ivanović-Šašić, Ana | |
dc.creator | Kolar-Anić, Ljiljana | |
dc.date.accessioned | 2019-01-30T17:26:34Z | |
dc.date.available | 2019-01-30T17:26:34Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 0036-0244 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/824 | |
dc.description.abstract | Stoichiometric network analysis (SNA) represents a powerful mathematical tool for stability analysis of complex stoichiometric networks. Recently, the important improvement of the method has been made, according to which instability relations can be entirely expressed via reaction rates, instead of thus far used, in general case undefined, current rates. Such an improved SNA methodology was applied to the determination of exact instability conditions of the extended model of the hypothalamic-pituitary-adrenal (HPA) axis, a neuroendocrinological system, whose hormone concentrations exert complex oscillatory evolution. For emergence of oscillations, the Hopf bifurcation condition was utilized. Instability relations predicted by SNA showed good correlation with numerical simulation data of the HPA axis model. | en |
dc.publisher | Maik Nauka/Interperiodica/Springer, New York | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172015/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45001/RS// | |
dc.rights | restrictedAccess | |
dc.source | Russian Journal of Physical Chemistry A | |
dc.subject | stoichiometric network analysis | en |
dc.subject | hypothalamic-pituitary-adrenal axis | en |
dc.title | The stability of the extended model of hypothalamic-pituitary-adrenal axis examined by stoichiometric network analysis | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Марковиц, В. М.; Колар-Aниц, Љ.; Чупић, Жељко; Ивановић-Шашић, Aна; | |
dc.citation.volume | 85 | |
dc.citation.issue | 13 | |
dc.citation.spage | 2327 | |
dc.citation.epage | 2335 | |
dc.citation.other | 85(13): 2327-2335 | |
dc.citation.rank | M23 | |
dc.identifier.doi | 10.1134/S0036024411130115 | |
dc.identifier.scopus | 2-s2.0-84963764160 | |
dc.identifier.wos | 000297922700016 | |
dc.type.version | publishedVersion |