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Cobalt(II) and magnesium(II) complexes with 1,3-pdta-type of ligands: influence of an alkyl substituent at 1,3-propanediamine chain on the structural and antimicrobial properties of the complex
dc.creator | Gitarić, Jelena | |
dc.creator | Stanojević, Ivana | |
dc.creator | Radanović, Dušanka | |
dc.creator | Crochet, Aurélien | |
dc.creator | Ašanin, Darko | |
dc.creator | Janković, Vukašin | |
dc.creator | Skaro-Bogojević, Sanja | |
dc.creator | Đuran, Miloš | |
dc.creator | Glišić, Biljana | |
dc.date.accessioned | 2022-09-30T07:35:19Z | |
dc.date.available | 2022-09-30T07:35:19Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 0095-8972 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/5322 | |
dc.description.abstract | To investigate how modification in the structure of 1,3-propanediamine chain of 1,3-pdta (1,3-propanediamine-N,N,N′,N′-tetraacetate) ligand affects the structural and biological properties of the corresponding metal complexes, two new octahedral complexes, [Co(H2O)5Co(2,2-diMe-1,3-pdta)]·H2O (1) and [Mg(H2O)5Mg(2,2-diMe-1,3-pdta)]·1.5H2O (2) (2,2-diMe-1,3-pdta = 2,2-dimethyl-1,3-propanediamine-N,N,N′,N′-tetraacetate), were synthesized and characterized by IR spectroscopy and single-crystal X-ray diffraction analysis. Additionally, UV-Vis and NMR spectroscopic methods were applied for the characterization of 1 and 2, respectively. Crystallographic data indicate that these complexes contain 2,2-diMe-1,3-pdta coordinated to the metal ion through 2 N and 4 O atoms forming [M(H2O)5M′(2,2-diMe-1,3-pdta)] complex unit (M, M′ = Co(II), Co(II) (1) and M, M′ = Mg(II), Mg(II) (2)), which is composed of [M′(2,2-diMe-1,3-pdta)]2− and [M(H2O)5O]2+ octahedra bridged by one of the axial carboxylate groups. The antimicrobial activities of 1 and 2 were evaluated against different bacteria and Candida spp., while their cytotoxic effect was tested on the normal human lung fibroblasts (MRC-5). The ability of 1 and 2 to inhibit formation of C. glabrata biofilms was also assessed. The obtained structural parameters and biological properties of the two complexes were compared to Co(II) and Mg(II) complexes with 1,3-pdta ligand. | sr |
dc.language.iso | en | sr |
dc.publisher | Taylor &Francis | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200026/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200042/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200122/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200378/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200383/RS// | sr |
dc.relation | The Serbian Academy of Sciences and Arts (Project No. F128) | sr |
dc.rights | restrictedAccess | sr |
dc.source | Journal of Coordination Chemistry | sr |
dc.subject | Cobalt(II) complexes | sr |
dc.subject | magnesium(II) complexes | sr |
dc.subject | 1,3-pdta-type ligands | sr |
dc.subject | structural characterization | sr |
dc.subject | antimicrobial activity | sr |
dc.title | Cobalt(II) and magnesium(II) complexes with 1,3-pdta-type of ligands: influence of an alkyl substituent at 1,3-propanediamine chain on the structural and antimicrobial properties of the complex | sr |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dc.citation.volume | 75 | |
dc.citation.issue | 11-14 | |
dc.citation.spage | 1899 | |
dc.citation.epage | 1914 | |
dc.citation.rank | M22~ | |
dc.identifier.doi | 10.1080/00958972.2022.2101365 | |
dc.identifier.scopus | 2-s2.0-85134630082 | |
dc.identifier.wos | 00082858000000 | |
dc.type.version | publishedVersion | sr |