Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations
2020
Преузимање 🢃
Аутори
Vajdle, OlgaŠekuljica, Sanja
Guzsvány, Valéria
Nagy, László
Kónya, Zoltán
Avramov Ivić, Milka
Mijin, Dušan
Petrović, Slobodan D.
Anojčić, Jasmina
Чланак у часопису (Рецензирана верзија)
Метаподаци
Приказ свих података о документуАпстракт
In this work, carbon paste electrode (CPE) and carbon paste electrode modified with gold nanoparticles (AuNPs/CPE) were employed with rapid direct anodic square wave voltammetry (SWV) for macrolide antibiotics erythromycin ethylsuccinate (EES), azithromycin (AZI), clarithromycin (CLA) and roxithromycin (ROX) determination. The surfaceof working electrodes was morphologically characterized by scanning electron microscopic (SEM) measurements whereby the presence of randomly distributed AuNPs of 10 nmdiameter size on CPE surface was confirmed by energy dispersive spectrometer (EDS). SWV determination of four macrolide antibiotics using CPE was performed in aqueous Britton-Robinson buffer solutions (pH 2.0 to 11.98) showing that oxidation signals strongly depend upon pH (at pH ≥ 6) and exhibited the most favorable characteristics at pH 8.0 in the case of EES and pH 11.98 in the case of AZI, CLA and ROX. Under optimized conditions, the SWV method using CPE enables determination of all inve...stigated macrolide antibiotics in low μg mL−1 concentration ranges with relative standard deviations (RSDs) lower than 6%and achieved detection limits (LODs) as 0.18, 0.045, 1.43 and 0.30 μgmL−1 for EES, AZI, CLA and ROX, respectively. In the case of AZI and ROX, it was demonstrated that the use of AuNPs/CPE as working electrode could additionally improve the results obtained with the SWV method concerning exhibited sensitivity, reproducibility and linear concentrationrange, due to the electrocatalytic properties of synthesized AuNPs. The optimized experimental parameters with the use of SWV method and CPE or AuNPs/CPE were successfully applied for determination of ROX and AZI in their pharmaceutical preparations Runac® and Hemomycin®, respectively. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of HPLC-DAD measurements.
Кључне речи:
Macrolide antibiotics / Square wave voltammetry / Carbon paste electrode / Gold nanoparticles / Pharmaceutical preparationsИзвор:
Journal of Electroanalytical Chemistry, 2020, 873, 114324-Издавач:
- Elsevier
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200125 (Универзитет у Новом Саду, Природно-математички факултет) (RS-MESTD-inst-2020-200125)
- CEEPUSIII (CZ-0212-13- 1920)
Напомена:
- This is the peer-reviewed version of the article: O. Vajdle, S. Šekuljica, V. Guzsvány, et al., Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations, Journal of Electroanalytical Chemistry (2020), 873, 114324, doi: https://doi.org/10.1016/j.jelechem.2020.114324
- The published version: http://cer.ihtm.bg.ac.rs/handle/123456789/3615
DOI: 10.1016/j.jelechem.2020.114324
ISSN: 1572-6657
WoS: 000572073600001
Scopus: 2-s2.0-85086820704
Институција/група
IHTMTY - JOUR AU - Vajdle, Olga AU - Šekuljica, Sanja AU - Guzsvány, Valéria AU - Nagy, László AU - Kónya, Zoltán AU - Avramov Ivić, Milka AU - Mijin, Dušan AU - Petrović, Slobodan D. AU - Anojčić, Jasmina PY - 2020 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/3619 AB - In this work, carbon paste electrode (CPE) and carbon paste electrode modified with gold nanoparticles (AuNPs/CPE) were employed with rapid direct anodic square wave voltammetry (SWV) for macrolide antibiotics erythromycin ethylsuccinate (EES), azithromycin (AZI), clarithromycin (CLA) and roxithromycin (ROX) determination. The surfaceof working electrodes was morphologically characterized by scanning electron microscopic (SEM) measurements whereby the presence of randomly distributed AuNPs of 10 nmdiameter size on CPE surface was confirmed by energy dispersive spectrometer (EDS). SWV determination of four macrolide antibiotics using CPE was performed in aqueous Britton-Robinson buffer solutions (pH 2.0 to 11.98) showing that oxidation signals strongly depend upon pH (at pH ≥ 6) and exhibited the most favorable characteristics at pH 8.0 in the case of EES and pH 11.98 in the case of AZI, CLA and ROX. Under optimized conditions, the SWV method using CPE enables determination of all investigated macrolide antibiotics in low μg mL−1 concentration ranges with relative standard deviations (RSDs) lower than 6%and achieved detection limits (LODs) as 0.18, 0.045, 1.43 and 0.30 μgmL−1 for EES, AZI, CLA and ROX, respectively. In the case of AZI and ROX, it was demonstrated that the use of AuNPs/CPE as working electrode could additionally improve the results obtained with the SWV method concerning exhibited sensitivity, reproducibility and linear concentrationrange, due to the electrocatalytic properties of synthesized AuNPs. The optimized experimental parameters with the use of SWV method and CPE or AuNPs/CPE were successfully applied for determination of ROX and AZI in their pharmaceutical preparations Runac® and Hemomycin®, respectively. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of HPLC-DAD measurements. PB - Elsevier T2 - Journal of Electroanalytical Chemistry T1 - Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations VL - 873 SP - 114324 DO - 10.1016/j.jelechem.2020.114324 ER -
@article{ author = "Vajdle, Olga and Šekuljica, Sanja and Guzsvány, Valéria and Nagy, László and Kónya, Zoltán and Avramov Ivić, Milka and Mijin, Dušan and Petrović, Slobodan D. and Anojčić, Jasmina", year = "2020", abstract = "In this work, carbon paste electrode (CPE) and carbon paste electrode modified with gold nanoparticles (AuNPs/CPE) were employed with rapid direct anodic square wave voltammetry (SWV) for macrolide antibiotics erythromycin ethylsuccinate (EES), azithromycin (AZI), clarithromycin (CLA) and roxithromycin (ROX) determination. The surfaceof working electrodes was morphologically characterized by scanning electron microscopic (SEM) measurements whereby the presence of randomly distributed AuNPs of 10 nmdiameter size on CPE surface was confirmed by energy dispersive spectrometer (EDS). SWV determination of four macrolide antibiotics using CPE was performed in aqueous Britton-Robinson buffer solutions (pH 2.0 to 11.98) showing that oxidation signals strongly depend upon pH (at pH ≥ 6) and exhibited the most favorable characteristics at pH 8.0 in the case of EES and pH 11.98 in the case of AZI, CLA and ROX. Under optimized conditions, the SWV method using CPE enables determination of all investigated macrolide antibiotics in low μg mL−1 concentration ranges with relative standard deviations (RSDs) lower than 6%and achieved detection limits (LODs) as 0.18, 0.045, 1.43 and 0.30 μgmL−1 for EES, AZI, CLA and ROX, respectively. In the case of AZI and ROX, it was demonstrated that the use of AuNPs/CPE as working electrode could additionally improve the results obtained with the SWV method concerning exhibited sensitivity, reproducibility and linear concentrationrange, due to the electrocatalytic properties of synthesized AuNPs. The optimized experimental parameters with the use of SWV method and CPE or AuNPs/CPE were successfully applied for determination of ROX and AZI in their pharmaceutical preparations Runac® and Hemomycin®, respectively. The reliability of the elaborated procedures and thus the accuracy of the obtained results were validated by comparing them with those obtained by means of HPLC-DAD measurements.", publisher = "Elsevier", journal = "Journal of Electroanalytical Chemistry", title = "Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations", volume = "873", pages = "114324", doi = "10.1016/j.jelechem.2020.114324" }
Vajdle, O., Šekuljica, S., Guzsvány, V., Nagy, L., Kónya, Z., Avramov Ivić, M., Mijin, D., Petrović, S. D.,& Anojčić, J.. (2020). Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations. in Journal of Electroanalytical Chemistry Elsevier., 873, 114324. https://doi.org/10.1016/j.jelechem.2020.114324
Vajdle O, Šekuljica S, Guzsvány V, Nagy L, Kónya Z, Avramov Ivić M, Mijin D, Petrović SD, Anojčić J. Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations. in Journal of Electroanalytical Chemistry. 2020;873:114324. doi:10.1016/j.jelechem.2020.114324 .
Vajdle, Olga, Šekuljica, Sanja, Guzsvány, Valéria, Nagy, László, Kónya, Zoltán, Avramov Ivić, Milka, Mijin, Dušan, Petrović, Slobodan D., Anojčić, Jasmina, "Use of carbon paste electrode and modified by gold nanoparticles for selected macrolide antibiotics determination as standard and in pharmaceutical preparations" in Journal of Electroanalytical Chemistry, 873 (2020):114324, https://doi.org/10.1016/j.jelechem.2020.114324 . .