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Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential
dc.creator | Tomić, Mirko | |
dc.creator | Kundaković, M | |
dc.creator | Butorović, B | |
dc.creator | Janać, B | |
dc.creator | Andrić, Deana | |
dc.creator | Roglić, Goran | |
dc.creator | Ignjatović, D | |
dc.creator | Kostić Rajačić, Slađana | |
dc.date.accessioned | 2019-05-02T09:09:36Z | |
dc.date.available | 2019-05-02T09:09:36Z | |
dc.date.issued | 2004 | |
dc.identifier.issn | 0960-894X | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/2820 | |
dc.description.abstract | Six active compounds, among previously synthesized and screened arylpiperazines, were selected and evaluated for the binding affinity to rat dopamine, serotonin and α 1 receptors. Two compounds with benztriazole group had a 5-HT 2A /D 2 binding ratio characteristic for atypical neuroleptics (>1, pK i values). Compound 2, 5-{2-[4-(2,3-dimethyl-phenyl)-piperazin-1-yl]ethyl}1H-benzotriazole, expressed clozapine-like in vitro binding profile at D 2 , 5-HT 2A and α1 receptors and a higher affinity for 5-HT 1A receptors than clozapine. Also, it exhibited the noncataleptic behavioural pattern of atypical antipsychotics and antagonized d-amphetamine-induced hyperlocomotion in rats. © 2004 Elsevier Ltd. All rights reserved. | en |
dc.publisher | Elsevier | |
dc.relation | Ministry for Science, Technology and Development of Serbia, grants #1704 and #1698 | |
dc.rights | restrictedAccess | |
dc.source | Bioorganic and Medicinal Chemistry Letters | |
dc.subject | Arylpiperazine | |
dc.subject | Dopamine receptors | |
dc.subject | Serotonin receptors | |
dc.title | Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Костић-Рајачић, Слађана; Јанаћ, Б; Игњатовић, Д; Кундаковић, М; Буторовић, Б; Роглић, Горан; Aндрић, Деана; Томић, М; | |
dc.rights.holder | Elsevier | |
dc.citation.volume | 14 | |
dc.citation.issue | 16 | |
dc.citation.spage | 4263 | |
dc.citation.epage | 4266 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 15261283 | |
dc.identifier.doi | 10.1016/j.bmcl.2004.06.005 | |
dc.identifier.scopus | 2-s2.0-3142691095 | |
dc.identifier.wos | 000222923300029 | |
dc.type.version | publishedVersion |