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Investigation of clofazimine acid-base supersolubilization using various weak organic acids
(Belgrade : Serbian Chemical SocietyBelgrade : Serbian Young Chemists’ Club, 2022)
Nowadays, more than two-thirds of potential drugs currently being discovered are practically insoluble in water with solubility <100 μg/mL. Despite that, compounds with even lower solubility (<0.1 μg/mL) are commonly ...
Comparative analysis of ionization constants determination using spectrophotometry and potentiometry: 3-aminobenzoic acid, 1,3,5-benzenetricarboxylic acid and tyrosine
(Belgrade : Serbian Chemical SocietyBelgrade : Serbian Young Chemists’ Club, 2022)
The ionization constant (usually expressed in logarithmic form, pKa) is important physicochemical parameter which is used to characterize the acid-base chemistry of a compound. Since most drugs contain one or more ionizable ...
The effect of methanesulfonic and glutaric acids on the solubility of clofazimine
(Belgrade : Serbian Chemical SocietyBelgrade : Serbian Young Chemists’ Club, 2022)
In the modern drug research the number of practically insoluble potential drugs is increasing. Poor aqueous solubility can cause poor oral absorption and low bioavailability of drugs. Hence, solubility enhancement is ...
The influence of competing counterions on the solubility of imipramine
(Belgrade : Serbian Chemical SocietyBelgrade : Serbian Young Chemists’ Club, 2022)
Experimental studies of solubility are important in all phases of drug design and development. Solubility data are used to screen out drug-like candidates, biopharmaceutical classification and formulation optimization. The ...
Synthesis and characterization of octahedral Ni(II) complex with condensation product of 2-acetylthiazole and thiosemicarbazide
(Belgrade : Serbian Chemical SocietyBelgrade : Serbian Young Chemists’ Club, 2022)
The ligand (HL) was synthetized by the reaction of 2-acetylthiazole and
thiosemicarbazide in molar ratio 1:1 in water. In the reaction of ligand (HL) and
nickel(II) tetrafluoroborate hexahydrate [Ni(HL)2](BF4)2 complex ...