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Desipramine solubility studies: enhanced solubility due to drug-buffer aggregates
(International Association of Physical Chemists, 2019)
The solution behavior of desipramine hydrochloride (DsHCl) in phosphate-buffered and unbuffered solutions is evidently complicated and only tentatively understood. The computer program pDISOL-X was used to design the ...
pH-Dependent solubility profiles of imipramine and amitriptyline hydrochlorides
(International Association of Physical Chemists, 2019)
The aim of this study was to examine solubility-pH behavior of desipramine structural analogues:
imipramine and amitriptyline hydrochlorides. Appearance of aggregates (trimer, around pH 4 in imipramine case), which lead ...