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Desipramine solubility studies: enhanced solubility due to drug-buffer aggregates

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2019
Saopštenje sa međunarodnog skupa štampano u izvodu (497.5Kb)
Authors
Marković, Olivera
Pešić, Miloš P.
Shah, Ankita V.
Serajuddin, Abu T. M.
Avdeef, Alex
Verbić, Tatjana
Conference object (Published version)
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Abstract
The solution behavior of desipramine hydrochloride (DsHCl) in phosphate-buffered and unbuffered solutions is evidently complicated and only tentatively understood. The computer program pDISOL-X was used to design the structured pH-ramp shake flask experiments (pHRSF method), to process the data, and to refine the equilibrium constants.
Keywords:
desipramine hydrochloride / pH-ramp shake flask / pDISOL-X computer program / equilibrium constants
Source:
8th World Conference on Physico-Chemical Methods in Drug Discovery, Split, Croatia, September 9-11, 2019 - Book of Abstracts, 2019, 17-17
Publisher:
  • International Association of Physical Chemists
Funding / projects:
  • The synthesis of aminoquinoline-based antimalarials and botulinum neurotoxin A inhibitors (RS-172008)
  • Rational design and synthesis of biologically active and coordination compounds and functional materials, relevant for (bio)nanotechnology (RS-172035)
[ Google Scholar ]
Handle
https://hdl.handle.net/21.15107/rcub_cer_3405
URI
https://cer.ihtm.bg.ac.rs/handle/123456789/3405
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
IHTM
TY  - CONF
AU  - Marković, Olivera
AU  - Pešić, Miloš P.
AU  - Shah, Ankita V.
AU  - Serajuddin, Abu T. M.
AU  - Avdeef, Alex
AU  - Verbić, Tatjana
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3405
AB  - The solution behavior of desipramine hydrochloride (DsHCl) in phosphate-buffered and unbuffered solutions is evidently complicated and only tentatively understood. The computer program pDISOL-X was used to design the structured pH-ramp shake flask experiments (pHRSF method), to process the data, and to refine the equilibrium constants.
PB  - International Association of Physical Chemists
C3  - 8th World Conference on Physico-Chemical Methods in Drug Discovery, Split, Croatia, September 9-11, 2019 - Book of Abstracts
T1  - Desipramine solubility studies: enhanced solubility due to drug-buffer aggregates
SP  - 17
EP  - 17
UR  - https://hdl.handle.net/21.15107/rcub_cer_3405
ER  - 
@conference{
author = "Marković, Olivera and Pešić, Miloš P. and Shah, Ankita V. and Serajuddin, Abu T. M. and Avdeef, Alex and Verbić, Tatjana",
year = "2019",
abstract = "The solution behavior of desipramine hydrochloride (DsHCl) in phosphate-buffered and unbuffered solutions is evidently complicated and only tentatively understood. The computer program pDISOL-X was used to design the structured pH-ramp shake flask experiments (pHRSF method), to process the data, and to refine the equilibrium constants.",
publisher = "International Association of Physical Chemists",
journal = "8th World Conference on Physico-Chemical Methods in Drug Discovery, Split, Croatia, September 9-11, 2019 - Book of Abstracts",
title = "Desipramine solubility studies: enhanced solubility due to drug-buffer aggregates",
pages = "17-17",
url = "https://hdl.handle.net/21.15107/rcub_cer_3405"
}
Marković, O., Pešić, M. P., Shah, A. V., Serajuddin, A. T. M., Avdeef, A.,& Verbić, T.. (2019). Desipramine solubility studies: enhanced solubility due to drug-buffer aggregates. in 8th World Conference on Physico-Chemical Methods in Drug Discovery, Split, Croatia, September 9-11, 2019 - Book of Abstracts
International Association of Physical Chemists., 17-17.
https://hdl.handle.net/21.15107/rcub_cer_3405
Marković O, Pešić MP, Shah AV, Serajuddin ATM, Avdeef A, Verbić T. Desipramine solubility studies: enhanced solubility due to drug-buffer aggregates. in 8th World Conference on Physico-Chemical Methods in Drug Discovery, Split, Croatia, September 9-11, 2019 - Book of Abstracts. 2019;:17-17.
https://hdl.handle.net/21.15107/rcub_cer_3405 .
Marković, Olivera, Pešić, Miloš P., Shah, Ankita V., Serajuddin, Abu T. M., Avdeef, Alex, Verbić, Tatjana, "Desipramine solubility studies: enhanced solubility due to drug-buffer aggregates" in 8th World Conference on Physico-Chemical Methods in Drug Discovery, Split, Croatia, September 9-11, 2019 - Book of Abstracts (2019):17-17,
https://hdl.handle.net/21.15107/rcub_cer_3405 .

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