Desipramine solubility studies: enhanced solubility due to drug-buffer aggregates
Pešić, Miloš P.
Shah, Ankita V.
Serajuddin, Abu T.M.
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The solution behavior of desipramine hydrochloride (DsHCl) in phosphate-buffered and unbuffered solutions is evidently complicated and only tentatively understood. The computer program pDISOL-X was used to design the structured pH-ramp shake flask experiments (pHRSF method), to process the data, and to refine the equilibrium constants.
Keywords:desipramine hydrochloride / pH-ramp shake flask / pDISOL-X computer program / equilibrium constants
Source:8th World Conference on Physico-Chemical Methods in Drug Discovery, Split, Croatia, September 9-11, 2019 - Book of Abstracts, 2019, 17-17
- International Association of Physical Chemists