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Desipramine solubility studies: enhanced solubility due to drug-buffer aggregates

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2019
Saopštenje sa međunarodnog skupa štampano u izvodu (497.5Kb)
Authors
Marković, Olivera
Pešić, Miloš P.
Shah, Ankita V.
Serajuddin, Abu T.M.
Avdeef, Alex
Verbić, Tatjana
Conference object (Published version)
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Abstract
The solution behavior of desipramine hydrochloride (DsHCl) in phosphate-buffered and unbuffered solutions is evidently complicated and only tentatively understood. The computer program pDISOL-X was used to design the structured pH-ramp shake flask experiments (pHRSF method), to process the data, and to refine the equilibrium constants.
Keywords:
desipramine hydrochloride / pH-ramp shake flask / pDISOL-X computer program / equilibrium constants
Source:
8th World Conference on Physico-Chemical Methods in Drug Discovery, Split, Croatia, September 9-11, 2019 - Book of Abstracts, 2019, 17-17
Publisher:
  • International Association of Physical Chemists
Projects:
  • The synthesis of aminoquinoline-based antimalarials and botulinum neurotoxin A inhibitors (RS-172008)
  • Rational design and synthesis of biologically active and coordination compounds and functional materials, relevant for (bio)nanotechnology (RS-172035)
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/3405
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Institution
IHTM

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