Desipramine solubility studies: enhanced solubility due to drug-buffer aggregates
Authors
Marković, Olivera
Pešić, Miloš P.
Shah, Ankita V.
Serajuddin, Abu T.M.
Avdeef, Alex
Verbić, Tatjana
Conference object (Published version)
Metadata
Show full item recordAbstract
The solution behavior of desipramine hydrochloride (DsHCl) in phosphate-buffered and unbuffered solutions is evidently complicated and only tentatively understood. The computer program pDISOL-X was used to design the structured pH-ramp shake flask experiments (pHRSF method), to process the data, and to refine the equilibrium constants.
Keywords:
desipramine hydrochloride / pH-ramp shake flask / pDISOL-X computer program / equilibrium constantsSource:
8th World Conference on Physico-Chemical Methods in Drug Discovery, Split, Croatia, September 9-11, 2019 - Book of Abstracts, 2019, 17-17Publisher:
- International Association of Physical Chemists
Projects:
- The synthesis of aminoquinoline-based antimalarials and botulinum neurotoxin A inhibitors (RS-172008)
- Rational design and synthesis of biologically active and coordination compounds and functional materials, relevant for (bio)nanotechnology (RS-172035)