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A refined pharmacophore identifies potent 4-amino-7-chloroquinoline-based inhibitors of the botulinum neurotoxin serotype A metalloprotease
(American Chemical Society (ACS), 2007)
We previously identified structurally diverse small molecule (non-peptidic) inhibitors (SMNPIs) of the botulinum neurotoxin serotype A (BoNT/A) light chain (LC). Of these, several (including antimalarial drugs) contained ...
Determination of glass temperature of polymers by inverse gas chromatography
(Elsevier, 2008)
Inverse gas chromatography (IGC) is an attractive technique for polymer characterization due to possible simultaneous determination of various physicochemical properties of polymer systems merely from retention times of ...
Removal of organically bound sulfur from oil shale by iron(III)-ion generated-regenerated from pyrite by the action of Acidithiobacillus ferrooxidans - Research on a model system
(Elsevier, 2008)
Oil shale is one of the alternative sources of hydrocarbon fuels ("synthetic petroleum") but is characterized by increased sulfur and nitrogen contents, which represent even greater ecological problems in its use compared ...
Far infrared properties of sintered NiO
(Elsevier, 2007)
Far infrared reflection spectra of NiO polycrystals sintered at 1100 °C for various times (30–240 min) were measured at room temperature using a FTIR Spectrometer—Brucker 113V. The measured spectra depended on the sintering ...
The effects of the pause to pulse ratio in the regime of pulsating overpotential on the formation of honeycomb-like structures
(Elsevier Science Inc, New York, 2009)
The formation of honeycomb-like structures in the pulsating overpotential (PO) regime was examined by scanning electron microscopy (SEM). The honeycomb-like structures obtained with a square-wave PO of different pause to ...
Cell wall invertase immobilization within calcium alginate beads
(Elsevier, 2007)
Yeast cell wall invertase (CWI) was immobilized within calcium alginate beads. The result of entrapment was the complete immobilization of all the added CWI. Three types of biocatalysts were prepared: CWI-S, CWI-155 and ...
Alumina/silica supported K2CO3 as a catalyst for biodiesel synthesis from sunflower oil
(Elsevier Sci Ltd, Oxford, 2009)
The new type of catalyst for fatty acid methyl esters (FAME or biodiesel) synthesis with K2CO3 as active component on alumina/silica support was synthesized using sol-gel method. Corresponding catalyst (xerogel) was prepared ...
Novel 4-aminoquinolines active against chloroquine-resistant and sensitive P. falciparum strains that also inhibit botulinum serotype A
(American Chemical Society (ACS), 2008)
We report on the initial result of the coupling of 4-amino-7- chloroquinoline with steroidal and adamantane constituents to provide small molecules with excellent in vitro antimalarial activities (IC90 (W2) down to 6.74 ...
New chimeric antimalarials with 4-aminoquinoline moiety linked to a tetraoxane skeleton
(American Chemical Society (ACS), 2008)
The synthesis of the chimeric molecules consisting of two pharmacophores, tetraoxane and 7-chloro-4-aminoquinoline, is reported. The tetraoxanes 2, 4, and 8 show relatively potent in vitro antimalarial activities, with ...
Synthesis and antioxidant properties of fullero-steroidal covalent conjugates
(Oxford : Pergamon-Elsevier Science Ltd, 2007)
Four new fullero-steroids were synthesized starting from gamma-aminobutyric acid (GABA)-incorporated fulleropyrrolidine and corresponding sterols. The synthesis, characterization, preliminary study on in vitro antioxidant ...