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Synthesis and biological evaluation of some 17-picolyl and 17-picolinylidene androst-5-ene derivatives
(Elsevier, 2007)
Starting from dehydroepiandrosterone (1) 17-picolyl (2), 17-picolinylidene (7), 17-picolinylidene-16-one (10 and 11), and 17-picolyl-16-one (15) derivatives of androst-5-ene were synthesized in one, two, four and five steps ...
Synthesis of some steroidal oximes, lactams, thiolactams and their antitumor activities
(Elsevier, 2007)
The antiproliferative activity of previously synthesized (Z)-cholest-4-en-6-one oxime (1), (E)-cholest-4-en-6-one oxime (2), 7-aza-B-homocholest-4-en-6-one (3) and 6-aza-B-homocholest-4-en-7-one (4) and newly synthesized ...
Estrone derived steroidal diepoxide: Biologically active compound and precursor of a stable steroidal A,B-spiro system
(Elsevier Science Inc, New York, 2009)
A simple approach to a stable steroidal estrone derived A,B-spiro system is reported. Treatment of estrone derived A-ring diepoxyalcohol with the Ac2O-TMSOTf system at the ambient temperature led to acetylation, while at ...