Estrone derived steroidal diepoxide: Biologically active compound and precursor of a stable steroidal A,B-spiro system
Само за регистроване кориснике
2009
Аутори
Milić, DraganaKop, Tatjana
Csanadi, J.
Juranić, Zorica
Žižak, Željko
Gašić, Miroslav J.
Šolaja, Bogdan
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
A simple approach to a stable steroidal estrone derived A,B-spiro system is reported. Treatment of estrone derived A-ring diepoxyalcohol with the Ac2O-TMSOTf system at the ambient temperature led to acetylation, while at the reflux temperature the acid-catalysed rearrangement took place affording the spiro-compound. Results of extensive in vitro and in vivo anticancer tests on the diepoxide, as well as preliminary data on the antiproliferative activity of the spiro-product against three cancer cell lines, are also presented.
Кључне речи:
A,B-spiro / Anticancer activity / Rearrangement / Steroidal epoxide / TMSOTfИзвор:
Steroids, 2009, 74, 12, 890-895Издавач:
- Elsevier Science Inc, New York
Финансирање / пројекти:
DOI: 10.1016/j.steroids.2009.06.002
ISSN: 0039-128X
PubMed: 19538979
WoS: 000270759500003
Scopus: 2-s2.0-70049110807
Институција/група
IHTMTY - JOUR AU - Milić, Dragana AU - Kop, Tatjana AU - Csanadi, J. AU - Juranić, Zorica AU - Žižak, Željko AU - Gašić, Miroslav J. AU - Šolaja, Bogdan PY - 2009 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/618 AB - A simple approach to a stable steroidal estrone derived A,B-spiro system is reported. Treatment of estrone derived A-ring diepoxyalcohol with the Ac2O-TMSOTf system at the ambient temperature led to acetylation, while at the reflux temperature the acid-catalysed rearrangement took place affording the spiro-compound. Results of extensive in vitro and in vivo anticancer tests on the diepoxide, as well as preliminary data on the antiproliferative activity of the spiro-product against three cancer cell lines, are also presented. PB - Elsevier Science Inc, New York T2 - Steroids T1 - Estrone derived steroidal diepoxide: Biologically active compound and precursor of a stable steroidal A,B-spiro system VL - 74 IS - 12 SP - 890 EP - 895 DO - 10.1016/j.steroids.2009.06.002 ER -
@article{ author = "Milić, Dragana and Kop, Tatjana and Csanadi, J. and Juranić, Zorica and Žižak, Željko and Gašić, Miroslav J. and Šolaja, Bogdan", year = "2009", abstract = "A simple approach to a stable steroidal estrone derived A,B-spiro system is reported. Treatment of estrone derived A-ring diepoxyalcohol with the Ac2O-TMSOTf system at the ambient temperature led to acetylation, while at the reflux temperature the acid-catalysed rearrangement took place affording the spiro-compound. Results of extensive in vitro and in vivo anticancer tests on the diepoxide, as well as preliminary data on the antiproliferative activity of the spiro-product against three cancer cell lines, are also presented.", publisher = "Elsevier Science Inc, New York", journal = "Steroids", title = "Estrone derived steroidal diepoxide: Biologically active compound and precursor of a stable steroidal A,B-spiro system", volume = "74", number = "12", pages = "890-895", doi = "10.1016/j.steroids.2009.06.002" }
Milić, D., Kop, T., Csanadi, J., Juranić, Z., Žižak, Ž., Gašić, M. J.,& Šolaja, B.. (2009). Estrone derived steroidal diepoxide: Biologically active compound and precursor of a stable steroidal A,B-spiro system. in Steroids Elsevier Science Inc, New York., 74(12), 890-895. https://doi.org/10.1016/j.steroids.2009.06.002
Milić D, Kop T, Csanadi J, Juranić Z, Žižak Ž, Gašić MJ, Šolaja B. Estrone derived steroidal diepoxide: Biologically active compound and precursor of a stable steroidal A,B-spiro system. in Steroids. 2009;74(12):890-895. doi:10.1016/j.steroids.2009.06.002 .
Milić, Dragana, Kop, Tatjana, Csanadi, J., Juranić, Zorica, Žižak, Željko, Gašić, Miroslav J., Šolaja, Bogdan, "Estrone derived steroidal diepoxide: Biologically active compound and precursor of a stable steroidal A,B-spiro system" in Steroids, 74, no. 12 (2009):890-895, https://doi.org/10.1016/j.steroids.2009.06.002 . .