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Mixed tetraoxanes containing the acetone subunit as antimalarials
(Oxford : Pergamon-Elsevier Science Ltd, 2008)
Eleven new tetraoxanes possessing cholic acid-derived carrier and isopropylidene moiety were synthesized and were tested in vitro and in vivo. In vitro screening revealed that nine of them were more potent against CQ-resistant ...
Antimalarial and antiproliferative evaluation of bis-steroidal tetraoxanes
(Elsevier, 2003)
Several cis and trans bis-steroidal 1,2,4,5-tetraoxanes possessing amide terminus were synthesised and evaluated as antimalarials and antiproliferatives. The compounds exhibited submicromolar antimalarial activity against ...
Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements
(Oxford : Pergamon-Elsevier Science Ltd, 2008)
The present study identifies xanthones gentiakochianin and gentiacaulein as the active principles responsible for the in vitro antiglioma action of ether and methanolic extracts of the plant Gentiana kochiana. Gentiakochianin ...