Antimalarial and antiproliferative evaluation of bis-steroidal tetraoxanes
Само за регистроване кориснике
2003
Аутори
Opsenica, DejanAngelovski, Goran
Pocsfalvi, Gabriella
Juranić, Zorica
Žižak, Željko
Kyle, Dennis
Milhous, Wilbur K.
Šolaja, Bogdan
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Several cis and trans bis-steroidal 1,2,4,5-tetraoxanes possessing amide terminus were synthesised and evaluated as antimalarials and antiproliferatives. The compounds exhibited submicromolar antimalarial activity against Plasmodium falciparum D6 and W2 strains. The existence of HN-C(O) moiety was found necessary for pronounced antimalarial and antiproliferative activity. In antiproliferative screen, the trans tetraoxane 6 was found to exhibit a pronounced cytotoxicity on 14 cancer cell lines. In addition, tetraoxanes 11 and 12 exhibited significant cytotoxic activity too; microscopic examination of treated HeLa cells showed morphological appearance reminiscent for apoptosis (condensed and/or fragmented nuclei).
Кључне речи:
tetraoxanes / antimalarial activity / antiproliferative activity / Cis/transИзвор:
Bioorganic and Medicinal Chemistry, 2003, 11, 13, 2761-2768Издавач:
- Elsevier
DOI: 10.1016/S0968-0896(03)00224-4
ISSN: 0968-0896
PubMed: 12788350
WoS: 000183590100011
Scopus: 2-s2.0-0037871977
Институција/група
IHTMTY - JOUR AU - Opsenica, Dejan AU - Angelovski, Goran AU - Pocsfalvi, Gabriella AU - Juranić, Zorica AU - Žižak, Željko AU - Kyle, Dennis AU - Milhous, Wilbur K. AU - Šolaja, Bogdan PY - 2003 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/7446 AB - Several cis and trans bis-steroidal 1,2,4,5-tetraoxanes possessing amide terminus were synthesised and evaluated as antimalarials and antiproliferatives. The compounds exhibited submicromolar antimalarial activity against Plasmodium falciparum D6 and W2 strains. The existence of HN-C(O) moiety was found necessary for pronounced antimalarial and antiproliferative activity. In antiproliferative screen, the trans tetraoxane 6 was found to exhibit a pronounced cytotoxicity on 14 cancer cell lines. In addition, tetraoxanes 11 and 12 exhibited significant cytotoxic activity too; microscopic examination of treated HeLa cells showed morphological appearance reminiscent for apoptosis (condensed and/or fragmented nuclei). PB - Elsevier T2 - Bioorganic and Medicinal Chemistry T1 - Antimalarial and antiproliferative evaluation of bis-steroidal tetraoxanes VL - 11 IS - 13 SP - 2761 EP - 2768 DO - 10.1016/S0968-0896(03)00224-4 ER -
@article{ author = "Opsenica, Dejan and Angelovski, Goran and Pocsfalvi, Gabriella and Juranić, Zorica and Žižak, Željko and Kyle, Dennis and Milhous, Wilbur K. and Šolaja, Bogdan", year = "2003", abstract = "Several cis and trans bis-steroidal 1,2,4,5-tetraoxanes possessing amide terminus were synthesised and evaluated as antimalarials and antiproliferatives. The compounds exhibited submicromolar antimalarial activity against Plasmodium falciparum D6 and W2 strains. The existence of HN-C(O) moiety was found necessary for pronounced antimalarial and antiproliferative activity. In antiproliferative screen, the trans tetraoxane 6 was found to exhibit a pronounced cytotoxicity on 14 cancer cell lines. In addition, tetraoxanes 11 and 12 exhibited significant cytotoxic activity too; microscopic examination of treated HeLa cells showed morphological appearance reminiscent for apoptosis (condensed and/or fragmented nuclei).", publisher = "Elsevier", journal = "Bioorganic and Medicinal Chemistry", title = "Antimalarial and antiproliferative evaluation of bis-steroidal tetraoxanes", volume = "11", number = "13", pages = "2761-2768", doi = "10.1016/S0968-0896(03)00224-4" }
Opsenica, D., Angelovski, G., Pocsfalvi, G., Juranić, Z., Žižak, Ž., Kyle, D., Milhous, W. K.,& Šolaja, B.. (2003). Antimalarial and antiproliferative evaluation of bis-steroidal tetraoxanes. in Bioorganic and Medicinal Chemistry Elsevier., 11(13), 2761-2768. https://doi.org/10.1016/S0968-0896(03)00224-4
Opsenica D, Angelovski G, Pocsfalvi G, Juranić Z, Žižak Ž, Kyle D, Milhous WK, Šolaja B. Antimalarial and antiproliferative evaluation of bis-steroidal tetraoxanes. in Bioorganic and Medicinal Chemistry. 2003;11(13):2761-2768. doi:10.1016/S0968-0896(03)00224-4 .
Opsenica, Dejan, Angelovski, Goran, Pocsfalvi, Gabriella, Juranić, Zorica, Žižak, Željko, Kyle, Dennis, Milhous, Wilbur K., Šolaja, Bogdan, "Antimalarial and antiproliferative evaluation of bis-steroidal tetraoxanes" in Bioorganic and Medicinal Chemistry, 11, no. 13 (2003):2761-2768, https://doi.org/10.1016/S0968-0896(03)00224-4 . .