TY  - JOUR
AU  - Adžić, Miroslav
AU  - Nićiforović, Ana
AU  - Vucić, Vesna
AU  - Nešković-Konstantinović, Zora
AU  - Spasić, Snežana
AU  - Jones, David
AU  - Radojčić, Marija
AU  - Spasić, Mihajlo
PY  - 2006
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3965
AB  - There is a well-established role for reactive oxygen and nitrogen species, chronic inflammation and immune response in the pathogenesis of breast cancer. Complex interactions between breast cancer cells and surrounding blood vessels are prerequisites for cancer growth and invasion. Reports in the literature concerning the systemic response to, and the effect of, common breast cancer therapy on NF-kappaB and antioxidative defence enzyme expression and activity under clinical conditions are scarce. We determined these parameters in whole blood cell lysate from 16 women with breast cancer before and after combined (cyclophosphamide, doxorubicin, 5-fluorouracil; CAF) therapy and compared the results with 16 healthy women. Significantly higher levels of NF-kappaB and Mn-SOD (both their protein level and their activity) were found in breast cancer patients before and after CAF therapy, in comparison with healthy women. In parallel measurements, no change in the level or activity of catalase (CAT) was detected. According to our findings, it appears that breast cancer creates conditions that increase the level of hydrogen peroxide in the circulating cells and that the applied CAF therapy fails to compensate, therefore creating systemic conditions that favour survival and invasion of breast cancer cells.
PB  - Maney Publishing
T2  - Redox Report
T1  - Systemic NF-kappaB activation in blood cells of breast cancer patients
VL  - 11
IS  - 1
SP  - 39
SP  - 44
DO  - 10.1179/135100006X101002
ER  - 

@article{
author = "Adžić, Miroslav and Nićiforović, Ana and Vucić, Vesna and Nešković-Konstantinović, Zora and Spasić, Snežana and Jones, David and Radojčić, Marija and Spasić, Mihajlo",
year = "2006",
abstract = "There is a well-established role for reactive oxygen and nitrogen species, chronic inflammation and immune response in the pathogenesis of breast cancer. Complex interactions between breast cancer cells and surrounding blood vessels are prerequisites for cancer growth and invasion. Reports in the literature concerning the systemic response to, and the effect of, common breast cancer therapy on NF-kappaB and antioxidative defence enzyme expression and activity under clinical conditions are scarce. We determined these parameters in whole blood cell lysate from 16 women with breast cancer before and after combined (cyclophosphamide, doxorubicin, 5-fluorouracil; CAF) therapy and compared the results with 16 healthy women. Significantly higher levels of NF-kappaB and Mn-SOD (both their protein level and their activity) were found in breast cancer patients before and after CAF therapy, in comparison with healthy women. In parallel measurements, no change in the level or activity of catalase (CAT) was detected. According to our findings, it appears that breast cancer creates conditions that increase the level of hydrogen peroxide in the circulating cells and that the applied CAF therapy fails to compensate, therefore creating systemic conditions that favour survival and invasion of breast cancer cells.",
publisher = "Maney Publishing",
journal = "Redox Report",
title = "Systemic NF-kappaB activation in blood cells of breast cancer patients",
volume = "11",
number = "1",
pages = "39-44",
doi = "10.1179/135100006X101002"
}

Adžić, M., Nićiforović, A., Vucić, V., Nešković-Konstantinović, Z., Spasić, S., Jones, D., Radojčić, M.,& Spasić, M.. (2006). Systemic NF-kappaB activation in blood cells of breast cancer patients. in Redox Report
Maney Publishing., 11(1), 39.
https://doi.org/10.1179/135100006X101002

Adžić M, Nićiforović A, Vucić V, Nešković-Konstantinović Z, Spasić S, Jones D, Radojčić M, Spasić M. Systemic NF-kappaB activation in blood cells of breast cancer patients. in Redox Report. 2006;11(1):39.
doi:10.1179/135100006X101002 .

Adžić, Miroslav, Nićiforović, Ana, Vucić, Vesna, Nešković-Konstantinović, Zora, Spasić, Snežana, Jones, David, Radojčić, Marija, Spasić, Mihajlo, "Systemic NF-kappaB activation in blood cells of breast cancer patients" in Redox Report, 11, no. 1 (2006):39,
https://doi.org/10.1179/135100006X101002 . .