TY  - CONF
AU  - Nikolić, Jasmina
AU  - Božić, Katarina
AU  - Kuburović, Nataša
AU  - Drmanić, Saša
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6517
AB  - Supstituisani estri 1,4-dihidropiridina (1,4-DHP) nastaju u reakciji etil-acetoacetata i odgovarajućih supstituisanih aldehida u prisustvu amonijaka. Nastali estri sa primarnim aminima formiraju amide. Serija amida nastalih od navednih jedinjenja je sintetisana sa namerom da se ispitaju njihove karakteristike i antioksidativna aktivnost. U ovde prikazanom istraživanju za aminolizu upotrebljen je 2-aminotiazol. Antioksidativna aktivnost je ispitivana DPPH (2,2-difenil-1-pikrilhidrazil-radikal) i ABTS (2,2'-azino-bis(3-etilbenzotiazolin-6-sulfonska kiselina)) metodama, a pored toga određene su tačke topljenje, snimljeni IR spektri i izvršena je elementalna analiza.
AB  - The substituted esters of 1,4-dihydropyirdines (1,4-DHP) are formed in the reaction of ethyl acetoacetate and corresponding substituted aldehydes in the presence of ammonia. Amides form from esters of substituted 1,4-DHP by aminolysis employing primary amines. A series of amides of the mentioned compounds was synthesized with the aim to analyze their chemical properties and antioxidative activity. The amine used in the present research was 2-aminothiazole. The antioxidative activity was determined by DPPH (2,2-diphenyl-1-picrylhydrazyl radical) and ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) methods; melting points and IR were measured and elemental analysis was performed.
PB  - Beograd, Srbija : Srpsko hemijsko društvo
C3  - Kratki izvodi radova, knjiga radova - 58. Savetovanje Srpskog hemijskog društva, 9. i 10. jun, Beograd, Srbija / Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, June 9-10, Belgrade, Serbia
T1  - Sinteza, karakterizacija i antioksidativna aktivnost proizvoda aminolize Hančovih dihidropiridina
T1  - Synthesis, characterization and antioxidative activity of aminolysis products of Hantzsch dihydropyridines
SP  - 140
EP  - 140
UR  - https://hdl.handle.net/21.15107/rcub_cer_6517
ER  - 

@conference{
author = "Nikolić, Jasmina and Božić, Katarina and Kuburović, Nataša and Drmanić, Saša",
year = "2022",
abstract = "Supstituisani estri 1,4-dihidropiridina (1,4-DHP) nastaju u reakciji etil-acetoacetata i odgovarajućih supstituisanih aldehida u prisustvu amonijaka. Nastali estri sa primarnim aminima formiraju amide. Serija amida nastalih od navednih jedinjenja je sintetisana sa namerom da se ispitaju njihove karakteristike i antioksidativna aktivnost. U ovde prikazanom istraživanju za aminolizu upotrebljen je 2-aminotiazol. Antioksidativna aktivnost je ispitivana DPPH (2,2-difenil-1-pikrilhidrazil-radikal) i ABTS (2,2'-azino-bis(3-etilbenzotiazolin-6-sulfonska kiselina)) metodama, a pored toga određene su tačke topljenje, snimljeni IR spektri i izvršena je elementalna analiza., The substituted esters of 1,4-dihydropyirdines (1,4-DHP) are formed in the reaction of ethyl acetoacetate and corresponding substituted aldehydes in the presence of ammonia. Amides form from esters of substituted 1,4-DHP by aminolysis employing primary amines. A series of amides of the mentioned compounds was synthesized with the aim to analyze their chemical properties and antioxidative activity. The amine used in the present research was 2-aminothiazole. The antioxidative activity was determined by DPPH (2,2-diphenyl-1-picrylhydrazyl radical) and ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) methods; melting points and IR were measured and elemental analysis was performed.",
publisher = "Beograd, Srbija : Srpsko hemijsko društvo",
journal = "Kratki izvodi radova, knjiga radova - 58. Savetovanje Srpskog hemijskog društva, 9. i 10. jun, Beograd, Srbija / Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, June 9-10, Belgrade, Serbia",
title = "Sinteza, karakterizacija i antioksidativna aktivnost proizvoda aminolize Hančovih dihidropiridina, Synthesis, characterization and antioxidative activity of aminolysis products of Hantzsch dihydropyridines",
pages = "140-140",
url = "https://hdl.handle.net/21.15107/rcub_cer_6517"
}

Nikolić, J., Božić, K., Kuburović, N.,& Drmanić, S.. (2022). Sinteza, karakterizacija i antioksidativna aktivnost proizvoda aminolize Hančovih dihidropiridina. in Kratki izvodi radova, knjiga radova - 58. Savetovanje Srpskog hemijskog društva, 9. i 10. jun, Beograd, Srbija / Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, June 9-10, Belgrade, Serbia
Beograd, Srbija : Srpsko hemijsko društvo., 140-140.
https://hdl.handle.net/21.15107/rcub_cer_6517

Nikolić J, Božić K, Kuburović N, Drmanić S. Sinteza, karakterizacija i antioksidativna aktivnost proizvoda aminolize Hančovih dihidropiridina. in Kratki izvodi radova, knjiga radova - 58. Savetovanje Srpskog hemijskog društva, 9. i 10. jun, Beograd, Srbija / Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, June 9-10, Belgrade, Serbia. 2022;:140-140.
https://hdl.handle.net/21.15107/rcub_cer_6517 .

Nikolić, Jasmina, Božić, Katarina, Kuburović, Nataša, Drmanić, Saša, "Sinteza, karakterizacija i antioksidativna aktivnost proizvoda aminolize Hančovih dihidropiridina" in Kratki izvodi radova, knjiga radova - 58. Savetovanje Srpskog hemijskog društva, 9. i 10. jun, Beograd, Srbija / Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, June 9-10, Belgrade, Serbia (2022):140-140,
https://hdl.handle.net/21.15107/rcub_cer_6517 .

TY  - CONF
AU  - Drmanić, Saša
AU  - Božić, Katarina
AU  - Marojević, Andrijana
AU  - Nikolić, Jasmina
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6516
AB  - Izvršena je sinteza četiri 1,3-dihidro-3-[4-supstituisanih-(fenilmetil)imino]-2H-indol-2-ona i to: 1,3-dihidro-3-[(fenilmetil)imino]-2H-indol-2-ona, 1,3-dihidro-3-[4-brom-(fenilmetil)imino]-2H-indol-2-ona, 1,3-dihidro-3-[4-hidroksi-(fenilmetil) imino]-2H-indol-2-ona, 1,3-dihidro-3-[4-metoksi-(fenilmetil)imino]-2H-indol-2-ona, kao i jedinjenja slične strukture, 1,3-dihidro-3-[(2-feniletil)imino]-2H-indol-2-ona. Urađena je karakterizacija sintetisanih jedinjenja primenom FTIR spektroskopije, određivanjem temperature topljenja i elementalnom analizom, nakon čega je izvršeno ispitivanje antioksidativne aktivnosti svih pet jedinjenja. Antioksidativna aktivnost je određena primenom DPPH (1,1-difenil-2-pikril-hidrazil radikal) metode, u cilju određivanja najefikasinijeg jedinjenja od značaja za dalje istraživanje.
AB  - The synthesis of 1,3-dihydro-3-[4-substituted-(phenylmethyl)imino]-2H-indole-2-ones: 1,3-dihydro-3-[(phenylmethyl)imino]-2H-indol-2-one, 1,3-dihydro-3-[4-bromo-(phenylmethyl)imino]-2H-indol-2-one, 1,3-dihydro-3-[4-hydroxy-phenyl-methyl)imino]-2H-indol-2-one, 1,3-dihydro-3-[4-methoxy-(phenylmethyl)imino]-2H-indol-2-one, as well as of the compound of similar structure, 1,3-dihydro-3-[(2-phenylethyl)imino]-2H-indol-2-one, was performed. The characterization of the obtained five compounds was carried out using FTIR, melting points and elemental analysis. Their antioxydative activity was then tested by DPPH (2,2-diphenyl-1-picrylhydrazyl radical) method and the results were compared in order to determine the most efficient compound, significant for further research.
PB  - Beograd, Srbija : Srpsko hemijsko društvo
C3  - Kratki izvodi radova, knjiga radova - 58. Savetovanje Srpskog hemijskog društva, 9. i 10. jun, Beograd, Srbija / Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, June 9-10, Belgrade, Serbia
T1  - Sinteza, karakterizacija i antioksidativna aktivnost 1,3-dihidro-3-[4-supstituisanih-(fenilmetil)imino]-2H-indol-2-ona
T1  - Synthesis, characterization and antioxidative activity of 1,3-dihydro-3-[4-substituted-(phenylmethyl)imino]-2H-indole-2-ones
SP  - 132
EP  - 132
UR  - https://hdl.handle.net/21.15107/rcub_cer_6516
ER  - 

@conference{
author = "Drmanić, Saša and Božić, Katarina and Marojević, Andrijana and Nikolić, Jasmina",
year = "2022",
abstract = "Izvršena je sinteza četiri 1,3-dihidro-3-[4-supstituisanih-(fenilmetil)imino]-2H-indol-2-ona i to: 1,3-dihidro-3-[(fenilmetil)imino]-2H-indol-2-ona, 1,3-dihidro-3-[4-brom-(fenilmetil)imino]-2H-indol-2-ona, 1,3-dihidro-3-[4-hidroksi-(fenilmetil) imino]-2H-indol-2-ona, 1,3-dihidro-3-[4-metoksi-(fenilmetil)imino]-2H-indol-2-ona, kao i jedinjenja slične strukture, 1,3-dihidro-3-[(2-feniletil)imino]-2H-indol-2-ona. Urađena je karakterizacija sintetisanih jedinjenja primenom FTIR spektroskopije, određivanjem temperature topljenja i elementalnom analizom, nakon čega je izvršeno ispitivanje antioksidativne aktivnosti svih pet jedinjenja. Antioksidativna aktivnost je određena primenom DPPH (1,1-difenil-2-pikril-hidrazil radikal) metode, u cilju određivanja najefikasinijeg jedinjenja od značaja za dalje istraživanje., The synthesis of 1,3-dihydro-3-[4-substituted-(phenylmethyl)imino]-2H-indole-2-ones: 1,3-dihydro-3-[(phenylmethyl)imino]-2H-indol-2-one, 1,3-dihydro-3-[4-bromo-(phenylmethyl)imino]-2H-indol-2-one, 1,3-dihydro-3-[4-hydroxy-phenyl-methyl)imino]-2H-indol-2-one, 1,3-dihydro-3-[4-methoxy-(phenylmethyl)imino]-2H-indol-2-one, as well as of the compound of similar structure, 1,3-dihydro-3-[(2-phenylethyl)imino]-2H-indol-2-one, was performed. The characterization of the obtained five compounds was carried out using FTIR, melting points and elemental analysis. Their antioxydative activity was then tested by DPPH (2,2-diphenyl-1-picrylhydrazyl radical) method and the results were compared in order to determine the most efficient compound, significant for further research.",
publisher = "Beograd, Srbija : Srpsko hemijsko društvo",
journal = "Kratki izvodi radova, knjiga radova - 58. Savetovanje Srpskog hemijskog društva, 9. i 10. jun, Beograd, Srbija / Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, June 9-10, Belgrade, Serbia",
title = "Sinteza, karakterizacija i antioksidativna aktivnost 1,3-dihidro-3-[4-supstituisanih-(fenilmetil)imino]-2H-indol-2-ona, Synthesis, characterization and antioxidative activity of 1,3-dihydro-3-[4-substituted-(phenylmethyl)imino]-2H-indole-2-ones",
pages = "132-132",
url = "https://hdl.handle.net/21.15107/rcub_cer_6516"
}

Drmanić, S., Božić, K., Marojević, A.,& Nikolić, J.. (2022). Sinteza, karakterizacija i antioksidativna aktivnost 1,3-dihidro-3-[4-supstituisanih-(fenilmetil)imino]-2H-indol-2-ona. in Kratki izvodi radova, knjiga radova - 58. Savetovanje Srpskog hemijskog društva, 9. i 10. jun, Beograd, Srbija / Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, June 9-10, Belgrade, Serbia
Beograd, Srbija : Srpsko hemijsko društvo., 132-132.
https://hdl.handle.net/21.15107/rcub_cer_6516

Drmanić S, Božić K, Marojević A, Nikolić J. Sinteza, karakterizacija i antioksidativna aktivnost 1,3-dihidro-3-[4-supstituisanih-(fenilmetil)imino]-2H-indol-2-ona. in Kratki izvodi radova, knjiga radova - 58. Savetovanje Srpskog hemijskog društva, 9. i 10. jun, Beograd, Srbija / Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, June 9-10, Belgrade, Serbia. 2022;:132-132.
https://hdl.handle.net/21.15107/rcub_cer_6516 .

Drmanić, Saša, Božić, Katarina, Marojević, Andrijana, Nikolić, Jasmina, "Sinteza, karakterizacija i antioksidativna aktivnost 1,3-dihidro-3-[4-supstituisanih-(fenilmetil)imino]-2H-indol-2-ona" in Kratki izvodi radova, knjiga radova - 58. Savetovanje Srpskog hemijskog društva, 9. i 10. jun, Beograd, Srbija / Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, June 9-10, Belgrade, Serbia (2022):132-132,
https://hdl.handle.net/21.15107/rcub_cer_6516 .

TY  - JOUR
AU  - Porobić, Slavica
AU  - Božić, Bojan
AU  - Dramićanin, Miroslav
AU  - Vitnik, Vesna
AU  - Vitnik, Željko
AU  - Marinović-Cincović, Milena
AU  - Mijin, Dušan
PY  - 2020
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3417
AB  - A series of nine 5-(4-substituted phenylazo)-3-amido-6-hydroxy-4-methyl-2-pyridones were synthesized and characterized by FT–IR, 1H and 13C NMR, UV–Vis, and PL spectroscopy. Photophysical properties of the dyes were examined in solvents of various polarities and at different pH values. The solvent effects on the absorbance and emission spectral shift were analyzed using Lippert–Mataga, Reichardt–Dimroth and Kamlet-Taft equations. Moreover, UV–Vis absorption and emission frequencies were correlated with Hammett substituent constants applying the linear free energy relationships. DFT calculations of the investigated dyes were accomplished to determine their structural and electronic properties.
PB  - Elsevier
T2  - Dyes and Pigments
T1  - Absorption and fluorescence spectral properties of azo dyes based on 3-amido-6-hydroxy-4-methyl-2-pyridone: Solvent and substituent effects
VL  - 175
SP  - 108139
DO  - 10.1016/j.dyepig.2019.108139
ER  - 

@article{
author = "Porobić, Slavica and Božić, Bojan and Dramićanin, Miroslav and Vitnik, Vesna and Vitnik, Željko and Marinović-Cincović, Milena and Mijin, Dušan",
year = "2020",
abstract = "A series of nine 5-(4-substituted phenylazo)-3-amido-6-hydroxy-4-methyl-2-pyridones were synthesized and characterized by FT–IR, 1H and 13C NMR, UV–Vis, and PL spectroscopy. Photophysical properties of the dyes were examined in solvents of various polarities and at different pH values. The solvent effects on the absorbance and emission spectral shift were analyzed using Lippert–Mataga, Reichardt–Dimroth and Kamlet-Taft equations. Moreover, UV–Vis absorption and emission frequencies were correlated with Hammett substituent constants applying the linear free energy relationships. DFT calculations of the investigated dyes were accomplished to determine their structural and electronic properties.",
publisher = "Elsevier",
journal = "Dyes and Pigments",
title = "Absorption and fluorescence spectral properties of azo dyes based on 3-amido-6-hydroxy-4-methyl-2-pyridone: Solvent and substituent effects",
volume = "175",
pages = "108139",
doi = "10.1016/j.dyepig.2019.108139"
}

Porobić, S., Božić, B., Dramićanin, M., Vitnik, V., Vitnik, Ž., Marinović-Cincović, M.,& Mijin, D.. (2020). Absorption and fluorescence spectral properties of azo dyes based on 3-amido-6-hydroxy-4-methyl-2-pyridone: Solvent and substituent effects. in Dyes and Pigments
Elsevier., 175, 108139.
https://doi.org/10.1016/j.dyepig.2019.108139

Porobić S, Božić B, Dramićanin M, Vitnik V, Vitnik Ž, Marinović-Cincović M, Mijin D. Absorption and fluorescence spectral properties of azo dyes based on 3-amido-6-hydroxy-4-methyl-2-pyridone: Solvent and substituent effects. in Dyes and Pigments. 2020;175:108139.
doi:10.1016/j.dyepig.2019.108139 .

Porobić, Slavica, Božić, Bojan, Dramićanin, Miroslav, Vitnik, Vesna, Vitnik, Željko, Marinović-Cincović, Milena, Mijin, Dušan, "Absorption and fluorescence spectral properties of azo dyes based on 3-amido-6-hydroxy-4-methyl-2-pyridone: Solvent and substituent effects" in Dyes and Pigments, 175 (2020):108139,
https://doi.org/10.1016/j.dyepig.2019.108139 . .

TY  - JOUR
AU  - Porobić, Slavica
AU  - Božić, Bojan
AU  - Dramićanin, Miroslav
AU  - Vitnik, Vesna
AU  - Vitnik, Željko
AU  - Marinović-Cincović, Milena
AU  - Mijin, Dušan
PY  - 2020
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3418
AB  - A series of nine 5-(4-substituted phenylazo)-3-amido-6-hydroxy-4-methyl-2-pyridones were synthesized and characterized by FT–IR, 1H and 13C NMR, UV–Vis, and PL spectroscopy. Photophysical properties of the dyes were examined in solvents of various polarities and at different pH values. The solvent effects on the absorbance and emission spectral shift were analyzed using Lippert–Mataga, Reichardt–Dimroth and Kamlet-Taft equations. Moreover, UV–Vis absorption and emission frequencies were correlated with Hammett substituent constants applying the linear free energy relationships. DFT calculations of the investigated dyes were accomplished to determine their structural and electronic properties.
PB  - Elsevier
T2  - Dyes and Pigments
T1  - Absorption and fluorescence spectral properties of azo dyes based on 3-amido-6-hydroxy-4-methyl-2-pyridone: Solvent and substituent effects
VL  - 175
SP  - 108139
DO  - 10.1016/j.dyepig.2019.108139
ER  - 

@article{
author = "Porobić, Slavica and Božić, Bojan and Dramićanin, Miroslav and Vitnik, Vesna and Vitnik, Željko and Marinović-Cincović, Milena and Mijin, Dušan",
year = "2020",
abstract = "A series of nine 5-(4-substituted phenylazo)-3-amido-6-hydroxy-4-methyl-2-pyridones were synthesized and characterized by FT–IR, 1H and 13C NMR, UV–Vis, and PL spectroscopy. Photophysical properties of the dyes were examined in solvents of various polarities and at different pH values. The solvent effects on the absorbance and emission spectral shift were analyzed using Lippert–Mataga, Reichardt–Dimroth and Kamlet-Taft equations. Moreover, UV–Vis absorption and emission frequencies were correlated with Hammett substituent constants applying the linear free energy relationships. DFT calculations of the investigated dyes were accomplished to determine their structural and electronic properties.",
publisher = "Elsevier",
journal = "Dyes and Pigments",
title = "Absorption and fluorescence spectral properties of azo dyes based on 3-amido-6-hydroxy-4-methyl-2-pyridone: Solvent and substituent effects",
volume = "175",
pages = "108139",
doi = "10.1016/j.dyepig.2019.108139"
}

Porobić, S., Božić, B., Dramićanin, M., Vitnik, V., Vitnik, Ž., Marinović-Cincović, M.,& Mijin, D.. (2020). Absorption and fluorescence spectral properties of azo dyes based on 3-amido-6-hydroxy-4-methyl-2-pyridone: Solvent and substituent effects. in Dyes and Pigments
Elsevier., 175, 108139.
https://doi.org/10.1016/j.dyepig.2019.108139

Porobić S, Božić B, Dramićanin M, Vitnik V, Vitnik Ž, Marinović-Cincović M, Mijin D. Absorption and fluorescence spectral properties of azo dyes based on 3-amido-6-hydroxy-4-methyl-2-pyridone: Solvent and substituent effects. in Dyes and Pigments. 2020;175:108139.
doi:10.1016/j.dyepig.2019.108139 .

Porobić, Slavica, Božić, Bojan, Dramićanin, Miroslav, Vitnik, Vesna, Vitnik, Željko, Marinović-Cincović, Milena, Mijin, Dušan, "Absorption and fluorescence spectral properties of azo dyes based on 3-amido-6-hydroxy-4-methyl-2-pyridone: Solvent and substituent effects" in Dyes and Pigments, 175 (2020):108139,
https://doi.org/10.1016/j.dyepig.2019.108139 . .

TY  - CONF
AU  - Perendija, Jovana
AU  - Milošević, Dragana
AU  - Bugarčić, Mladen
AU  - Marinković, Aleksandar
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7456
AB  - The industries of leather-tanning, mining and textile dyeing, generate large amounts ofchromium-containing wastewater. Hexavalent Cr(VI) is highly poisonous and extremelymobile in the surface-water and groundwater in a broad pH range and therefore it hasbeen identified as a potentially carcinogenic substance. The aim of the presented workwas to develop cellulose-based membrane functionalized with magnetite, which couldbe used as an efficient adsorbent for the removal of hexavalent chromium Cr(VI) ionsfrom aqueous solutions. Cellulose-based filter (CF) was functionalized with magnetitein three-step process. In the first and second step CF surface was modified usingan ethanolic solution of (3-aminopropyl)triethoxysilane (APTES), anddiethylenetriaminepentaacetic acid dianhydride, respectively. The introduction of aminoand carboxylic groups provided successful precipitation of magnetite in the third step.The obtained cellulose-magnetite membrane (CelMag-M) was characterized by FTIRand SEM analysis. Adsorption of Cr(VI) onto CelMag-M was studied using batchadsorptiontest. Under optimum pH conditions, the maximum experimental adsorptioncapacity of CelMag-M for Cr(VI) was found to be 111.2 mg g–1. The adsorption processwas endothermic, the equilibrium adsorption data could be best fitted to the Langmuiradsorption isotherm model and kinetics was in agreement with the pseudo-second-orderrate equation.
PB  - Belgrade : Development and Research Centre of Graphic Engineering Faculty of Technology and Metallurgy
C3  - 7th Conference of the Young Chemists of Serbia
T1  - Removal of hexavalent chromium Cr(VI) from aqueous solutions using cellulose-magnetite membrane CelMag-M
SP  - 146
EP  - 146
UR  - https://hdl.handle.net/21.15107/rcub_cer_7456
ER  - 

@conference{
author = "Perendija, Jovana and Milošević, Dragana and Bugarčić, Mladen and Marinković, Aleksandar",
year = "2019",
abstract = "The industries of leather-tanning, mining and textile dyeing, generate large amounts ofchromium-containing wastewater. Hexavalent Cr(VI) is highly poisonous and extremelymobile in the surface-water and groundwater in a broad pH range and therefore it hasbeen identified as a potentially carcinogenic substance. The aim of the presented workwas to develop cellulose-based membrane functionalized with magnetite, which couldbe used as an efficient adsorbent for the removal of hexavalent chromium Cr(VI) ionsfrom aqueous solutions. Cellulose-based filter (CF) was functionalized with magnetitein three-step process. In the first and second step CF surface was modified usingan ethanolic solution of (3-aminopropyl)triethoxysilane (APTES), anddiethylenetriaminepentaacetic acid dianhydride, respectively. The introduction of aminoand carboxylic groups provided successful precipitation of magnetite in the third step.The obtained cellulose-magnetite membrane (CelMag-M) was characterized by FTIRand SEM analysis. Adsorption of Cr(VI) onto CelMag-M was studied using batchadsorptiontest. Under optimum pH conditions, the maximum experimental adsorptioncapacity of CelMag-M for Cr(VI) was found to be 111.2 mg g–1. The adsorption processwas endothermic, the equilibrium adsorption data could be best fitted to the Langmuiradsorption isotherm model and kinetics was in agreement with the pseudo-second-orderrate equation.",
publisher = "Belgrade : Development and Research Centre of Graphic Engineering Faculty of Technology and Metallurgy",
journal = "7th Conference of the Young Chemists of Serbia",
title = "Removal of hexavalent chromium Cr(VI) from aqueous solutions using cellulose-magnetite membrane CelMag-M",
pages = "146-146",
url = "https://hdl.handle.net/21.15107/rcub_cer_7456"
}

Perendija, J., Milošević, D., Bugarčić, M.,& Marinković, A.. (2019). Removal of hexavalent chromium Cr(VI) from aqueous solutions using cellulose-magnetite membrane CelMag-M. in 7th Conference of the Young Chemists of Serbia
Belgrade : Development and Research Centre of Graphic Engineering Faculty of Technology and Metallurgy., 146-146.
https://hdl.handle.net/21.15107/rcub_cer_7456

Perendija J, Milošević D, Bugarčić M, Marinković A. Removal of hexavalent chromium Cr(VI) from aqueous solutions using cellulose-magnetite membrane CelMag-M. in 7th Conference of the Young Chemists of Serbia. 2019;:146-146.
https://hdl.handle.net/21.15107/rcub_cer_7456 .

Perendija, Jovana, Milošević, Dragana, Bugarčić, Mladen, Marinković, Aleksandar, "Removal of hexavalent chromium Cr(VI) from aqueous solutions using cellulose-magnetite membrane CelMag-M" in 7th Conference of the Young Chemists of Serbia (2019):146-146,
https://hdl.handle.net/21.15107/rcub_cer_7456 .

TY  - CONF
AU  - Kovačina, Jovanka
AU  - Milošević, Milena D.
AU  - Božić, Aleksandra
AU  - Jovanović, Aleksandar
AU  - Marinković, Aleksandar D.
AU  - Onjia, Antonije E.
AU  - Povrenović, Dragan
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3939
AB  - Usled razvoja industrije i rastom populacije tokom poslednjih godina javljaju se
problemi u vezi sa otpadnim vodama iz proizvodnje koje je neophodno rešavati na ekološki i
ekonomičan način. Sve otpadne vode iz postrojenja bez obzira kako su nastale sadrže štetne
materije koje mogu da imaju i određen stepen toksičnih primesa, moraju se prečistiti ako njihov
kvalitet ne odgovara zakonskim okvirima. Svrha tretmana otpadnih voda je uklanjanje štetnih
materija čime se postiže smanjnje stepena njene zagađenosti, a istovremeno se ostvaruje i određen
ekonomski i ekološki efekat, stoga je u ovom radu izvršeno prečišćavanje otpadne vode postupkom
taloženja upotrebom kalcijum-oksida u cilju uklanjanja koloidnih materija i teških metala. Većina
zagađujućih materija su organskog porekla i njihovo ukljanjanje vršiće se primenom naprednih
oksidacionih procesa korišćenjem ozona i ozona u kombinaciji sa ultrazvukom u cilju postizanja
kvaliteta vode koji odgovara zakonskoj regulativi. Proces prečišćavanja će se optimizovati u
odnosu na tehnološki postupak, koncentraciju, vreme tretmana i količinu primenjenog oksidacionog
sredstva. Stepen zagađenosti vode organskim jedinjenjima će se određivati na osnovu merenja
HPK, BPK i koncentracije teških metala (olovo, gvožđe, hrom, bakar, cink, aluminijum).
AB  - Due to the development of industry and population growth during the in recent years, there are problems with wastewater from production that needs to be addressed in an environmentally and economical way. All wastewaters from industry, no matter how they are created, contain harmful substances that may have some degree of toxicity, must be treated if their quality does not meet the legal requirements. The purpose of wastewater treatment is to remove
harmful substances, thereby reducing its pollution level, and at the same time, it also has a certain economic and environmental effect. Therefore, wastewater treatment was carried out in this work by precipitation using calcium oxide to remove colloidal substances and heavy metals. Most pollutants are of organic origin and their removal will be carried in this work out using advanced
oxidation processes using ozone, and ozone in combination with ultrasound to achieve water quality that complies with the law. The purification process will be optimized with respect to, method, time and amount of oxidizing agent applied. The degree of pollution of water by organic compounds will be determined on the basis of measurements of HPK, BOD and the concentration of heavy metals (lead, ferrum, chromium, copper, zinc, aluminum).
PB  - Beograd : Beogradska politehnika
C3  - Zbornik radova - Peti naučno-stručni skup politehnika
T1  - Prečišćavanje otpadnih voda primenom ozonizacije
T1  - Purification of waste water using ozonization
SP  - 142
EP  - 147
UR  - https://hdl.handle.net/21.15107/rcub_cer_3939
ER  - 

@conference{
author = "Kovačina, Jovanka and Milošević, Milena D. and Božić, Aleksandra and Jovanović, Aleksandar and Marinković, Aleksandar D. and Onjia, Antonije E. and Povrenović, Dragan",
year = "2019",
abstract = "Usled razvoja industrije i rastom populacije tokom poslednjih godina javljaju se
problemi u vezi sa otpadnim vodama iz proizvodnje koje je neophodno rešavati na ekološki i
ekonomičan način. Sve otpadne vode iz postrojenja bez obzira kako su nastale sadrže štetne
materije koje mogu da imaju i određen stepen toksičnih primesa, moraju se prečistiti ako njihov
kvalitet ne odgovara zakonskim okvirima. Svrha tretmana otpadnih voda je uklanjanje štetnih
materija čime se postiže smanjnje stepena njene zagađenosti, a istovremeno se ostvaruje i određen
ekonomski i ekološki efekat, stoga je u ovom radu izvršeno prečišćavanje otpadne vode postupkom
taloženja upotrebom kalcijum-oksida u cilju uklanjanja koloidnih materija i teških metala. Većina
zagađujućih materija su organskog porekla i njihovo ukljanjanje vršiće se primenom naprednih
oksidacionih procesa korišćenjem ozona i ozona u kombinaciji sa ultrazvukom u cilju postizanja
kvaliteta vode koji odgovara zakonskoj regulativi. Proces prečišćavanja će se optimizovati u
odnosu na tehnološki postupak, koncentraciju, vreme tretmana i količinu primenjenog oksidacionog
sredstva. Stepen zagađenosti vode organskim jedinjenjima će se određivati na osnovu merenja
HPK, BPK i koncentracije teških metala (olovo, gvožđe, hrom, bakar, cink, aluminijum)., Due to the development of industry and population growth during the in recent years, there are problems with wastewater from production that needs to be addressed in an environmentally and economical way. All wastewaters from industry, no matter how they are created, contain harmful substances that may have some degree of toxicity, must be treated if their quality does not meet the legal requirements. The purpose of wastewater treatment is to remove
harmful substances, thereby reducing its pollution level, and at the same time, it also has a certain economic and environmental effect. Therefore, wastewater treatment was carried out in this work by precipitation using calcium oxide to remove colloidal substances and heavy metals. Most pollutants are of organic origin and their removal will be carried in this work out using advanced
oxidation processes using ozone, and ozone in combination with ultrasound to achieve water quality that complies with the law. The purification process will be optimized with respect to, method, time and amount of oxidizing agent applied. The degree of pollution of water by organic compounds will be determined on the basis of measurements of HPK, BOD and the concentration of heavy metals (lead, ferrum, chromium, copper, zinc, aluminum).",
publisher = "Beograd : Beogradska politehnika",
journal = "Zbornik radova - Peti naučno-stručni skup politehnika",
title = "Prečišćavanje otpadnih voda primenom ozonizacije, Purification of waste water using ozonization",
pages = "142-147",
url = "https://hdl.handle.net/21.15107/rcub_cer_3939"
}

Kovačina, J., Milošević, M. D., Božić, A., Jovanović, A., Marinković, A. D., Onjia, A. E.,& Povrenović, D.. (2019). Prečišćavanje otpadnih voda primenom ozonizacije. in Zbornik radova - Peti naučno-stručni skup politehnika
Beograd : Beogradska politehnika., 142-147.
https://hdl.handle.net/21.15107/rcub_cer_3939

Kovačina J, Milošević MD, Božić A, Jovanović A, Marinković AD, Onjia AE, Povrenović D. Prečišćavanje otpadnih voda primenom ozonizacije. in Zbornik radova - Peti naučno-stručni skup politehnika. 2019;:142-147.
https://hdl.handle.net/21.15107/rcub_cer_3939 .

Kovačina, Jovanka, Milošević, Milena D., Božić, Aleksandra, Jovanović, Aleksandar, Marinković, Aleksandar D., Onjia, Antonije E., Povrenović, Dragan, "Prečišćavanje otpadnih voda primenom ozonizacije" in Zbornik radova - Peti naučno-stručni skup politehnika (2019):142-147,
https://hdl.handle.net/21.15107/rcub_cer_3939 .

TY  - JOUR
AU  - Assaleh, Mohamed H.
AU  - Božić, Aleksandra R.
AU  - Bjelogrlić, Snežana
AU  - Milošević, Milena D.
AU  - Simić, Milena R.
AU  - Marinković, Aleksandar D.
AU  - Cvijetić, Ilija
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3037
AB  - Thiocarbohydrazones (TCHs) and structurally related molecules are versatile organic compounds which exert antioxidant, anticancer, and other beneficial health effects. The combination of UV/Vis, NMR spectroscopy, and quantum chemical calculations was used to rationalize the experimentally observed increase in the radical scavenging activity upon the addition of water in DMSO solution of TCHs. Mono- and bis(salicylaldehyde) TCHs (compounds 1 and 2) undergo water-induced E-to-Z isomerization which is followed by disruption of intramolecular hydrogen bond, ground state destabilization, and 11 kcal/mol decrease in the bond dissociation enthalpy (BDE). Electron spin delocalization is more pronounced in Z-isomers of 1 and 2. On the other hand, 2-acetylpyridine TCHs (compounds 3 and 4) undergo thione-to-thiol tautomerism which also decreases the BDE and facilitates the hydrogen atom transfer to 2,2-diphenyl-1-picrylhydrazyl radical (DPPH∙). The appearance of thiolic –SH group as another reactive site toward free radicals improves the antioxidant activity of 3 and 4. The spin density of 3- and 4-thiol radicals is delocalized over the entire thiocarbohydrazide moiety compared to more localized spin of thione radicals. Additional stabilization of thiol radicals corroborates with the increased antioxidant activity. This study provides the new insights on the solution structure of TCHs, and also highlights the importance of solution structure determination when studying the structure-antioxidant relationships of isomerizable compounds.
PB  - Springer
T2  - Structural Chemistry
T1  - Water-induced isomerism of salicylaldehyde and 2-acetylpyridine mono- and bis-(thiocarbohydrazones) improves the antioxidant activity: spectroscopic and DFT study
VL  - 30
SP  - 2447
EP  - 2457
DO  - 10.1007/s11224-019-01371-4
ER  - 

@article{
author = "Assaleh, Mohamed H. and Božić, Aleksandra R. and Bjelogrlić, Snežana and Milošević, Milena D. and Simić, Milena R. and Marinković, Aleksandar D. and Cvijetić, Ilija",
year = "2019",
abstract = "Thiocarbohydrazones (TCHs) and structurally related molecules are versatile organic compounds which exert antioxidant, anticancer, and other beneficial health effects. The combination of UV/Vis, NMR spectroscopy, and quantum chemical calculations was used to rationalize the experimentally observed increase in the radical scavenging activity upon the addition of water in DMSO solution of TCHs. Mono- and bis(salicylaldehyde) TCHs (compounds 1 and 2) undergo water-induced E-to-Z isomerization which is followed by disruption of intramolecular hydrogen bond, ground state destabilization, and 11 kcal/mol decrease in the bond dissociation enthalpy (BDE). Electron spin delocalization is more pronounced in Z-isomers of 1 and 2. On the other hand, 2-acetylpyridine TCHs (compounds 3 and 4) undergo thione-to-thiol tautomerism which also decreases the BDE and facilitates the hydrogen atom transfer to 2,2-diphenyl-1-picrylhydrazyl radical (DPPH∙). The appearance of thiolic –SH group as another reactive site toward free radicals improves the antioxidant activity of 3 and 4. The spin density of 3- and 4-thiol radicals is delocalized over the entire thiocarbohydrazide moiety compared to more localized spin of thione radicals. Additional stabilization of thiol radicals corroborates with the increased antioxidant activity. This study provides the new insights on the solution structure of TCHs, and also highlights the importance of solution structure determination when studying the structure-antioxidant relationships of isomerizable compounds.",
publisher = "Springer",
journal = "Structural Chemistry",
title = "Water-induced isomerism of salicylaldehyde and 2-acetylpyridine mono- and bis-(thiocarbohydrazones) improves the antioxidant activity: spectroscopic and DFT study",
volume = "30",
pages = "2447-2457",
doi = "10.1007/s11224-019-01371-4"
}

Assaleh, M. H., Božić, A. R., Bjelogrlić, S., Milošević, M. D., Simić, M. R., Marinković, A. D.,& Cvijetić, I.. (2019). Water-induced isomerism of salicylaldehyde and 2-acetylpyridine mono- and bis-(thiocarbohydrazones) improves the antioxidant activity: spectroscopic and DFT study. in Structural Chemistry
Springer., 30, 2447-2457.
https://doi.org/10.1007/s11224-019-01371-4

Assaleh MH, Božić AR, Bjelogrlić S, Milošević MD, Simić MR, Marinković AD, Cvijetić I. Water-induced isomerism of salicylaldehyde and 2-acetylpyridine mono- and bis-(thiocarbohydrazones) improves the antioxidant activity: spectroscopic and DFT study. in Structural Chemistry. 2019;30:2447-2457.
doi:10.1007/s11224-019-01371-4 .

Assaleh, Mohamed H., Božić, Aleksandra R., Bjelogrlić, Snežana, Milošević, Milena D., Simić, Milena R., Marinković, Aleksandar D., Cvijetić, Ilija, "Water-induced isomerism of salicylaldehyde and 2-acetylpyridine mono- and bis-(thiocarbohydrazones) improves the antioxidant activity: spectroscopic and DFT study" in Structural Chemistry, 30 (2019):2447-2457,
https://doi.org/10.1007/s11224-019-01371-4 . .

TY  - CONF
AU  - Kovačina, Jovanka
AU  - Kojić, Jovan D.
AU  - Milošević, Milena D.
AU  - Marinković, Aleksandar D.
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6866
AB  - Levulinic acid (4-oxopentanoic acid) (LA) is a two-functional γ-keto acid widely used in a production of pharmaceuticals, ethyl levulinate, the substance which is
widely used in the cream and perfume industry, polymers, plasticizers, biofuel, resins, and various other additives.
LA was synthesized by the dehydration of fructose in a strongly acidic aqueous medium, using diluted hydrochloric acid, and subjected to microwave irradiation at
different operational conditions. LA was further used in two subsequent steps of peroxidation and dehydration to obtain 3-hydroxypropanoic acid and maleic
anhydride (MA) and acrylic acid (AA), respectively, which could be used for acrylic ester synthesis which could be used as a monomer in a polyacrylate
production (Figure 1).
T1  - Microwave-Assisted of synthesis and characterizations of levulinic acid (LA)
UR  - https://hdl.handle.net/21.15107/rcub_cer_6866
ER  - 

@conference{
author = "Kovačina, Jovanka and Kojić, Jovan D. and Milošević, Milena D. and Marinković, Aleksandar D.",
year = "2019",
abstract = "Levulinic acid (4-oxopentanoic acid) (LA) is a two-functional γ-keto acid widely used in a production of pharmaceuticals, ethyl levulinate, the substance which is
widely used in the cream and perfume industry, polymers, plasticizers, biofuel, resins, and various other additives.
LA was synthesized by the dehydration of fructose in a strongly acidic aqueous medium, using diluted hydrochloric acid, and subjected to microwave irradiation at
different operational conditions. LA was further used in two subsequent steps of peroxidation and dehydration to obtain 3-hydroxypropanoic acid and maleic
anhydride (MA) and acrylic acid (AA), respectively, which could be used for acrylic ester synthesis which could be used as a monomer in a polyacrylate
production (Figure 1).",
title = "Microwave-Assisted of synthesis and characterizations of levulinic acid (LA)",
url = "https://hdl.handle.net/21.15107/rcub_cer_6866"
}

Kovačina, J., Kojić, J. D., Milošević, M. D.,& Marinković, A. D.. (2019). Microwave-Assisted of synthesis and characterizations of levulinic acid (LA). .
https://hdl.handle.net/21.15107/rcub_cer_6866

Kovačina J, Kojić JD, Milošević MD, Marinković AD. Microwave-Assisted of synthesis and characterizations of levulinic acid (LA). 2019;.
https://hdl.handle.net/21.15107/rcub_cer_6866 .

Kovačina, Jovanka, Kojić, Jovan D., Milošević, Milena D., Marinković, Aleksandar D., "Microwave-Assisted of synthesis and characterizations of levulinic acid (LA)" (2019),
https://hdl.handle.net/21.15107/rcub_cer_6866 .

TY  - JOUR
AU  - Avramov Ivić, Milka
AU  - Lović, Jelena
AU  - Stevanović, Sanja
AU  - Nikolić, Nebojša D.
AU  - Trišović, Nemanja
AU  - Lađarević, Jelena
AU  - Vuković, Dragan
AU  - Drmanić, Saša Ž.
AU  - Mladenović, Aleksandar R.
AU  - Jadranin, Milka
AU  - Petrović, Slobodan D.
AU  - Mijin, Dušan
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3062
AB  - Esomeprazole is the most effective of the proton-pump inhibitors for the acid-related diseases and at first was examined for the electroanalytical purposes. The drug standard and as a content of injection powder was investigated by cyclic voltammetry (CV) and quantitatively determined using square wave voltammetry (SWV) via its electrooxidation at Au electrode in 0.05 M NaHCO3. SWV showed a linear dependency of the anodic peak currents vs. esomeprazole standard concentrations in the range from 3.0 to 500 μg mL−1 with the values of limit of detection (LOD) and limit of quantification (LOQ): 1.4 and 4.6 μg mL−1, respectively. Using the constructed and validated calibration curve, the values of unknown esomeprazole concentrations in injection powder and in human serum spiked with standard were determined. Before the electrochemical oxidation, it was shown by atomic force microscopy (AFM) that the small esomeprazole islands formed inside holes were visible and their diameter was about 200 nm attributed to physico-chemical characteristics of esomeprazole. After the electrochemical oxidation, the morphology of esomeprazole standard on Au surface was completely changed and composed of spherical particles in a diameter between 200 and 600 nm. With esomeprazole suspended in human serum, the process of crystallization partly occurred in the form of spherical grains with the average size of these grains was about 4 μm. The analysis at the macro level done by the optical microscopy (OM) confirmed this opinion. The study of esomeprazole degradation showed that at Au electrode, after 3 h of cycling, a neglectable amount of the esomeprazole was changed. Using IrOx electrode under directed stress conditions, its almost complete degradation was realized after 3 h confirmed by high performance liquid chromatography (HPLC). Total organic carbon (TOC) analysis showed that 95% of esomeprazole was mineralized. The HPLC and Liquid chromatography-mass spectrometry (LC-MS) study revealed the formation of 4-hydroxy omeprazole sulphide, 4-hydroxy omeprazole sulphone, esomeprazole sulphone and methylated esomeprazole.
PB  - Elsevier
T2  - Journal of Electroanalytical Chemistry
T1  - Electrochemical behavior of esomeprazole: Its determination at Au electrode as standard and in injection powder combined with the study of its degradation
VL  - 848
SP  - 113303
DO  - 10.1016/j.jelechem.2019.113303
ER  - 

@article{
author = "Avramov Ivić, Milka and Lović, Jelena and Stevanović, Sanja and Nikolić, Nebojša D. and Trišović, Nemanja and Lađarević, Jelena and Vuković, Dragan and Drmanić, Saša Ž. and Mladenović, Aleksandar R. and Jadranin, Milka and Petrović, Slobodan D. and Mijin, Dušan",
year = "2019",
abstract = "Esomeprazole is the most effective of the proton-pump inhibitors for the acid-related diseases and at first was examined for the electroanalytical purposes. The drug standard and as a content of injection powder was investigated by cyclic voltammetry (CV) and quantitatively determined using square wave voltammetry (SWV) via its electrooxidation at Au electrode in 0.05 M NaHCO3. SWV showed a linear dependency of the anodic peak currents vs. esomeprazole standard concentrations in the range from 3.0 to 500 μg mL−1 with the values of limit of detection (LOD) and limit of quantification (LOQ): 1.4 and 4.6 μg mL−1, respectively. Using the constructed and validated calibration curve, the values of unknown esomeprazole concentrations in injection powder and in human serum spiked with standard were determined. Before the electrochemical oxidation, it was shown by atomic force microscopy (AFM) that the small esomeprazole islands formed inside holes were visible and their diameter was about 200 nm attributed to physico-chemical characteristics of esomeprazole. After the electrochemical oxidation, the morphology of esomeprazole standard on Au surface was completely changed and composed of spherical particles in a diameter between 200 and 600 nm. With esomeprazole suspended in human serum, the process of crystallization partly occurred in the form of spherical grains with the average size of these grains was about 4 μm. The analysis at the macro level done by the optical microscopy (OM) confirmed this opinion. The study of esomeprazole degradation showed that at Au electrode, after 3 h of cycling, a neglectable amount of the esomeprazole was changed. Using IrOx electrode under directed stress conditions, its almost complete degradation was realized after 3 h confirmed by high performance liquid chromatography (HPLC). Total organic carbon (TOC) analysis showed that 95% of esomeprazole was mineralized. The HPLC and Liquid chromatography-mass spectrometry (LC-MS) study revealed the formation of 4-hydroxy omeprazole sulphide, 4-hydroxy omeprazole sulphone, esomeprazole sulphone and methylated esomeprazole.",
publisher = "Elsevier",
journal = "Journal of Electroanalytical Chemistry",
title = "Electrochemical behavior of esomeprazole: Its determination at Au electrode as standard and in injection powder combined with the study of its degradation",
volume = "848",
pages = "113303",
doi = "10.1016/j.jelechem.2019.113303"
}

Avramov Ivić, M., Lović, J., Stevanović, S., Nikolić, N. D., Trišović, N., Lađarević, J., Vuković, D., Drmanić, S. Ž., Mladenović, A. R., Jadranin, M., Petrović, S. D.,& Mijin, D.. (2019). Electrochemical behavior of esomeprazole: Its determination at Au electrode as standard and in injection powder combined with the study of its degradation. in Journal of Electroanalytical Chemistry
Elsevier., 848, 113303.
https://doi.org/10.1016/j.jelechem.2019.113303

Avramov Ivić M, Lović J, Stevanović S, Nikolić ND, Trišović N, Lađarević J, Vuković D, Drmanić SŽ, Mladenović AR, Jadranin M, Petrović SD, Mijin D. Electrochemical behavior of esomeprazole: Its determination at Au electrode as standard and in injection powder combined with the study of its degradation. in Journal of Electroanalytical Chemistry. 2019;848:113303.
doi:10.1016/j.jelechem.2019.113303 .

Avramov Ivić, Milka, Lović, Jelena, Stevanović, Sanja, Nikolić, Nebojša D., Trišović, Nemanja, Lađarević, Jelena, Vuković, Dragan, Drmanić, Saša Ž., Mladenović, Aleksandar R., Jadranin, Milka, Petrović, Slobodan D., Mijin, Dušan, "Electrochemical behavior of esomeprazole: Its determination at Au electrode as standard and in injection powder combined with the study of its degradation" in Journal of Electroanalytical Chemistry, 848 (2019):113303,
https://doi.org/10.1016/j.jelechem.2019.113303 . .

TY  - JOUR
AU  - Matović, Luka
AU  - Tasić, Nikola
AU  - Trišović, Nemanja
AU  - Lađarević, Jelena
AU  - Vitnik, Vesna
AU  - Vitnik, Željko
AU  - Grgur, Branimir N.
AU  - Mijin, Dušan
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3242
PB  - The Scientific and Technological Research Council of Turkey  (TÜBİTAK)
T2  - Turkish Journal of Chemistry
T1  - On the azo dyes derived from benzoic and cinnamic acids used as photosensitizersin dye-sensitized solar cells
VL  - 43
IS  - 4
SP  - 1183
EP  - 1203
DO  - 10.3906/kim-1903-76
ER  - 

@article{
author = "Matović, Luka and Tasić, Nikola and Trišović, Nemanja and Lađarević, Jelena and Vitnik, Vesna and Vitnik, Željko and Grgur, Branimir N. and Mijin, Dušan",
year = "2019",
publisher = "The Scientific and Technological Research Council of Turkey  (TÜBİTAK)",
journal = "Turkish Journal of Chemistry",
title = "On the azo dyes derived from benzoic and cinnamic acids used as photosensitizersin dye-sensitized solar cells",
volume = "43",
number = "4",
pages = "1183-1203",
doi = "10.3906/kim-1903-76"
}

Matović, L., Tasić, N., Trišović, N., Lađarević, J., Vitnik, V., Vitnik, Ž., Grgur, B. N.,& Mijin, D.. (2019). On the azo dyes derived from benzoic and cinnamic acids used as photosensitizersin dye-sensitized solar cells. in Turkish Journal of Chemistry
The Scientific and Technological Research Council of Turkey  (TÜBİTAK)., 43(4), 1183-1203.
https://doi.org/10.3906/kim-1903-76

Matović L, Tasić N, Trišović N, Lađarević J, Vitnik V, Vitnik Ž, Grgur BN, Mijin D. On the azo dyes derived from benzoic and cinnamic acids used as photosensitizersin dye-sensitized solar cells. in Turkish Journal of Chemistry. 2019;43(4):1183-1203.
doi:10.3906/kim-1903-76 .

Matović, Luka, Tasić, Nikola, Trišović, Nemanja, Lađarević, Jelena, Vitnik, Vesna, Vitnik, Željko, Grgur, Branimir N., Mijin, Dušan, "On the azo dyes derived from benzoic and cinnamic acids used as photosensitizersin dye-sensitized solar cells" in Turkish Journal of Chemistry, 43, no. 4 (2019):1183-1203,
https://doi.org/10.3906/kim-1903-76 . .

TY  - JOUR
AU  - Lović, Jelena
AU  - Avramov Ivić, Milka
AU  - Božić, Bojan
AU  - Lađarević, Jelena
AU  - Mijin, Dušan
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2874
AB  - The inclusion complexes of the selected, potentially biologically active, succinimides with β-cyclodextrin (βCD) and
(2-hydroxypropyl)-β-cyclodextrin (HPβCD) were prepared. the formation of the inclusion complexes of the investigated
monophenyl and diphenyl succinimide derivatives was confirmed using attenuated total reflection (ATR) study. Their
electrochemical behavior was examined by cyclic voltammetry (CV) and square wave voltammetry (SWV) in 0.05 M
NaHCO3 on a gold electrode. The stability constants for compound 1 were determined by cyclic voltammetry and calculated
as KβCD = 350.87 M–1 and KHPβCD = 250.67 M–1. The SWV measurements reveal well defined peak at potential Ep =
~ 60 mV and the higher currents at Ep for both inclusion complex of the succinimides compared to the free compounds.
The impact of chlorine atom in the phenyl moiety of succinimide derivatives on the activity in electrooxidation reaction
is presented. Among the studied succinimides, according to SWV measurements, the most active is the monophenyl
succinimide derivative (compound 1) in complex with βCD. The difference of peak current of compound 1 + βCD compared
to compound 1 + HPβCD and free compound is 6.3 and 35.2 μA cm–2, respectively.
PB  - Ljubljana : Slovenian Chemical Society
T2  - Acta Chimica Slovenica
T1  - Voltammetric Investigation of Inclusion Complexes of the Selected Succinimides with β-Cyclodextrin and (2-Hydroxypropyl)-β-Cyclodextrin
VL  - 66
SP  - 182
EP  - 189
DO  - 10.17344/acsi.2018.4767
ER  - 

@article{
author = "Lović, Jelena and Avramov Ivić, Milka and Božić, Bojan and Lađarević, Jelena and Mijin, Dušan",
year = "2019",
abstract = "The inclusion complexes of the selected, potentially biologically active, succinimides with β-cyclodextrin (βCD) and
(2-hydroxypropyl)-β-cyclodextrin (HPβCD) were prepared. the formation of the inclusion complexes of the investigated
monophenyl and diphenyl succinimide derivatives was confirmed using attenuated total reflection (ATR) study. Their
electrochemical behavior was examined by cyclic voltammetry (CV) and square wave voltammetry (SWV) in 0.05 M
NaHCO3 on a gold electrode. The stability constants for compound 1 were determined by cyclic voltammetry and calculated
as KβCD = 350.87 M–1 and KHPβCD = 250.67 M–1. The SWV measurements reveal well defined peak at potential Ep =
~ 60 mV and the higher currents at Ep for both inclusion complex of the succinimides compared to the free compounds.
The impact of chlorine atom in the phenyl moiety of succinimide derivatives on the activity in electrooxidation reaction
is presented. Among the studied succinimides, according to SWV measurements, the most active is the monophenyl
succinimide derivative (compound 1) in complex with βCD. The difference of peak current of compound 1 + βCD compared
to compound 1 + HPβCD and free compound is 6.3 and 35.2 μA cm–2, respectively.",
publisher = "Ljubljana : Slovenian Chemical Society",
journal = "Acta Chimica Slovenica",
title = "Voltammetric Investigation of Inclusion Complexes of the Selected Succinimides with β-Cyclodextrin and (2-Hydroxypropyl)-β-Cyclodextrin",
volume = "66",
pages = "182-189",
doi = "10.17344/acsi.2018.4767"
}

Lović, J., Avramov Ivić, M., Božić, B., Lađarević, J.,& Mijin, D.. (2019). Voltammetric Investigation of Inclusion Complexes of the Selected Succinimides with β-Cyclodextrin and (2-Hydroxypropyl)-β-Cyclodextrin. in Acta Chimica Slovenica
Ljubljana : Slovenian Chemical Society., 66, 182-189.
https://doi.org/10.17344/acsi.2018.4767

Lović J, Avramov Ivić M, Božić B, Lađarević J, Mijin D. Voltammetric Investigation of Inclusion Complexes of the Selected Succinimides with β-Cyclodextrin and (2-Hydroxypropyl)-β-Cyclodextrin. in Acta Chimica Slovenica. 2019;66:182-189.
doi:10.17344/acsi.2018.4767 .

Lović, Jelena, Avramov Ivić, Milka, Božić, Bojan, Lađarević, Jelena, Mijin, Dušan, "Voltammetric Investigation of Inclusion Complexes of the Selected Succinimides with β-Cyclodextrin and (2-Hydroxypropyl)-β-Cyclodextrin" in Acta Chimica Slovenica, 66 (2019):182-189,
https://doi.org/10.17344/acsi.2018.4767 . .

TY  - JOUR
AU  - Lović, Jelena
AU  - Lađarević, Jelena
AU  - Mijin, Dušan
AU  - Jadranin, Milka
AU  - Petrović, Slobodan D.
AU  - Avramov Ivić, Milka
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3159
AB  - In this study the electrochemical behavior of metformin (MET), oral antihyperglycaemic agent, was assayed at three different electrodes. The drug standard was investigated by cyclic voltammetry (CV) and square wave volta-mmetry (SWV) via its electrooxidation at Au and glassy carbon (GC) electrode in 0.05 M NaHCO3. Under these conditions transformation of MET to corresponding N-carbonyl guanidine via oxime intermediate is suggested. The stability of MET was tested under directed stress conditions using IrOx elec-trode with sodium sulphate as an electrolyte and cyclic 4-amino-2-imino-1-me-thyl-1,2-dihydro-1,3,5-triazine (4,2,1-AIMT) appeared as the main end-product. The courses of the electrochemical processes at three electrodes are followed by UV spectroscopy and evaluated by total organic carbon (TOC) analysis.
AB  - У оквиру рада изучавано је електрохемијско понашање метформина, лека са антихипергликемијским дејством, на три различите електроде. Стандард лека испитан је
цикличном волтаметријом и волтаметријом са правоугаоним импулсима у 0,05 М
раствору NaHCO3 на елекроди од злата и електроди од стакластог угљеника. Под овим
условима, предложена је трансформација лека до одговарајућег N-карбонил гуанидина
преко оксима као интермедијера. Стабилност метформина тестирана је и под условима
електрохемијске оксидације на IrOx електроди у присуству натријум сулфата као
електолита. У овом случају, предложено је настајање цикличног 4-амино-2-имино-1-
метил-1,2-дихидро-1,3,5-триазина као главног производа. Ток електрохемијских процеса
на све три електроде праћен је УВ спектроскопијом. Степен минерализације утврђен је
анализом укупног органског угљеника.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes
T1  - Електрохемијска стабилност метформина у воденим растворима NaHCO3 И Na2SO4 на Au, GC и IrOx електродама
VL  - 84
IS  - 11
SP  - 1319
EP  - 1327
DO  - 10.2298/JSC190731091L
ER  - 

@article{
author = "Lović, Jelena and Lađarević, Jelena and Mijin, Dušan and Jadranin, Milka and Petrović, Slobodan D. and Avramov Ivić, Milka",
year = "2019",
abstract = "In this study the electrochemical behavior of metformin (MET), oral antihyperglycaemic agent, was assayed at three different electrodes. The drug standard was investigated by cyclic voltammetry (CV) and square wave volta-mmetry (SWV) via its electrooxidation at Au and glassy carbon (GC) electrode in 0.05 M NaHCO3. Under these conditions transformation of MET to corresponding N-carbonyl guanidine via oxime intermediate is suggested. The stability of MET was tested under directed stress conditions using IrOx elec-trode with sodium sulphate as an electrolyte and cyclic 4-amino-2-imino-1-me-thyl-1,2-dihydro-1,3,5-triazine (4,2,1-AIMT) appeared as the main end-product. The courses of the electrochemical processes at three electrodes are followed by UV spectroscopy and evaluated by total organic carbon (TOC) analysis., У оквиру рада изучавано је електрохемијско понашање метформина, лека са антихипергликемијским дејством, на три различите електроде. Стандард лека испитан је
цикличном волтаметријом и волтаметријом са правоугаоним импулсима у 0,05 М
раствору NaHCO3 на елекроди од злата и електроди од стакластог угљеника. Под овим
условима, предложена је трансформација лека до одговарајућег N-карбонил гуанидина
преко оксима као интермедијера. Стабилност метформина тестирана је и под условима
електрохемијске оксидације на IrOx електроди у присуству натријум сулфата као
електолита. У овом случају, предложено је настајање цикличног 4-амино-2-имино-1-
метил-1,2-дихидро-1,3,5-триазина као главног производа. Ток електрохемијских процеса
на све три електроде праћен је УВ спектроскопијом. Степен минерализације утврђен је
анализом укупног органског угљеника.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes, Електрохемијска стабилност метформина у воденим растворима NaHCO3 И Na2SO4 на Au, GC и IrOx електродама",
volume = "84",
number = "11",
pages = "1319-1327",
doi = "10.2298/JSC190731091L"
}

Lović, J., Lađarević, J., Mijin, D., Jadranin, M., Petrović, S. D.,& Avramov Ivić, M.. (2019). Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 84(11), 1319-1327.
https://doi.org/10.2298/JSC190731091L

Lović J, Lađarević J, Mijin D, Jadranin M, Petrović SD, Avramov Ivić M. Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes. in Journal of the Serbian Chemical Society. 2019;84(11):1319-1327.
doi:10.2298/JSC190731091L .

Lović, Jelena, Lađarević, Jelena, Mijin, Dušan, Jadranin, Milka, Petrović, Slobodan D., Avramov Ivić, Milka, "Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes" in Journal of the Serbian Chemical Society, 84, no. 11 (2019):1319-1327,
https://doi.org/10.2298/JSC190731091L . .

TY  - JOUR
AU  - Lović, Jelena
AU  - Lađarević, Jelena
AU  - Mijin, Dušan
AU  - Jadranin, Milka
AU  - Petrović, Slobodan D.
AU  - Avramov Ivić, Milka
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3383
AB  - In this study the electrochemical behavior of metformin (MET), oral antihyperglycaemic agent, was assayed at three different electrodes. The drug standard was investigated by cyclic voltammetry (CV) and square wave volta-mmetry (SWV) via its electrooxidation at Au and glassy carbon (GC) electrode in 0.05 M NaHCO3. Under these conditions transformation of MET to corresponding N-carbonyl guanidine via oxime intermediate is suggested. The stability of MET was tested under directed stress conditions using IrOx elec-trode with sodium sulphate as an electrolyte and cyclic 4-amino-2-imino-1-me-thyl-1,2-dihydro-1,3,5-triazine (4,2,1-AIMT) appeared as the main end-product. The courses of the electrochemical processes at three electrodes are followed by UV spectroscopy and evaluated by total organic carbon (TOC) analysis.
AB  - У оквиру рада изучавано је електрохемијско понашање метформина, лека са антихипергликемијским дејством, на три различите електроде. Стандард лека испитан јецикличном волтаметријом и волтаметријом са правоугаоним импулсима у 0,05 Мраствору NaHCO3 на елекроди од злата и електроди од стакластог угљеника. Под овимусловима, предложена је трансформација лека до одговарајућег N-карбонил гуанидинапреко оксима као интермедијера. Стабилност метформина тестирана је и под условимаелектрохемијске оксидације на IrOx електроди у присуству натријум сулфата каоелектолита. У овом случају, предложено је настајање цикличног 4-амино-2-имино-1-метил-1,2-дихидро-1,3,5-триазина као главног производа. Ток електрохемијских процесана све три електроде праћен је УВ спектроскопијом. Степен минерализације утврђен јеанализом укупног органског угљеника.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes
T1  - Електрохемијска стабилност метформина у воденим растворима NaHCO3 И Na2SO4 на Au, GC и IrOx електродама
VL  - 84
IS  - 11
SP  - 1319
EP  - 1327
DO  - 10.2298/JSC190731091L
ER  - 

@article{
author = "Lović, Jelena and Lađarević, Jelena and Mijin, Dušan and Jadranin, Milka and Petrović, Slobodan D. and Avramov Ivić, Milka",
year = "2019",
abstract = "In this study the electrochemical behavior of metformin (MET), oral antihyperglycaemic agent, was assayed at three different electrodes. The drug standard was investigated by cyclic voltammetry (CV) and square wave volta-mmetry (SWV) via its electrooxidation at Au and glassy carbon (GC) electrode in 0.05 M NaHCO3. Under these conditions transformation of MET to corresponding N-carbonyl guanidine via oxime intermediate is suggested. The stability of MET was tested under directed stress conditions using IrOx elec-trode with sodium sulphate as an electrolyte and cyclic 4-amino-2-imino-1-me-thyl-1,2-dihydro-1,3,5-triazine (4,2,1-AIMT) appeared as the main end-product. The courses of the electrochemical processes at three electrodes are followed by UV spectroscopy and evaluated by total organic carbon (TOC) analysis., У оквиру рада изучавано је електрохемијско понашање метформина, лека са антихипергликемијским дејством, на три различите електроде. Стандард лека испитан јецикличном волтаметријом и волтаметријом са правоугаоним импулсима у 0,05 Мраствору NaHCO3 на елекроди од злата и електроди од стакластог угљеника. Под овимусловима, предложена је трансформација лека до одговарајућег N-карбонил гуанидинапреко оксима као интермедијера. Стабилност метформина тестирана је и под условимаелектрохемијске оксидације на IrOx електроди у присуству натријум сулфата каоелектолита. У овом случају, предложено је настајање цикличног 4-амино-2-имино-1-метил-1,2-дихидро-1,3,5-триазина као главног производа. Ток електрохемијских процесана све три електроде праћен је УВ спектроскопијом. Степен минерализације утврђен јеанализом укупног органског угљеника.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes, Електрохемијска стабилност метформина у воденим растворима NaHCO3 И Na2SO4 на Au, GC и IrOx електродама",
volume = "84",
number = "11",
pages = "1319-1327",
doi = "10.2298/JSC190731091L"
}

Lović, J., Lađarević, J., Mijin, D., Jadranin, M., Petrović, S. D.,& Avramov Ivić, M.. (2019). Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 84(11), 1319-1327.
https://doi.org/10.2298/JSC190731091L

Lović J, Lađarević J, Mijin D, Jadranin M, Petrović SD, Avramov Ivić M. Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes. in Journal of the Serbian Chemical Society. 2019;84(11):1319-1327.
doi:10.2298/JSC190731091L .

Lović, Jelena, Lađarević, Jelena, Mijin, Dušan, Jadranin, Milka, Petrović, Slobodan D., Avramov Ivić, Milka, "Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes" in Journal of the Serbian Chemical Society, 84, no. 11 (2019):1319-1327,
https://doi.org/10.2298/JSC190731091L . .

TY  - JOUR
AU  - Trišović, Nemanja
AU  - Radovanović, Lidija
AU  - Janjić, Goran
AU  - Jelić, Stefan
AU  - Rogan, Jelena R.
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3277
AB  - A series of five derivatives of the anticonvulsant drug phenytoin was synthesized, and their crystal structures were determined. The relationship between the molecular and crystal structure of the investigated compounds was rationalized in the context of contribution of intermolecular interactions and supramolecular structural motifs. The conformational preferences were analyzed by comparing the rotational freedom of the phenyl groups in the investigated compounds with 5,5-diphenylhydantoins from the Cambridge Structural Database. With the exception of compound 3 bearing the cyclopropyl group, the crystal packing of the investigated compounds contains centrosymmetric dimers linked by paired N–H···O hydrogen bonds, which further self-organize through pairs of C–H···O interactions and a parallel interaction of two phenyl rings at a large offset into chains running along the c-axis. The principal feature of the crystal structure of compound 3 is formation of the chains by N–H···O hydrogen bonds and C–H···O and C–H···π interactions. The coordination of phenytoin enables more rotational freedom for the phenyl groups. An emphasis was placed on docking of the investigated compounds into the voltage-gated ion channel in the open and closed state. The obtained results indicate that hydrogen bonding and hydrophobic interactions are dominant in stabilizing energetically favored orientations of the investigated compounds bound to the protein.
PB  - American Chemical Society (ACS)
T2  - Crystal Growth & Design
T1  - Substituent Effects on the Patterns of Intermolecular Interactions of 3-Alkyl and 3-Cycloalkyl Derivatives of Phenytoin: A Crystallographic and Quantum-Chemical Study
VL  - 19
IS  - 4
SP  - 2163
EP  - 2174
DO  - 10.1021/acs.cgd.8b01776
ER  - 

@article{
author = "Trišović, Nemanja and Radovanović, Lidija and Janjić, Goran and Jelić, Stefan and Rogan, Jelena R.",
year = "2019",
abstract = "A series of five derivatives of the anticonvulsant drug phenytoin was synthesized, and their crystal structures were determined. The relationship between the molecular and crystal structure of the investigated compounds was rationalized in the context of contribution of intermolecular interactions and supramolecular structural motifs. The conformational preferences were analyzed by comparing the rotational freedom of the phenyl groups in the investigated compounds with 5,5-diphenylhydantoins from the Cambridge Structural Database. With the exception of compound 3 bearing the cyclopropyl group, the crystal packing of the investigated compounds contains centrosymmetric dimers linked by paired N–H···O hydrogen bonds, which further self-organize through pairs of C–H···O interactions and a parallel interaction of two phenyl rings at a large offset into chains running along the c-axis. The principal feature of the crystal structure of compound 3 is formation of the chains by N–H···O hydrogen bonds and C–H···O and C–H···π interactions. The coordination of phenytoin enables more rotational freedom for the phenyl groups. An emphasis was placed on docking of the investigated compounds into the voltage-gated ion channel in the open and closed state. The obtained results indicate that hydrogen bonding and hydrophobic interactions are dominant in stabilizing energetically favored orientations of the investigated compounds bound to the protein.",
publisher = "American Chemical Society (ACS)",
journal = "Crystal Growth & Design",
title = "Substituent Effects on the Patterns of Intermolecular Interactions of 3-Alkyl and 3-Cycloalkyl Derivatives of Phenytoin: A Crystallographic and Quantum-Chemical Study",
volume = "19",
number = "4",
pages = "2163-2174",
doi = "10.1021/acs.cgd.8b01776"
}

Trišović, N., Radovanović, L., Janjić, G., Jelić, S.,& Rogan, J. R.. (2019). Substituent Effects on the Patterns of Intermolecular Interactions of 3-Alkyl and 3-Cycloalkyl Derivatives of Phenytoin: A Crystallographic and Quantum-Chemical Study. in Crystal Growth & Design
American Chemical Society (ACS)., 19(4), 2163-2174.
https://doi.org/10.1021/acs.cgd.8b01776

Trišović N, Radovanović L, Janjić G, Jelić S, Rogan JR. Substituent Effects on the Patterns of Intermolecular Interactions of 3-Alkyl and 3-Cycloalkyl Derivatives of Phenytoin: A Crystallographic and Quantum-Chemical Study. in Crystal Growth & Design. 2019;19(4):2163-2174.
doi:10.1021/acs.cgd.8b01776 .

Trišović, Nemanja, Radovanović, Lidija, Janjić, Goran, Jelić, Stefan, Rogan, Jelena R., "Substituent Effects on the Patterns of Intermolecular Interactions of 3-Alkyl and 3-Cycloalkyl Derivatives of Phenytoin: A Crystallographic and Quantum-Chemical Study" in Crystal Growth & Design, 19, no. 4 (2019):2163-2174,
https://doi.org/10.1021/acs.cgd.8b01776 . .

TY  - JOUR
AU  - Trišović, Nemanja
AU  - Radovanović, Lidija
AU  - Janjić, Goran
AU  - Jelić, Stefan
AU  - Rogan, Jelena R.
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3278
AB  - A series of five derivatives of the anticonvulsant drug phenytoin was synthesized, and their crystal structures were determined. The relationship between the molecular and crystal structure of the investigated compounds was rationalized in the context of contribution of intermolecular interactions and supramolecular structural motifs. The conformational preferences were analyzed by comparing the rotational freedom of the phenyl groups in the investigated compounds with 5,5-diphenylhydantoins from the Cambridge Structural Database. With the exception of compound 3 bearing the cyclopropyl group, the crystal packing of the investigated compounds contains centrosymmetric dimers linked by paired N–H···O hydrogen bonds, which further self-organize through pairs of C–H···O interactions and a parallel interaction of two phenyl rings at a large offset into chains running along the c-axis. The principal feature of the crystal structure of compound 3 is formation of the chains by N–H···O hydrogen bonds and C–H···O and C–H···π interactions. The coordination of phenytoin enables more rotational freedom for the phenyl groups. An emphasis was placed on docking of the investigated compounds into the voltage-gated ion channel in the open and closed state. The obtained results indicate that hydrogen bonding and hydrophobic interactions are dominant in stabilizing energetically favored orientations of the investigated compounds bound to the protein.
PB  - American Chemical Society (ACS)
T2  - Crystal Growth & Design
T1  - Substituent Effects on the Patterns of Intermolecular Interactions of 3-Alkyl and 3-Cycloalkyl Derivatives of Phenytoin: A Crystallographic and Quantum-Chemical Study
VL  - 19
IS  - 4
SP  - 2163
EP  - 2174
DO  - 10.1021/acs.cgd.8b01776
ER  - 

@article{
author = "Trišović, Nemanja and Radovanović, Lidija and Janjić, Goran and Jelić, Stefan and Rogan, Jelena R.",
year = "2019",
abstract = "A series of five derivatives of the anticonvulsant drug phenytoin was synthesized, and their crystal structures were determined. The relationship between the molecular and crystal structure of the investigated compounds was rationalized in the context of contribution of intermolecular interactions and supramolecular structural motifs. The conformational preferences were analyzed by comparing the rotational freedom of the phenyl groups in the investigated compounds with 5,5-diphenylhydantoins from the Cambridge Structural Database. With the exception of compound 3 bearing the cyclopropyl group, the crystal packing of the investigated compounds contains centrosymmetric dimers linked by paired N–H···O hydrogen bonds, which further self-organize through pairs of C–H···O interactions and a parallel interaction of two phenyl rings at a large offset into chains running along the c-axis. The principal feature of the crystal structure of compound 3 is formation of the chains by N–H···O hydrogen bonds and C–H···O and C–H···π interactions. The coordination of phenytoin enables more rotational freedom for the phenyl groups. An emphasis was placed on docking of the investigated compounds into the voltage-gated ion channel in the open and closed state. The obtained results indicate that hydrogen bonding and hydrophobic interactions are dominant in stabilizing energetically favored orientations of the investigated compounds bound to the protein.",
publisher = "American Chemical Society (ACS)",
journal = "Crystal Growth & Design",
title = "Substituent Effects on the Patterns of Intermolecular Interactions of 3-Alkyl and 3-Cycloalkyl Derivatives of Phenytoin: A Crystallographic and Quantum-Chemical Study",
volume = "19",
number = "4",
pages = "2163-2174",
doi = "10.1021/acs.cgd.8b01776"
}

Trišović, N., Radovanović, L., Janjić, G., Jelić, S.,& Rogan, J. R.. (2019). Substituent Effects on the Patterns of Intermolecular Interactions of 3-Alkyl and 3-Cycloalkyl Derivatives of Phenytoin: A Crystallographic and Quantum-Chemical Study. in Crystal Growth & Design
American Chemical Society (ACS)., 19(4), 2163-2174.
https://doi.org/10.1021/acs.cgd.8b01776

Trišović N, Radovanović L, Janjić G, Jelić S, Rogan JR. Substituent Effects on the Patterns of Intermolecular Interactions of 3-Alkyl and 3-Cycloalkyl Derivatives of Phenytoin: A Crystallographic and Quantum-Chemical Study. in Crystal Growth & Design. 2019;19(4):2163-2174.
doi:10.1021/acs.cgd.8b01776 .

Trišović, Nemanja, Radovanović, Lidija, Janjić, Goran, Jelić, Stefan, Rogan, Jelena R., "Substituent Effects on the Patterns of Intermolecular Interactions of 3-Alkyl and 3-Cycloalkyl Derivatives of Phenytoin: A Crystallographic and Quantum-Chemical Study" in Crystal Growth & Design, 19, no. 4 (2019):2163-2174,
https://doi.org/10.1021/acs.cgd.8b01776 . .

TY  - JOUR
AU  - Lazić, Anita M.
AU  - Radovanović, Lidija D.
AU  - Božić, Bojan
AU  - Božić, Nedeljković B.
AU  - Vitnik, Vesna
AU  - Vitnik, Željko
AU  - Rogan, Jelena R.
AU  - Valentić, Nataša V.
AU  - Ušćumlić, Gordana
AU  - Trišović, Nemanja
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2489
AB  - Two series of cycloalkanespiro-5-hydantoins, namely cyclohexanespiro-5-hydantoins and cycloheptanespiro-5-hydantoins with a 4-substituted benzyl or a 2-(4-substituted phenyl)-2-oxoethyl group at N3 position, were synthesized and their effects on proliferation of human colon (HCT-116), leukemia (K562) and breast (MDA-MB-231) cancer cell lines were tested. For comparison, we also described the 5,5-diphenylhydantoin analogues. The structural features of the investigated compounds were characterized by elemental analysis, FT-IR, UV–Vis, 1H and 13C NMR spectroscopy and X-ray crystallography. Regarding their structure–activity relationships, it was shown that the substitution on the benzyl moiety with the methoxy, chloro or bromo group potentiated the antiproliferative activity relative to the parent compounds, while an increase in the size of the cycloalkyl group resulted mostly in a decrease of the antiproliferative activity. The single crystal X-ray analysis revealed the existence of dimers and chains formed by the N–H⋯O hydrogen bonds. The analysis of the molecular descriptors of Lipinski demonstrated that all investigated compounds obeyed the rule of five. To further understand their geometry and electronic structure, DFT calculations with B3LYP method using 6-311++G(d,p) basic set were performed. In this context, the UV–Vis spectra of the investigated compounds were analyzed in detail, whereby the predicted absorption spectra from DFT calculation matched the experimentally obtained ones, with a good correlation. The interesting physico-chemical and pharmacologically relevant properties of the investigated compounds warrant their further investigation.
PB  - Elsevier
T2  - Journal of Molecular Structure
T1  - Synthesis, structural characterization, DFT calculations and antiproliferative evaluation of novel spirohydantoin derivatives containing a substituted benzyl moiety
VL  - 1180
SP  - 48
EP  - 62
DO  - 10.1016/j.molstruc.2018.11.071
ER  - 

@article{
author = "Lazić, Anita M. and Radovanović, Lidija D. and Božić, Bojan and Božić, Nedeljković B. and Vitnik, Vesna and Vitnik, Željko and Rogan, Jelena R. and Valentić, Nataša V. and Ušćumlić, Gordana and Trišović, Nemanja",
year = "2019",
abstract = "Two series of cycloalkanespiro-5-hydantoins, namely cyclohexanespiro-5-hydantoins and cycloheptanespiro-5-hydantoins with a 4-substituted benzyl or a 2-(4-substituted phenyl)-2-oxoethyl group at N3 position, were synthesized and their effects on proliferation of human colon (HCT-116), leukemia (K562) and breast (MDA-MB-231) cancer cell lines were tested. For comparison, we also described the 5,5-diphenylhydantoin analogues. The structural features of the investigated compounds were characterized by elemental analysis, FT-IR, UV–Vis, 1H and 13C NMR spectroscopy and X-ray crystallography. Regarding their structure–activity relationships, it was shown that the substitution on the benzyl moiety with the methoxy, chloro or bromo group potentiated the antiproliferative activity relative to the parent compounds, while an increase in the size of the cycloalkyl group resulted mostly in a decrease of the antiproliferative activity. The single crystal X-ray analysis revealed the existence of dimers and chains formed by the N–H⋯O hydrogen bonds. The analysis of the molecular descriptors of Lipinski demonstrated that all investigated compounds obeyed the rule of five. To further understand their geometry and electronic structure, DFT calculations with B3LYP method using 6-311++G(d,p) basic set were performed. In this context, the UV–Vis spectra of the investigated compounds were analyzed in detail, whereby the predicted absorption spectra from DFT calculation matched the experimentally obtained ones, with a good correlation. The interesting physico-chemical and pharmacologically relevant properties of the investigated compounds warrant their further investigation.",
publisher = "Elsevier",
journal = "Journal of Molecular Structure",
title = "Synthesis, structural characterization, DFT calculations and antiproliferative evaluation of novel spirohydantoin derivatives containing a substituted benzyl moiety",
volume = "1180",
pages = "48-62",
doi = "10.1016/j.molstruc.2018.11.071"
}

Lazić, A. M., Radovanović, L. D., Božić, B., Božić, N. B., Vitnik, V., Vitnik, Ž., Rogan, J. R., Valentić, N. V., Ušćumlić, G.,& Trišović, N.. (2019). Synthesis, structural characterization, DFT calculations and antiproliferative evaluation of novel spirohydantoin derivatives containing a substituted benzyl moiety. in Journal of Molecular Structure
Elsevier., 1180, 48-62.
https://doi.org/10.1016/j.molstruc.2018.11.071

Lazić AM, Radovanović LD, Božić B, Božić NB, Vitnik V, Vitnik Ž, Rogan JR, Valentić NV, Ušćumlić G, Trišović N. Synthesis, structural characterization, DFT calculations and antiproliferative evaluation of novel spirohydantoin derivatives containing a substituted benzyl moiety. in Journal of Molecular Structure. 2019;1180:48-62.
doi:10.1016/j.molstruc.2018.11.071 .

Lazić, Anita M., Radovanović, Lidija D., Božić, Bojan, Božić, Nedeljković B., Vitnik, Vesna, Vitnik, Željko, Rogan, Jelena R., Valentić, Nataša V., Ušćumlić, Gordana, Trišović, Nemanja, "Synthesis, structural characterization, DFT calculations and antiproliferative evaluation of novel spirohydantoin derivatives containing a substituted benzyl moiety" in Journal of Molecular Structure, 1180 (2019):48-62,
https://doi.org/10.1016/j.molstruc.2018.11.071 . .

TY  - JOUR
AU  - Cvetković, J.P.
AU  - Božić, Bojan
AU  - Banjac, Nebojša R.
AU  - Petrović, J.
AU  - Soković, Marina
AU  - Vitnik, Vesna
AU  - Vitnik, Željko
AU  - Ušćumlić, Gordana
AU  - Valentić, Nataša V.
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2494
AB  - In the present study, twelve new 1-aryl-3-ethyl-3-methylpyrrolidine-2,5-diones were synthesized and their structures were characterized by FT-IR, 1H NMR, 13C NMR spectroscopy and elemental analysis. In the final step of synthetic rout, condensation between corresponding succinic acid and substituted anilines has been improved using the microwave irradiation. Significantly higher yields compared to conventional condensation have been observed. The preliminary biological results indicated that some of the synthesized compounds showed promising in vitro antifungal activities towards several test fungi. 1-(4-Bromophenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione (8) exhibited significant in vitro inhibitory activities against broad spectra of fungus, and on the basis of obtained data, the investigated bromo derivative has to be observed as novel potential fungicide. The density functional theory (DFT) calculations have been performed in order to study the structure-activity relationship (SAR) of the investigated molecules. In order to prediction of the chemical activity of the molecule, the molecular electrostatic potential (MEP) map was analyzed for the optimized geometry of 1-phenyl-3-ethyl-3-methylpyrrolidine-2,5-dione (4) and 1-(4-bromophenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione (8).
PB  - Elsevier
T2  - Journal of Molecular Structure
T1  - Synthesis, antimicrobial activity and quantum chemical investigation of novel succinimide derivatives
VL  - 1181
SP  - 148
EP  - 156
DO  - 10.1016/j.molstruc.2018.12.083
ER  - 

@article{
author = "Cvetković, J.P. and Božić, Bojan and Banjac, Nebojša R. and Petrović, J. and Soković, Marina and Vitnik, Vesna and Vitnik, Željko and Ušćumlić, Gordana and Valentić, Nataša V.",
year = "2019",
abstract = "In the present study, twelve new 1-aryl-3-ethyl-3-methylpyrrolidine-2,5-diones were synthesized and their structures were characterized by FT-IR, 1H NMR, 13C NMR spectroscopy and elemental analysis. In the final step of synthetic rout, condensation between corresponding succinic acid and substituted anilines has been improved using the microwave irradiation. Significantly higher yields compared to conventional condensation have been observed. The preliminary biological results indicated that some of the synthesized compounds showed promising in vitro antifungal activities towards several test fungi. 1-(4-Bromophenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione (8) exhibited significant in vitro inhibitory activities against broad spectra of fungus, and on the basis of obtained data, the investigated bromo derivative has to be observed as novel potential fungicide. The density functional theory (DFT) calculations have been performed in order to study the structure-activity relationship (SAR) of the investigated molecules. In order to prediction of the chemical activity of the molecule, the molecular electrostatic potential (MEP) map was analyzed for the optimized geometry of 1-phenyl-3-ethyl-3-methylpyrrolidine-2,5-dione (4) and 1-(4-bromophenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione (8).",
publisher = "Elsevier",
journal = "Journal of Molecular Structure",
title = "Synthesis, antimicrobial activity and quantum chemical investigation of novel succinimide derivatives",
volume = "1181",
pages = "148-156",
doi = "10.1016/j.molstruc.2018.12.083"
}

Cvetković, J.P., Božić, B., Banjac, N. R., Petrović, J., Soković, M., Vitnik, V., Vitnik, Ž., Ušćumlić, G.,& Valentić, N. V.. (2019). Synthesis, antimicrobial activity and quantum chemical investigation of novel succinimide derivatives. in Journal of Molecular Structure
Elsevier., 1181, 148-156.
https://doi.org/10.1016/j.molstruc.2018.12.083

Cvetković J, Božić B, Banjac NR, Petrović J, Soković M, Vitnik V, Vitnik Ž, Ušćumlić G, Valentić NV. Synthesis, antimicrobial activity and quantum chemical investigation of novel succinimide derivatives. in Journal of Molecular Structure. 2019;1181:148-156.
doi:10.1016/j.molstruc.2018.12.083 .

Cvetković, J.P., Božić, Bojan, Banjac, Nebojša R., Petrović, J., Soković, Marina, Vitnik, Vesna, Vitnik, Željko, Ušćumlić, Gordana, Valentić, Nataša V., "Synthesis, antimicrobial activity and quantum chemical investigation of novel succinimide derivatives" in Journal of Molecular Structure, 1181 (2019):148-156,
https://doi.org/10.1016/j.molstruc.2018.12.083 . .

TY  - JOUR
AU  - Lazić, Anita M.
AU  - Radovanović, Lidija D.
AU  - Božić, Bojan
AU  - Božić, Nedeljković B.
AU  - Vitnik, Vesna
AU  - Vitnik, Željko
AU  - Rogan, Jelena R.
AU  - Valentić, Nataša V.
AU  - Ušćumlić, Gordana
AU  - Trišović, Nemanja
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2906
AB  - Two series of cycloalkanespiro-5-hydantoins, namely cyclohexanespiro-5-hydantoins and cycloheptanespiro-5-hydantoins with a 4-substituted benzyl or a 2-(4-substituted phenyl)-2-oxoethyl group at N3 position, were synthesized and their effects on proliferation of human colon (HCT-116), leukemia (K562) and breast (MDA-MB-231) cancer cell lines were tested. For comparison, we also described the 5,5-diphenylhydantoin analogues. The structural features of the investigated compounds were characterized by elemental analysis, FT-IR, UV–Vis, 1H and 13C NMR spectroscopy and X-ray crystallography. Regarding their structure–activity relationships, it was shown that the substitution on the benzyl moiety with the methoxy, chloro or bromo group potentiated the antiproliferative activity relative to the parent compounds, while an increase in the size of the cycloalkyl group resulted mostly in a decrease of the antiproliferative activity. The single crystal X-ray analysis revealed the existence of dimers and chains formed by the N–H⋯O hydrogen bonds. The analysis of the molecular descriptors of Lipinski demonstrated that all investigated compounds obeyed the rule of five. To further understand their geometry and electronic structure, DFT calculations with B3LYP method using 6-311++G(d,p) basic set were performed. In this context, the UV–Vis spectra of the investigated compounds were analyzed in detail, whereby the predicted absorption spectra from DFT calculation matched the experimentally obtained ones, with a good correlation. The interesting physico-chemical and pharmacologically relevant properties of the investigated compounds warrant their further investigation.
PB  - Elsevier
T2  - Journal of Molecular Structure
T1  - Synthesis, structural characterization, DFT calculations and antiproliferative evaluation of novel spirohydantoin derivatives containing a substituted benzyl moiety
VL  - 1180
SP  - 48
EP  - 62
DO  - 10.1016/j.molstruc.2018.11.071
ER  - 

@article{
author = "Lazić, Anita M. and Radovanović, Lidija D. and Božić, Bojan and Božić, Nedeljković B. and Vitnik, Vesna and Vitnik, Željko and Rogan, Jelena R. and Valentić, Nataša V. and Ušćumlić, Gordana and Trišović, Nemanja",
year = "2019",
abstract = "Two series of cycloalkanespiro-5-hydantoins, namely cyclohexanespiro-5-hydantoins and cycloheptanespiro-5-hydantoins with a 4-substituted benzyl or a 2-(4-substituted phenyl)-2-oxoethyl group at N3 position, were synthesized and their effects on proliferation of human colon (HCT-116), leukemia (K562) and breast (MDA-MB-231) cancer cell lines were tested. For comparison, we also described the 5,5-diphenylhydantoin analogues. The structural features of the investigated compounds were characterized by elemental analysis, FT-IR, UV–Vis, 1H and 13C NMR spectroscopy and X-ray crystallography. Regarding their structure–activity relationships, it was shown that the substitution on the benzyl moiety with the methoxy, chloro or bromo group potentiated the antiproliferative activity relative to the parent compounds, while an increase in the size of the cycloalkyl group resulted mostly in a decrease of the antiproliferative activity. The single crystal X-ray analysis revealed the existence of dimers and chains formed by the N–H⋯O hydrogen bonds. The analysis of the molecular descriptors of Lipinski demonstrated that all investigated compounds obeyed the rule of five. To further understand their geometry and electronic structure, DFT calculations with B3LYP method using 6-311++G(d,p) basic set were performed. In this context, the UV–Vis spectra of the investigated compounds were analyzed in detail, whereby the predicted absorption spectra from DFT calculation matched the experimentally obtained ones, with a good correlation. The interesting physico-chemical and pharmacologically relevant properties of the investigated compounds warrant their further investigation.",
publisher = "Elsevier",
journal = "Journal of Molecular Structure",
title = "Synthesis, structural characterization, DFT calculations and antiproliferative evaluation of novel spirohydantoin derivatives containing a substituted benzyl moiety",
volume = "1180",
pages = "48-62",
doi = "10.1016/j.molstruc.2018.11.071"
}

Lazić, A. M., Radovanović, L. D., Božić, B., Božić, N. B., Vitnik, V., Vitnik, Ž., Rogan, J. R., Valentić, N. V., Ušćumlić, G.,& Trišović, N.. (2019). Synthesis, structural characterization, DFT calculations and antiproliferative evaluation of novel spirohydantoin derivatives containing a substituted benzyl moiety. in Journal of Molecular Structure
Elsevier., 1180, 48-62.
https://doi.org/10.1016/j.molstruc.2018.11.071

Lazić AM, Radovanović LD, Božić B, Božić NB, Vitnik V, Vitnik Ž, Rogan JR, Valentić NV, Ušćumlić G, Trišović N. Synthesis, structural characterization, DFT calculations and antiproliferative evaluation of novel spirohydantoin derivatives containing a substituted benzyl moiety. in Journal of Molecular Structure. 2019;1180:48-62.
doi:10.1016/j.molstruc.2018.11.071 .

Lazić, Anita M., Radovanović, Lidija D., Božić, Bojan, Božić, Nedeljković B., Vitnik, Vesna, Vitnik, Željko, Rogan, Jelena R., Valentić, Nataša V., Ušćumlić, Gordana, Trišović, Nemanja, "Synthesis, structural characterization, DFT calculations and antiproliferative evaluation of novel spirohydantoin derivatives containing a substituted benzyl moiety" in Journal of Molecular Structure, 1180 (2019):48-62,
https://doi.org/10.1016/j.molstruc.2018.11.071 . .

TY  - JOUR
AU  - Petković Cvetković, Jelena
AU  - Božić, Bojan
AU  - Banjac, Nebojša R.
AU  - Lađarević, Jelena
AU  - Vitnik, Vesna
AU  - Vitnik, Željko
AU  - Valentić, Nataša V.
AU  - Ušćumlić, Gordana
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3206
AB  - Novel succinimide derivatives were synthesized from 3-methyl-3-phenylsuccinic acid and substituted anilines under solvent-free conditions by using microwave irradiation. All obtained compounds were characterized by ultraviolet (UV), Fourier-transform infrared (FT-IR), 1H and 13С nuclear magnetic resonance (NMR) spectroscopy as well as by elemental analysis. The influence of the substituent electronic effects on spectroscopic data was analyzed by applying the Hammett equation. Moreover, a detailed interpretation and comparison of experimentally obtained and theoretically calculated FT-IR, UV and NMR spectra was performed. Density functional theory (DFT) calculated data of the investigated succinimides were obtained and analyzed in order to determine their structural, spectroscopic and electronic properties. Furthermore, ADMET factor profiling and in-silico prediction of potential biological activities of novel succinimide derivatives have been performed.
AB  - Novi derivati sukcinimida sintetisani su polazeći od 3-metil-3-fenilćilibarne kiseline i supstituisanih analina u mikrotalasnom reaktoru u odsustvu rastvarača. Sva jedinjenja su okarakterisana primenom UV-vidljive spektroskopije, infracrvene spektroskopije sa Furijeovom transformacijom (FT-IR), protonske nuklearne magnetne rezonancije (1H NMR), nuklearne magnetne rezonancije ugljenika-13, (13С NMR), kao i elementalnom analizom. Uticaj elektronskih efekata supstituenata na spektroskopske podatke analiziran je upotrebom Hametove jednačine. Takođe, izvršena je detaljna interpretacija, kao i poređenje eksperimentalno dobijenih i teorijski izračunatih FT-IR, UV i NMR spektara. Pored toga, urađeno je ADMET (engl. absorption, distribution, metabolism, excretion and toxicity) profilisanje i in-silico predviđanje potencijalne biološke aktivnosti novosintetisanih derivata sukcinimida.
PB  - Belgrade : Association of the Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - Spectroscopic and quantum chemical elucidation of newly synthesized 1-aryl-3-methyl-3-phenylpyrrolidine-2,5-diones as potential anticonvulsant agents
VL  - 73
IS  - 2
SP  - 125
EP  - 137
DO  - 10.2298/HEMIND190214011P
ER  - 

@article{
author = "Petković Cvetković, Jelena and Božić, Bojan and Banjac, Nebojša R. and Lađarević, Jelena and Vitnik, Vesna and Vitnik, Željko and Valentić, Nataša V. and Ušćumlić, Gordana",
year = "2019",
abstract = "Novel succinimide derivatives were synthesized from 3-methyl-3-phenylsuccinic acid and substituted anilines under solvent-free conditions by using microwave irradiation. All obtained compounds were characterized by ultraviolet (UV), Fourier-transform infrared (FT-IR), 1H and 13С nuclear magnetic resonance (NMR) spectroscopy as well as by elemental analysis. The influence of the substituent electronic effects on spectroscopic data was analyzed by applying the Hammett equation. Moreover, a detailed interpretation and comparison of experimentally obtained and theoretically calculated FT-IR, UV and NMR spectra was performed. Density functional theory (DFT) calculated data of the investigated succinimides were obtained and analyzed in order to determine their structural, spectroscopic and electronic properties. Furthermore, ADMET factor profiling and in-silico prediction of potential biological activities of novel succinimide derivatives have been performed., Novi derivati sukcinimida sintetisani su polazeći od 3-metil-3-fenilćilibarne kiseline i supstituisanih analina u mikrotalasnom reaktoru u odsustvu rastvarača. Sva jedinjenja su okarakterisana primenom UV-vidljive spektroskopije, infracrvene spektroskopije sa Furijeovom transformacijom (FT-IR), protonske nuklearne magnetne rezonancije (1H NMR), nuklearne magnetne rezonancije ugljenika-13, (13С NMR), kao i elementalnom analizom. Uticaj elektronskih efekata supstituenata na spektroskopske podatke analiziran je upotrebom Hametove jednačine. Takođe, izvršena je detaljna interpretacija, kao i poređenje eksperimentalno dobijenih i teorijski izračunatih FT-IR, UV i NMR spektara. Pored toga, urađeno je ADMET (engl. absorption, distribution, metabolism, excretion and toxicity) profilisanje i in-silico predviđanje potencijalne biološke aktivnosti novosintetisanih derivata sukcinimida.",
publisher = "Belgrade : Association of the Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "Spectroscopic and quantum chemical elucidation of newly synthesized 1-aryl-3-methyl-3-phenylpyrrolidine-2,5-diones as potential anticonvulsant agents",
volume = "73",
number = "2",
pages = "125-137",
doi = "10.2298/HEMIND190214011P"
}

Petković Cvetković, J., Božić, B., Banjac, N. R., Lađarević, J., Vitnik, V., Vitnik, Ž., Valentić, N. V.,& Ušćumlić, G.. (2019). Spectroscopic and quantum chemical elucidation of newly synthesized 1-aryl-3-methyl-3-phenylpyrrolidine-2,5-diones as potential anticonvulsant agents. in Hemijska industrija
Belgrade : Association of the Chemical Engineers of Serbia., 73(2), 125-137.
https://doi.org/10.2298/HEMIND190214011P

Petković Cvetković J, Božić B, Banjac NR, Lađarević J, Vitnik V, Vitnik Ž, Valentić NV, Ušćumlić G. Spectroscopic and quantum chemical elucidation of newly synthesized 1-aryl-3-methyl-3-phenylpyrrolidine-2,5-diones as potential anticonvulsant agents. in Hemijska industrija. 2019;73(2):125-137.
doi:10.2298/HEMIND190214011P .

Petković Cvetković, Jelena, Božić, Bojan, Banjac, Nebojša R., Lađarević, Jelena, Vitnik, Vesna, Vitnik, Željko, Valentić, Nataša V., Ušćumlić, Gordana, "Spectroscopic and quantum chemical elucidation of newly synthesized 1-aryl-3-methyl-3-phenylpyrrolidine-2,5-diones as potential anticonvulsant agents" in Hemijska industrija, 73, no. 2 (2019):125-137,
https://doi.org/10.2298/HEMIND190214011P . .

TY  - CONF
AU  - Lović, Jelena
AU  - Avramov Ivić, Milka
AU  - Lađarević, Jelena
AU  - Mijin, Dušan
AU  - Stevanović, Sanja
AU  - Nikolić, Nebojša D.
AU  - Vuković, Dragan
AU  - Petrović, Slobodan
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6319
AB  - Esomeprazole has been shown to be the most effective oral PPI for controlling
intragastric pH. The persistence of esomeprasole in environmental systems
could be solved by different types of its degradation. In this work
electrocatalytic degradation of esomeprasole has been investigated in the
presence of sodium sulfate and sodium chloride using IrOx electrode and was
monitored using UV-Vis spectrophotometer at 303 nm. Also the electro
degradation process was examined and on Au electrode. NanoScope III A
(Veeco, USA) microscope was used to study the morphology of Esomeprazole
on the gold surface by atomic force microscopy. By optical microscopy the
morphology of Esomeprazole dissolved in human serum on the gold surface
was studied as well.
PB  - Crnogorsko društvo za koroziju, zaštitu materijala i zaštitu životne sredine
C3  - Proceedings - Fourth international symposium on corrosion and materials protection, environmental protection and protection against fire, 18-21. 09. 2018, Bar / Knjiga radova - Četvrti međunarodni simpozijum o koroziji i zaštiti materijala, životnoj sredini i zaštiti od požara, 18-21. septembar 2018. godine, Bar, 2018
T1  - Electrochemical degradation of esomeprazole on different electrodes in a sense of environment protection
SP  - 61
EP  - 65
UR  - https://hdl.handle.net/21.15107/rcub_cer_6319
ER  - 

@conference{
author = "Lović, Jelena and Avramov Ivić, Milka and Lađarević, Jelena and Mijin, Dušan and Stevanović, Sanja and Nikolić, Nebojša D. and Vuković, Dragan and Petrović, Slobodan",
year = "2018",
abstract = "Esomeprazole has been shown to be the most effective oral PPI for controlling
intragastric pH. The persistence of esomeprasole in environmental systems
could be solved by different types of its degradation. In this work
electrocatalytic degradation of esomeprasole has been investigated in the
presence of sodium sulfate and sodium chloride using IrOx electrode and was
monitored using UV-Vis spectrophotometer at 303 nm. Also the electro
degradation process was examined and on Au electrode. NanoScope III A
(Veeco, USA) microscope was used to study the morphology of Esomeprazole
on the gold surface by atomic force microscopy. By optical microscopy the
morphology of Esomeprazole dissolved in human serum on the gold surface
was studied as well.",
publisher = "Crnogorsko društvo za koroziju, zaštitu materijala i zaštitu životne sredine",
journal = "Proceedings - Fourth international symposium on corrosion and materials protection, environmental protection and protection against fire, 18-21. 09. 2018, Bar / Knjiga radova - Četvrti međunarodni simpozijum o koroziji i zaštiti materijala, životnoj sredini i zaštiti od požara, 18-21. septembar 2018. godine, Bar, 2018",
title = "Electrochemical degradation of esomeprazole on different electrodes in a sense of environment protection",
pages = "61-65",
url = "https://hdl.handle.net/21.15107/rcub_cer_6319"
}

Lović, J., Avramov Ivić, M., Lađarević, J., Mijin, D., Stevanović, S., Nikolić, N. D., Vuković, D.,& Petrović, S.. (2018). Electrochemical degradation of esomeprazole on different electrodes in a sense of environment protection. in Proceedings - Fourth international symposium on corrosion and materials protection, environmental protection and protection against fire, 18-21. 09. 2018, Bar / Knjiga radova - Četvrti međunarodni simpozijum o koroziji i zaštiti materijala, životnoj sredini i zaštiti od požara, 18-21. septembar 2018. godine, Bar, 2018
Crnogorsko društvo za koroziju, zaštitu materijala i zaštitu životne sredine., 61-65.
https://hdl.handle.net/21.15107/rcub_cer_6319

Lović J, Avramov Ivić M, Lađarević J, Mijin D, Stevanović S, Nikolić ND, Vuković D, Petrović S. Electrochemical degradation of esomeprazole on different electrodes in a sense of environment protection. in Proceedings - Fourth international symposium on corrosion and materials protection, environmental protection and protection against fire, 18-21. 09. 2018, Bar / Knjiga radova - Četvrti međunarodni simpozijum o koroziji i zaštiti materijala, životnoj sredini i zaštiti od požara, 18-21. septembar 2018. godine, Bar, 2018. 2018;:61-65.
https://hdl.handle.net/21.15107/rcub_cer_6319 .

Lović, Jelena, Avramov Ivić, Milka, Lađarević, Jelena, Mijin, Dušan, Stevanović, Sanja, Nikolić, Nebojša D., Vuković, Dragan, Petrović, Slobodan, "Electrochemical degradation of esomeprazole on different electrodes in a sense of environment protection" in Proceedings - Fourth international symposium on corrosion and materials protection, environmental protection and protection against fire, 18-21. 09. 2018, Bar / Knjiga radova - Četvrti međunarodni simpozijum o koroziji i zaštiti materijala, životnoj sredini i zaštiti od požara, 18-21. septembar 2018. godine, Bar, 2018 (2018):61-65,
https://hdl.handle.net/21.15107/rcub_cer_6319 .

TY  - JOUR
AU  - Milošević, Milena
AU  - Prlainović, Nevena
AU  - Milčić, Miloš
AU  - Nikolić, Vesna
AU  - Božić, Aleksandra
AU  - Bigović, Miljan
AU  - Marinković, Aleksandar
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6959
AB  - 15 symmetric 1-methyl-2,6-bis[2-(substituted phenyl)ethenyl]pyridinium iodides were synthesized in this work. Their structures were characterized using IR, H-1 and C-13 NMR, and UV-Vis spectroscopy. DFT calculations indicated that s-trans/s-trans conformation prevail in all compounds. The effects of specific and non-specific solvent-solute interactions on the UV-Vis absorption maxima shifts were evaluated using linear solvation-free energy relationships (LSER), i.e., Kamlet-Taft and Catalan models. A linear free energy relationship (LFER) in the form of single substituent parameter equations (SSP) was used to postulate quantitative structure-property relations of substituent effect on NMR data. TD-DFT results showed dependence of electronic transition on the substituent effects. The push-pull character of these compounds was analyzed by differences in C-13 chemical shift of the ethylenic double bond in 2- and 6-positions of cross-conjugated with pyridinum central ring. Also, the quotient of the occupations for the bonding pi and anti-bonding pi* orbitals of this bond was considered. Good correlations of the selected parameter between double bond lengths with pi*/pi and C-13 chemical shift differences of the bridging group proved them to be adequate descriptor of push-pull character. Synthesized compounds were screened for the antioxidant activity, using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical methods, and results demonstrated moderate antioxidant potential.
PB  - Springer
T2  - Journal of the Iranian Chemical Society
T1  - Solvent, structural, quantum chemical study and antioxidative activity of symmetrical 1-methyl-2,6-bis[2-(substituted phenyl)ethenyl]pyridinium iodides
VL  - 15
IS  - 11
SP  - 2483
EP  - 2501
DO  - 10.1007/s13738-018-1437-5
ER  - 

@article{
author = "Milošević, Milena and Prlainović, Nevena and Milčić, Miloš and Nikolić, Vesna and Božić, Aleksandra and Bigović, Miljan and Marinković, Aleksandar",
year = "2018",
abstract = "15 symmetric 1-methyl-2,6-bis[2-(substituted phenyl)ethenyl]pyridinium iodides were synthesized in this work. Their structures were characterized using IR, H-1 and C-13 NMR, and UV-Vis spectroscopy. DFT calculations indicated that s-trans/s-trans conformation prevail in all compounds. The effects of specific and non-specific solvent-solute interactions on the UV-Vis absorption maxima shifts were evaluated using linear solvation-free energy relationships (LSER), i.e., Kamlet-Taft and Catalan models. A linear free energy relationship (LFER) in the form of single substituent parameter equations (SSP) was used to postulate quantitative structure-property relations of substituent effect on NMR data. TD-DFT results showed dependence of electronic transition on the substituent effects. The push-pull character of these compounds was analyzed by differences in C-13 chemical shift of the ethylenic double bond in 2- and 6-positions of cross-conjugated with pyridinum central ring. Also, the quotient of the occupations for the bonding pi and anti-bonding pi* orbitals of this bond was considered. Good correlations of the selected parameter between double bond lengths with pi*/pi and C-13 chemical shift differences of the bridging group proved them to be adequate descriptor of push-pull character. Synthesized compounds were screened for the antioxidant activity, using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical methods, and results demonstrated moderate antioxidant potential.",
publisher = "Springer",
journal = "Journal of the Iranian Chemical Society",
title = "Solvent, structural, quantum chemical study and antioxidative activity of symmetrical 1-methyl-2,6-bis[2-(substituted phenyl)ethenyl]pyridinium iodides",
volume = "15",
number = "11",
pages = "2483-2501",
doi = "10.1007/s13738-018-1437-5"
}

Milošević, M., Prlainović, N., Milčić, M., Nikolić, V., Božić, A., Bigović, M.,& Marinković, A.. (2018). Solvent, structural, quantum chemical study and antioxidative activity of symmetrical 1-methyl-2,6-bis[2-(substituted phenyl)ethenyl]pyridinium iodides. in Journal of the Iranian Chemical Society
Springer., 15(11), 2483-2501.
https://doi.org/10.1007/s13738-018-1437-5

Milošević M, Prlainović N, Milčić M, Nikolić V, Božić A, Bigović M, Marinković A. Solvent, structural, quantum chemical study and antioxidative activity of symmetrical 1-methyl-2,6-bis[2-(substituted phenyl)ethenyl]pyridinium iodides. in Journal of the Iranian Chemical Society. 2018;15(11):2483-2501.
doi:10.1007/s13738-018-1437-5 .

Milošević, Milena, Prlainović, Nevena, Milčić, Miloš, Nikolić, Vesna, Božić, Aleksandra, Bigović, Miljan, Marinković, Aleksandar, "Solvent, structural, quantum chemical study and antioxidative activity of symmetrical 1-methyl-2,6-bis[2-(substituted phenyl)ethenyl]pyridinium iodides" in Journal of the Iranian Chemical Society, 15, no. 11 (2018):2483-2501,
https://doi.org/10.1007/s13738-018-1437-5 . .

TY  - JOUR
AU  - Milosavljević, Milutin
AU  - Babicev, Ljiljana
AU  - Belošević, Svetlana
AU  - Daničić, Dunja
AU  - Milošević, Milena D.
AU  - Rusmirović, Jelena
AU  - Marinković, Aleksandar D.
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3686
AB  - The innovative laboratory procedure for the synthesis of copper(II) hydroxide in the form of the aqueous suspension was developed. The reaction mechanism consists of the reaction between copper(II) sulphate pentahydrate and sodium carbonate by successive ion exchange of carbonate ions with the hydroxide ones in a multistep process. Production of copper(II) carbonate and sodium sulphate by reacting of copper(II) sulphate with sodium carbonate was followed by addition of sodium hydroxide solution whereby the product, copper(II) hydroxide, was obtained by releasing an equimolar amount of sodium carbonate. It was determined that, the equimolar reaction of copper(II) sulphate and sodium hydroxide lead to the maximal reactants exploitation. Sodium phosphate, formed in the final process stage by addition of 10 % phosphoric acid solution, acted as a copper(II) hydroxide stabilizer. High yield of the product was obtained by optimizing the synthesis parameters: reaction time, molar ratio of reactants and the reaction temperature. The obtained product was formulated to obtain a commercial product, which is used as a fungicide and bactericide.
AB  - U radu je predstavljena inovativna laboratorijska procedura za sintezu bakar(II)-hidroksida u obliku vodene suspenzije. Procedura se zasniva na reakciji između bakar(II)-sulfata pentahidrata i natrijum-hidroksida. Mehanizam reakcije se sastoji iz sukcesivne jonske izmene karbonatnih jona sa hidroksidnim jonima i odvija se u više stupnjeva. Prvi stupanj predstavlja proizvodnju bakar(II)-karbonata i natrijum-sulfata reakcijom bakar(II)-sulfata sa natrijum-karbonatom, nakon čega sledi dodavanje rastvora natrijum-hidroksida, pri čemu se proizvod, bakar(II)-hidroksid, dobija oslobađanjem ekvimolarne količine natrijum-karbonata. Potom sledi ekvimolarna reakcija bakar(II)-sulfata i natrijum-hidroksida koja dovodi do maksimalnog iskorišćenja reaktanata. Natrijum fosfat, formiran u završnoj fazi procesa dodavanjem 10 % rastvora fosforne kiseline, deluje kao stabilizator bakar(II)-hidroksida. Visok prinos proizvoda dobija se optimizacijom parametara sinteze: vremena reakcije, molarnog odnosa reaktanata i temperature reakcije, a sam proizvod je formulisan radi dobijanja komercijalnog proizvoda koji se koristi kao fungicid i baktericid.
PB  - Association of Chemists and Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - Innovative environmentally friendly technology for copper(II) hydroxide production
T1  - Inovativna ekološki prihvatljiva tehnologija proizvodnje bakar(II)-hidroksida
VL  - 72
IS  - 6
SP  - 363
EP  - 370
DO  - 10.2298/HEMIND180630023M
ER  - 

@article{
author = "Milosavljević, Milutin and Babicev, Ljiljana and Belošević, Svetlana and Daničić, Dunja and Milošević, Milena D. and Rusmirović, Jelena and Marinković, Aleksandar D.",
year = "2018",
abstract = "The innovative laboratory procedure for the synthesis of copper(II) hydroxide in the form of the aqueous suspension was developed. The reaction mechanism consists of the reaction between copper(II) sulphate pentahydrate and sodium carbonate by successive ion exchange of carbonate ions with the hydroxide ones in a multistep process. Production of copper(II) carbonate and sodium sulphate by reacting of copper(II) sulphate with sodium carbonate was followed by addition of sodium hydroxide solution whereby the product, copper(II) hydroxide, was obtained by releasing an equimolar amount of sodium carbonate. It was determined that, the equimolar reaction of copper(II) sulphate and sodium hydroxide lead to the maximal reactants exploitation. Sodium phosphate, formed in the final process stage by addition of 10 % phosphoric acid solution, acted as a copper(II) hydroxide stabilizer. High yield of the product was obtained by optimizing the synthesis parameters: reaction time, molar ratio of reactants and the reaction temperature. The obtained product was formulated to obtain a commercial product, which is used as a fungicide and bactericide., U radu je predstavljena inovativna laboratorijska procedura za sintezu bakar(II)-hidroksida u obliku vodene suspenzije. Procedura se zasniva na reakciji između bakar(II)-sulfata pentahidrata i natrijum-hidroksida. Mehanizam reakcije se sastoji iz sukcesivne jonske izmene karbonatnih jona sa hidroksidnim jonima i odvija se u više stupnjeva. Prvi stupanj predstavlja proizvodnju bakar(II)-karbonata i natrijum-sulfata reakcijom bakar(II)-sulfata sa natrijum-karbonatom, nakon čega sledi dodavanje rastvora natrijum-hidroksida, pri čemu se proizvod, bakar(II)-hidroksid, dobija oslobađanjem ekvimolarne količine natrijum-karbonata. Potom sledi ekvimolarna reakcija bakar(II)-sulfata i natrijum-hidroksida koja dovodi do maksimalnog iskorišćenja reaktanata. Natrijum fosfat, formiran u završnoj fazi procesa dodavanjem 10 % rastvora fosforne kiseline, deluje kao stabilizator bakar(II)-hidroksida. Visok prinos proizvoda dobija se optimizacijom parametara sinteze: vremena reakcije, molarnog odnosa reaktanata i temperature reakcije, a sam proizvod je formulisan radi dobijanja komercijalnog proizvoda koji se koristi kao fungicid i baktericid.",
publisher = "Association of Chemists and Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "Innovative environmentally friendly technology for copper(II) hydroxide production, Inovativna ekološki prihvatljiva tehnologija proizvodnje bakar(II)-hidroksida",
volume = "72",
number = "6",
pages = "363-370",
doi = "10.2298/HEMIND180630023M"
}

Milosavljević, M., Babicev, L., Belošević, S., Daničić, D., Milošević, M. D., Rusmirović, J.,& Marinković, A. D.. (2018). Innovative environmentally friendly technology for copper(II) hydroxide production. in Hemijska industrija
Association of Chemists and Chemical Engineers of Serbia., 72(6), 363-370.
https://doi.org/10.2298/HEMIND180630023M

Milosavljević M, Babicev L, Belošević S, Daničić D, Milošević MD, Rusmirović J, Marinković AD. Innovative environmentally friendly technology for copper(II) hydroxide production. in Hemijska industrija. 2018;72(6):363-370.
doi:10.2298/HEMIND180630023M .

Milosavljević, Milutin, Babicev, Ljiljana, Belošević, Svetlana, Daničić, Dunja, Milošević, Milena D., Rusmirović, Jelena, Marinković, Aleksandar D., "Innovative environmentally friendly technology for copper(II) hydroxide production" in Hemijska industrija, 72, no. 6 (2018):363-370,
https://doi.org/10.2298/HEMIND180630023M . .

TY  - DATA
AU  - Božić, Aleksandra R.
AU  - Bjelogrlić, Snežana K.
AU  - Novaković, Irena
AU  - Filipovic, Nenad R.
AU  - Petrović, Predrag M.
AU  - Marinković, Aleksandar D.
AU  - Todorović, Tamara
AU  - Cvijetić, Ilija
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4480
AB  - Table S1. Statistics of the PCA model generated after 2 FFD cycle. Table S2. Statistics of 3LV PLS model applying different CV procedures. Table S3. Statistics of the PCA model generated after 2 FFD cycle. Table S4. Statistics of 2LV PLS model applying different CV procedures. Experimental Section: materials, methods, general procedure for synthesis of m-TCHs 1-11, general procedure for synthesis of b-TCHs 12-22,. Antimicrobial activity: agar diffusion method, Broth microdilution antimicrobial assay. Alignment-independent 3D QSAR models. Figure S1. 1H NMR spectrum of 3 in DMSO-d6. Figure S2.13C NMR spectrum of 3 in DMSO-d6. Figure S3. 1H NMR spectrum of 4 in DMSO-d6. Figure S4.13C NMR spectrum of 4 in DMSO-d6. Figure S5. 1H NMR spectrum of 6 in DMSO-d6. Figure S6.13C NMR spectrum of 6 in DMSO-d6. Additional references.
PB  - Wiley
T2  - Chemistryselect
T1  - Supporting information for: "Antimicrobial Activity of Thiocarbohydrazones: Experimental Studies and Alignment-Independent 3D QSAR Models"
UR  - https://hdl.handle.net/21.15107/rcub_cer_4480
ER  - 

@misc{
author = "Božić, Aleksandra R. and Bjelogrlić, Snežana K. and Novaković, Irena and Filipovic, Nenad R. and Petrović, Predrag M. and Marinković, Aleksandar D. and Todorović, Tamara and Cvijetić, Ilija",
year = "2018",
abstract = "Table S1. Statistics of the PCA model generated after 2 FFD cycle. Table S2. Statistics of 3LV PLS model applying different CV procedures. Table S3. Statistics of the PCA model generated after 2 FFD cycle. Table S4. Statistics of 2LV PLS model applying different CV procedures. Experimental Section: materials, methods, general procedure for synthesis of m-TCHs 1-11, general procedure for synthesis of b-TCHs 12-22,. Antimicrobial activity: agar diffusion method, Broth microdilution antimicrobial assay. Alignment-independent 3D QSAR models. Figure S1. 1H NMR spectrum of 3 in DMSO-d6. Figure S2.13C NMR spectrum of 3 in DMSO-d6. Figure S3. 1H NMR spectrum of 4 in DMSO-d6. Figure S4.13C NMR spectrum of 4 in DMSO-d6. Figure S5. 1H NMR spectrum of 6 in DMSO-d6. Figure S6.13C NMR spectrum of 6 in DMSO-d6. Additional references.",
publisher = "Wiley",
journal = "Chemistryselect",
title = "Supporting information for: "Antimicrobial Activity of Thiocarbohydrazones: Experimental Studies and Alignment-Independent 3D QSAR Models"",
url = "https://hdl.handle.net/21.15107/rcub_cer_4480"
}

Božić, A. R., Bjelogrlić, S. K., Novaković, I., Filipovic, N. R., Petrović, P. M., Marinković, A. D., Todorović, T.,& Cvijetić, I.. (2018). Supporting information for: "Antimicrobial Activity of Thiocarbohydrazones: Experimental Studies and Alignment-Independent 3D QSAR Models". in Chemistryselect
Wiley..
https://hdl.handle.net/21.15107/rcub_cer_4480

Božić AR, Bjelogrlić SK, Novaković I, Filipovic NR, Petrović PM, Marinković AD, Todorović T, Cvijetić I. Supporting information for: "Antimicrobial Activity of Thiocarbohydrazones: Experimental Studies and Alignment-Independent 3D QSAR Models". in Chemistryselect. 2018;.
https://hdl.handle.net/21.15107/rcub_cer_4480 .

Božić, Aleksandra R., Bjelogrlić, Snežana K., Novaković, Irena, Filipovic, Nenad R., Petrović, Predrag M., Marinković, Aleksandar D., Todorović, Tamara, Cvijetić, Ilija, "Supporting information for: "Antimicrobial Activity of Thiocarbohydrazones: Experimental Studies and Alignment-Independent 3D QSAR Models"" in Chemistryselect (2018),
https://hdl.handle.net/21.15107/rcub_cer_4480 .

TY  - JOUR
AU  - Božić, Aleksandra R.
AU  - Bjelogrlić, Snežana K.
AU  - Novaković, Irena
AU  - Filipovic, Nenad R.
AU  - Petrović, Predrag M.
AU  - Marinković, Aleksandar D.
AU  - Todorović, Tamara
AU  - Cvijetić, Ilija
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2329
AB  - Due to the rise of microbial strains resistant to conventional therapies, there is an urgent need for finding the new antimicrobial chemotypes. Heterocyclic compounds such as thiocarbohydrazones (TCHs) are able to interact with many metalloenzymes essential for microbes, while sulfur atom increases lipophilicity which is generally positively correlated with potency. In this paper, we report antibacterial and antifungal activity of twenty-two TCHs toward eight bacterial and three fungal strains. Furthermore, three alignment independent 3D QSAR models based on descriptors derived from molecular interaction fields (MIFs) are developed in order to rationalize structure-activity relationships for activities of TCHs toward S. aureus, P. aeruginosa and C. albicans. Several structural fragments important for biological activity are recognized in each model, and structural modifications which could lead to increased potency are suggested. Designed structures will be synthesized accordingly and tested toward the same microbial strains in order to obtain more potent derivatives.
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - Chemistryselect
T1  - Antimicrobial Activity of Thiocarbohydrazones: Experimental Studies and Alignment-Independent 3D QSAR Models
VL  - 3
IS  - 7
SP  - 2215
EP  - 2221
DO  - 10.1002/slct.201702691
ER  - 

@article{
author = "Božić, Aleksandra R. and Bjelogrlić, Snežana K. and Novaković, Irena and Filipovic, Nenad R. and Petrović, Predrag M. and Marinković, Aleksandar D. and Todorović, Tamara and Cvijetić, Ilija",
year = "2018",
abstract = "Due to the rise of microbial strains resistant to conventional therapies, there is an urgent need for finding the new antimicrobial chemotypes. Heterocyclic compounds such as thiocarbohydrazones (TCHs) are able to interact with many metalloenzymes essential for microbes, while sulfur atom increases lipophilicity which is generally positively correlated with potency. In this paper, we report antibacterial and antifungal activity of twenty-two TCHs toward eight bacterial and three fungal strains. Furthermore, three alignment independent 3D QSAR models based on descriptors derived from molecular interaction fields (MIFs) are developed in order to rationalize structure-activity relationships for activities of TCHs toward S. aureus, P. aeruginosa and C. albicans. Several structural fragments important for biological activity are recognized in each model, and structural modifications which could lead to increased potency are suggested. Designed structures will be synthesized accordingly and tested toward the same microbial strains in order to obtain more potent derivatives.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Chemistryselect",
title = "Antimicrobial Activity of Thiocarbohydrazones: Experimental Studies and Alignment-Independent 3D QSAR Models",
volume = "3",
number = "7",
pages = "2215-2221",
doi = "10.1002/slct.201702691"
}

Božić, A. R., Bjelogrlić, S. K., Novaković, I., Filipovic, N. R., Petrović, P. M., Marinković, A. D., Todorović, T.,& Cvijetić, I.. (2018). Antimicrobial Activity of Thiocarbohydrazones: Experimental Studies and Alignment-Independent 3D QSAR Models. in Chemistryselect
Wiley-V C H Verlag Gmbh, Weinheim., 3(7), 2215-2221.
https://doi.org/10.1002/slct.201702691

Božić AR, Bjelogrlić SK, Novaković I, Filipovic NR, Petrović PM, Marinković AD, Todorović T, Cvijetić I. Antimicrobial Activity of Thiocarbohydrazones: Experimental Studies and Alignment-Independent 3D QSAR Models. in Chemistryselect. 2018;3(7):2215-2221.
doi:10.1002/slct.201702691 .

Božić, Aleksandra R., Bjelogrlić, Snežana K., Novaković, Irena, Filipovic, Nenad R., Petrović, Predrag M., Marinković, Aleksandar D., Todorović, Tamara, Cvijetić, Ilija, "Antimicrobial Activity of Thiocarbohydrazones: Experimental Studies and Alignment-Independent 3D QSAR Models" in Chemistryselect, 3, no. 7 (2018):2215-2221,
https://doi.org/10.1002/slct.201702691 . .

TY  - JOUR
AU  - Lović, Jelena
AU  - Stevanović, Sanja
AU  - Anđelković, Boban D.
AU  - Petrovic, S.
AU  - Vukovic, D.
AU  - Prlainović, Nevena Ž.
AU  - Mijin, Dušan
AU  - Nikolić, Nebojša D.
AU  - Avramov Ivić, Milka
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2364
AB  - Glucose biosensor containing cysteine (Cys), glutaraldehyde (GA) and glucose oxidase (GOx) onto gold electrode is constructed and already electrochemically tested. Now, the electrochemical behavior of biosensor in human serum is further investigated and supported by morphological characterization of layers for the first time. The morphology and microstructure of layers was examined by Fourier transformed infra red spectroscopy (FTIR), atomic force (AFM) and optical microscopy (OM). The electrochemical indication that the Cys-GA-GOx film on Au surface is not compact and that there were some bare regions which remain catalytically active is supported by AFM and OM results. The construction and the nature of bonding of Au-Cys-GA-GOx biosensor layers is confirmed by the FTIR study.
PB  - Esg, Belgrade
T2  - International Journal of Electrochemical Science
T1  - Electrochemical glucose biosensor with the characterization of surface morphology and content of glucose oxidase-glutaraldehyde-cysteine layers on gold electrode
VL  - 13
IS  - 12
SP  - 12340
EP  - 12348
DO  - 10.20964/2018.12.59
ER  - 

@article{
author = "Lović, Jelena and Stevanović, Sanja and Anđelković, Boban D. and Petrovic, S. and Vukovic, D. and Prlainović, Nevena Ž. and Mijin, Dušan and Nikolić, Nebojša D. and Avramov Ivić, Milka",
year = "2018",
abstract = "Glucose biosensor containing cysteine (Cys), glutaraldehyde (GA) and glucose oxidase (GOx) onto gold electrode is constructed and already electrochemically tested. Now, the electrochemical behavior of biosensor in human serum is further investigated and supported by morphological characterization of layers for the first time. The morphology and microstructure of layers was examined by Fourier transformed infra red spectroscopy (FTIR), atomic force (AFM) and optical microscopy (OM). The electrochemical indication that the Cys-GA-GOx film on Au surface is not compact and that there were some bare regions which remain catalytically active is supported by AFM and OM results. The construction and the nature of bonding of Au-Cys-GA-GOx biosensor layers is confirmed by the FTIR study.",
publisher = "Esg, Belgrade",
journal = "International Journal of Electrochemical Science",
title = "Electrochemical glucose biosensor with the characterization of surface morphology and content of glucose oxidase-glutaraldehyde-cysteine layers on gold electrode",
volume = "13",
number = "12",
pages = "12340-12348",
doi = "10.20964/2018.12.59"
}

Lović, J., Stevanović, S., Anđelković, B. D., Petrovic, S., Vukovic, D., Prlainović, N. Ž., Mijin, D., Nikolić, N. D.,& Avramov Ivić, M.. (2018). Electrochemical glucose biosensor with the characterization of surface morphology and content of glucose oxidase-glutaraldehyde-cysteine layers on gold electrode. in International Journal of Electrochemical Science
Esg, Belgrade., 13(12), 12340-12348.
https://doi.org/10.20964/2018.12.59

Lović J, Stevanović S, Anđelković BD, Petrovic S, Vukovic D, Prlainović NŽ, Mijin D, Nikolić ND, Avramov Ivić M. Electrochemical glucose biosensor with the characterization of surface morphology and content of glucose oxidase-glutaraldehyde-cysteine layers on gold electrode. in International Journal of Electrochemical Science. 2018;13(12):12340-12348.
doi:10.20964/2018.12.59 .

Lović, Jelena, Stevanović, Sanja, Anđelković, Boban D., Petrovic, S., Vukovic, D., Prlainović, Nevena Ž., Mijin, Dušan, Nikolić, Nebojša D., Avramov Ivić, Milka, "Electrochemical glucose biosensor with the characterization of surface morphology and content of glucose oxidase-glutaraldehyde-cysteine layers on gold electrode" in International Journal of Electrochemical Science, 13, no. 12 (2018):12340-12348,
https://doi.org/10.20964/2018.12.59 . .