TY  - CONF
AU  - Avramović, Nataša
AU  - Simić, Katarina
AU  - Miladinović, Zoran
AU  - Todorović, Nina
AU  - Trifunović, Snežana
AU  - Gavrilović, Aleksandra
AU  - Jovanović, Silvana
AU  - Gođevac, Dejan
AU  - Vujisić, Ljubodrag
AU  - Tešević, Vele
AU  - Tasić, Ljubica
AU  - Mandić, Boris
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7392
AB  - Schizophrenia (SCZ) is a brain disease leading to significant functional impairments and premature death, and it affects 20 million people worldwide. Due to the complexity of this disease including different genetic and environmental factors, there is a lack in understanding pathophysiology and diagnosis of schizophrenia. In order to overcome existing gaps, the establishment of a universal set of SCZ biomarkers has a crucial role. Metabonomic study of serum samples of Serbian patients with schizophrenia (51) and healthy controls (39) by 1H-NMR analyses associated with chemometrics, provided the identification of 26 metabolites/biomarkers for this disorder. The biomarker set including aspartate/aspartic acid, lysine, 2-hydroxybutyric acid, and acylglycerols was established for the first-time in SCZ serum samples of Serbian patients by 1H-NMR experiments. The other 22 identified metabolites are in agreement with the previously confirmed NMR-based serum biomarker sets of Brazilian and/or Chinese patient samples. The same 13 metabolites (lactate/lactic acid, threonine, leucine, isoleucine, valine, glutamine, asparagine, alanine, gamma-aminobutyric acid, choline, glucose, glycine and tyrosine) were established in all SCZ samples from three countries of different ethnicity and geographical origins (Serbia, Brazil and China). These results emphasize the crucial role in the possibility of their application as biomarkers for diagnosis of SCZ, reliable monitoring of treatment response and clinical outcomes.
PB  - International Association of Physical Chemists
C3  - Book of Abstracts, 10th IAPC Meeting Tenth World Conference on Physico-Chemical Methods in Drug Discovery & Sixth World Conference on ADMET and DMPK, September 4-6, 2023, Belgrade, Serbia
T1  - 1H-NMR metabonomic view on schizophrenia
SP  - 68
EP  - 68
UR  - https://hdl.handle.net/21.15107/rcub_cer_7392
ER  - 

@conference{
author = "Avramović, Nataša and Simić, Katarina and Miladinović, Zoran and Todorović, Nina and Trifunović, Snežana and Gavrilović, Aleksandra and Jovanović, Silvana and Gođevac, Dejan and Vujisić, Ljubodrag and Tešević, Vele and Tasić, Ljubica and Mandić, Boris",
year = "2023",
abstract = "Schizophrenia (SCZ) is a brain disease leading to significant functional impairments and premature death, and it affects 20 million people worldwide. Due to the complexity of this disease including different genetic and environmental factors, there is a lack in understanding pathophysiology and diagnosis of schizophrenia. In order to overcome existing gaps, the establishment of a universal set of SCZ biomarkers has a crucial role. Metabonomic study of serum samples of Serbian patients with schizophrenia (51) and healthy controls (39) by 1H-NMR analyses associated with chemometrics, provided the identification of 26 metabolites/biomarkers for this disorder. The biomarker set including aspartate/aspartic acid, lysine, 2-hydroxybutyric acid, and acylglycerols was established for the first-time in SCZ serum samples of Serbian patients by 1H-NMR experiments. The other 22 identified metabolites are in agreement with the previously confirmed NMR-based serum biomarker sets of Brazilian and/or Chinese patient samples. The same 13 metabolites (lactate/lactic acid, threonine, leucine, isoleucine, valine, glutamine, asparagine, alanine, gamma-aminobutyric acid, choline, glucose, glycine and tyrosine) were established in all SCZ samples from three countries of different ethnicity and geographical origins (Serbia, Brazil and China). These results emphasize the crucial role in the possibility of their application as biomarkers for diagnosis of SCZ, reliable monitoring of treatment response and clinical outcomes.",
publisher = "International Association of Physical Chemists",
journal = "Book of Abstracts, 10th IAPC Meeting Tenth World Conference on Physico-Chemical Methods in Drug Discovery & Sixth World Conference on ADMET and DMPK, September 4-6, 2023, Belgrade, Serbia",
title = "1H-NMR metabonomic view on schizophrenia",
pages = "68-68",
url = "https://hdl.handle.net/21.15107/rcub_cer_7392"
}

Avramović, N., Simić, K., Miladinović, Z., Todorović, N., Trifunović, S., Gavrilović, A., Jovanović, S., Gođevac, D., Vujisić, L., Tešević, V., Tasić, L.,& Mandić, B.. (2023). 1H-NMR metabonomic view on schizophrenia. in Book of Abstracts, 10th IAPC Meeting Tenth World Conference on Physico-Chemical Methods in Drug Discovery & Sixth World Conference on ADMET and DMPK, September 4-6, 2023, Belgrade, Serbia
International Association of Physical Chemists., 68-68.
https://hdl.handle.net/21.15107/rcub_cer_7392

Avramović N, Simić K, Miladinović Z, Todorović N, Trifunović S, Gavrilović A, Jovanović S, Gođevac D, Vujisić L, Tešević V, Tasić L, Mandić B. 1H-NMR metabonomic view on schizophrenia. in Book of Abstracts, 10th IAPC Meeting Tenth World Conference on Physico-Chemical Methods in Drug Discovery & Sixth World Conference on ADMET and DMPK, September 4-6, 2023, Belgrade, Serbia. 2023;:68-68.
https://hdl.handle.net/21.15107/rcub_cer_7392 .

Avramović, Nataša, Simić, Katarina, Miladinović, Zoran, Todorović, Nina, Trifunović, Snežana, Gavrilović, Aleksandra, Jovanović, Silvana, Gođevac, Dejan, Vujisić, Ljubodrag, Tešević, Vele, Tasić, Ljubica, Mandić, Boris, "1H-NMR metabonomic view on schizophrenia" in Book of Abstracts, 10th IAPC Meeting Tenth World Conference on Physico-Chemical Methods in Drug Discovery & Sixth World Conference on ADMET and DMPK, September 4-6, 2023, Belgrade, Serbia (2023):68-68,
https://hdl.handle.net/21.15107/rcub_cer_7392 .

TY  - CONF
AU  - Avramović, Nataša
AU  - Simić, Katarina
AU  - Miladinović, Zoran
AU  - Todorović, Nina
AU  - Trifunović, Snežana
AU  - Gavrilović, Aleksandra
AU  - Jovanović, Silvana
AU  - Gođevac, Dejan
AU  - Vujisić, Ljubodrag
AU  - Tešević, Vele
AU  - Tasić, Ljubica
AU  - Mandić, Boris
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7390
AB  - Bipolar disorder (BD) is a mental disorder that causes alteration of mood states including mania, depression, and euthymia and it is ranked as one of the leading causes of disability and premature mortality, with a prevalence of 60 million people worldwide. BD is a heterogenous illness including diverse genetic, environmental, and biochemical factors and its pathophysiology is still largely unknown. Diagnosis of BD exclusively depends on the subjective recognition of symptoms without any objective methods such as a clinical test of biomarker identification, instigating misdiagnosis, inadequate treatments and deficient clinical outcomes. 1H-NMR-based serum metabolomics of Serbian patients with BD (33) and healthy controls (39) contributed to identification of 22 metabolites for this disease. Threonine, aspartate, gamma-aminobutyric acid, 2-hydroxybutyric acid, serine, and mannose make a unique biomarker set, and were confirmed for the first time in BD Serbian serum samples. Additional six identified metabolites (3-hydroxybutyric acid, arginine, lysine, tyrosine, phenylalanine, and glycerol) are in accordance with the previously determined NMR-based sets of serum BD biomarkers in Brazilian and/or Chinese patient samples, while nine identified metabolites (lactate, alanine, valine, leucine, isoleucine, glutamine, glutamate, glucose, and choline) are the same established biomarkers in three different ethnic and geographic origins (Serbia, Brazil, and China). The same confirmed metabolites are an indicator of the right path in discovery of the universal set of BD biomarkers by NMR.
PB  - International Association of Physical Chemists
C3  - Book of Abstracts, 10th IAPC Meeting Tenth World Conference on Physico-Chemical Methods in Drug Discovery & Sixth World Conference on ADMET and DMPK, September 4-6, 2023, Belgrade, Serbia
T1  - 1H-NMR-based serum metabolomics of bipolar disorder patients
SP  - 67
EP  - 67
UR  - https://hdl.handle.net/21.15107/rcub_cer_7390
ER  - 

@conference{
author = "Avramović, Nataša and Simić, Katarina and Miladinović, Zoran and Todorović, Nina and Trifunović, Snežana and Gavrilović, Aleksandra and Jovanović, Silvana and Gođevac, Dejan and Vujisić, Ljubodrag and Tešević, Vele and Tasić, Ljubica and Mandić, Boris",
year = "2023",
abstract = "Bipolar disorder (BD) is a mental disorder that causes alteration of mood states including mania, depression, and euthymia and it is ranked as one of the leading causes of disability and premature mortality, with a prevalence of 60 million people worldwide. BD is a heterogenous illness including diverse genetic, environmental, and biochemical factors and its pathophysiology is still largely unknown. Diagnosis of BD exclusively depends on the subjective recognition of symptoms without any objective methods such as a clinical test of biomarker identification, instigating misdiagnosis, inadequate treatments and deficient clinical outcomes. 1H-NMR-based serum metabolomics of Serbian patients with BD (33) and healthy controls (39) contributed to identification of 22 metabolites for this disease. Threonine, aspartate, gamma-aminobutyric acid, 2-hydroxybutyric acid, serine, and mannose make a unique biomarker set, and were confirmed for the first time in BD Serbian serum samples. Additional six identified metabolites (3-hydroxybutyric acid, arginine, lysine, tyrosine, phenylalanine, and glycerol) are in accordance with the previously determined NMR-based sets of serum BD biomarkers in Brazilian and/or Chinese patient samples, while nine identified metabolites (lactate, alanine, valine, leucine, isoleucine, glutamine, glutamate, glucose, and choline) are the same established biomarkers in three different ethnic and geographic origins (Serbia, Brazil, and China). The same confirmed metabolites are an indicator of the right path in discovery of the universal set of BD biomarkers by NMR.",
publisher = "International Association of Physical Chemists",
journal = "Book of Abstracts, 10th IAPC Meeting Tenth World Conference on Physico-Chemical Methods in Drug Discovery & Sixth World Conference on ADMET and DMPK, September 4-6, 2023, Belgrade, Serbia",
title = "1H-NMR-based serum metabolomics of bipolar disorder patients",
pages = "67-67",
url = "https://hdl.handle.net/21.15107/rcub_cer_7390"
}

Avramović, N., Simić, K., Miladinović, Z., Todorović, N., Trifunović, S., Gavrilović, A., Jovanović, S., Gođevac, D., Vujisić, L., Tešević, V., Tasić, L.,& Mandić, B.. (2023). 1H-NMR-based serum metabolomics of bipolar disorder patients. in Book of Abstracts, 10th IAPC Meeting Tenth World Conference on Physico-Chemical Methods in Drug Discovery & Sixth World Conference on ADMET and DMPK, September 4-6, 2023, Belgrade, Serbia
International Association of Physical Chemists., 67-67.
https://hdl.handle.net/21.15107/rcub_cer_7390

Avramović N, Simić K, Miladinović Z, Todorović N, Trifunović S, Gavrilović A, Jovanović S, Gođevac D, Vujisić L, Tešević V, Tasić L, Mandić B. 1H-NMR-based serum metabolomics of bipolar disorder patients. in Book of Abstracts, 10th IAPC Meeting Tenth World Conference on Physico-Chemical Methods in Drug Discovery & Sixth World Conference on ADMET and DMPK, September 4-6, 2023, Belgrade, Serbia. 2023;:67-67.
https://hdl.handle.net/21.15107/rcub_cer_7390 .

Avramović, Nataša, Simić, Katarina, Miladinović, Zoran, Todorović, Nina, Trifunović, Snežana, Gavrilović, Aleksandra, Jovanović, Silvana, Gođevac, Dejan, Vujisić, Ljubodrag, Tešević, Vele, Tasić, Ljubica, Mandić, Boris, "1H-NMR-based serum metabolomics of bipolar disorder patients" in Book of Abstracts, 10th IAPC Meeting Tenth World Conference on Physico-Chemical Methods in Drug Discovery & Sixth World Conference on ADMET and DMPK, September 4-6, 2023, Belgrade, Serbia (2023):67-67,
https://hdl.handle.net/21.15107/rcub_cer_7390 .